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1.发明授权Use of angiogenin or angiogenin agonists for treating diseases and disorders 有权使用血管生成素或血管生成素激动剂治疗疾病和病症公开(公告)号：US09119818B2
公开(公告)日：2015-09-01
申请号：US12992501
申请日：2009-05-14
Applicant: Matthew McDonagh , Benjamin Cocks , Angus Tester , Peter Hobman
Inventor： Matthew McDonagh , Benjamin Cocks , Angus Tester , Peter Hobman
CPC classification number: A61K38/465 , A23K20/142 , A23L33/19 , A61K9/0053 , A61K35/20 , A61K38/1709 , A61K38/1891 , C12Y301/27 , A61K2300/00
Abstract: The invention provides a method of treating a disorder characterized by elevated or dysregulated myostatin, disorders where the interaction between follistatin and angiogenin can be used to improve function in tissues, neurological diseases or disorders, spinal injuries or diseases, bone diseases or disorders, diseases involving glucose homeostasis, wound healing, neuroprotection, nervous system functional support or managing metabolic diseases, the method comprising administering an effective amount of angiogenin or an angiogenin agonist. Compositions and neutraceuticals comprising angiogenin are also provided.
Abstract translation: 本发明提供了一种治疗以升高或失调的肌生长抑制素为特征的疾病的方法，其中卵泡抑素和血管生成素之间的相互作用可用于改善组织，神经系统疾病或病症，脊髓损伤或疾病，骨疾病或病症中涉及的疾病， 葡萄糖体内平衡，伤口愈合，神经保护，神经系统功能支持或代谢疾病的治疗，所述方法包括施用有效量的血管生成素或血管生成素激动剂。 还提供了包含血管生成素的组合物和营养物质。
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公开(公告)号：US08383125B2
公开(公告)日：2013-02-26
申请号：US12294000
申请日：2007-03-23
Applicant: Benjamin Cocks , Jianghui Wang , Jane Whitley
Inventor： Benjamin Cocks , Jianghui Wang , Jane Whitley
IPC: A61K39/00 , A61K38/00 , A01N63/00 , A01N25/34 , C07K1/00 , C07K14/00 , C07K17/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K16/00
CPC classification number: C07K14/47 , A61K38/00 , Y02A50/473 , Y02A50/481
Abstract: The present invention provides improved antimicrobial compositions comprising peptide fragments of tammar wallaby milk proteins and analogs and derivatives thereof exemplified by the amino acid sequences of SEQ ID Nos: 1-40 and uses therefor in the treatment of a range of infections by bacteria and fungi. The antimicrobial compositions are particularly useful for broad spectrum applications, especially for the treatment of bacterial infections.
Abstract translation: 本发明提供了改进的抗微生物组合物，其包含塔马尔母乳蛋白质的肽片段及其类似物及其衍生物，其由SEQ ID NO：1-40的氨基酸序列示例，并用于治疗细菌和真菌的一系列感染。 抗微生物组合物特别适用于广谱应用，特别是用于治疗细菌感染。
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公开(公告)号：US20110209228A1
公开(公告)日：2011-08-25
申请号：US12736143
申请日：2009-03-13
Applicant: Benjamin Cocks , German Spangenberg , Jianghui Wang
Inventor： Benjamin Cocks , German Spangenberg , Jianghui Wang
IPC: A61K38/02 , C07K2/00 , A61K31/7088 , A61P31/04 , A61P11/00 , A61P1/00 , C12N15/63 , C12N7/01 , A01K67/00 , C12P21/00 , C12N5/10 , A23C9/12
CPC classification number: C07K14/4723 , A01K67/0275 , A01K2217/052 , A01K2217/206 , A01K2227/101 , A01K2227/102 , A01K2267/02 , A23C9/123 , A23C9/1322 , A23C2230/15 , A61K38/00 , A61K48/00 , C12N15/8509 , C12N2830/008
Abstract: The present invention provides peptides and analogs and derivatives thereof having antimicrobial activity at least against Streptococcus uberis for the treatment of a range of infectious disease mastitis, otitis externa, clostridial intestinal disease and respiratory disease.
Abstract translation: 本发明提供具有抗微生物活性的肽及其衍生物，其至少针对乳房链球菌，用于治疗一系列感染性疾病乳腺炎，外耳炎，梭菌肠道疾病和呼吸系统疾病。
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4.发明申请USE OF ANGIOGENIN OR ANGIOGENIN AGONISTS FOR TREATING DISEASES AND DISORDERS 有权用于治疗疾病和疾病的血管生成素或神经氨酸激素的使用公开(公告)号：US20110151016A1
公开(公告)日：2011-06-23
申请号：US12992501
申请日：2009-05-14
Applicant: Matthew McDonagh , Benjamin Cocks , Angus Tester , Peter Hobman
Inventor： Matthew McDonagh , Benjamin Cocks , Angus Tester , Peter Hobman
IPC: A61K35/20 , A61K38/14 , A61P21/00 , A61P3/04 , A61P25/00 , A61P19/00 , A61P3/00 , A61P3/08 , A61P17/02 , A61P19/02 , A61P3/02 , A61P3/10
CPC classification number: A61K38/465 , A23K20/142 , A23L33/19 , A61K9/0053 , A61K35/20 , A61K38/1709 , A61K38/1891 , C12Y301/27 , A61K2300/00
Abstract: The invention provides a method of treating a disorder characterised by elevated or dysregulated myostatin, disorders where the interaction between follistatin and angiogenin can be used to improve function in tissues, neurological diseases or disorders, spinal injuries or diseases, bone diseases or disorders, diseases involving glucose homeostasis, wound healing, neuro-protection, nervous system functional support or managing metabolic diseases, the method comprising administering an effective amount of angiogenin or an angiogenin agonist. Compositions and neutraceuticals comprising angiogenin are also provided.
Abstract translation: 本发明提供了一种治疗以升高或失调的肌生长抑制素为特征的疾病的方法，其中卵泡抑素和血管生成素之间的相互作用可用于改善组织，神经系统疾病或病症，脊髓损伤或疾病，骨疾病或病症中涉及的疾病， 葡萄糖体内平衡，伤口愈合，神经保护，神经系统功能支持或管理代谢疾病，所述方法包括施用有效量的血管生成素或血管生成素激动剂。 还提供了包含血管生成素的组合物和营养物质。
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公开(公告)号：US09247766B2
公开(公告)日：2016-02-02
申请号：US12992530
申请日：2009-05-14
Applicant: Matthew McDonagh , Benjamin Cocks , Angus Tester , Peter Hobman , Andrew Brown
Inventor： Matthew McDonagh , Benjamin Cocks , Angus Tester , Peter Hobman , Andrew Brown
CPC classification number: A23L1/3053 , A23J1/20 , A23L33/18 , A23L33/19 , A61K38/00 , C07K14/515
Abstract: The invention provides methods for enriching a milk extract for angiogenin, such methods involving separation by size, charge or immunoaffinity. The invention also provides the angiogenin enriched extract produced by the methods and provides them in pharmaceutical and neutraceutical compositions and foods for treating a variety of diseases or disorders that can be treated by angiogenin.
Abstract translation: 本发明提供了用于富集血管生成素的乳提取物的方法，所述方法涉及通过大小，电荷或免疫亲和力分离。 本发明还提供了通过该方法产生的血管生成素富集的提取物，并将其提供于药物和营养组合物以及用于治疗可被血管生成素治疗的多种疾病或病症的食物。
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Patent Agency Ranking
公开(公告)号：US20130039889A1
公开(公告)日：2013-02-14
申请号：US13510172
申请日：2011-11-18
Applicant: Matthew McDonagh , Benjamin Cocks , Angus Tester , Ross Crittenden
Inventor： Matthew McDonagh , Benjamin Cocks , Angus Tester , Ross Crittenden
CPC classification number: C07K14/4703 , C07K14/515
Abstract: The invention relates to a recombinant microorganism comprising a transgene encoding angiogenin and optionally follistatin, a food product, beverage product or animal feed produced from or comprising said microorganism and uses thereof.
Abstract translation: 本发明涉及包含编码血管生成素和任选的卵泡抑素的转基因的重组微生物，由所述微生物产生或包含所述微生物的食品，饮料产品或动物饲料及其用途。
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公开(公告)号：US20120331575A1
公开(公告)日：2012-12-27
申请号：US13510171
申请日：2010-11-18
Applicant: Peter Hobman , Matthew McDonagh , Benjamin Cocks , Angus Tester
Inventor： Peter Hobman , Matthew McDonagh , Benjamin Cocks , Angus Tester
IPC: A01K67/027 , A61K38/19 , A61P21/00 , A61P19/10 , A61P19/08 , A23L1/32 , A61P29/00 , A61P3/06 , A61D19/04 , A23C9/00 , A23L1/31 , C12N15/85 , A61P25/00
CPC classification number: A61K35/20 , A01K67/0275 , A01K2217/052 , A01K2217/206 , A01K2227/101 , A01K2227/105 , A01K2267/01 , A23C2230/05 , A61K38/00 , C07K14/515 , C12N15/8509 , A61K2300/00
Abstract: The invention provides a non-human transgenic animal comprising a transgene encoding angiogenin and food products comprising or obtained from the non-human transgenic animal and uses thereof.
Abstract translation: 本发明提供一种非人转基因动物，其包含编码血管生成素的转基因和包含非获得性转基因动物及其用途的食品。
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公开(公告)号：US20120328591A1
公开(公告)日：2012-12-27
申请号：US13510167
申请日：2010-11-18
Applicant: Matthew McDonagh , Angus Tester , Benjamin Cocks , Ross Crittenden , Jianghui Wang
Inventor： Matthew McDonagh , Angus Tester , Benjamin Cocks , Ross Crittenden , Jianghui Wang
CPC classification number: C07K14/515 , A61K38/00 , A61K47/64
Abstract: The invention provides a method of improving the oral delivery of a therapeutic agent, comprising the step of linking the therapeutic agent to a carrier protein comprising angiogenin, fusion proteins or conjugates comprising angiogenin and a therapeutic agent and their use in medicine.
Abstract translation: 本发明提供了一种改善治疗剂的口服递送的方法，包括将治疗剂与包含血管生成素，融合蛋白或包含血管生成素和治疗剂的缀合物的载体蛋白质连接的方法及其在药物中的用途。
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公开(公告)号：US20100136172A1
公开(公告)日：2010-06-03
申请号：US12447889
申请日：2007-11-09
Applicant: Andrew Brown , Michelle Rowney , Peter Hobman , Matthew McDonagh , Angus Tester , Benjamin Cocks
Inventor： Andrew Brown , Michelle Rowney , Peter Hobman , Matthew McDonagh , Angus Tester , Benjamin Cocks
IPC: A23C9/146
Abstract: The invention provides a process for the preparation of an angiogenin-enriched fraction from a milk product, the process comprising contacting the milk product with a cation exchange resin and eluting the angiogenin-enriched fraction from the cation exchange resin with a mobile phase. The invention also provides angiogenin-enriched fractions produced by process and food products, neutraceuticals and pharmaceutical comprising such angiogenin.
Abstract translation: 本发明提供了一种从乳制品制备富含血管生成素的级分的方法，该方法包括使乳制品与阳离子交换树脂接触，并用流动相从阳离子交换树脂中洗脱含血管生成素的部分。 本发明还提供了通过方法和食品产生的血管生成素富集级分，包含这种血管生成素的中性药物和药物。
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公开(公告)号：US20050033018A1
公开(公告)日：2005-02-10
申请号：US10477714
申请日：2002-05-16
Applicant: Preeti Lal , Bridget Warren , Yuming Xu , Brendan Duggan , Cynthia Honchell , Deborah Kallick , Mariah Baughn , Y. Tang , Henry Yue , Olga Bandman , Karen Jones , Shanya Becha , Uyen Tran , Janice Au-Young , Jennifer Griffin , Yeganeh Zebarjadian , Ernestie Lee , Vicki Elliott , Kavitha Thangavelu , Jayalaxmi Ramkumar , Yan Lu , April Hafalia , Narinder Chawla , Craig Ison , Michael Thornton , Anita Swarnakar , Junming Yang , Thomas Richardson , Brooke Emerling , Monique Yao , Benjamin Cocks , Bharati Sanjanwala , Patricia Mason , Ameena Gandhi , Joana Li , Rajagopal Gururajan , Kimberly Gietzen , Ian Forsythe
Inventor： Preeti Lal , Bridget Warren , Yuming Xu , Brendan Duggan , Cynthia Honchell , Deborah Kallick , Mariah Baughn , Y. Tang , Henry Yue , Olga Bandman , Karen Jones , Shanya Becha , Uyen Tran , Janice Au-Young , Jennifer Griffin , Yeganeh Zebarjadian , Ernestie Lee , Vicki Elliott , Kavitha Thangavelu , Jayalaxmi Ramkumar , Yan Lu , April Hafalia , Narinder Chawla , Craig Ison , Michael Thornton , Anita Swarnakar , Junming Yang , Thomas Richardson , Brooke Emerling , Monique Yao , Benjamin Cocks , Bharati Sanjanwala , Patricia Mason , Ameena Gandhi , Joana Li , Rajagopal Gururajan , Kimberly Gietzen , Ian Forsythe
IPC: G01N33/50 , A61K45/00 , A61K49/00 , A61P1/00 , A61P3/00 , A61P25/00 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/06 , C07K14/47 , C07K14/705 , C07K16/28 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/02 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C07H21/04
CPC classification number: C07K14/705 , C07K14/47
Abstract: The invention provides human receptors and membrane-associated proteins (REMAP) and polynucleotides which identify and encode REMAP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of REMAP.
Abstract translation: 本发明提供鉴定和编码REMAP的人受体和膜相关蛋白（REMAP）和多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供用于诊断，治疗或预防与REMAP的异常表达相关的紊乱的方法。
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