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76 条记录 (耗时 0.033 秒)

    Plasmodium falciparum merozoite antigen peptides
    71.
    发明授权
    Plasmodium falciparum merozoite antigen peptides 失效
    PLASMODIUM FALCIPARUM MEROZOITE抗原肽

    公开(公告)号：US5238836A

    公开(公告)日：1993-08-24

    申请号：US167811

    申请日：1988-03-14

    申请人： Ulrich Certa ,  Reiner Gentz ,  Bela Takacs

    发明人： Ulrich Certa ,  Reiner Gentz ,  Bela Takacs

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K39/00 ,  A61K39/015 ,  A61P33/02 ,  A61P37/04 ,  C07K1/22 ,  C07K14/00 ,  C07K14/44 ,  C07K14/445 ,  C07K14/76 ,  C07K16/00 ,  C07K19/00 ,  C12N1/21 ,  C12P21/00 ,  C12P21/02 ,  C12P21/08 ,  C12R1/125 ,  C12R1/19

    CPC分类号： C07K14/445 ,  A61K39/00 ,  C07K2319/00 ,  C07K2319/40

    摘要： The present invention provides polypeptides having an amino acid sequence derived from the 190 kD precursor to the major merozoite surface antigens of the K1 isolate of Plasmodium falciparum. These polypeptides are capable of eliciting an immune response against different isolates of Plasmodium falciparum. The invention further provides immunogenic compositions and vaccines containing such polypeptides, antibodies raised against the polypeptides. a DNA sequence coding for one of the polypeptides, a replicable microbial vector containing such a DNA sequence and a microorganism transformed with such a vector. The invention also provides processes for the production of the polypeptides, immunogenic compositions, microorganisms and antibodies of the invention and for the use of the polypeptides and immunogenic compositions for the immunization of mammals against malaria.

    摘要翻译： 本发明提供具有衍生自恶性疟原虫K1分离株的主要裂殖子表面抗原的190kD前体的氨基酸序列的多肽。 这些多肽能够引发针对恶性疟原虫不同分离株的免疫应答。 本发明还提供了含有这种多肽的免疫原性组合物和疫苗，针对多肽产生的抗体。 编码多肽之一的DNA序列，含有这样的DNA序列的可复制微生物载体和用这种载体转化的微生物。 本发明还提供了生产本发明的多肽，免疫原性组合物，微生物和抗体以及用于免疫哺乳动物免于疟疾的多肽和免疫原性组合物的方法。

    Human TNF receptor
    73.
    发明授权
    Human TNF receptor 失效
    人类TNF受体

    公开(公告)号：US08163522B1

    公开(公告)日：2012-04-24

    申请号：US08444791

    申请日：1995-05-19

    申请人： Manfred Brockhaus ,  Reiner Gentz ,  Dembic Zlatko ,  Werner Lesslauer ,  Hansruedi Lotscher ,  Ernst-Jurgen Schlaeger

    发明人： Manfred Brockhaus ,  Reiner Gentz ,  Dembic Zlatko ,  Werner Lesslauer ,  Hansruedi Lotscher ,  Ernst-Jurgen Schlaeger

    IPC分类号： C12N15/12 ,  C12N15/63 ,  C12N5/10 ,  C12P21/00

    CPC分类号： C07K14/7151 ,  C07K16/2866 ,  C12N2799/026 ,  Y10S930/144

    摘要： The present invention is concerned with non-soluble proteins and soluble or insoluble fragments thereof, which bind TNF, in homogeneous form, as well as their physiologically compatible salts, especially those proteins having a molecular weight of about 55 or 75 kD (non-reducing SDS-PAGE conditions), a process for the isolation of such proteins, antibodies against such proteins, DNA sequences which code for non-soluble proteins and soluble or non-soluble fragments thereof, which bind TNF, as well as those which code for proteins comprising partly of a soluble fragment, which binds TNF, and partly of all domains except the first of the constant region of the heavy chain of human immunoglobulins and the recombinant proteins coded thereby as well as a process for their manufacture using transformed pro- and eukaryotic host cells.

    摘要翻译： 本发明涉及不溶性蛋白质及其可溶性或不溶性片段，其以均质形式结合TNF，以及它们的生理相容性盐，特别是分子量为约55或75kD的蛋白质（非还原型 SDS-PAGE条件），分离这些蛋白质的方法，针对这些蛋白质的抗体，编码结合TNF的不溶性蛋白质的DNA序列和可溶性或非可溶性片段，以及编码蛋白质的蛋白质 其部分包含结合TNF的可溶性片段，以及部分除了人免疫球蛋白重链的恒定区域的第一个区域以外的所有结构域，以及由此编码的重组蛋白质以及其使用转化的真核和真核生物的方法 宿主细胞。

    Human TNF receptor fusion protein
    74.
    发明授权
    Human TNF receptor fusion protein 失效
    人TNF受体融合蛋白

    公开(公告)号：US08063182B1

    公开(公告)日：2011-11-22

    申请号：US08444790

    申请日：1995-05-19

    申请人： Manfred Brockhaus ,  Reiner Gentz ,  Dembic Zlatko ,  Werner Lesslauer ,  Hansruedi Lotscher ,  Ernst-Jurgen Schlaeger

    发明人： Manfred Brockhaus ,  Reiner Gentz ,  Dembic Zlatko ,  Werner Lesslauer ,  Hansruedi Lotscher ,  Ernst-Jurgen Schlaeger

    IPC分类号： C07K14/715 ,  A61P29/00 ,  A61K38/17 ,  C07K19/00 ,  C07H21/04

    CPC分类号： C07K14/7151 ,  C07K16/2866 ,  C12N2799/026 ,  Y10S930/144

    摘要： The present invention is concerned with non-soluble proteins and soluble or insoluble fragments thereof, which bind TNF, in homogeneous form, as well as their physiologically compatible salts, especially those proteins having a molecular weight of about 55 or 75 kD (non-reducing SDS-PAGE conditions), a process for the isolation of such proteins, antibodies against such proteins, DNA sequences which code for non-soluble proteins and soluble or non-soluble fragments thereof, which bind TNF, as well as those which code for proteins comprising partly of a soluble fragment, which binds TNF, and partly of all domains except the first of the constant region of the heavy chain of human immunoglobulins and the recombinant proteins coded thereby as well as a process for their manufacture using transformed pro- and eukaryotic host cells.

    摘要翻译： 本发明涉及不溶性蛋白质及其可溶性或不溶性片段，其以均质形式结合TNF，以及它们的生理相容性盐，特别是分子量为约55或75kD的蛋白质（非还原型 SDS-PAGE条件），分离这些蛋白质的方法，针对这些蛋白质的抗体，编码结合TNF的不溶性蛋白质的DNA序列和可溶性或非可溶性片段，以及编码蛋白质的蛋白质 其部分包含结合TNF的可溶性片段，以及部分除了人免疫球蛋白重链的恒定区域的第一个区域以外的所有结构域，以及由此编码的重组蛋白质以及其使用转化的真核和真核生物的方法 宿主细胞。