公开(公告)号：US07075658B2

公开(公告)日：2006-07-11

申请号：US10765010

申请日：2004-01-26

申请人： Joseph A. Izatt ,  Divakar K. Rao ,  Changhuei Yang ,  Michael A. Choma ,  Siavash Yazdanfar ,  Andrew M. Rollins ,  Brian E. Applegate

发明人： Joseph A. Izatt ,  Divakar K. Rao ,  Changhuei Yang ,  Michael A. Choma ,  Siavash Yazdanfar ,  Andrew M. Rollins ,  Brian E. Applegate

IPC分类号： G01B9/02

CPC分类号： G01B9/02004 ,  G01B9/02002 ,  G01B9/02007 ,  G01B9/02014 ,  G01B9/02044 ,  G01B9/02069 ,  G01B9/02091 ,  G01B2290/70

摘要： Spatial information, such as concentration and displacement, about a specific molecular contrast agent, may be determined by stimulating a sample containing the agent, thereby altering an optical property of the agent. A plurality of optical coherence tomography (OCT) images may be acquired, at least some of which are acquired at different stimulus intensities. The acquired images are used to profile the molecular contrast agent concentration distribution of the sample.

摘要翻译： 关于特定分子造影剂的空间信息，例如浓度和位移可以通过刺激含有试剂的样品来确定，从而改变试剂的光学性质。 可以获取多个光学相干断层摄影（OCT）图像，其中至少一些在不同的刺激强度下被获取。 采集的图像用于分析样品的分子造影剂浓度分布。

公开(公告)号：US07061622B2

公开(公告)日：2006-06-13

申请号：US10213326

申请日：2002-08-05

申请人： Andrew M. Rollins ,  Joseph A. Izatt ,  Volker Westphal ,  Siavash Yazdanfar

发明人： Andrew M. Rollins ,  Joseph A. Izatt ,  Volker Westphal ,  Siavash Yazdanfar

IPC分类号： G01B9/02

CPC分类号： G01N21/4795 ,  A61B5/0066 ,  G01B11/2441

摘要： An optical coherence tomography (OCT) system including an interferometer provides illuminating light along a first optical path to a sample and an optical delay line and collects light from the sample along a second optical path remitted at several scattering angles to a detector. In one embodiment, illuminating light is directed along a number of incident light paths through a focusing lens to a sample. The light paths and focusing lens are related to the sample and to both the incident light source and the detector. In another embodiment, a focusing system directs light to a location in the sample. A transmission grating or acousto-optic modulator directs light from the sample at an angle representative of the wavelength of the incident light on the transmission grating or acousto-optic modulator.

公开(公告)号：US06735463B2

公开(公告)日：2004-05-11

申请号：US09468674

申请日：1999-12-21

申请人： Joseph A. Izatt ,  Manish D. Kulkarni ,  Siavash Yazdanfar ,  Andrew Rollins ,  Michael V. Sivak

发明人： Joseph A. Izatt ,  Manish D. Kulkarni ,  Siavash Yazdanfar ,  Andrew Rollins ,  Michael V. Sivak

IPC分类号： A61B502

CPC分类号： A61B5/0073 ,  A61B5/0066 ,  A61B5/7257 ,  G01B9/02045 ,  G01B9/02069 ,  G01B9/02071 ,  G01B9/02072 ,  G01B9/02083 ,  G01B9/02091 ,  G01B2290/35 ,  G01B2290/60

摘要： A method for generating a velocity-indicating, tomographic image of a sample in an optical coherence tomography system includes the steps of (a) acquiring cross-correlation data from the interferometer; (b) generating a grayscale image from the cross-correlation data indicative of a depth-dependent positions of scatterers in the sample; (c) processing the cross-correlation data to produce a velocity value and location of a moving scatterer in the sample; (d) assigning a color to the velocity value; and (f) merging the color into the grayscale image, at a point in the grayscale image indicative of the moving scatterer's location, to produce a velocity-indicating, tomographic image. Preferably a first color is assigned for a positive velocity value and a second color is assigned for a negative velocity value.

摘要翻译： 一种用于在光学相干断层摄影系统中产生样本的速度指示断层图像的方法包括以下步骤：（a）从干涉仪获取互相关数据; （b）从指示样品中散射体的深度相关位置的互相关数据中生成灰度图像; （c）处理互相关数据以产生样品中运动散射体的速度值和位置; （d）为速度值分配颜色; 以及（f）在指示运动散射体位置的灰度图像中将颜色合并成灰度图像，以产生速度指示的断层图像。 优选地，将第一颜色分配给正速度值，并且将第二颜色分配给负速度值。

公开(公告)号：US06657727B1

公开(公告)日：2003-12-02

申请号：US09393761

申请日：1999-09-10

申请人： Joseph A. Izatt ,  Andrew M. Rollins

发明人： Joseph A. Izatt ,  Andrew M. Rollins

IPC分类号： G01B902

CPC分类号： G01B9/02091 ,  G01B9/02022 ,  G01B2290/35 ,  G01B2290/70 ,  G01N21/4795

摘要： An interferometer system includes an optical radiation source, an optical circulator connected between the optical radiation source and a sample location for transmitting optical radiation from the optical radiation source to the sample location, an output of the optical circulator connected to direct optical radiation to an optical detector. Various embodiments of such a system are possible. A method of performing OCDR or OCT imaging of a sample which involves the steps of: (a) producing low coherence optical radiation; (b) directing at least some of the low coherence optical radiation through an optical circulator to the sample; (c) reflecting at least some of the low coherence optical radiation off of the sample; and (d) detecting at least some of the reflected low coherence optical radiation and producing an electrical signal corresponding thereto.

摘要翻译： 干涉仪系统包括光辐射源，连接在光辐射源和用于将光辐射从光辐射源传送到采样位置的采样位置之间的光循环器，连接到直接光辐射的光循环器的输出到光学 探测器。 这种系统的各种实施例是可能的。 执行样本的OCDR或OCT成像的方法，其包括以下步骤：（a）产生低相干光辐射; （b）将至少一些低相干光辐射通过光循环器引导到样品; （c）反射离开样品的至少一些低相干光辐射; 和（d）检测至少一些反射的低相干光辐射并产生与其对应的电信号。

公开(公告)号：US20160338589A1

公开(公告)日：2016-11-24

申请号：US15113800

申请日：2015-01-30

申请人： Oscar M. CARRASCO-ZEVALLOS ,  Joseph A. IZATT ,  Christian B. VIEHLAND ,  Ryan MCNABB ,  DUKE UNIVERSITY

发明人： Oscar M. Carrasco-Zevallos ,  Joseph A. Izatt ,  Christian B. Viehland ,  Ryan McNabb

IPC分类号： A61B3/15 ,  A61B3/117 ,  A61B3/12 ,  A61B3/10 ,  A61B3/113

摘要： Systems and methods for eye tracking for motion corrected ophthalmic optical coherence tomography (OCT) are disclosed. According to an aspect, an imaging system includes an eye tracking device configured to determine movement of an eye. The imaging system also includes an OCT apparatus configured to generate OCT images of a retina of the eye. The OCT apparatus includes a scanner operable to be moved for relocating an OCT scan pivot at a pupil plane for image capture and during capture of the OCT images. The imaging system also includes a controller configured to control the scanner to relocate the OCT scan pivot at the pupil plane based on the determined movement of the eye.

摘要翻译： 公开了用于运动矫正眼用光学相干断层扫描（OCT）的眼睛跟踪的系统和方法。 根据一个方面，成像系统包括被配置为确定眼睛移动的眼睛跟踪装置。 成像系统还包括被配置为产生眼睛视网膜的OCT图像的OCT装置。 OCT设备包括可操作以移动以用于在瞳平面处重新定位OCT扫描枢轴用于图像捕获和在OCT图像的捕获期间的扫描仪。 成像系统还包括控制器，其被配置为基于所确定的眼睛的运动来控制扫描仪在瞳孔平面处重新定位OCT扫描枢轴。

公开(公告)号：US20120092615A1

公开(公告)日：2012-04-19

申请号：US13010497

申请日：2011-01-20

申请人： Joseph A. Izatt ,  Yuankai K. Tao ,  Cynthia A. Toth

发明人： Joseph A. Izatt ,  Yuankai K. Tao ,  Cynthia A. Toth

IPC分类号： A61B3/14 ,  A61B3/12 ,  G01B9/02

CPC分类号： G01B9/02091 ,  A61B3/102 ,  A61B3/13 ,  G01B9/0203

摘要： A surgical microscope assembly includes a microscope main objective and microscope imaging optics. The microscope main objective and microscope imaging optics define a viewing beam path that passes from a sample through the microscope main objective and the microscope imaging optics. The assembly includes an optical coherence tomography (OCT) unit having an illumination beam and a collection beam and a beamsplitter between the microscope main objective and the microscope imaging optics. The beamsplitter is configured to direct a portion of light from the microscope main objective to the microscope imaging optics and to direct another portion of light from the microscope main objective to the OCT unit collection beam. The beamsplitter is further configured to direct an illumination beam from the OCT unit to the microscope main objective and to the sample. A beam forming unit is between the OCT unit and the beamsplitter. The beam forming unit is configured to form the illumination beam of the OCT unit so as to generally correspond to a size of the microscope main objective.

摘要翻译： 手术显微镜组件包括显微镜主要目标和显微镜成像光学元件。 显微镜主要目标和显微镜成像光学器件定义了从样品通过显微镜主要目标和显微镜成像光学器件的观察光束路径。 组件包括具有照明光束和收集光束的光学相干断层摄影（OCT）单元和在显微镜主要物镜和显微镜成像光学器件之间的分束器。 分束器被配置为将来自显微镜主物镜的光的一部分引导到显微镜成像光学器件，并将来自显微镜主物镜的另一部分光引导到OCT单元收集光束。 分束器还被配置成将来自OCT单元的照明光束引导到显微镜主目标和样品。 光束形成单元位于OCT单元和分束器之间。 光束形成单元被配置为形成OCT单元的照明光束，以便大致对应于显微镜主要物镜的尺寸。

公开(公告)号：US08077325B2

公开(公告)日：2011-12-13

申请号：US12634153

申请日：2009-12-09

申请人： Michael Choma ,  Joseph A. Izatt ,  Audrey Ellerbee ,  Marinko Sarunic

发明人： Michael Choma ,  Joseph A. Izatt ,  Audrey Ellerbee ,  Marinko Sarunic

IPC分类号： G01N21/41

CPC分类号： G01N21/4795 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/0073 ,  A61B5/7257 ,  G01B9/02004 ,  G01B9/0203 ,  G01B9/02044 ,  G01B9/02057 ,  G01B9/02083 ,  G01B9/02091 ,  G01J3/2823 ,  G01J3/453 ,  G01N21/39 ,  G01N2021/1787

摘要： Structure profiles from optical interferometric data can be identified by obtaining a plurality of broadband interferometric optical profiles of a structure as a function of structure depth in an axial direction. Each of the plurality of interferometric optical profiles include a reference signal propagated through a reference path and a sample signal reflected from a sample reflector in the axial direction. An axial position corresponding to at least a portion of the structure is selected. Phase variations of the plurality of interferometric optical profiles are determined at the selected axial position. A physical displacement of the structure is identified based on the phase variations at the selected axial position.

摘要翻译： 可以通过获得作为轴向方向上的结构深度的函数的结构的多个宽带干涉光学轮廓来识别来自光学干涉测量数据的结构轮廓。 多个干涉光学轮廓中的每一个包括通过参考路径传播的参考信号和在轴向方向上从样本反射器反射的样本信号。 选择对应于结构的至少一部分的轴向位置。 在所选择的轴向位置处确定多个干涉光学轮廓的相位变化。 基于所选轴向位置处的相位变化来识别结构的物理位移。

公开(公告)号：US20110222020A1

公开(公告)日：2011-09-15

申请号：US13010517

申请日：2011-01-20

申请人： Joseph A. Izatt ,  Ryan P. McNabb ,  Anthony N. Kuo

发明人： Joseph A. Izatt ,  Ryan P. McNabb ,  Anthony N. Kuo

IPC分类号： A61B3/10 ,  G01B11/02

CPC分类号： G01B9/02044 ,  A61B3/102 ,  G01B9/02057 ,  G01B9/02077 ,  G01B9/02091 ,  G01B2290/65

摘要： Methods of reducing motion artifacts in Optical Coherence Tomography (OCT) include scanning a sample with a scan pattern to acquire OCT data at a plurality of data locations. The data locations are distributed in the scan pattern across the sample such that at least some spatially adjacent data locations are acquired non-sequentially in time. A profile of the sample corresponding to a sample surface or an aspect of an internal structure of the sample is estimated responsive the OCT data.

摘要翻译： 减少光学相干层析成像（OCT）中的运动伪影的方法包括用扫描图案扫描样本以在多个数据位置获取OCT数据。 数据位置以扫描图案分布在样本上，使得在时间上非依次获取至少一些空间上相邻的数据位置。 根据OCT数据估计对应于样品表面的样品的轮廓或样品的内部结构的方面。

公开(公告)号：US20110032533A1

公开(公告)日：2011-02-10

申请号：US12799890

申请日：2010-05-04

申请人： Joseph A. Izatt ,  Mingtao Zhao ,  Anthony N. Kuo

发明人： Joseph A. Izatt ,  Mingtao Zhao ,  Anthony N. Kuo

IPC分类号： G01B11/02

CPC分类号： G06T15/00 ,  A61B3/102 ,  G01B9/02083 ,  G01B9/02091 ,  G01B11/2441 ,  G06F19/00 ,  G06T5/006 ,  G06T2207/10101 ,  G06T2207/30041

摘要： Methods and computer program products for quantitative three-dimensional (“3D”) image correction in optical coherence tomography. Using the methods and computer program products, index interface (refracting) surfaces from the raw optical coherence tomography (“OCT”) dataset from an OCT system can be segmented. Normal vectors or partial derivatives of the curvature at a refracting surface can be calculated to obtain a refracted image voxel. A new position of each desired refracted image voxel can be iteratively computed. New refracted corrected voxel positions to an even sampling grid can be interpolated to provide corrected image data. In some embodiments, clinical outputs from the corrected image data can be computed.

摘要翻译： 光学相干断层扫描中定量三维（“3D”）图像校正的方法和计算机程序产品。 使用方法和计算机程序产品，可以对来自OCT系统的原始光学相干断层扫描（“OCT”）数据集的索引接口（折射）表面进行分割。 可以计算折射表面处的曲率的法向矢量或偏导数，以获得折射的图像体素。 可以迭代地计算每个期望的折射图像体素的新位置。 可以将针对均匀采样网格的新的折射校正体素位置进行内插以提供校正的图像数据。 在一些实施例中，可以计算来自校正图像数据的临床输出。

公开(公告)号：US07826059B2

公开(公告)日：2010-11-02

申请号：US10055282

申请日：2002-01-22

申请人： Jonathan E. Roth ,  Joseph A. Izatt ,  Andrew M. Rollins

发明人： Jonathan E. Roth ,  Joseph A. Izatt ,  Andrew M. Rollins

IPC分类号： G01B9/02

CPC分类号： A61B5/0066 ,  A61B5/0073 ,  G01B9/02011 ,  G01B9/02072 ,  G01B9/02091 ,  G01B9/04 ,  G01B2290/70 ,  G01N21/4795 ,  Y10T29/49716

摘要： A method and apparatus for extracting the vector optical properties of biological samples with micron-scale resolution in three dimensions, using polarization-sensitive optical coherence tomography (PS-OCT). The method measures net retardance, net fast axis, and reflectivity. Polarization sensing is accomplished by illuminating the sample with at least three separate polarization states, using consecutive acquisitions of the same pixel, A-scan, or B-scan. The method can be implemented using non-polarization-maintaining fiber and a single detector. This PS-OCT method reported measures fast axis explicitly. In a calibration test of the system, net retardance was measured with an average error of 7.5° (standard deviation 2.2°) over the retardance range 0° to 180°, and fast axis with average error of 4.8° over the range 0° to 180°.

摘要翻译： 一种使用偏振光敏光学相干断层扫描（PS-OCT）三维提取微尺度分辨率的生物样品的矢量光学性质的方法和装置。 该方法测量净延迟，净快轴和反射率。 通过使用相同像素，A扫描或B扫描的连续采集，以至少三个单独的极化状态照射样本来实现极化感测。 该方法可以使用非偏振维持光纤和单个检测器来实现。 这种PS-OCT方法报道了快轴测量。 在系统的校准测试中，在0°至180°的延迟范围内测量平均误差为7.5°（标准偏差2.2°）的净延迟，平均误差为4.8°的快轴在0°至 180°。