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115 条记录 (耗时 0.059 秒)

    Monitoring, preventing, and treating rejection of transplanted organs
    72.
    发明授权
    Monitoring, preventing, and treating rejection of transplanted organs 失效
    监测，预防和治疗移植器官的排斥

    公开(公告)号：US06970741B1

    公开(公告)日：2005-11-29

    申请号：US10246554

    申请日：2002-09-17

    申请人： Todd K. Whitehurst ,  James P. McGivern ,  Kelly H. McClure ,  Goran N. Marnfeldt ,  James R. Thacker

    发明人： Todd K. Whitehurst ,  James P. McGivern ,  Kelly H. McClure ,  Goran N. Marnfeldt ,  James R. Thacker

    IPC分类号： A61M5/00 ,  A61M5/142 ,  A61M5/172 ,  A61N1/00 ,  A61N1/30 ,  A61N1/32

    CPC分类号： A61B5/413 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/41 ,  A61B5/415 ,  A61B5/416 ,  A61B5/418 ,  A61B5/4244 ,  A61B2560/0219 ,  A61M5/14276 ,  A61M5/1723 ,  A61N1/30 ,  A61N1/32

    摘要： An implantable system control unit (SCU) includes means for measuring tissue impedance or other condition to determine allograft health, in order to predict or detect allograft rejection. The SCU also includes at least two electrodes coupled to means for delivering electrical stimulation to a patient within whom the device is implanted, and may also include a reservoir for holding one or more drugs and a driver means for delivering the drug(s) to the patient. In certain embodiments, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one SCU includes a sensor, and the sensed condition is used to adjust stimulation parameters. Alternatively, this sensory “SCU” sounds an alarm, communicates an alarm to an external device, and/or is responsive to queries regarding sensed information, such as tissue impedance.

    摘要翻译： 可植入系统控制单元（SCU）包括用于测量组织阻抗或其他条件以确定同种异体移植物健康的装置，以便预测或检测同种异体移植排斥。 SCU还包括至少两个电极，其耦合到用于将电刺激递送到其中植入该装置的患者的装置，并且还可以包括用于容纳一种或多种药物的储存器和用于将药物递送至 患者。 在某些实施例中，系统能够进行开环和闭环操作。 在闭环操作中，至少一个SCU包括传感器，并且使用感测到的条件来调整刺激参数。 或者，该感官“SCU”发出警报，向外部设备通报警报，和/或响应关于感测信息（例如组织阻抗）的查询。

    Method and apparatus for blanking T-waves from combipolar atrial cardiac signals based on expected T-wave locations
    73.
    发明授权
    Method and apparatus for blanking T-waves from combipolar atrial cardiac signals based on expected T-wave locations 有权
    基于预期的T波位置从组合极心房心脏信号消隐T波的方法和装置

    公开(公告)号：US06711438B1

    公开(公告)日：2004-03-23

    申请号：US10033410

    申请日：2001-10-25

    申请人： Kelly H. McClure ,  Joseph J. Florio ,  Gene A. Bornzin

    发明人： Kelly H. McClure ,  Joseph J. Florio ,  Gene A. Bornzin

    IPC分类号： A61N1362

    CPC分类号： A61N1/368 ,  A61N1/3704

    摘要： The stimulation device blanks T-waves from the atrial channel of an electrical cardiac signal by employing a T-wave blanking interval localized to the expected location and duration of the T-wave. To this end, the stimulation device determines the average interval between an R-wave and a T-wave in the patient in which the device is implanted and also determines the average duration of a T-wave within the patient. A T-wave blanking interval is initiated following the average R-T interval subsequent to detection of an R-wave and lasts for a period of time equal to the average T-wave duration. In this manner, highly localized T-wave blanking is achieved permitting P-waves or other atrial signals to be detected during remaining non-blanked portions of the atrial channel of the cardiac signal at least for the purposes of atrial rate detection. The relatively short T-wave blanking interval of the invention is particularly well suited for use in combipolar sensing systems. Method and apparatus implementations are described.

    摘要翻译： 刺激装置通过采用局限于T波的预期位置和持续时间的T波消隐间隔来消除来自心电信号心房通道的T波。 为此，刺激装置确定在其中植入装置的患者中的R波和T波之间的平均间隔，并且还确定患者内的T波的平均持续时间。 在检测到R波之后的平均R-T间隔之后开始T波消隐间隔，并且持续一段时间等于平均T波持续时间。 以这种方式，实现高度局部化的T波消隐，允许在心脏信号的心房通道的剩余非消隐部分期间检测P波或其他心房信号，至少用于心房率检测。 本发明的相对较短的T波消隐间隔特别适用于组合极检测系统。 描述了方法和装置实现。

    Cardiac wall motion-based automatic capture verification system and method
    74.
    发明授权
    Cardiac wall motion-based automatic capture verification system and method 失效
    基于心脏壁运动的自动捕获验证系统及方法

    公开(公告)号：US5549652A

    公开(公告)日：1996-08-27

    申请号：US152659

    申请日：1993-11-15

    申请人： Kelly H. McClure ,  Sheldon B. Moberg

    发明人： Kelly H. McClure ,  Sheldon B. Moberg

    IPC分类号： A61N1/365 ,  A61N1/37

    CPC分类号： A61N1/3712 ,  A61N1/36578

    摘要： An improved implantable cardiac stimulating device that performs cardiac wall motion-based automatic capture verification system is provided. Pacing pulses of varying energy content are administered to a patient's heart, and the response of the patient's heart is sensed by a cardiac wall motion sensor. The cardiac wall motion sensor provides a signal which is analyzed to determine the patient's capture threshold, defined as the minimum amount of electrical stimulation required to evoke a cardiac contraction. The device then sets the amount of electrical stimulation at a level safely above the measured capture threshold. Capture verification may be performed at predetermined time intervals, on demand, or upon the occurrence of a significant cardiac event. Capture verification can also be performed on every pacing pulse delivered by the implantable cardiac stimulating device.

    摘要翻译： 提供了一种改进的可植入心脏刺激装置，其执行基于心脏壁运动的自动捕获验证系统。 将不同能量的起搏脉冲施用于患者的心脏，并且由心脏壁运动传感器感测患者心脏的反应。 心脏壁运动传感器提供被分析的信号以确定患者的捕获阈值，定义为唤起心脏收缩所需的最小电刺激量。 然后，该装置将电刺激的量设置在高于所测量的捕获阈值的水平。 捕获验证可以按照预定的时间间隔，按需或者发生重要的心脏事件进行。 捕获验证也可以在可植入心脏刺激装置递送的每个起搏脉冲上进行。

    TREATMENT OF MOVEMENT DISORDERS BY BRAIN STIMULATION
    76.
    发明申请
    TREATMENT OF MOVEMENT DISORDERS BY BRAIN STIMULATION 有权
    通过脑刺激治疗运动障碍

    公开(公告)号：US20100331807A1

    公开(公告)日：2010-12-30

    申请号：US12873170

    申请日：2010-08-31

    申请人： Todd K. Whitehurst ,  James P. McGivern ,  Kelly H. McClure

    发明人： Todd K. Whitehurst ,  James P. McGivern ,  Kelly H. McClure

    IPC分类号： A61N1/36 ,  A61M37/00

    CPC分类号： A61M5/14276 ,  A61K9/0085 ,  A61M2205/3523 ,  A61M2205/3569 ,  A61M2210/0693 ,  A61N1/0529 ,  A61N1/0534 ,  A61N1/325 ,  A61N1/36082 ,  A61N1/37205

    摘要： Systems for treating a movement disorder include a system control unit configured to be implanted at least partially within a patient and to generate at least one stimulus in accordance with one or more stimulation parameters adjusted to treat the movement disorder. The systems further include a programmable memory unit in communication with the system control unit and programmed to store the one or more stimulation parameters to at least partially define the stimulus such that the stimulus is configured to treat the movement disorder. A means for applying the stimulus to one or more stimulation sites within the patient is operably connected to the system control unit.

    摘要翻译： 用于治疗运动障碍的系统包括系统控制单元，该系统控制单元被配置为至少部分地植入患者体内，并根据被调整以治疗运动障碍的一个或多个刺激参数产生至少一个刺激。 系统还包括与系统控制单元通信的可编程存储器单元，并被编程为存储一个或多个刺激参数以至少部分地限定刺激，使得刺激被配置为治疗运动障碍。 将刺激施加到患者体内的一个或多个刺激部位的手段可操作地连接到系统控制单元。

    Method and apparatus for detecting natural electrical coherence within the heart and for administering therapy based thereon
    78.
    发明授权
    Method and apparatus for detecting natural electrical coherence within the heart and for administering therapy based thereon 有权
    用于检测心脏内的自然电相干性并用于基于其进行治疗的方法和装置

    公开(公告)号：US06766195B1

    公开(公告)日：2004-07-20

    申请号：US09686630

    申请日：2000-10-10

    申请人： Gene A. Bornzin ,  Peter Boileau ,  Joseph J. Florio ,  John W. Poore ,  Kelly H. McClure

    发明人： Gene A. Bornzin ,  Peter Boileau ,  Joseph J. Florio ,  John W. Poore ,  Kelly H. McClure

    IPC分类号： A61N0118

    CPC分类号： A61N1/3962 ,  A61N1/395

    摘要： Techniques are provided for detecting natural electrical coherence within the heart and for administering or adjusting therapy based upon whether natural electrical coherence is detected. In one example, an implantable cardioverter defibrillator (ICD), upon detecting atrial fibrillation, delays administering an atrial defibrillation pulse until a period of natural electrical coherence is detected between the left and the right atria of the heart. The ICD may further delay the pulse until the ventricles of the heart are refractory so as to help prevent triggering ventricular fibrillation. The pulses are administered at a time selected based upon the period of electrical coherence to reduce the amount of electrical energy required within the pulse to reliably defibrillate the heart. Other types of therapy besides defibrillation therapy such as anti-tachycardia pacing pulses may also be timed based upon detection periods of natural electrical coherence. Method and apparatus embodiments are described.

    摘要翻译： 提供了用于检测心脏内的自然电连贯性的技术，并且用于基于是否检测到自然电连贯来施用或调整治疗。 在一个实例中，在检测心房颤动时，植入式心律转复除颤器（ICD）延迟施用心房除颤脉冲，直到在心脏的左心房和右心房之间检测到自然电相干的时间段。 ICD可以进一步延迟脉冲，直到心脏的心室难以耐受，以便有助于防止触发心室颤动。 在基于电相干周期选择的时间施加脉冲以减少脉冲内所需的电能量以可靠地除颤心脏。 除了除颤疗法之外的其他类型的治疗，如抗心动过速起搏脉冲也可以基于自然电连续性的检测周期来计时。 描述了方法和设备实施例。

    System and method of automatically determining the onsets and ends of cardiac events and far-field signals
    79.
    发明授权
    System and method of automatically determining the onsets and ends of cardiac events and far-field signals 有权
    自动确定心脏事件和远场信号的开始和结束的系统和方法

    公开(公告)号：US06650931B1

    公开(公告)日：2003-11-18

    申请号：US09992740

    申请日：2001-11-14

    申请人： Kelly H. McClure ,  Gene A. Bornzin ,  Junyu Mai

    发明人： Kelly H. McClure ,  Gene A. Bornzin ,  Junyu Mai

    IPC分类号： A61B504

    CPC分类号： A61B5/0452 ,  A61B5/7257

    摘要： A system and method for determining the onset and termination of cardiac events, such as the R-wave, the T-wave and the far-field signals sensed in the atria associated with the R-wave (FFR) and T-wave (FFT). The onset is defined as the time of the first sampled point of the cardiac signal whose magnitude exceeds a pre-defined threshold for the particular event. Once the onset of an event is positively determined, the cardiac signal is sampled at given intervals. The change in magnitude of these sampled points is determined. The termination of the event is identified through an algorithm that compares the difference in magnitude of these sampled points.

    摘要翻译： 用于确定心脏事件的发作和终止的系统和方法，例如与R波（FFR）和T波（FFT）相关联的心房中感测到的R波，T波和远场信号 ）。 起始被定义为心脏信号的第一采样点的时间，其幅度超过特定事件的预定阈值。 一旦确定了事件的开始，就以给定的间隔对心脏信号进行采样。 确定这些采样点的幅度变化。 通过比较这些采样点的幅度差异的算法来识别事件的终止。

    System and method for deriving hemodynamic signals from a cardiac wall motion sensor
    80.
    发明授权
    System and method for deriving hemodynamic signals from a cardiac wall motion sensor 失效
    用于从心脏壁运动传感器导出血液动力学信号的系统和方法

    公开(公告)号：US6009349A

    公开(公告)日：1999-12-28

    申请号：US942237

    申请日：1997-10-01

    申请人： Gabriel Mouchawar ,  Kelly H. McClure ,  Sheldon B. Moberg

    发明人： Gabriel Mouchawar ,  Kelly H. McClure ,  Sheldon B. Moberg

    IPC分类号： A61N1/365 ,  A61N1/39 ,  A61N5/00

    CPC分类号： A61N1/36542 ,  A61N1/3956

    摘要： A processing system and method are provided for deriving an improved hemodynamic indicator from cardiac wall acceleration signals. The cardiac wall acceleration signals are provided by a cardiac wall motion sensor that responds to cardiac mechanical activity. The cardiac wall acceleration signals are integrated over time to derive cardiac wall velocity signals, which are further integrated over time to derive cardiac wall displacement signals. The cardiac wall displacement signals correlate to known hemodynamic indicators, and are shown to be strongly suggestive of hemodynamic performance. An implantable cardiac stimulating device which uses cardiac wall displacement signals to detect and discriminate cardiac arrhythmias is also provided.

    摘要翻译： 提供了一种用于从心脏壁加速度信号导出改进的血液动力学指标的处理系统和方法。 心脏壁加速度信号由响应于心脏机械活动的心脏壁运动传感器提供。 随着时间的推移，心脏壁加速度信号被积分以导出心脏壁速度信号，其随时间进一步积分以导出心脏壁位移信号。 心脏壁位移信号与已知的血液动力学指标相关，并且显示出强烈地提示血流动力学性能。 还提供了使用心脏壁位移信号来检测和区分心律不齐的可植入心脏刺激装置。