公开(公告)号：US06993969B2

公开(公告)日：2006-02-07

申请号：US10808544

申请日：2004-03-25

申请人： Hirofumi Higuchi

发明人： Hirofumi Higuchi

IPC分类号： G01C19/56

CPC分类号： G01C19/5719

摘要： An oscillation type of micro gyro sensor equipped with two vibrators is provided. The gyro sensor has a monitoring electrode, a signal processor, and a driving electrode attached to both the vibrators. The monitoring electrode monitors a vibration of only one of the two vibrators to output signal indicative of the monitored vibration. The signal processor drives the two vibrators in mutually opposite phases, by using the signal from said monitoring electrode. The driving electrode drives both the vibrators on the basis of the two driving signals.

摘要翻译： 提供了配有两个振动器的微型陀螺传感器的振荡型。 陀螺仪传感器具有监测电极，信号处理器和连接到两个振动器的驱动电极。 监视电极仅监测两个振动器中的一个的振动，以输出指示所监视的振动的信号。 信号处理器通过使用来自所述监控电极的信号来驱动两个相互相反相位的振动器。 驱动电极基于两个驱动信号驱动振动器。

公开(公告)号：US6121939A

公开(公告)日：2000-09-19

申请号：US961767

申请日：1997-10-31

申请人： Hiroaki Imaizumi ,  Koji Sakauchi ,  Shuji Hagiwara ,  Hirofumi Higuchi ,  Ryotaro Manabe

发明人： Hiroaki Imaizumi ,  Koji Sakauchi ,  Shuji Hagiwara ,  Hirofumi Higuchi ,  Ryotaro Manabe

IPC分类号： H01Q1/24 ,  H01Q3/18 ,  H01Q5/00 ,  H01Q5/45 ,  H01Q11/08 ,  H01Q13/06 ,  H01Q19/12 ,  H01Q19/17 ,  H01Q21/24 ,  H01Q25/00 ,  H01Q13/00

CPC分类号： H01Q25/007 ,  H01Q1/247 ,  H01Q11/08 ,  H01Q13/065 ,  H01Q19/12 ,  H01Q19/17 ,  H01Q21/245 ,  H01Q25/00 ,  H01Q3/18 ,  H01Q5/45

摘要： When a converter 14 is rotated via a rotation mechanism 17, the arrangement inclination angle of two primary radiators 15a and 15b can be adjusted in the range of 0 to 20 deg. with respect to an axis which is in parallel with the ground. Also the reception polarization angle due to probes of the primary radiators 15a and 15b can be adjusted in the range of 0 to 20 deg. while maintaining a preset difference in polarization angle among the satellites. Therefore, the arrangement inclination angle of the primary radiators 15a and 15b for respectively receiving signals from the two satellites, and the reception polarization angle in the primary radiators 15a and 15b can be simultaneously easily adjusted by rotating the converter 14 via the rotation mechanism 17.

公开(公告)号：US6114143A

公开(公告)日：2000-09-05

申请号：US513968

申请日：1995-09-11

申请人： Yasuyuki Eda ,  Hiroaki Maeda ,  Keiichi Makizumi ,  Kouichi Shiosaki ,  Kiyoshi Osatomi ,  Kazuhiko Kimachi ,  Hirofumi Higuchi ,  Sachio Tokiyoshi

发明人： Yasuyuki Eda ,  Hiroaki Maeda ,  Keiichi Makizumi ,  Kouichi Shiosaki ,  Kiyoshi Osatomi ,  Kazuhiko Kimachi ,  Hirofumi Higuchi ,  Sachio Tokiyoshi

IPC分类号： A61K38/00 ,  C07K16/10 ,  C12P21/04 ,  C12P21/08 ,  C12N15/09 ,  A61K39/395 ,  C12P11/00

CPC分类号： C07K16/1063 ,  A61K38/00 ,  C07K2317/24

摘要： A monoclonal antibody useful for clinical application which recognizes the conserved region of V3-PND region of glycoprotein antigen having a molecular weight of about 1.2.times.10.sup.5 daltons (gp120) on a coating membrane of human immunodeficiency virus (HIV) and which has an ability to neutralize a broad range of various HIV variants, or a fragment thereof, and the chimeric and humanized antibodies derived therefrom are provided. By using as an immunogen a plurality of peptides having PND-Tip region containing the highly conserved GPGR sequence within PND of HIV gp120, a monoclonal antibody having a neutralizing activity to many HIV variants can be prepared. By transplanting the gene fragment coding for the variable region of said monoclonal antibody or complementarity determining region (CDR) of said region to a human antibody gene, a chimeric antibody or a reshaped antibody having an anti-HIV neutralizing activity which are effective for clinical application can be obtained.

摘要翻译： PCT No.PCT / JP94 / 00371 Sec。 371 1995年9月11日第 102（e）1995年9月11日PCT PCT 1994年3月9日PCT公布。 公开号WO94 / 20632 日期1994年9月15日一种可用于临床应用的单克隆抗体，其识别在人免疫缺陷病毒（HIV）的包被膜上具有约1.2×10 5道尔顿（gp120）分子量的糖蛋白抗原的V3-PND区的保守区， 具有中和各种各样的HIV变体或其片段的能力，并且提供了由其衍生的嵌合和人源化抗体。 通过使用多种具有含有HIV gp120的PND内的高度保守的GPGR序列的PND-Tip区的肽，可以制备对许多HIV变体具有中和活性的单克隆抗体。 通过将编码所述区域的所述单克隆抗体或互补决定区（CDR）的可变区的基因片段移植到人抗体基因，嵌合抗体或具有抗HIV中和活性的重构抗体，其对临床应用有效 可以获得。

公开(公告)号：US5434620A

公开(公告)日：1995-07-18

申请号：US127475

申请日：1993-09-28

申请人： Hirofumi Higuchi ,  Yasuaki Makino

发明人： Hirofumi Higuchi ,  Yasuaki Makino

IPC分类号： H04N1/028 ,  H04N1/19 ,  H04N5/217 ,  H04N5/335 ,  H04N5/341 ,  H04N5/357 ,  H04N5/361 ,  H04N5/365 ,  H04N5/369 ,  H04N5/372 ,  H04N5/374 ,  H04N5/376 ,  H04N5/378

CPC分类号： H04N5/3575 ,  H04N5/361 ,  H04N5/365 ,  H04N5/374

摘要： An image sensor can reduce fixed pattern noise (FPN) caused by transistors used for reading pixel signals. The image sensor comprises photodiodes D.sub.1, D.sub.2, . . . connected to a precharge line L.sub.PR through respective precharge transistors (Tr1).sub.1, (Tr1).sub.2 ; and pixel amplification transistors (Tr2).sub.1, (Tr2).sub.2, . . . , one end thereof being connected to a signal read line L.sub.RE, the other end thereof being grounded through respective pixel switching transistors (Tr3).sub.1, (Tr3).sub.2, . . . , and the gates thereof being connected to respective nodes between the precharge transistors Tr1, (Tr1).sub.2, . . . and the photodiodes D.sub.1, D.sub.2, . . . According to signals provided by a timing signal generator 3, the pixel switching transistors (Tr3).sub.1, (Tr3).sub.2, . . . are sequentially turned ON and OFF one after another. During ON and OFF states of each of the pixel switching transistors, a correlated double sampling circuit provides a difference between values read out of the signal read line L.sub.RE.

摘要翻译： 图像传感器可以减少由用于读取像素信号的晶体管引起的固定图案噪声（FPN）。 图像传感器包括光电二极管D1，D2。 。 。 通过相应的预充电晶体管（Tr1）1，（Tr1）2连接到预充电线路LPR; 和像素放大晶体管（Tr2）1，（Tr2）2，...。 。 。 ，其一端连接到信号读取线LRE，其另一端通过各个像素开关晶体管（Tr3）1，（Tr3）2接地。 。 。 ，其栅极连接到预充电晶体管Tr1，（Tr1）2之间的各个节点。 。 。 和光电二极管D1，D2。 。 。 根据由定时信号发生器3提供的信号，像素开关晶体管（Tr3）1，（Tr3）2，...， 。 。 依次顺序地打开和关闭。 在每个像素开关晶体管的ON和OFF状态期间，相关双采样电路提供从信号读取线LRE读出的值之间的差异。

公开(公告)号：US5087736A

公开(公告)日：1992-02-11

申请号：US530089

申请日：1990-05-29

申请人： Hirofumi Higuchi ,  Koichi Kida

发明人： Hirofumi Higuchi ,  Koichi Kida

IPC分类号： C07C67/317 ,  C07C67/20 ,  C07C67/327 ,  C07C69/54

CPC分类号： C07C67/20 ,  C07C67/327

摘要： Disclosed is a process for producing methyl methacrylate which comprises:(I) a step of reacting acetone and prussic acid to form acetonecyanhydrin;(II) a step of hydrating the acetonecyanhydrin obtained in the step (I) to form .alpha.-hydroxyisobutyric acid amide;(III) a step of reacting the .alpha.-hydroxyisobutyric acid amide obtained in the step (II) which methyl formate to form methyl .alpha.-hydroxyisobutyrate and formamide;(IV) a step of dehydrating the methyl .alpha.-hydroxyisobutyrate obtained in the step (III) to form methyl methancrylate; and(V) a step of decomposing the formamide obtained in the step (IV) into ammonia and carbon monoxide.The process can produce methyl methacrylate at high yields without by-production of acidic ammonium sulfate.