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    METHODS AND APPARATUS FOR ENHANCING CARDIAC PACING
    73.
    发明申请
    METHODS AND APPARATUS FOR ENHANCING CARDIAC PACING 有权
    用于增强心脏肥大的方法和装置

    公开(公告)号：US20070219591A1

    公开(公告)日：2007-09-20

    申请号：US11680509

    申请日：2007-02-28

    申请人： Mark Zdeblick ,  Joseph Ruggio

    发明人： Mark Zdeblick ,  Joseph Ruggio

    IPC分类号： A61N1/368

    CPC分类号： A61N1/365 ,  A61B5/02028 ,  A61B5/02055 ,  A61B5/0215 ,  A61B5/02158 ,  A61B5/026 ,  A61B5/14535 ,  A61B5/14539 ,  A61B5/1459 ,  A61B5/6883 ,  A61N1/3627 ,  A61N1/36528 ,  A61N1/3655 ,  A61N1/36557 ,  A61N1/36564 ,  A61N1/36571 ,  A61N1/36585 ,  A61N1/3682 ,  A61N1/3684

    摘要： Methods, apparatus and systems for enhancing cardiac pacing generally provide for measuring at least one cardiac characteristic, calculating at least one cardiac performance parameter based on the measured characteristic(s), and adjusting at least one functional parameter of a cardiac pacing device. Devices may include at least one catheter (such as a multiplexed catheter with one or more sensors and/or actuators), at least one implant (such as a sensor implantable in a heart wall), or a combination of both. Various cardiac performance parameters and/or pacing device performance parameters may be weighted, and the parameters and their respective weights may be used to determine one or more adjustments to be made to the pacing device. In some instances, the adjustments are made automatically.

    摘要翻译： 用于增强心脏起搏的方法，装置和系统通常提供测量至少一个心脏特征，基于所测量的特征来计算至少一个心脏性能参数，以及调整心脏起搏装置的至少一个功能参数。 装置可以包括至少一个导管（例如具有一个或多个传感器和/或致动器的多路导管），至少一个植入物（例如可植入心脏壁的传感器）或两者的组合。 可以对各种心脏性能参数和/或起搏装置性能参数进行加权，并且可以使用参数及其各自的权重来确定对起搏装置进行的一项或多项调整。 在某些情况下，会自动进行调整。

    Methods and apparatus for tissue activation and monitoring
    74.
    发明申请
    Methods and apparatus for tissue activation and monitoring 有权

    公开(公告)号：US20070185537A1

    公开(公告)日：2007-08-09

    申请号：US11731247

    申请日：2007-03-29

    申请人： Mark Zdeblick

    发明人： Mark Zdeblick

    IPC分类号： A61N1/00

    CPC分类号： A61N1/372 ,  A61B5/04011 ,  A61B5/0422 ,  A61N1/056 ,  A61N1/36185 ,  A61N1/368 ,  A61N1/3684 ,  A61N1/3686 ,  A61N1/37211 ,  A61N1/37276 ,  A61N1/37288 ,  A61N2001/0585

    摘要： Techniques for controlling one or more modular circuits (“satellites”) that are intended for placement in a subject's body. The one or more satellites are controlled by sending signals over a bus that includes first and second conduction paths. Also coupled to the bus in system embodiments is a device such as a pacemaker that provides power and includes control circuitry. Each satellite includes satellite circuitry and one or more effectors that interact with the tissue. The satellite circuitry is coupled to the bus, and thus interfaces the controller to the one or more effectors, which may function as actuators, sensors, or both. The effectors may be electrodes that are used to introduce analog electrical signals (e.g., one or more pacing pulses) into the tissue in the local areas where the electrodes are positioned (e.g., heart muscles) or to sense analog signals (e.g., a propagating depolarization signal) within the tissue.

    Implantable pressure sensors
    76.
    发明授权
    Implantable pressure sensors 有权
    可植入压力传感器

    公开(公告)号：US07028550B2

    公开(公告)日：2006-04-18

    申请号：US11025657

    申请日：2004-12-28

    申请人： Mark Zdeblick ,  Benedict James Costello

    发明人： Mark Zdeblick ,  Benedict James Costello

    IPC分类号： G01L7/08

    CPC分类号： A61B5/0215 ,  A61B5/412 ,  A61B2562/02 ,  A61N1/3627 ,  A61N1/36564 ,  G01L9/0042 ,  G01L9/0055 ,  G01L9/045 ,  G01L9/065

    摘要： Implantable pressure sensors and methods for making and using the same. A feature of at least some of the subject pressure sensors is that they are low-drift sensors. Additional features of representative pressure sensors include the presence of at least one strain transducer that is fabricated from a stable gauge material. The subject pressure sensors find use in a variety of applications.

    摘要翻译： 可植入压力传感器及其制造和使用方法。 至少一些目标压力传感器的特征在于它们是低漂移传感器。 代表性压力传感器的附加特征包括存在由稳定的规格材料制成的至少一个应变换能器。 主题压力传感器可用于各种应用。

    Pressure sensors having stable gauge transducers
    77.
    发明授权
    Pressure sensors having stable gauge transducers 有权
    压力传感器具有稳定的换能器

    公开(公告)号：US07013734B2

    公开(公告)日：2006-03-21

    申请号：US11025876

    申请日：2004-12-28

    申请人： Mark Zdeblick ,  Benedict James Costello

    发明人： Mark Zdeblick ,  Benedict James Costello

    IPC分类号： G01L7/08

    CPC分类号： A61B5/0215 ,  A61B5/412 ,  A61B2562/02 ,  A61N1/3627 ,  A61N1/36564 ,  G01L9/0042 ,  G01L9/0055 ,  G01L9/045 ,  G01L9/065

    摘要： Implantable pressure sensors and methods for making and using the same. A feature of at least some of the subject pressure sensors is that they are low-drift sensors. Additional features of representative pressure sensors include the presence of at least one strain transducer that is fabricated from a stable gauge material. The subject pressure sensors find use in a variety of applications.

    摘要翻译： 可植入压力传感器及其制造和使用方法。 至少一些目标压力传感器的特征在于它们是低漂移传感器。 代表性压力传感器的附加特征包括存在由稳定的规格材料制成的至少一个应变换能器。 主题压力传感器可用于各种应用。

    Methods and apparatus for tissue activation and monitoring
    78.
    发明申请
    Methods and apparatus for tissue activation and monitoring 有权
    组织活化和监测的方法和装置

    公开(公告)号：US20060058588A1

    公开(公告)日：2006-03-16

    申请号：US11219305

    申请日：2005-09-01

    申请人： Mark Zdeblick

    发明人： Mark Zdeblick

    IPC分类号： A61B5/00

    CPC分类号： A61N1/372 ,  A61B5/04011 ,  A61B5/0422 ,  A61N1/056 ,  A61N1/36185 ,  A61N1/368 ,  A61N1/3684 ,  A61N1/3686 ,  A61N1/37211 ,  A61N1/37276 ,  A61N1/37288 ,  A61N2001/0585

    摘要： Techniques for controlling one or more modular circuits (“satellites”) that are intended for placement in a subject's body. The one or more satellites are controlled by sending signals over a bus that includes first and second conduction paths. Also coupled to the bus in system embodiments is a device such as a pacemaker that provides power and includes control circuitry. Each satellite includes satellite circuitry and one or more effectors that interact with the tissue. The satellite circuitry is coupled to the bus, and thus interfaces the controller to the one or more effectors, which may function as actuators, sensors, or both. The effectors may be electrodes that are used to introduce analog electrical signals (e.g., one or more pacing pulses) into the tissue in the local areas where the electrodes are positioned (e.g., heart muscles) or to sense analog signals (e.g., a propagating depolarization signal) within the tissue.

    摘要翻译： 用于控制用于放置在受检者体内的一个或多个模块化电路（“卫星”）的技术。 通过在包括第一和第二导电路径的总线上发送信号来控制一个或多个卫星。 在系统实施例中还耦合到总线的是诸如提供电力并包括控制电路的起搏器的装置。 每个卫星包括卫星电路和与组织相互作用的一个或多个效应器。 卫星电路耦合到总线，并且因此使控制器与一个或多个效应器接合，这些效应器可以用作致动器，传感器或两者。 效应器可以是用于将模拟电信号（例如，一个或多个起搏脉冲）引入电极定位的局部区域（例如，心脏肌肉）中的组织中或用于感测模拟信号（例如，传播 去极化信号）。

    Method of making an integrated, microminiature electric-to-fluidic valve
    80.
    发明授权
    Method of making an integrated, microminiature electric-to-fluidic valve 失效
    制造集成的微型电动流体阀的方法

    公开(公告)号：US4966646A

    公开(公告)日：1990-10-30

    申请号：US263117

    申请日：1988-10-26

    申请人： Mark Zdeblick

    发明人： Mark Zdeblick

    IPC分类号： F15C3/04 ,  F15C5/00 ,  F16K99/00 ,  G02B3/00 ,  G02B6/36 ,  H01L21/306

    CPC分类号： F16K99/0001 ,  F15C3/04 ,  F15C5/00 ,  F16K99/0015 ,  F16K99/0044 ,  F16K99/0061 ,  G02B3/14 ,  H01L21/30608 ,  F16K2099/0074 ,  F16K2099/008 ,  F16K2099/0084 ,  F16K2099/009 ,  G02B3/0006 ,  G02B3/0012 ,  G02B6/3692

    摘要： A method of making an integrated, microminiature, electric-to-fluidic valve. The method comprises, in one embodiment, anisotropically etching a cavity in a silicon wafer to form a thin membrane at the bottom of a trench. Then a second wafer is etched to form an exit path surrounded by a valve seat positioned such that when these two wafers are sandwiched together, the valve seat lies under the membrane. An input passageway joining a manifold cavity formed around the valve seat is then etched in the surface of the second wafer which will mate with the diaphragm side of the first wafer. The two wafers are then bonded together after suitable alignment. A third pyrex wafer is then coated with a resistor material which will be over the cavity in the first wafer when the first and third wafers are bonded together. Conductive leads and wire attach pads are also formed. Finally, a fill hole is etched into the third wafer over the position of the cavity such that the cavity can be filled. The first and third wafers are then bonded together to complete the valve.

    摘要翻译： 一种制造集成的微型电流对阀的方法。 在一个实施例中，该方法包括各向异性地蚀刻硅晶片中的空腔以在沟槽的底部形成薄膜。 然后蚀刻第二晶片以形成由阀座包围的出口路径，所述阀座定位成使得当这两个晶片夹在一起时，阀座位于膜下方。 接着形成在阀座周围形成的歧管腔的输入通道然后在与第一晶片的隔膜侧匹配的第二晶片的表面中被蚀刻。 然后两个晶片在适当的对准之后结合在一起。 然后，当第一和第三晶片结合在一起时，第三个Pyrex晶片涂覆有电阻材料，该电阻材料将在第一晶片中的空腔上方。 还形成导电引线和引线附接焊盘。 最后，在空腔的位置上在第三晶片中蚀刻填充孔，使得可以填充空腔。 然后将第一和第三晶片结合在一起以完成阀。