公开(公告)号：US09138513B2

公开(公告)日：2015-09-22

申请号：US13102791

申请日：2011-05-06

Applicant: Ni Ding

Inventor： Ni Ding

IPC: A61F2/82 ,  A61L31/16 ,  A61K38/17 ,  A61L31/10

CPC classification number: A61L31/16 ,  A61F2/82 ,  A61K38/1709 ,  A61L31/10 ,  A61L2300/252 ,  A61L2300/416

Abstract: Method are disclosed for local and systemic administration HDL, recombinant HDL or HDLm for the prevention, treatment, or amelioration of a vascular disorder, disease or occlusion such as restenosis or vulnerable plaque.

Abstract translation: 公开了局部和全身给药HDL，重组HDL或HDLm用于预防，治疗或改善血管疾病，疾病或闭塞如再狭窄或易损斑块的方法。

公开(公告)号：US08841412B2

公开(公告)日：2014-09-23

申请号：US13207656

申请日：2011-08-11

Applicant: Bethany Steichen ,  Stephen D. Pacetti ,  Manish Gada ,  Thierry Glauser ,  Lothar W. Kleiner ,  Yunbing Wang ,  James P. Oberhauser ,  Ni Ding

Inventor： Bethany Steichen ,  Stephen D. Pacetti ,  Manish Gada ,  Thierry Glauser ,  Lothar W. Kleiner ,  Yunbing Wang ,  James P. Oberhauser ,  Ni Ding

IPC: C08F6/00

CPC classification number: B29C47/0078 ,  B29B13/06 ,  B29B13/065 ,  B29C47/0014 ,  B29C47/0021 ,  B29C47/0023 ,  B29C47/1018 ,  B29C47/1072 ,  B29C47/76 ,  B29C47/92 ,  B29C2947/922 ,  B29C2947/92228 ,  B29C2947/92342 ,  B29C2947/92695 ,  B29C2947/92704 ,  B29C2947/92723 ,  B29K2995/006

Abstract: Methods and systems for controlling the moisture content of biodegradable and bioresorbable polymer resin during extrusion above a lower limit that allows for plasticization of the polymer resin melt and below an upper limit to reduce or prevent molecular weight loss are disclosed. Methods are further disclosed involving plasticization of a polymer resin for feeding into an extruder with carbon dioxide and freon.

Abstract translation: 公开了用于在挤出之前控制可生物降解和生物可再吸收的聚合物树脂的含水量的方法和系统，其允许聚合物树脂熔体增塑并低于上限以降低或防止分子量损失。 进一步公开的方法涉及用二氧化碳和氟利昂进料到挤出机中的聚合物树脂的增塑。

公开(公告)号：US08741378B1

公开(公告)日：2014-06-03

申请号：US11022228

申请日：2004-12-23

Applicant: Wouter E. Roorda ,  Ni Ding

Inventor： Wouter E. Roorda ,  Ni Ding

IPC: B05D3/02 ,  B05D1/02 ,  A61L33/00

CPC classification number: A61L31/08 ,  A61F2/82 ,  A61F2002/30062 ,  A61F2002/30064 ,  A61K31/436 ,  A61K31/439 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/216 ,  A61L2300/606 ,  A61L2420/02 ,  A61L2420/06 ,  B05D1/02

Abstract: Methods of coating an implantable device, such as a stent, are provided.

Abstract translation: 提供了诸如支架之类的可植入装置的涂覆方法。

公开(公告)号：US08613880B2

公开(公告)日：2013-12-24

申请号：US13093755

申请日：2011-04-25

Applicant: Yunbing Wang ,  Xiao Ma ,  Fuh-Wei Tang ,  Ni Ding

Inventor： Yunbing Wang ,  Xiao Ma ,  Fuh-Wei Tang ,  Ni Ding

IPC: B29B17/00

CPC classification number: B29C71/02 ,  A61F2/82 ,  A61F2/915 ,  A61F2002/91558 ,  A61F2002/91583 ,  A61F2210/0004 ,  A61F2240/001 ,  A61L2/007 ,  A61L2/08 ,  A61L2/087 ,  A61L31/06 ,  A61L31/148 ,  A61L2202/21 ,  A61L2202/24 ,  A61L2400/18 ,  B29C35/02 ,  B29C2035/0877 ,  B29C2071/022 ,  B29L2031/753 ,  C08J7/08 ,  C08J7/123 ,  C08J2367/04 ,  C08L67/04

Abstract: Methods are disclosed for conditioning a polymeric stent after sterilization, and/or after crimping and before packaging, such that the properties of the polymeric stent fall within a narrower range of values. The stent is exposed to a controlled temperature at or above ambient for a period of time after radiation sterilization and/or after crimping and before sterilization. As a result, the polymeric stent properties, particularly radial strength and number-average molecular weight of the polymer of the polymeric stent, fall within a narrower range.

Abstract translation: 公开了用于在灭菌后和/或在卷曲之后和包装之前调节聚合物支架的方法，使得聚合物支架的性质落在较窄的值范围内。 在辐射灭菌后和/或在压接之后和灭菌之前将支架暴露于等于或高于环境的受控温度一段时间。 结果，聚合物支架的聚合物支架性质，特别是聚合物支架的聚合物的径向强度和数均分子量落在更窄的范围内。

公开(公告)号：US20130261735A1

公开(公告)日：2013-10-03

申请号：US13436538

申请日：2012-03-30

Applicant: Stephen D. Pacetti ,  Yunbing Wang ,  Ni Ding

Inventor： Stephen D. Pacetti ,  Yunbing Wang ,  Ni Ding

IPC: A61F2/82 ,  C23C8/42 ,  C23C8/80 ,  C23C8/00

CPC classification number: A61F2/915 ,  A61F2/82 ,  A61F2210/0004 ,  A61F2210/0009 ,  A61F2240/001 ,  A61F2250/003 ,  A61F2310/00041 ,  A61L31/022 ,  A61L31/086 ,  A61L31/088 ,  A61L31/10 ,  A61L31/124 ,  A61L31/148 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2400/18 ,  B22D21/007 ,  B22D25/02 ,  B22D27/00 ,  B23K26/38 ,  B23K26/40 ,  B23K2103/15 ,  C23C8/00 ,  C23C8/10 ,  C23C8/42 ,  C23C8/80 ,  C23C26/00 ,  C23C28/04 ,  C23C28/30 ,  C23C30/00

Abstract: Stents or scaffolds made from magnesium or magnesium alloys including additives or barrier coatings that modify the corrosion rate of the stent are disclosed. Methods of forming barrier coatings that modify the corrosion rate of the stent are disclosed.

Abstract translation: 公开了由镁或镁合金制成的支架或支架，包括改变支架腐蚀速率的添加剂或阻隔涂层。 公开了形成改变支架腐蚀速率的阻挡涂层的方法。

公开(公告)号：US08398676B2

公开(公告)日：2013-03-19

申请号：US12608769

申请日：2009-10-29

Applicant: Wouter E. Roorda ,  Kelly J. McCrystle ,  Ian J. Clark ,  Laveille K. Voss ,  Ni Ding

Inventor： Wouter E. Roorda ,  Kelly J. McCrystle ,  Ian J. Clark ,  Laveille K. Voss ,  Ni Ding

IPC: A61B17/08

CPC classification number: A61B17/0057 ,  A61B2017/00004 ,  A61B2017/00575 ,  A61B2017/00592 ,  A61B2017/00606 ,  A61B2017/00619 ,  A61B2017/00623 ,  A61B2017/00654 ,  A61B2017/00659 ,  A61B2017/00986 ,  A61B2017/00991 ,  A61B2090/0811

Abstract: A device for closing an opening in a wall of a body lumen includes a closure element with a first flange and a second flange. Both the first flange and the second flange may have a delivery cross-sectional dimension and a deployed cross-sectional dimension. The device for closing an opening further includes a first coupler element disposed on the first flange and a second coupler element disposed on the second flange, the first and second coupler elements cooperating to couple the first flange to the second flange.

Abstract translation: 用于关闭体腔内的开口的装置包括具有第一凸缘和第二凸缘的闭合元件。 第一凸缘和第二凸缘都可以具有输送横截面尺寸和展开的横截面尺寸。 用于关闭开口的装置还包括设置在第一凸缘上的第一耦合器元件和设置在第二凸缘上的第二耦合器元件，第一和第二耦合器元件协作以将第一凸缘耦合到第二凸缘。

公开(公告)号：US08377116B2

公开(公告)日：2013-02-19

申请号：US12052452

申请日：2008-03-20

Applicant: Shaw Ling Hsu ,  Yiwen Tang ,  Lothar W. Kleiner ,  Fuh-Wei Tang ,  Ni Ding ,  Syed Faiyaz Ahmed Hossainy

Inventor： Shaw Ling Hsu ,  Yiwen Tang ,  Lothar W. Kleiner ,  Fuh-Wei Tang ,  Ni Ding ,  Syed Faiyaz Ahmed Hossainy

IPC: A61F2/06

CPC classification number: A61L27/34 ,  A61L31/10 ,  A61L2420/08 ,  C08L67/04

Abstract: The present invention provides an implantable medical device coating that has improved stability, a medical device coated with such coating, and a method of increasing the stability of an implantable medical device coating, wherein the coating comprises a stereocomplex f poly(D-lactic acid) and poly(L-lactice acid).

Abstract translation: 本发明提供了具有改善的稳定性的可植入医疗装置涂层，涂覆有这种涂层的医疗装置以及增加可植入医疗装置涂层的稳定性的方法，其中所述涂层包含立体络合物f聚（D-乳酸） 和聚（L-乳酸））。

公开(公告)号：US20120219521A1

公开(公告)日：2012-08-30

申请号：US13468956

申请日：2012-05-10

Applicant: Eugene T. Michal ,  Evgenia Mandrusov ,  Charles D. Claude ,  Ni Ding ,  Murthy Simhambhatia ,  Syed Faiyez Ahmed Hossainy ,  Srinivasan Sridharan ,  Paul Consigny

Inventor： Eugene T. Michal ,  Evgenia Mandrusov ,  Charles D. Claude ,  Ni Ding ,  Murthy Simhambhatia ,  Syed Faiyez Ahmed Hossainy ,  Srinivasan Sridharan ,  Paul Consigny

IPC: A61K31/765 ,  A61M25/00

CPC classification number: A61K9/0019 ,  A61K9/0024 ,  A61K31/7088

Abstract: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.

Abstract translation: 用于治疗心肌梗塞的方法，装置，试剂盒和组合物。 在一个实施例中，该方法包括防止脑室梗死区的重塑。 在其它实施方案中，该方法包括引入结构上增强剂。 在其它实施方案中，将药剂引入心室以增加心室的依从性。 在替代实施例中，预防重塑包括防止心室梗塞区变薄。 在另一个实施方案中，预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。 在其它实施方案中，结构上增强剂可以伴随其它治疗剂。 这些药剂可以包括但不限于前成纤维细胞和血管生成剂。

公开(公告)号：US07682669B1

公开(公告)日：2010-03-23

申请号：US09918365

申请日：2001-07-30

Applicant: Eugene T. Michal ,  Ni Ding ,  Christopher J. Buchko

Inventor： Eugene T. Michal ,  Ni Ding ,  Christopher J. Buchko

IPC: B05D3/06

CPC classification number: A61L31/10 ,  A61L31/16 ,  A61L33/0029 ,  A61L33/0088 ,  A61L2300/42 ,  A61L2420/08

Abstract: The present invention is directed to a medical device having a polymerized base coat layer for the immobilization of an anti-thrombogenic material, such as heparin, thereon. The binding coat layer is comprised of various chemically functional groups which are stable and allow for the immobilization of the anti-thrombogenic material thereto. Methods for immobilizing the anti-thrombogenic material within the base coat layer posited on a surface of the medical device are also provided.

Abstract translation: 本发明涉及一种具有用于固定抗血栓形成材料如肝素的聚合底涂层的医疗装置。 粘合涂层由各种化学官能团组成，它们是稳定的并允许将抗血栓形成材料固定在其上。 还提供了将抗凝血栓塞材料固定在医疗装置表面上的底涂层内的方法。

公开(公告)号：US20090258055A1

公开(公告)日：2009-10-15

申请号：US12489227

申请日：2009-06-22

Applicant: Syed Faiyaz Ahmed Hossainy ,  Ni Ding

Inventor： Syed Faiyaz Ahmed Hossainy ,  Ni Ding

IPC: A61K31/727 ,  A61F2/00 ,  A61P9/00

CPC classification number: A61K31/727 ,  A61K47/61 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/236 ,  A61L2300/606 ,  A61L2300/80 ,  C08B37/0075 ,  C09D105/10

Abstract: A prodrug comprising a heparin and a drug is provided. The prodrug can be used to form a coating on a medical device. The prodrug can also be used with a polymeric material to form a coating on a medical device. The polymeric material can be a hydrophobic polymer, a hydrophilic polymer, a non-fouling polymer, or combinations thereof. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.