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公开(公告)号：US20120072122A1
公开(公告)日：2012-03-22
申请号：US13246906
申请日：2011-09-28
IPC分类号： G06F19/00
CPC分类号： G06F16/2462 , G16C20/20 , G16C20/90
摘要： A system and method to search spectral databases and to identify unknown materials. A library comprising sublibraries is provided, each sublibrary containing a plurality of reference data sets corresponding to known materials. Test data sets are provided, characteristic of an unknown material. Each test data set is generated by one or more spectroscopic data generating instruments. Each sublibrary is searched and a corresponding set of scores is produced, indicating a likelihood of a match. Relative probability values are calculated for each searched sublibrary. All relative probability values are fused producing a set of final probability values, used to determine whether the unknown material is represented through a known material in the library. A highest final probability value is selected compared to a minimum confidence value. If the probability value is greater than or equal to the minimum confidence value, the known material is reported.
摘要翻译： 搜索光谱数据库并识别未知材料的系统和方法。 提供了包括子库的库，每个子库包含对应于已知材料的多个参考数据集。 提供测试数据集，是未知材料的特征。 每个测试数据集由一个或多个光谱数据产生装置产生。 搜索每个子图书馆，并产生相应的一组分数，指示匹配的可能性。 对于每个搜索的子图库计算相对概率值。 所有相对概率值被融合，产生一组最终概率值，用于确定未知材料是否通过库中的已知材料表示。 与最小置信度值相比，选择最高最终概率值。 如果概率值大于或等于最小置信度值，则报告已知材料。
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公开(公告)号：US20110299071A1
公开(公告)日：2011-12-08
申请号：US12422360
申请日：2009-04-13
CPC分类号： G01N21/65 , G01N21/64 , G01N21/6402 , G01N21/8483 , G01N2021/6417
摘要： The invention relates to apparatus and methods for assessing occurrence of a hazardous agent in a sample by performing multipoint spectral analysis of the sample. Methods of employing Raman spectroscopy and other spectrophotometric methods are disclosed. Devices and systems suitable for performing such multipoint methods are also disclosed.
摘要翻译： 本发明涉及通过对样品进行多点光谱分析来评估样品中危险剂的发生的装置和方法。 公开了采用拉曼光谱法和其他分光光度法的方法。 还公开了适于执行这种多点方法的设备和系统。
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公开(公告)号：US07808634B2
公开(公告)日：2010-10-05
申请号：US12273169
申请日：2008-11-18
IPC分类号： G01J3/44
CPC分类号： G01J3/28 , A61B5/0059 , A61B2560/0223 , G01J2003/2866
摘要： A method and apparatus for automated spectral calibration of a spectroscopy device. In one embodiment, the disclosure relates to a method for simultaneous calibration and spectral imaging of a sample by: simultaneously illuminating the sample and a calibrant with a plurality of illuminating photons; receiving, at the spectrometer, a first plurality of photons collected from the sample and a second plurality of photons collected from the calibrant; forming a calibrant spectrum from the first plurality of collected photons and a sample spectrum from the second plurality of collected photons; comparing the calibrant spectrum with a reference spectrum of the calibrant to determine a wavelength-shift in the calibrant spectrum; applying the wavelength-shift to the sample spectrum to obtain a calibrated sample spectrum; and forming a spatially accurate wavelength resolved image of the sample from the first plurality of collected photons.
摘要翻译： 一种用于光谱装置的自动光谱校准的方法和装置。 在一个实施方案中，本公开涉及通过以下步骤同时校准和光谱成像的方法：同时用多个照明光子照射样品和校准物; 在光谱仪处接收从样品收集的第一组多个光子和从校准物收集的第二组多个光子; 从所述第一多个收集的光子形成校准谱，以及来自所述第二多个收集的光子的样品光谱; 将校准谱与校准物的参考光谱进行比较，以确定校准谱中的波长漂移; 将波长偏移应用于样本光谱以获得校准的样本光谱; 以及从所述第一多个收集的光子形成所述样品的空间上准确的波长分辨图像。
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公开(公告)号：US20090303471A1
公开(公告)日：2009-12-10
申请号：US11645132
申请日：2006-12-22
IPC分类号： G01J3/44
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0218 , G01N21/6456 , G01N21/65 , G01N33/227 , G01N2001/024 , G01N2021/6417 , G01N2021/6484
摘要： A system and method of detecting explosive compounds located on a sample. The sample is irradiated with animal-safe ultra-violet radiation generating a fluorescence data set. A fluorescence database is searched based on the fluorescence data set in order to identify a known fluorescence data set. If the searching of the fluorescence database identifies a known fluorescence data set, an area of interest in the sample is identified based on the known fluorescence data set identified in the fluorescence database searching. The area of interest is irradiated with substantially monochromatic radiation to generate a Raman data set of the area of interest. A Raman database is searched based on the Raman data set in order to identify a known Raman data set. An explosive compound in the area of interest is identified based on the known Raman data set identified by searching the Raman database.
摘要翻译： 一种检测位于样品上的爆炸性化合物的系统和方法。 用动物安全的紫外线辐射照射样品，产生荧光数据组。 基于荧光数据集搜索荧光数据库，以识别已知的荧光数据集。 如果荧光数据库的搜索识别已知荧光数据集，则基于在荧光数据库搜索中识别的已知荧光数据集来识别样品中的感兴趣区域。 用基本上单色的辐射照射感兴趣的区域以产生感兴趣区域的拉曼数据集。 基于拉曼数据集搜索拉曼数据库，以便识别已知的拉曼数据集。 基于通过搜索拉曼数据库识别的已知拉曼数据集来识别感兴趣区域中的爆炸性化合物。
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75.发明授权System and method for structured illumination and collection for improved optical confocality of raman fiber array spectral translator imaging and interactive raman probing 有权用于结构化照明和采集的系统和方法，用于改进拉曼光纤阵列光谱翻译器成像和交互式拉曼探测的光学共焦公开(公告)号：US07629591B2
公开(公告)日：2009-12-08
申请号：US11712917
申请日：2007-03-02
IPC分类号： G01N21/64
CPC分类号： G01J3/2803 , G01J3/0221 , G01J3/44 , G01N21/474 , G01N21/55 , G01N21/645 , G01N21/6456 , G01N21/65 , G01N2021/6423 , G01N2021/6484 , G01N2201/0833 , G01N2201/0846 , G02B6/06
摘要： The disclosure relates generally to methods and apparatus for using a fiber array spectral translator-based (“FAST”) spectroscopic system for improved imaging, spectral analysis, and interactive probing of a sample. In an embodiment, the confocality of a fiber array spectral translator-based spectroscopic system is improved through the use of structured illumination and/or structured collection of photons. User input may be received and acted upon to allow a user to interactively in real time and/or near real time view and analyze specific regions of the sample.
摘要翻译： 本公开一般涉及使用用于改进样品的成像，光谱分析和交互式探测的光纤阵列基于光谱转换器的（“FAST”）光谱系统的方法和装置。 在一个实施例中，通过使用结构化照明和/或光子的结构化收集来提高基于光纤阵列光谱转换器的光谱系统的共焦度。 可以接收用户输入并执行操作以允许用户以实时和/或接近实时的方式进行交互式查看和分析样本的特定区域。
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76.发明授权公开(公告)号：US07486395B2
公开(公告)日：2009-02-03
申请号：US11544648
申请日：2006-10-10
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0205 , G01J3/0218 , G01J3/0224 , G01J3/0227 , G01J3/0256 , G01J3/0264 , G01J3/027 , G01J3/0272 , G01J3/0283 , G01J3/0286 , G01J3/0289 , G01J3/0291 , G01J3/10 , G01J3/26 , G01J3/2803 , G01J3/2823 , G01J3/44 , G01J3/4406 , G01J3/447 , G01N2021/656 , G01N2201/0846
摘要： The disclosure relates to a portable and/or handheld bioagent detector and methodology described herein that is based in part on advanced Raman Chemical Imaging (“RCI”) technology. According to one embodiment of the present disclosure, the detection system may include a fiber array spectral translator (“FAST”) and may also include a probe which may include a complementary metal oxide semiconductor (CMOS) camera. The probe alleviates the need to place the main instrument close to an unconfined release of a potentially hazardous material and facilitates analysis of a sample that is situated in a hard-to-reach location while minimizing contamination of the detector and operator.
摘要翻译： 本公开涉及部分基于先进的拉曼化学成像（“RCI”）技术的本文描述的便携式和/或手持式生物代谢检测器和方法。 根据本公开的一个实施例，检测系统可以包括光纤阵列光谱转换器（“FAST”），并且还可以包括可以包括互补金属氧化物半导体（CMOS）照相机的探针。 探头减轻了将主仪器置于非限制性释放潜在危险物质的需要，并有助于分析位于难以到达的位置的样品，同时最大限度地减少检测器和操作者的污染。
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77.发明申请FORENSIC INTEGRATED SEARCH TECHNOLOGY WITH INSTRUMENT WEIGHT FACTOR DETERMINATION 有权威信集成搜索技术与仪器重量因子确定公开(公告)号：US20080300826A1
公开(公告)日：2008-12-04
申请号：US12017445
申请日：2008-01-22
IPC分类号： G06F17/18
CPC分类号： G06K9/00536 , G06F19/703 , G06F19/709 , H01J49/0036
摘要： A system and method to search spectral databases and to identify unknown materials from multiple spectroscopic data in the databases. The methodology may be substantially automated and is configurable to determine weights to be accorded to spectroscopic data from different spectroscopic data generating instruments for improved identification of unknown materials. Library spectra from known materials are divided into training and validation sets. Initial, instrument-specific weighting factors are determined using a weight grid or weight scale. The training and validation spectra are weighted with the weighting factors and indicator probabilities for various sets of “coarse” weighting factors are determined through an iterative process. The finally-selected set of coarse weighting factors is further “fine tuned” using a weight grid with finer values of weights. The instrument-specific finer weight values may be applied to test data sets (or spectra) of an unknown material as well as to the library spectra from corresponding spectroscopic instruments. Instrument-specific weights for each class of samples may also be computed for additional customization and accuracy.
摘要翻译： 一种用于搜索光谱数据库并从数据库中的多个光谱数据中识别未知物质的系统和方法。 该方法可以基本上是自动化的，并且可配置为确定要与来自不同光谱数据生成装置的光谱数据一致的权重，以改进未知材料的识别。 已知材料的谱图谱分为训练和验证集。 使用权重网格或权重量表确定初始的仪器特定加权因子。 训练和验证光谱通过加权因子加权，并且通过迭代过程确定各组“粗”加权因子的指标概率。 最终选择的粗加权系数集合使用具有更精确的权重值的权重网格进一步“精细调整”。 仪器特定的更精细的重量值可以应用于未知材料的测试数据集（或光谱）以及来自相应光谱仪的文库光谱。 也可以计算每类样品的仪器特定重量，以获得额外的定制和准确性。
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公开(公告)号：US07379179B2
公开(公告)日：2008-05-27
申请号：US11000778
申请日：2004-11-30
IPC分类号： G01N21/44
CPC分类号： G01N15/1475 , G01N21/65 , G01N2015/1493
摘要： The invention relates to methods of assessing one or more geometric properties of a particle of a substance using a Raman spectroscopic property of the substance. The method is useful, for example, for assessing particle sizes and size distributions in mixtures containing both particles of the substance and other materials.
摘要翻译： 本发明涉及使用该物质的拉曼光谱性质评估物质颗粒的一种或多种几何性质的方法。 该方法例如用于评估含有物质颗粒和其它材料的混合物的粒度和尺寸分布是有用的。
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79.发明授权Method and apparatus for compact birefringent interference imaging spectrometer 有权紧凑型双折射干涉成像光谱仪的方法和装置公开(公告)号：US07262839B2
公开(公告)日：2007-08-28
申请号：US11216175
申请日：2005-09-01
申请人： Patrick J. Treado , G. Steven Vanni
发明人： Patrick J. Treado , G. Steven Vanni
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0224 , G01J3/0229 , G01J3/0256 , G01J3/0264 , G01J3/0272 , G01J3/0283 , G01J3/10 , G01J3/44 , G01J3/4406 , G01N21/6456 , G01N2021/6417 , G01N2021/6423 , G01N2021/6471 , G01N2201/0221 , G01N2201/0627 , G02F1/133371 , G02F1/1347
摘要： The disclosure relates to a method and apparatus for a compact birefringent interference imaging spectrometer. More specifically, the disclosure relates to a portable system for obtaining a spectrum of a sample. The portable system may include a first photon emission source for illuminating the sample with a first plurality of photons to thereby produce photons scattered by the sample; an optical lens for collecting the scattered photons; a filter for receiving the collected scattered photons and providing therefrom filtered photons; a first photon detector for receiving the filtered photons and obtaining therefrom a spectrum of the sample; and a rejection filter for blocking the photons from said first photon emission source from entering said first photon detector. The disclosure additionally relates to methods of using such portable systems.
摘要翻译： 本发明涉及紧凑型双折射干涉成像光谱仪的方法和装置。 更具体地，本公开涉及一种用于获得样品的光谱的便携式系统。 便携式系统可以包括用于用第一多个光子照射样品从而产生由样品散射的光子的第一光子发射源; 用于收集散射光子的光学透镜; 用于接收所收集的散射光子并从其提供过滤的光子的滤光器; 第一光子检测器，用于接收经滤光的光子并从中获得样品的光谱; 以及用于阻挡来自所述第一光子发射源的光子进入所述第一光子检测器的滤波器。 本公开另外涉及使用这种便携式系统的方法。
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公开(公告)号：US07239782B1
公开(公告)日：2007-07-03
申请号：US10934885
申请日：2004-09-03
CPC分类号： G02B6/06 , A61B1/00165 , A61B1/043 , A61B1/063 , A61B1/0638 , A61B1/0646 , A61B1/07 , A61B5/0075 , A61B5/0084 , G01J3/02 , G01J3/0208 , G01J3/0218 , G01J3/0227 , G01J3/024 , G01J3/0256 , G01J3/0262 , G01J3/0286 , G01J3/44 , G01J2003/1213
摘要： A fiberscope device is disclosed which is suitable for video imaging, laser Raman spectroscopy and laser Raman spectroscopic (i.e. chemical) imaging. The fiberscope design minimizes fiber background interference arising from the laser delivery fiber optic and the coherent fiber optic light gathering bundle while maintaining high light throughput efficiency through the use of integrated spectral filters. In the fiberscope design, the laser delivery fiber optic is offset from the coherent fiber optic light gathering bundle. The laser delivery field is captured entirely by the light gathering field of view of the coherent fiber bundle. The fiberscope incorporates spectral filter optical elements that provide environmental insensitivity, particularly to temperature and moisture. The fiberscope is suited to the analysis of a wide range of condensed phase materials (solids and liquids), including the analysis of biological materials such as breast tissue lesions and arterial plaques, in such a manner to delineate abnormal from normal tissues.
摘要翻译： 公开了适用于视频成像，激光拉曼光谱和激光拉曼光谱（即化学）成像的纤维内窥镜装置。 纤维镜设计可以最大限度地减少激光传输光纤和相干光纤采集光束产生的光纤背景干扰，同时通过使用集成光谱滤波器保持高光通量效率。 在纤维镜设计中，激光传输光纤与相干光纤聚光束偏移。 激光输送场完全由相干光纤束的聚光场捕获。 纤维镜包含光谱滤光器光学元件，其提供环境不敏感性，特别是对温度和湿度。 纤维内窥镜适用于分析各种凝聚相材料（固体和液体），包括分析生物材料如乳房组织损伤和动脉斑块，以便从正常组织中描绘异常。
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