-
公开(公告)号：US06300093B1
公开(公告)日：2001-10-09
申请号：US08811481
申请日：1997-03-05
申请人： Wayne Kindsvogel , Laura J. Jelinek , Paul O. Sheppard , William A. Hagopian , James M. LaGasse
发明人： Wayne Kindsvogel , Laura J. Jelinek , Paul O. Sheppard , William A. Hagopian , James M. LaGasse
IPC分类号： C12P2106
CPC分类号： C07K14/4713 , A61K38/00 , C12N9/16
摘要： A mammalian islet cell antigen polypeptide involved in the development of insulin-dependent diabetes mellitus (IDDM) is disclosed. This islet cell antigen polypeptide, 1851, was found to contain regions of homology to the protein tyrosine phosphatase family. Methods for diagnosis and treatment, including use in immunoprecipitation assays and the induction of immune tolerance using the recombinant mammalian polypeptides and antibodies specific to mammalian islet cell antigen 1851 polypeptides are presented.
摘要翻译： 公开了涉及胰岛素依赖性糖尿病（IDDM）发展的哺乳动物胰岛细胞抗原多肽。 该胰岛细胞抗原多肽1851被发现含有与蛋白酪氨酸磷酸酶家族同源的区域。 提出了用于诊断和治疗的方法，包括在免疫沉淀测定中的应用和使用重组哺乳动物多肽和对哺乳动物胰岛细胞抗原1851多肽特异的抗体诱导免疫耐受。
-
公开(公告)号：US5989866A
公开(公告)日：1999-11-23
申请号：US951822
申请日：1997-10-16
申请人： Theresa A. Deisher , Darrell C. Conklin , Fenella Raymond , Thomas R. Bukowski , Susan D. Holderman , Birgit Hansen , Paul O. Sheppard
发明人： Theresa A. Deisher , Darrell C. Conklin , Fenella Raymond , Thomas R. Bukowski , Susan D. Holderman , Birgit Hansen , Paul O. Sheppard
IPC分类号： C12N15/09 , A61K38/00 , A61P9/10 , A61P19/08 , A61P21/00 , C07K14/50 , C07K16/22 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/077 , C12N5/10 , C12N15/18 , C12P21/02 , C12P21/08 , C12N5/00 , C12N15/63
CPC分类号： A61K47/48238 , A61K47/48507 , C07K14/50 , C07K16/22 , C12N5/0657 , A61K38/00 , C07K2319/00 , C12N2501/119
摘要： The present invention relates to polynucleotide and polypeptide molecules for zFGF-5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells and may be used for remodelling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF-5 polypeptides.
摘要翻译： 本发明涉及用于zFGF-5的FGF家族的新成员的多核苷酸和多肽分子。 多肽和编码它们的多核苷酸对于肌肉细胞是增殖性的，并且可以用于重塑心脏组织和改善心脏功能。 本发明还包括对zFGF-5多肽的抗体。
-
公开(公告)号：US5952011A
公开(公告)日：1999-09-14
申请号：US452800
申请日：1995-05-30
CPC分类号： C12N9/1044 , C12Y203/02013 , A61K38/00
摘要： Human prostatic and placental transglutaminases are identified and cloned. The human transglutaminases herein are useful for, inter alia, therapeutic wound repair, closure of skin grafts, stabilizing food preparations, and markers for identifying agents which act as agonists or antagonists of cellular apoptosis.
摘要翻译： 人前列腺和胎盘转谷氨酰胺酶被鉴定和克隆。 本文中的人转谷氨酰胺酶尤其可用于治疗性伤口修复，皮肤移植物闭合，稳定食物制剂和用于鉴定作为细胞凋亡的激动剂或拮抗剂的药剂的标记物。
-
74.发明授权公开(公告)号：US08759066B2
公开(公告)日：2014-06-24
申请号：US12935235
申请日：2009-04-07
CPC分类号： C12N9/6418 , C07K2319/50
摘要： Disclosed are compositions for activating thrombin precursors to thrombin. The compositions provided include polypeptide compositions wherein the pre-pro-sequence comprises a thrombin cleavage site. The compositions provided also include polynucleotides encoding said polypeptides and recombinant systems for expressing said polypeptides. This disclosure also relates to methods for producing said compositions, recovering said compositions, activating said compositions purifying said compositions and producing active thrombin molecules using the active form of said compositions.
摘要翻译： 公开了用于激活凝血酶凝血酶前体的组合物。 提供的组合物包括多肽组合物，其中前序列包含凝血酶切割位点。 提供的组合物还包括编码所述多肽的多核苷酸和用于表达所述多肽的重组系统。 本公开还涉及生产所述组合物的方法，回收所述组合物，使用所述组合物的活性形式活化所述组合物来纯化所述组合物并产生活性凝血酶分子。
-
75.发明申请USE OF TRUNCATED CYSTEINE IL28 AND IL29 MUTANTS TO TREAT CANCERS AND AUTOIMMUNE DISORDERS 审中-公开使用截短的CYSTEINE IL28和IL29突变体治疗癌症和自身免疫性疾病公开(公告)号：US20120251488A1
公开(公告)日：2012-10-04
申请号：US13440066
申请日：2012-04-05
申请人： Paul O. Sheppard
发明人： Paul O. Sheppard
CPC分类号： C07K14/54 , A61K38/20 , A61K38/21 , A61K47/60 , A61K2300/00
摘要： Methods for treating patients with cancer and autoimmune disorders using IL-28 and IL-29 molecules. The IL-28 and IL-29 molecules include polypeptides that have homology to the human IL-28 or IL-29 polypeptide sequence and proteins fused to a polypeptide with IL-28 and IL-29 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer and/or autoimmune therapeutics.
摘要翻译： 使用IL-28和IL-29分子治疗患有癌症和自身免疫疾病的患者的方法。 IL-28和IL-29分子包括与人IL-28或IL-29多肽序列具有同源性的多肽，以及与具有IL-28和IL-29功能活性的多肽融合的蛋白质。 分子可以用作单一疗法或与其它已知的癌症和/或自身免疫治疗剂组合使用。
-
公开(公告)号：US08231866B2
公开(公告)日：2012-07-31
申请号：US13353524
申请日：2012-01-19
CPC分类号： C07K14/56 , C12Q2600/158
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
摘要翻译： 本发明涉及与氨基酸序列水平上与干扰素-α最密切相关的zcyto20，zcyto21，zcyto22，zycto24和zcyto25蛋白的多核苷酸和多肽分子。 该蛋白家族的受体是II类细胞因子受体。 本发明包括减少病毒感染和增加单核细胞计数的方法。 本发明还包括针对zcyto20多肽的抗体，以及产生多核苷酸和多肽的方法。
-
77.发明申请公开(公告)号：US20110151536A1
公开(公告)日：2011-06-23
申请号：US12935235
申请日：2009-04-07
CPC分类号： C12N9/6418 , C07K2319/50
摘要： Disclosed are compositions for activating thrombin precursors to thrombin. The compositions provided include polypeptide compositions wherein the pre-pro-sequence comprises a thrombin cleavage site. The compositions provided also include polynucleotides encoding said polypeptides and recombinant systems for expressing said polypeptides. This disclosure also relates to methods for producing said compositions, recovering said compositions, activating said compositions purifying said compositions and producing active thrombin molecules using the active form of said compositions.
摘要翻译： 公开了用于激活凝血酶凝血酶前体的组合物。 提供的组合物包括多肽组合物，其中前序列包含凝血酶切割位点。 提供的组合物还包括编码所述多肽的多核苷酸和用于表达所述多肽的重组系统。 本公开还涉及生产所述组合物的方法，回收所述组合物，使用所述组合物的活性形式活化所述组合物来纯化所述组合物并产生活性凝血酶分子。
-
公开(公告)号：US20110151480A1
公开(公告)日：2011-06-23
申请号：US13016537
申请日：2011-01-28
CPC分类号： C07K14/575 , A61K38/00
摘要： The present invention relates to a method of forming a peptide-receptor complex with zsig33 polypeptides and their receptors as well as antibodies. Methods of modulating gastric contractility, nutrient uptake, growth hormones, the secretion of digestive enzymes and hormones, and/or secretion of enzymes and/or hormones in the pancreas are also included.
摘要翻译： 本发明涉及与zsig33多肽及其受体以及抗体形成肽 - 受体复合物的方法。 还包括调节胃收缩力，营养摄取，生长激素，消化酶和激素分泌和/或胰腺中酶和/或激素分泌的方法。
-
79.发明授权Method of using interferon-like potein ZCYTO20 (IL-28A) or ZCYTO22(IL-28B) to treat hepatitis B 有权使用干扰素样potein ZCYTO20（IL-28A）或ZCYTO22（IL-28B）治疗乙型肝炎的方法公开(公告)号：US07829076B2
公开(公告)日：2010-11-09
申请号：US12630571
申请日：2009-12-03
CPC分类号： C07K14/715 , A61K38/20 , A61K38/21 , C07K14/56 , C07K16/24 , C07K16/2866 , C07K2317/76 , C12Q2600/158 , Y02A50/473
摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
摘要翻译： 本发明涉及与氨基酸序列水平上与干扰素-α最密切相关的zcyto20，zcyto21，zcyto22，zycto24和zcyto25蛋白的多核苷酸和多肽分子。 该蛋白家族的受体是II类细胞因子受体。 本发明包括减少病毒感染和增加单核细胞计数的方法。 本发明还包括针对zcyto20多肽的抗体，以及产生多核苷酸和多肽的方法。
-
80.发明授权Method of using IL-29 cysteine mutant to treat hepatitis C and hepatitis B 有权使用IL-29半胱氨酸突变体治疗丙型肝炎和乙型肝炎的方法公开(公告)号：US07727518B2
公开(公告)日：2010-06-01
申请号：US12043885
申请日：2008-03-06
申请人： Lowell J. Brady , Kevin M. Klucher , Chung Chan , Dennis L. Dong , Hong Y. Liu , Paul O. Sheppard , Thomas R. Bukowski
发明人： Lowell J. Brady , Kevin M. Klucher , Chung Chan , Dennis L. Dong , Hong Y. Liu , Paul O. Sheppard , Thomas R. Bukowski
CPC分类号： A61K38/20 , A61K38/00 , C07K14/54 , C07K14/555 , C07K2319/00 , Y10S435/81 , Y10S435/975 , Y10S514/894
摘要： Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
摘要翻译： 已经通过在编码成熟蛋白的多核苷酸序列中突变一个或多个半胱氨酸残基来产生IL-28A，IL-28B和IL-29的均质制剂。 可以显示半胱氨酸突变蛋白与其同源受体结合或表现出生物活性。 所示的一种生物活性是抗病毒活性。
-
-
-
-
-
-
-
-
-
搜索结果
175 条记录 (耗时 0.054 秒)