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公开(公告)号：US06214986B1
公开(公告)日：2001-04-10
申请号：US09323743
申请日：1999-06-02
IPC分类号： C07H2104
CPC分类号： C12N15/1135 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/3181 , C12N2310/321 , C12N2310/3233 , C12N2310/334 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12N2310/3525
摘要： Compositions and methods are provided for modulating the expression of bcl-x. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding bcl-x are preferred. Methods of using these compounds for modulation of bcl-x expression and for treatment of diseases associated with expression of bcl-x are also provided. Methods of sensitizing cells to apoptotic stimuli are also provided.
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公开(公告)号：US6159697A
公开(公告)日：2000-12-12
申请号：US487444
申请日：2000-01-09
申请人： Brett P. Monia , Lex M. Cowsert
发明人： Brett P. Monia , Lex M. Cowsert
IPC分类号： C12N15/09 , A61K31/711 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K38/00 , A61K48/00 , A61P9/00 , A61P17/02 , A61P35/00 , A61P43/00 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Smad7. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Smad7. Methods of using these compounds for modulation of Smad7 expression and for treatment of diseases associated with expression of Smad7 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节Smad7的表达。 组合物包含靶向编码Smad7的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节Smad7表达和治疗与Smad7表达有关的疾病的方法。
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公开(公告)号：US6130088A
公开(公告)日：2000-10-10
申请号：US358384
申请日：1999-07-21
申请人： Brett P. Monia , Lex M. Cowsert
发明人： Brett P. Monia , Lex M. Cowsert
IPC分类号： C12N15/09 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K38/00 , A61K48/00 , A61P35/00 , A61P43/00 , C12N15/113 , C07H21/04 , C12N15/85 , C12Q1/68
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Telomeric Repeat Binding Factor 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Telomeric Repeat Binding Factor 1. Methods of using these compounds for modulation of Telomeric Repeat Binding Factor 1 expression and for treatment of diseases associated with expression of Telomeric Repeat Binding Factor 1 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节端粒重复结合因子1的表达。组合物包含靶向编码端粒重复结合因子1的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节端粒重复的方法 提供了绑定因子1表达和治疗与端粒重复结合因子1表达相关的疾病。
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公开(公告)号：US6046049A
公开(公告)日：2000-04-04
申请号：US357070
申请日：1999-07-19
申请人： Brett P. Monia , Lex M. Cowsert
发明人： Brett P. Monia , Lex M. Cowsert
IPC分类号： C12N15/09 , A61K31/7125 , A61K38/00 , A61K48/00 , A61P11/06 , A61P19/02 , A61P29/00 , A61P43/00 , C12N15/113 , C07H21/04 , C12N15/00 , C12Q1/68
CPC分类号： C12N15/1137 , C12Y207/01137 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/334 , C12N2310/341 , C12N2310/346 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of PI3 kinase p110 delta. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PI3 kinase p110 delta. Methods of using these compounds for modulation of PI3 kinase p110 delta expression and for treatment of diseases associated with expression of PI3 kinase p110 delta are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节PI3激酶p110δ的表达。 组合物包含靶向编码PI3激酶p110δ的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节PI3激酶p110δ表达和治疗与PI3激酶p110δ表达相关的疾病的方法。
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公开(公告)号：US6043091A
公开(公告)日：2000-03-28
申请号：US357071
申请日：1999-07-19
申请人： Brett P. Monia , Lex M. Cowsert
发明人： Brett P. Monia , Lex M. Cowsert
IPC分类号： C12N15/09 , A61K9/10 , A61K31/711 , A61K45/00 , A61P3/10 , A61P43/00 , C07H21/00 , C12N9/10 , C12N9/99 , C07H21/04 , C12N15/85 , C12Q1/68
CPC分类号： C07H21/00 , C12N9/1051 , C07B2200/11 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of liver glycogen phosphorylase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding liver glycogen phosphorylase. Methods of using these compounds for modulation of liver glycogen phosphorylase expression and for treatment of diseases associated with expression of liver glycogen phosphorylase are provided.
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公开(公告)号：US5955589A
公开(公告)日：1999-09-21
申请号：US465880
申请日：1995-06-06
申请人： Phillip Dan Cook , Brett P. Monia
发明人： Phillip Dan Cook , Brett P. Monia
IPC分类号： A61K31/70 , A61K31/7125 , A61K38/00 , A61K48/00 , A61P31/00 , A61P35/00 , A61P43/00 , C07H19/04 , C07H21/00 , C07H21/04 , C07K9/00 , C07K14/00 , C12N15/09 , C12N15/11 , C12Q1/68
CPC分类号： C07H21/00 , C07H21/04 , C07K14/003 , C12Q1/6813 , C12Q1/6832 , C12Q2525/125
摘要： Oligonucleotides and other macromolecules are provided which have increased nuclease resistance, substituent groups for increasing binding affinity to complementary strand, and subsequences of 2'-deoxy-erythro-pentofuranosyl nucleotides that activate RNase H. Such oligonucleotides and macromolecules are useful for diagnostics and other research purposes, for modulating the expression of a protein in organisms, and for the diagnosis, detection and treatment of other conditions susceptible to oligonucleotide therapeutics.
摘要翻译： 提供具有增加的核酸酶抗性的寡核苷酸和其它大分子，增加对互补链的结合亲和力的取代基和激活核糖核酸酶H的2'-脱氧 - 赤 - 戊呋喃糖基核苷酸的亚序列。这样的寡核苷酸和大分子可用于诊断和其他研究 用于调节生物体中蛋白质的表达，以及用于诊断，检测和治疗对寡核苷酸治疗剂敏感的其它病症。
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公开(公告)号：US5872242A
公开(公告)日：1999-02-16
申请号：US889296
申请日：1997-07-08
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K48/00 , A61P35/00 , C07K14/82 , C12N15/113 , C07H21/04 , C12P19/34 , C12Q1/68
CPC分类号： C12N15/1135 , C07K14/82 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/333 , C12N2310/3521 , C12N2310/3527 , C12N2310/3533 , C12Q2525/125
摘要： Compositions and methods are provided for the modulation of ras expression. Oligonucleotides are provided which are targeted to nucleic acids encoding human ras. Oligonucleotides specifically hybridizable with mRNA encoding human H-ras, Ki-ras and N-ras are provided. Such oligonucleotides can be used for therapeutics and diagnostics as well as for research purposes. Methods are also disclosed for modulating ras gene expression in cells and tissues using the oligonucleotides provided, and for specific modulation of expression of activated ras. Methods for diagnosis, detection and treatment of conditions associated with ras are also disclosed.
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公开(公告)号：US20130331434A1
公开(公告)日：2013-12-12
申请号：US13884067
申请日：2011-11-08
IPC分类号： C12N15/113
CPC分类号： C12N15/1137 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/321 , C12N2310/3525
摘要： Disclosed herein are methods for decreasing Factor 12 and treating or preventing thromboembolic conditions in an individual in need thereof. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to Factor 12 include thrombosis, embolism, and thromboembolism, such as, deep vein thrombosis, pulmonary embolism, myocardial infarction, stroke, and mesenteric thrombosis. Methods for inhibiting Factor 12 can also be used as a prophylactic treatment to prevent individuals at risk for thrombosis and embolism.
摘要翻译： 本文公开了减少因子12并治疗或预防有此需要的个体血栓栓塞症状的方法。 通过施用靶向因子12的反义化合物可以改善的疾病状况的实例包括血栓形成，栓塞和血栓栓塞，例如深静脉血栓形成，肺栓塞，心肌梗塞，中风和肠系膜血栓形成。 抑制因子12的方法也可用作预防性治疗以预防患有血栓栓塞和栓塞危险的个体。
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公开(公告)号：US20120196921A1
公开(公告)日：2012-08-02
申请号：US13300404
申请日：2011-11-18
申请人： Susan M. Freier , Edward Wancewicz , Brett P. Monia , Andrew M. Siwkowski , Lynnetta Watts , Thomas A. Leedom
发明人： Susan M. Freier , Edward Wancewicz , Brett P. Monia , Andrew M. Siwkowski , Lynnetta Watts , Thomas A. Leedom
IPC分类号： A61K31/711 , A61P3/08 , A61K31/7105 , A61P3/10 , C07H21/04 , C07H21/02
CPC分类号： C07H21/02 , A61K31/70 , C07H21/04 , C12N15/111 , C12N15/1136 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/32 , C12N2500/40 , C12Q1/6886 , C12Q2600/158 , C12N2310/3525 , C12N2310/3527
摘要： Compounds, compositions and methods are provided for modulating the expression of SGLT2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding SGLT2. Methods of using these compounds for modulation of SGLT2 expression and for diagnosis and treatment of diseases and conditions associated with expression of SGLT2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节SGLT2的表达。 组合物包含靶向编码SGLT2的核酸的寡核苷酸。 提供了使用这些化合物调节SGLT2表达和用于诊断和治疗与SGLT2表达相关的疾病和病症的方法。
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80.发明申请公开(公告)号：US20120184031A1
公开(公告)日：2012-07-19
申请号：US13351511
申请日：2012-01-17
申请人： Brett P. Monia , Susan M. Freier , Muthiah Manoharan , William A. Gaarde , Richard H. Griffey , Eric E.` Swayze , C. Frank Bennett
发明人： Brett P. Monia , Susan M. Freier , Muthiah Manoharan , William A. Gaarde , Richard H. Griffey , Eric E.` Swayze , C. Frank Bennett
IPC分类号： C12N5/071
CPC分类号： C12N15/113 , A61K38/00 , C12N15/1137 , C12N2310/315 , C12N2310/318 , C12N2310/3181 , C12N2310/321 , C12N2310/322 , C12N2310/3233 , C12N2310/334 , C12N2310/3341 , C12N2310/345
摘要： The present invention provides compositions and methods for reducing levels of a preselected mRNA, using antisense compounds targeted to a splice site or a region up to 50 nucleobases upstream of an exon/intron junction on said mRNA. Preferably, said antisense compounds do not elicit RNAse H cleavage of the mRNA.
摘要翻译： 本发明提供了使用靶向剪接位点的反义化合物或在所述mRNA上的外显子/内含子结上游多达50个核碱基的区域来降低预选mRNA水平的组合物和方法。 优选地，所述反义化合物不引起mRNA的RNA酶H切割。
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