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130 条记录 (耗时 0.064 秒)

    Tropinol esters and related compounds to promote normal processing of APP
    72.
    发明授权
    Tropinol esters and related compounds to promote normal processing of APP 有权

    公开(公告)号：US11325904B2

    公开(公告)日：2022-05-10

    申请号：US14235405

    申请日：2012-08-01

    申请人： Varghese John ,  Dale E. Bredesen

    发明人： Varghese John ,  Dale E. Bredesen

    IPC分类号： C07D453/02 ,  C07D451/12 ,  A61K31/439 ,  A61K31/444 ,  A61K45/06

    摘要： In various embodiments, compositions and methods are provided for treatment and/or prevention of amyloidogenic diseases. In certain embodiments, the methods entail administering an effective amount of a tropinol ester to a subject in need thereof for prophylactic or therapeutic effect. The methods are particularly useful for prophylactic and therapeutic treatment of Alzheimer's disease. In certain embodiments, methods of reducing the risk, lessening the severity, or delaying the progression or onset of a disease characterized by beta-amyloid deposits in the brain of a mammal are also provided. In certain embodiments, methods of directly or indirectly inhibiting the C-terminal cleavage of APP resulting in the formation of APP-C31 peptide and APPneo (AP-P664) in a mammal are provided.

    TROPINOL ESTERS AND RELATED COMPOUNDS TO PROMOTE NORMAL PROCESSING OF APP
    73.
    发明申请
    TROPINOL ESTERS AND RELATED COMPOUNDS TO PROMOTE NORMAL PROCESSING OF APP 审中-公开
    TROPINOL ESTERS和相关化合物促进APP的正常加工

    公开(公告)号：US20140364451A1

    公开(公告)日：2014-12-11

    申请号：US14235405

    申请日：2012-08-01

    申请人： Varghese John ,  Dale E. Bredesen

    发明人： Varghese John ,  Dale E. Bredesen

    IPC分类号： C07D453/02 ,  C07D451/12

    CPC分类号： C07D453/02 ,  A61K31/439 ,  A61K31/444 ,  A61K45/06 ,  C07D451/12

    摘要： In various embodiments, compositions and methods are provided for treatment and/or prevention of amyloidogenic diseases. In certain embodiments, the methods entail administering an effective amount of a tropinol ester to a subject in need thereof for prophylactic or therapeutic effect. The methods are particularly useful for prophylactic and therapeutic treatment of Alzheimer's disease. In certain embodiments, methods of reducing the risk, lessening the severity, or delaying the progression or onset of a disease characterized by beta-amyloid deposits in the brain of a mammal are also provided. In certain embodiments, methods of directly or indirectly inhibiting the C-terminal cleavage of APP resulting in the formation of APP-C31 peptide and APPneo (AP-P664) in a mammal are provided.

    摘要翻译： 在各种实施方案中，提供用于治疗和/或预防淀粉样变性疾病的组合物和方法。 在某些实施方案中，所述方法需要向有需要的受试者施用有效量的托品醇酯用于预防或治疗效果。 该方法对阿尔茨海默病的预防和治疗特别有用。 在某些实施方案中，还提供了降低哺乳动物脑中β-淀粉样蛋白沉积特征的疾病的风险降低严重性或延缓进展或发作的方法。 在某些实施方案中，提供了在哺乳动物中直接或间接抑制APP的C末端切割导致形成APP-C31肽和APPneo（AP-P664）的方法。

    Device for neuromuscular peripheral body stimulation and electrical stimulation (ES) for wound healing using RF energy harvesting
    75.
    发明申请
    Device for neuromuscular peripheral body stimulation and electrical stimulation (ES) for wound healing using RF energy harvesting 审中-公开
    用于神经肌肉周边体刺激和电刺激（ES）的装置用于使用RF能量收获的伤口愈合

    公开(公告)号：US20060161216A1

    公开(公告)日：2006-07-20

    申请号：US11253905

    申请日：2005-10-18

    申请人： Constance John ,  Varghese John

    发明人： Constance John ,  Varghese John

    IPC分类号： A61N1/18

    CPC分类号： A61N1/3787 ,  A61N1/36007 ,  A61N1/3605 ,  A61N1/36053

    摘要： A device for electrical stimulation using radio frequency harvesting is disclosed. The device called the BioMed chip is implantable in a patient, the chip circuit comprising a radio frequency harvesting and power circuit and a stimulation circuit, and a plurality of electrodes coupled to the circuit, the plurality of electrodes providing stimulation to targeted areas of the human body. The electrodes may provide stimulation to targeted areas of the body including deep within the body.

    摘要翻译： 公开了一种使用射频收集进行电刺激的装置。 称为BioMed芯片的装置可植入患者体内，芯片电路包括射频收集和电源电路以及刺激电路，以及耦合到电路的多个电极，所述多个电极为人的目标区域提供刺激 身体。 电极可以对身体的目标区域提供刺激，包括身体内的深处。

    Amino acid derivatives useful for the treatment of alzheimer's disease
    77.
    发明申请
    Amino acid derivatives useful for the treatment of alzheimer's disease 审中-公开
    用于治疗阿尔茨海默病的氨基酸衍生物

    公开(公告)号：US20060079550A1

    公开(公告)日：2006-04-13

    申请号：US10496242

    申请日：2002-11-21

    申请人： Varghese John

    发明人： Varghese John

    IPC分类号： A61K31/47 ,  A61K31/325 ,  A61K31/198

    CPC分类号： A61K31/325 ,  A61K31/18 ,  A61K31/198 ,  A61K31/405 ,  A61K31/47

    摘要： The present invention is a method of treating Alzheimer's disease, and other diseases, and/or inhibiting beta-secretase enzyme, and/or inhibiting deposition of A beta peptide in a mammal, by use of known compounds of formula (I): wherein R1, R2, R3, R4, W and Cx are herein defined.

    摘要翻译： 本发明是通过使用已知的式（I）化合物治疗阿尔茨海默病和/或抑制β-分泌酶，和/或抑制Aβ肽在哺乳动物体中沉积的方法：其中R R 1，R 2，R 3，R 4，W和C x， 在此定义。

    Substituted pyrimidine compositions and methods of use
    78.
    发明授权
    Substituted pyrimidine compositions and methods of use 失效
    取代的嘧啶组合物和使用方法

    公开(公告)号：US06518424B1

    公开(公告)日：2003-02-11

    申请号：US09438103

    申请日：1999-11-10

    申请人： Varghese John ,  Russell E. Rydel ,  Michael S. Dappen ,  Eugene D. Thorsett

    发明人： Varghese John ,  Russell E. Rydel ,  Michael S. Dappen ,  Eugene D. Thorsett

    IPC分类号： C07D23924

    CPC分类号： C07D239/36 ,  C07D239/42

    摘要： Substituted pyrimidines that have the general structure: in which the symbol R1 represents a C1-C6 alkyl, C1-C6 alkoxy or halogen atom; R2 represents a phenyl group, substituted phenyl group, benzyl moiety, substituted benzyl moiety, C3-C7 cycloalkyl, or substituted C3-C7 cycloalkyl; R3 represents a hydrogen or C1-C6 alkyl group, R4 represents —H, —OH, —N3 or —NHCOCH3; and R5 represents H are provided. These compounds have activity as inhibitors of phospholipase A2, and are useful in treating disorders mediated by phospholipase A2.

    摘要翻译： 具有一般结构的取代的嘧啶：其中符号R1表示C1-C6烷基，C1-C6烷氧基或卤素原子; R 2表示苯基，取代的苯基，苄基部分，取代的苄基部分，C 3 -C 7环烷基或取代的C 3 -C 7环烷基; R 3表示氢或C 1 -C 6烷基，R 4表示-H，-OH，-N 3或-NHCOCH 3; 并且R5表示H。 这些化合物作为磷脂酶A2的抑制剂具有活性，可用于治疗由磷脂酶A2介导的病症。