公开(公告)号：US09102028B2

公开(公告)日：2015-08-11

申请号：US12942015

申请日：2010-11-08

申请人： Satoshi Miyamoto ,  Naoki Furukawa ,  Masahiro Oguma ,  Yusuke Ikeda ,  Yoichi Okamoto

发明人： Satoshi Miyamoto ,  Naoki Furukawa ,  Masahiro Oguma ,  Yusuke Ikeda ,  Yoichi Okamoto

IPC分类号： F25D11/02 ,  F25D17/02 ,  B23Q11/12 ,  B23Q11/14

CPC分类号： B23Q11/126 ,  B23Q11/14

摘要： A machine tool cooling system and cooling method which allow cost reduction by reducing the number of control valves, and in which opening/closing control is simple are disclosed. The machine tool cooling system and cooling method include a hot oil tank storing hot oil, a cold oil tank storing cold oil, a first to third hot oil passages and a first to third cold oil passages, which supply the hot oil and the cold oil to a first to third heat generating portions, a hot oil return passage returning the hot oil to the hot oil tank, a first to third supply control valves interposed in the first to third cold oil passages, and a valve controller controlling opening/closing of the first to third supply control valves so that the cold oil is supplied to the first to third heat generating portions intermittently at different timings.

摘要翻译： 公开了一种机床冷却系统和冷却方法，其通过减少控制阀的数量来进行成本降低，并且其中开/关控制简单。 机床冷却系统和冷却方法包括储存热油的热油箱，储存冷油的冷油罐，第一至第三热油通道和第一至第三冷油通道，其供应热油和冷油 第一至第三发热部分，将热油返回到热油箱的热油返回通道，设置在第一至第三冷油通道中的第一至第三供给控制阀，以及控制阀的开/关控制阀 第一至第三供给控制阀，使得冷油在不同的定时间歇地供给到第一至第三发热部。

公开(公告)号：US08632553B2

公开(公告)日：2014-01-21

申请号：US11953651

申请日：2007-12-10

申请人： Yuji Sakamoto ,  Norio Onishi ,  Satoshi Miyamoto

发明人： Yuji Sakamoto ,  Norio Onishi ,  Satoshi Miyamoto

IPC分类号： A61B17/10

CPC分类号： A61B17/10 ,  A61B17/00234 ,  A61B17/0467 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/0487 ,  A61B17/12 ,  A61B17/12013 ,  A61B17/1285 ,  A61B2017/00469 ,  A61B2017/0406 ,  A61B2017/0417 ,  A61B2017/0458 ,  A61B2017/0464 ,  A61B2017/0472 ,  A61B2017/0488 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2017/2905 ,  A61B2017/306

摘要： A ligature and suture device for medical application includes a distal end insertion portion, a needle body, a ligature tool, and an operation section. The operation section includes a housing that is provided in a base end portion of the distal end insertion portion, a puncture handle that is provided in the housing so as to be able to move freely backwards and forwards and that drives the needle body, a pressing handle that is provided in the housing so as to be able to move freely backwards and forwards and that drives a pressing member, a ligature tool operation unit that is provided in the housing so as to be able to move freely backwards and forwards and that drives a ligature sheath, and a ligature handle that is provided in the ligature tool operation unit so as to be able to move freely backwards and forwards and that drives an engaging portion.

摘要翻译： 用于医疗应用的结扎和缝合装置包括远端插入部分，针体，连线工具和操作部分。 操作部包括设置在前端插入部的基端部的壳体，设置在壳体内以能够自由前后移动并驱动针体的穿刺手柄，按压 手柄，其设置在壳体中，以便能够自由地前后移动，并且驱动按压构件;连接工具操作单元，其设置在壳体中以便能够自由地向前和向后移动，并且驱动 连接护套和连接手柄，其设置在连接工具操作单元中，以便能够自由地前后移动并且驱动接合部。

公开(公告)号：US08523762B2

公开(公告)日：2013-09-03

申请号：US12114235

申请日：2008-05-02

申请人： Satoshi Miyamoto ,  Kousuke Motai ,  Yasuhito Kura

发明人： Satoshi Miyamoto ,  Kousuke Motai ,  Yasuhito Kura

IPC分类号： A61B1/04

CPC分类号： A61B1/31 ,  A61B1/00039 ,  A61B1/00071 ,  A61B1/00082 ,  A61B1/00098 ,  A61B1/00135 ,  A61B1/00147 ,  A61B1/00177 ,  A61B1/0051 ,  A61B1/01 ,  A61B1/12

摘要： An endoscope system includes: an endoscope including an elongated insertion portion provided with a bendable bending portion, the insertion portion being inserted into a duodenum; and a first balloon to a fourth balloon for moving a one-side surface of a distal end portion located nearer to a distal end side than the bending portion in the insertion portion in parallel with respect to a field of view direction S of an objective lens which is a diameter direction of the insertion portion, separately from bending of the bending portion, the one-side surface being located in a circumferential direction along an insertion direction W of the insertion portion and parallel to a central axis P of the insertion portion.

摘要翻译： 一种内窥镜系统，包括：内窥镜，具有设置有弯曲弯曲部的细长插入部，所述插入部插入十二指肠; 以及第一气球到第四气球，用于相对于物镜的视场方向S平行地移动位于比插入部中的弯曲部更靠近前端侧的前端部的一侧表面 所述插入部分的直径方向与所述弯曲部分的弯曲分开，所述单侧表面沿着所述插入部分的插入方向W沿圆周方向位于所述插入部分的中心轴线P上。

公开(公告)号：US08399663B2

公开(公告)日：2013-03-19

申请号：US12753415

申请日：2010-04-02

申请人： Junya Ohmori ,  Makoto Kasai ,  Takenori Kimura ,  Noritaka Hamada ,  Ryo Mizoguchi ,  Satoshi Miyamoto ,  Noriyuki Kawano

发明人： Junya Ohmori ,  Makoto Kasai ,  Takenori Kimura ,  Noritaka Hamada ,  Ryo Mizoguchi ,  Satoshi Miyamoto ,  Noriyuki Kawano

IPC分类号： C07D403/12 ,  A61K31/53 ,  A61P25/28

CPC分类号： A61K31/53 ,  C07D403/12

摘要： Anytime obtained is uniform crystal of N-(4-fluorophenyl)-N′-phenyl-N″-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine (compound A) and/or N,N′-bis (4-fluorophenyl)-N″-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine (compound B) as a medicament or a starting material for the preparation of the medicament, and provided are a fumarate of the compound A and/or the compound B having excellent stability and a novel crystal thereof. A salt of the compound A and/or the compound B with fumaric acid enables uniform crystal to be anytime obtained, and thus, it is a compound that is very useful as a medicament or a starting material for the preparation of the medicament having excellent stability.

摘要翻译： 得到的N-（4-氟苯基）-N'-苯基-N“ - （嘧啶-2-基甲基）-1,3,5-三嗪-2,4,6-三胺（化合物A）和 /或N，N'-二（4-氟苯基）-N“ - （嘧啶-2-基甲基）-1,3,5-三嗪-2,4,6-三胺（化合物B）作为药物或起始物 用于制备药物的材料，并且提供具有优异的稳定性和新颖结晶的化合物A和/或化合物B的富马酸盐。 化合物A和/或化合物B与富马酸的盐能够随时获得均匀的结晶，因此，作为制备具有优异稳定性的药物的药物或原料非常有用的化合物 。

公开(公告)号：US08298250B2

公开(公告)日：2012-10-30

申请号：US12324986

申请日：2008-11-28

申请人： Yoshio Onuki ,  Satoshi Miyamoto ,  Koichi Kawashima

发明人： Yoshio Onuki ,  Satoshi Miyamoto ,  Koichi Kawashima

IPC分类号： A61B17/24 ,  A61B17/10 ,  A61B17/04

CPC分类号： A61B17/12013 ,  A61B17/32056 ,  A61B2017/0488 ,  A61B2017/12018

摘要： A medical ligating apparatus includes a medical ligating device having a member which is made of a flexible line and ligates living tissues, and a fixing member which is movably provided at the ligating member and fixes the living tissues in a ligated state, a manipulating device having a flexible sheath and a proximal manipulating section, and a cutting member for cutting the ligating member. The cutting member is provided on the manipulating device and is movably provided on the ligating member.

公开(公告)号：US08206407B2

公开(公告)日：2012-06-26

申请号：US11399664

申请日：2006-04-06

申请人： Yoshio Onuki ,  Satoshi Miyamoto

发明人： Yoshio Onuki ,  Satoshi Miyamoto

IPC分类号： A61B17/10

CPC分类号： A61B17/0401 ,  A61B17/0467 ,  A61B17/0487 ,  A61B17/12 ,  A61B17/12013 ,  A61B2017/0404 ,  A61B2017/0409 ,  A61B2017/0417 ,  A61B2017/0458 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61B2017/06052

摘要： A medical procedure tool equipped with: a flexible linear material for carrying out a specific procedure to a biological tissue; a linear material holding member provided covering the linear material in a freely advancing and retracting manner, for holding the linear material; a flexible first sheath provided so as to come into contact with the base end side of the linear material holding member; a flexible second sheath provided so as to be freely advancing and retracting with respect to the first sheath and the linear material holding member; an operator for advancing and retracting manipulation of the second sheath; and a cutting means for cutting the linear material; wherein the cutting means is provided with a first cutting part provided to the linear material holding member; and a second cutting part that is provided to the front end of the second sheath and which, together with the first cutting part, grips the linear material there between; and one of either the first cutting part or the second cutting part is a blade member.

摘要翻译： 一种医疗手术工具，配备有用于对生物组织进行特定程序的柔性线性材料; 线性材料保持构件，其以自由前进和后退的方式设置成覆盖线状材料，用于保持线材; 柔性第一护套，设置成与线状材料保持构件的基端侧接触; 柔性第二护套，其设置成相对于所述第一护套和所述线状材料保持构件自由前进和后退; 用于推进和缩回第二护套的操作的操作器; 以及用于切割线材的切割装置; 其中所述切割装置设置有设置在所述线状材料保持部件上的第一切割部; 以及第二切割部，其设置在所述第二护套的前端，并且与所述第一切割部一起在其间夹住所述线状材料; 并且第一切割部分或第二切割部分中的一个是叶片部件。

公开(公告)号：US08118819B2

公开(公告)日：2012-02-21

申请号：US11399538

申请日：2006-04-06

申请人： Satoshi Miyamoto ,  Norio Onishi

发明人： Satoshi Miyamoto ,  Norio Onishi

IPC分类号： A61B17/10

CPC分类号： A61B17/0469 ,  A61B17/12013 ,  A61B2017/0417 ,  A61B2017/0477 ,  A61B2017/0496

摘要： A medical treatment tool comprises: a flexible wire; a first wire holding member which holds the wire; a second wire holding member capable of holding the wire between itself and the first wire holding member; a first sheath which is provided in contact with a proximal side of the second wire holding member; a second sheath which is provided in a back-and-forth movable manner with respect to the first sheath; and a sheath operation portion which operates the second sheath. The first wire holding member and the second sheath have a connection device for connecting them to each other; the first wire holding member and the second wire holding member have a latching device which latches them to each other when holding the wire there between, and a cutting device which cuts the wire; and the second wire holding member has a connection releasing device which releases the connection of the connection device, when latched by the first wire holding member.

摘要翻译： 医疗工具包括：柔性线; 保持电线的第一电线保持构件; 第二线保持构件，其能够将线固定在其与第一线保持构件之间; 第一护套，其设置成与所述第二电线保持构件的近侧接触; 相对于第一护套以可前后移动的方式设置的第二护套; 以及操作第二护套的护套操作部。 第一线保持构件和第二护套具有用于将它们彼此连接的连接装置; 第一线保持构件和第二线保持构件具有闩锁装置，当将电线夹持在其间时彼此锁定，并且切割装置切割线; 并且第二线保持构件具有当由第一线保持构件锁定时释放连接装置的连接的连接释放装置。

公开(公告)号：US07893973B2

公开(公告)日：2011-02-22

申请号：US12187228

申请日：2008-08-06

申请人： Jiyun Du ,  Satoshi Miyamoto ,  Nobuhisa Yamazaki

发明人： Jiyun Du ,  Satoshi Miyamoto ,  Nobuhisa Yamazaki

IPC分类号： H04N5/238 ,  H04N9/64 ,  G06K9/00

CPC分类号： H04N1/401 ,  G06T5/006 ,  G06T5/008 ,  G06T5/40 ,  G06T2207/20012 ,  G06T2207/20021 ,  G06T2207/30176 ,  H04N1/00307 ,  H04N1/4072 ,  H04N2201/0084 ,  H04N2201/0096

摘要： Document image data is converted into luminance image data. Block image data is generated from the luminance image data. Start point block pixel data and end point block pixel data are set based on a change rate of luminance values of adjacent block pixel data. A luminance value of block pixel data between the start point block pixel data and the end point block pixel data is corrected based on a start point luminance value and an end point luminance value. The luminance value, of the block pixel data wherein each luminance value of an adjacent block pixel data cluster is less than an average value, is substituted by the average value. The luminance value of each pixel data is set based on the luminance value of the block pixel data. Post process luminance image data that includes each pixel data is reconverted into the document image data.

摘要翻译： 文件图像数据被转换为亮度图像数据。 从亮度图像数据生成块图像数据。 基于相邻块像素数据的亮度值的变化率来设定起始点块像素数据和终点块像素数据。 基于开始点亮度值和终点亮度值来校正开始点块像素数据和结束点块像素数据之间的块像素数据的亮度值。 其中相邻块像素数据簇的每个亮度值小于平均值的块像素数据的亮度值被平均值代替。 基于块像素数据的亮度值设定每个像素数据的亮度值。 将包含每个像素数据的后处理亮度图像数据重新转换为文档图像数据。

公开(公告)号：US20100324017A1

公开(公告)日：2010-12-23

申请号：US12526250

申请日：2008-02-06

申请人： Isao Kinoyama ,  Satoshi Miyamoto ,  Hiroaki Hoshii ,  Takehiro Miyazaki ,  Mayako Yamazaki

发明人： Isao Kinoyama ,  Satoshi Miyamoto ,  Hiroaki Hoshii ,  Takehiro Miyazaki ,  Mayako Yamazaki

IPC分类号： A61K31/403 ,  C07D209/88 ,  C07D401/04 ,  C07D405/04 ,  C07D403/04 ,  C07D405/06 ,  C07D413/06 ,  C07D409/04 ,  C07D495/04 ,  A61K31/4439 ,  A61K31/5377 ,  A61P25/18 ,  A61P25/28 ,  A61P25/00

CPC分类号： C07D401/04 ,  C07D209/88 ,  C07D401/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04

摘要： An object of the present invention is to provide a novel and excellent agent for treating or preventing dementia, schizophrenia and the like, based on the 5-HT5A receptor modulating action. It was confirmed that a compound characterized by a structure that a tricyclic hetero ring having a pyrrole ring at the center and guanidine are bonded via a carbonyl group has a potent 5-HT5A receptor modulating action and an excellent pharmacological action based thereon, and thus, it was found that the compound can be an excellent agent for treating or preventing dementia, schizophrenia, bipolar disorder, or attention deficit hyperactivity disorder, particularly for memory-related functional disorders such as cognitive impairments including dementia and schizophrenia, thereby completing the present invention.

摘要翻译： 本发明的目的是提供一种基于5-HT5A受体调节作用治疗或预防痴呆，精神分裂症等的新颖且优异的药剂。 证实了具有中心具有吡咯环的三环杂环和胍通过羰基键合的结构的化合物具有有效的5-HT5A受体调节作用和基于其的优异的药理作用，因此， 发现该化合物可以是用于治疗或预防痴呆，精神分裂症，双相情感障碍或注意缺陷多动障碍，特别是用于记忆相关功能障碍如认知障碍包括痴呆和精神分裂症的优良药剂，从而完成本发明。

公开(公告)号：US07704261B2

公开(公告)日：2010-04-27

申请号：US11099303

申请日：2005-04-05

申请人： Yuji Sakamoto ,  Yoshio Onuki ,  Koh Kimura ,  Satoshi Miyamoto ,  Pankaj Jay Pasricha ,  Takayuki Suzuki ,  Koichi Kawashima

发明人： Yuji Sakamoto ,  Yoshio Onuki ,  Koh Kimura ,  Satoshi Miyamoto ,  Pankaj Jay Pasricha ,  Takayuki Suzuki ,  Koichi Kawashima

IPC分类号： A61B17/10

CPC分类号： A61B17/0469 ,  A61B17/0482 ,  A61B17/0487 ,  A61B2017/00469 ,  A61B2017/0406 ,  A61B2017/0417 ,  A61B2017/0458 ,  A61B2017/0464 ,  A61B2017/0472 ,  A61B2017/0488 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2017/2905 ,  A61B2017/306

摘要： A ligature and suture device for medical application that ligatures or sutures biomedical tissue that has been suctioned by a suction device using a suturing member. The ligature and suture device includes an insertion portion having a lumen into which an endoscope can be inserted, and a distal end portion that is connected to the lumen and in which at least one side aperture is provided, at least one hollow needle that is able to support inside itself the suturing member, and that is placed inside the insertion portion such that a tip of the hollow needle is able to move between a first position, which is on a base end side of the side aperture, and a second position, which is on a distal end side of the side aperture, an operating section that performs an operation to move the needle, and at least one pledget that can be penetrated by the needle, and that is placed in a vicinity of the distal end of the side aperture so as to be freely removable from the distal end portion.

摘要翻译： 用于医疗应用的结扎和缝合装置，其连接或缝合已由使用缝合构件的抽吸装置抽吸的生物医学组织。 连线和缝合装置包括具有内窥镜可被插入的内腔的插入部分和连接到内腔并且至少设置有至少一个侧孔的远端部分，至少一个中空针头能够 将其固定在缝合部件的内侧，并将其放置在插入部内，使得中空针头的前端能够在侧孔的基端侧的第一位置与第二位置之间移动， 位于所述侧孔的前端侧的操作部，所述操作部进行所述针的移动操作，以及至少一个能够被针刺入的毛发，并且被放置在所述针的前端的附近 从而能够从前端部自由地移除。