公开(公告)号：US20180154142A1

公开(公告)日：2018-06-07

申请号：US15831845

申请日：2017-12-05

Applicant: Old Dominion University Research Foundation

Inventor： Siqi Guo ,  Stephen J. Beebe ,  Richard Heller

IPC: A61N1/36 ,  A61K45/00 ,  A61N1/05 ,  A61P35/00

CPC classification number: A61N1/36002 ,  A61B18/1206 ,  A61B18/1477 ,  A61B2018/00291 ,  A61B2018/00333 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00636 ,  A61K45/00 ,  A61N1/05 ,  A61N1/326 ,  A61P35/00

Abstract: Disclosed herein are methods and devices for stimulating an immune response to a disease in a subject, which involves passing sub-microsecond long pulses of electric fields having an amplitude between 5 kV/cm and 68 kV/cm through an abnormal growth of a subject sufficient to suppress myeloid-derived suppressor cell (MDSC) or regulatory T cell (Treg) production, increase adenosine triphosphate (ATP) or high mobility group box 1 (HMGB1) production, or stimulate dendritic cell activation in the subject.

公开(公告)号：US09852891B2

公开(公告)日：2017-12-26

申请号：US14688363

申请日：2015-04-16

Applicant: Svetozar Popovic ,  Janardan Upadhyay ,  Leposava Vuskovic ,  H. Lawrence Phillips ,  Anne-Marie Valente-Feliciano

Inventor： Svetozar Popovic ,  Janardan Upadhyay ,  Leposava Vuskovic ,  H. Lawrence Phillips ,  Anne-Marie Valente-Feliciano

IPC: B44C1/22 ,  C03C15/00 ,  C03C25/68 ,  C23F1/00 ,  H01J37/32

CPC classification number: H01J37/32192 ,  H01J37/32082 ,  H01J37/32394 ,  H01J37/32403 ,  H01J37/32449 ,  H01J37/32467 ,  H01J37/32541 ,  H01J37/32568 ,  H01J37/32596 ,  H01J37/32816 ,  H01J2237/334

Abstract: A method for efficient plasma etching of surfaces inside three-dimensional structures can include positioning an inner electrode within the chamber cavity; evacuating the chamber cavity; adding a first inert gas to the chamber cavity; regulating the pressure in the chamber; generating a plasma sheath along the inner wall of the chamber cavity; adjusting a positive D.C. bias on the inner electrode to establish an effective plasma sheath voltage; adding a first electronegative gas to the chamber cavity; optionally readjusting the positive D.C. bias on the inner electrode reestablish the effective plasma sheath voltage at the chamber cavity; etching the inner wall of the chamber cavity; and polishing the inner wall to a desired surface roughness.

公开(公告)号：US09333368B2

公开(公告)日：2016-05-10

申请号：US14170720

申请日：2014-02-03

Applicant: Shu Xiao ,  Andrei Pakhomov ,  Karl H. Schoenbach

Inventor： Shu Xiao ,  Andrei Pakhomov ,  Karl H. Schoenbach

IPC: A61N1/00 ,  A61B5/04 ,  A61N2/00 ,  A61N5/02 ,  A61N1/40

CPC classification number: A61N1/36014 ,  A61N1/40 ,  A61N2/006 ,  A61N5/02

Abstract: A system for treatment of biological tissues is provided. The system includes a lens having a hollow, substantially hemispherical shape with an outer surface and an inner surface, the inner surface defining a substantially hemispherical cavity for inserting the biological tissues. The system further includes an antenna assembly for generating and directing electromagnetic radiation towards the outer surface. In the system, the lens is configured to direct the electromagnetic energy to an area in the cavity, a dielectric constant of the lens at the inner surface substantially matches a dielectric constant of the biological tissues, the dielectric constant monotonically increases from the outer surface to the inner surface, and the electromagnetic energy is generated via a series of pulses having a transient of less than about 1 nanosecond.

Abstract translation: 提供了一种用于治疗生物组织的系统。 该系统包括具有中空的，基本上半球形的透镜，其具有外表面和内表面，内表面限定用于插入生物组织的基本上半球形的腔。 该系统还包括一个天线组件，用于产生和引导电磁辐射朝向外表面。 在该系统中，透镜被配置为将电磁能量引导到空腔中的区域，透镜在内表面的介电常数基本上与生物组织的介电常数相匹配，介电常数从外表面单调增加到 通过具有小于约1纳秒的瞬态的一系列脉冲来产生内表面和电磁能。

公开(公告)号：US20140302569A1

公开(公告)日：2014-10-09

申请号：US14236215

申请日：2012-07-24

Applicant: Andrew S. Gordon ,  Patrick G. Hatcher

Inventor： Andrew S. Gordon ,  Patrick G. Hatcher

IPC: C12P7/64

CPC classification number: C12P7/649 ,  C10G2300/1014 ,  C10G2300/202 ,  C10L1/026 ,  C11C3/003 ,  C11C3/04 ,  Y02E50/13 ,  Y02P30/20

Abstract: Use of an algal for biodiesel fuel selected for growing strain of production, the genus Desmodesmus wherein said strain was under high nutrient conditions and is characterized as having a determined fatty by acid nuclear methyl ester content of 2.6% magnetic resonance analysis, nitrogen content of 11.3% and a carbon content of 46.3%. Given the growth and elemental composition of this strain t the instant algal strain is of particular use as a biomass source for biofuel lipids and/or biodiesel fuel production.

Abstract translation: 使用藻类用于生产生物菌种的生物柴油，其中所述菌株处于高营养条件下，其特征在于具有2.6％磁共振分析的酸核甲酯含量确定的脂肪，氮含量为11.3 ％，碳含量为46.3％。 鉴于该菌株的生长和元素组成，即时藻类菌株特别用作生物燃料脂质和/或生物柴油燃料生产的生物质来源。

公开(公告)号：US20140296354A1

公开(公告)日：2014-10-02

申请号：US14242170

申请日：2014-04-01

Applicant: Guijun WANG ,  Hari P. R. MANGUNURU

Inventor： Guijun WANG ,  Hari P. R. MANGUNURU

IPC: C07C233/78 ,  A61K47/18 ,  C07C233/38 ,  C07C231/14 ,  C07B57/00 ,  C07C233/36 ,  C07H19/01 ,  B01J31/02

CPC classification number: B01J31/0271 ,  B01J20/291 ,  B01J31/0202 ,  B01J31/0207 ,  B01J31/0209 ,  B01J31/0247 ,  C07B57/00 ,  C07B2200/07 ,  C07C237/22 ,  C07C2601/14 ,  C07H15/04

Abstract: Described herein are the one-pot synthesis and characterization of a library of low molecular weight peptoid compounds that are able to form gels at room temperature. The compounds are synthesized from biologically-based starting materials, are biocompatible, and are resistant to degradation by proteases and peptidases. The compounds and gels synthesized therefrom can be used in such applications as tissue engineering, drug delivery, separation of biomolecules, and stimulus-responsive advanced materials

Abstract translation: 本文描述了能够在室温下形成凝胶的低分子量拟肽化合物文库的一锅合成和表征。 该化合物由基于生物学的起始物质合成，是生物相容的，并且对蛋白酶和肽酶的降解具有抗性。 由此合成的化合物和凝胶可用于组织工程，药物递送，生物分子分离和刺激反应先进材料

公开(公告)号：US20140199384A1

公开(公告)日：2014-07-17

申请号：US14162086

申请日：2014-01-23

Applicant: Ramjee Balasubramanian ,  Zaharoula M. Kalaitzis ,  Srujana Prayakarao

Inventor： Ramjee Balasubramanian ,  Zaharoula M. Kalaitzis ,  Srujana Prayakarao

IPC: A61K9/51

CPC classification number: A61K9/5138 ,  A61K47/32 ,  B82Y5/00 ,  B82Y40/00 ,  C08G75/045

Abstract: Described is a direct method for the fabrication of resorcinarene nanocapsules by photopolymerization of compounds of formula (I), such as resorcinarene tetraalkene tetrathiol (RTATT), in the absence of any template or preorganization. Further, by varying the polymerization media, a variety of other polymeric architectures like lattices, fibrous networks, and nanoparticles were obtained. The morphology and structure were characterized by transmission electron microscopy, energy dispersive spectroscopy, scanning electron microscopy, dynamic light scattering, infrared and nuclear magnetic resonance spectroscopy. These morphologically distinct resorcinarene polymeric architectures contain residual thiol and ene functional groups offering potential functionalization opportunities.

Abstract translation: 描述了在没有任何模板或预组织的情况下通过式（I）化合物如间苯二酚四烯四硫醇（RTATT）的光聚合制备间苯二酚纳米胶囊的直接方法。 此外，通过改变聚合介质，获得了各种其它聚合物结构如晶格，纤维网和纳米颗粒。 通过透射电子显微镜，能量色散光谱，扫描电子显微镜，动态光散射，红外和核磁共振光谱表征形态和结构。 这些形态上不同的间苯二酚聚合体系结构包含残留的硫醇和烯官能团，提供潜在的功能化机会。

公开(公告)号：US08778035B2

公开(公告)日：2014-07-15

申请号：US13096016

申请日：2011-04-28

Applicant: Patrick G. Hatcher ,  Elodie Salmon

Inventor： Patrick G. Hatcher ,  Elodie Salmon

IPC: C10L1/18 ,  C12P5/00 ,  C12N1/12

CPC classification number: C12N1/12 ,  C05F5/004 ,  C05F5/006 ,  C08H8/00 ,  C10G2300/1014 ,  C12P7/62 ,  C12P7/6436 ,  C12P7/649 ,  Y02A40/209 ,  Y02A40/211 ,  Y02E50/13 ,  Y02P30/20

Abstract: Disclosed herein is the production of hydrocarbon based fuel from micro-organisms and algae that comprise algaenan without requiring prior removal of water, as well as the production of hydrocarbon based fuel directly from the algaenan itself. Also disclosed herein are feed material for the processes disclosed herein comprising modified algae and algaenan that selectively produce hydrocarbon of desired chain lengths, along with the process of modifying the algae and algaenan. Also disclosed herein is the production of both hydrocarbon and organic fertilizer from algae without the need to remove the water from the algae prior to processing.

Abstract translation: 本文公开的是从微生物和藻类生产烃基燃料，其包含藻类，而不需要事先除去水，以及直接从藻类自身生产基于烃的燃料。 本文还公开了用于本文公开的方法的饲料，其包含改性藻类和藻类，其选择性地产生所需链长度的烃，以及改变藻类和藻类的方法。 本文还公开了从藻类生产碳氢化合物和有机肥料，而不需要在处理之前从藻类中除去水分。

公开(公告)号：US08649631B2

公开(公告)日：2014-02-11

申请号：US13758849

申请日：2013-02-04

Applicant: Old Dominion University Research Foundation

Inventor： Mohammed Nazrul Islam ,  K. Vijayan Asari ,  Mohammad A. Karim

IPC: G06K9/36 ,  G06K9/62

CPC classification number: G06K9/6256 ,  G06K9/209 ,  G06K9/746 ,  G06K9/748

Abstract: Disclosed is a distortion invariant system, method and computer readable medium for detecting the presence of one or more predefined targets in an input image. The input image and a synthetic discriminant function (SDF) reference image are correlated in a shift phase-encoded fringe-adjusted joint transform correlation (SPFJTC) correlator yielding a correlation output. A peak-to-clutter ratio (PCR) is determined for the correlation output and compared to a threshold value. A predefined target is present in the input image when the PCR is greater than or equal to the threshold value.

Abstract translation: 公开了一种用于检测输入图像中一个或多个预定义目标的存在的失真不变系统，方法和计算机可读介质。 输入图像和合成判别函数（SDF）参考图像在产生相关输出的相移编码条纹调整关联变换相关（SPFJTC）相关器中相关。 确定相关输出的峰 - 杂波比（PCR），并将其与阈值进行比较。 当PCR大于或等于阈值时，输入图像中存在预定义的目标。

公开(公告)号：US20130318947A1

公开(公告)日：2013-12-05

申请号：US13960463

申请日：2013-08-06

Applicant: Muhammad Arif MALIK ,  Karl H. SCHOENBACH ,  Richard HELLER

Inventor： Muhammad Arif MALIK ,  Karl H. SCHOENBACH ,  Richard HELLER

IPC: F01N3/08 ,  F01N3/36

CPC classification number: F01N3/0892 ,  B01D53/9431 ,  B01D2251/208 ,  B01D2258/012 ,  B01D2259/818 ,  F01N3/2073 ,  F01N3/36 ,  F01N2240/02 ,  F01N2240/04 ,  F01N2240/28 ,  F01N2240/30

Abstract: Systems and methods for treatment of a heated exhaust gas including hydrocarbons are provided. A method includes providing a first gas including a gaseous mixture of vaporized diesel fuel and steam and treating the first gas using at least one corona discharge including a combination of streamers to transform the first gas into a second gas including volatile partially oxidized hydrocarbons (PO—HC) and hydrogen gas (H2), the combination of streamers including primarily surface streamers. The method also includes extracting at least a portion of vaporized diesel fuel and steam from the second gas to form a third gas and directing a combination of the third gas and the exhaust gas into a nitrogen oxides (NOx) reduction reactor.

Abstract translation: 提供了用于处理包括烃的加热废气的系统和方法。 一种方法包括提供包括蒸发的柴油和蒸汽的气体混合物的第一气体，并使用包括拖缆组合的至少一个电晕放电来处理第一气体，以将第一气体转化成包括挥发性部分氧化的烃（PO- HC）和氢气（H2），拖缆的组合主要包括表面拖缆。 该方法还包括从第二气体提取蒸发的柴油燃料和蒸汽的至少一部分以形成第三气体，并将第三气体和废气的组合引入氮氧化物（NOx）还原反应器中。

公开(公告)号：US20130284588A1

公开(公告)日：2013-10-31

申请号：US13836440

申请日：2013-03-15

Applicant: Old Dominion University Research Foundation

Inventor： Muhammad Arif Malik ,  Karl H. Schoenbach ,  Richard Heller

IPC: B03C9/00

CPC classification number: B03C9/00 ,  B01D53/323 ,  B01D53/9431 ,  B01D2251/11 ,  B01D2251/208 ,  B01D2257/702 ,  B01D2257/708 ,  H05H1/2406 ,  H05H2001/2412 ,  H05H2001/483 ,  H05H2245/1215

Abstract: Systems and methods for the treatment of a gas are provided. A method includes providing multiple discharge chambers defined by dielectric sections, where each of the discharge chambers comprises sets of electrodes for producing electric fields in the discharge chambers, where the dielectric sections and the sets of electrodes are arranged to define a volume that inhibits the formation of volume-streamers and the discharge chambers are configured to either prevent pulsed electric fields generated in adjacent discharge chambers from substantially interacting or to allow interaction in constructive way. The method also includes directing the gas into the discharge chambers and treating the gas using a corona discharge in the discharge chambers produced by a pulsed electric field generated by each of the sets of the first and second electrodes in the discharge chambers, where the pulsed electric field is configured to produce the corona discharge to have surface-streamers and volume-streamers.

Abstract translation: 提供了用于处理气体的系统和方法。 一种方法包括提供由电介质部分限定的多个放电室，其中每个放电室包括用于在放电室中产生电场的电极组，其中电介质部分和电极组被布置成限定抑制形成的体积 的放电室和放电室被配置为防止在相邻放电室中产生的脉冲电场基本相互作用或允许以建设性的方式进行相互作用。 该方法还包括将气体引导到放电室中，并且通过由放电室中的每组第一和第二电极产生的脉冲电场产生的放电室中的电晕放电来处理气体，其中脉冲电 场被配置为产生电晕放电以具有表面拖缆和卷筒拖缆。