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188 条记录 (耗时 0.042 秒)

    Fluorescent dyes
    75.
    发明授权
    Fluorescent dyes 有权
    荧光染料

    公开(公告)号：US08674102B2

    公开(公告)日：2014-03-18

    申请号：US13733239

    申请日：2013-01-03

    申请人： Enzo Life Sciences, Inc.

    发明人： Praveen Pande ,  Zaiguo Li ,  Maciej Szczepanik ,  Wayne Forrest Patton

    IPC分类号： C07F9/28 ,  C12Q1/00

    CPC分类号： C09B23/164 ,  C09B23/0066 ,  C09B23/0075 ,  C09B23/0091 ,  C09B23/04 ,  C09B23/06 ,  C09B23/083 ,  C09B23/105 ,  C09B23/145 ,  C09B23/146 ,  C12Q1/68 ,  G01N33/583

    摘要： The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins, nucleic acids and cellular organelles. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified to provide beneficial properties.

    摘要翻译： 本发明提供可用于检测或定量所需靶分子（例如蛋白质，核酸和细胞器器）的染料，活性染料和标记试剂。 提供可以在染料与靶分子的结合提供信号产生的溶液中游离的染料。 还提供了包含可用于将染料连接到将与所需靶分子结合的探针的反应性基团的染料。 已经对本发明的新型染料进行了改进以提供有益的性质。

    Cyanine dye labelling reagents with meso-substitution
    79.
    发明申请
    Cyanine dye labelling reagents with meso-substitution 有权
    花青染料标记试剂与中观取代

    公开(公告)号：US20040186278A1

    公开(公告)日：2004-09-23

    申请号：US10394108

    申请日：2003-03-21

    发明人： Chung-Yuan Chen ,  Shiv Kumar

    IPC分类号： G01N033/53 ,  C07D417/02 ,  C07D413/02 ,  C07D43/02

    CPC分类号： C09B23/164 ,  C07D209/24 ,  C09B23/0058 ,  C09B23/02 ,  G01N33/582

    摘要： Disclosed are cyanine dyes having meso-substituents in the polymethine chain linking the heterocyclic ring systems. The dyes are of formula (1): 1 in which groups R3 and R4 are attached to the Z1 ring structure and groups R5 and R6 are attached to the Z2 ring structure, and nnull1, 2 or 3; Z1 and Z2 independently represent the atoms necessary to complete one ring, or two fused ring aromatic or heteroaromatic systems, each ring having five or six atoms selected from carbon atoms and optionally no more than two atoms selected from oxygen, nitrogen and sulphur; X and Y are the same or different and are selected from oxygen, sulphur, nullCHnullCHnull and the group: 2 at least one of groups R1, R2, R3, R4, R5, R6 (and R8 and R9 if present) is the group nullEnullF where E is a spacer group and F is a target bonding group; one of groups R7 is selected from nullCN, nullCl, nullF, nullCF3 and nullC(O)R10 wherein R10 is selected from H, C1-C6 alkyl and aryl. Preferred group R7 is meso-substituted nullCN, which confers an unexpected hypsochromic shift of approximately 40 nm in the emission spectrum, when compared with the corresponding unsubstituted analogue. The dyes are useful for labelling and detecting a variety of target molecules.

    摘要翻译： 公开了在连接杂环体系的聚甲炔链中具有内消旋取代基的花青染料。 染料具有式（1）：其中R 3和R 4基团连接到Z 1环结构，R 5和R 6基团连接到Z 2上， 环结构，n = 1,2或3; Z 1和Z 2独立地表示完成一个环或两个稠环芳族或杂芳族体系所必需的原子，每个环具有五个或六个选自碳原子和任选不超过两个选自氧， 氮和硫; X和Y相同或不同，选自氧，硫，-CH = CH-，基团R 1，R 2，R 3，R 4， R 5，R 6（和R 8和R 9如果存在）是基团-EF，其中E是间隔基团，F是目标键合基团; R 7中的一个选自-CN，-Cl，-F，-CF 3和-C（O）R 10，其中R 10选自H，C 1 -C 6烷基和芳基。 优选的基团R 7是内消旋的-CN，与相应的未取代的类似物相比，其在发射光谱中赋予约40nm的意想不到的脱色移。 染料可用于标记和检测各种靶分子。

    Optical recording materials having high storage density
    80.
    发明申请
    Optical recording materials having high storage density 审中-公开
    具有高存储密度的光记录材料

    公开(公告)号：US20040096775A1

    公开(公告)日：2004-05-20

    申请号：US10472636

    申请日：2003-09-18

    发明人： Urs Lehmann ,  Jean-Luc Budry ,  Beat Schmidhalter ,  Heinz Sphani ,  Peter Sutter

    IPC分类号： G03C001/492 ,  G03C001/494 ,  G03C001/76

    CPC分类号： G11B7/247 ,  C09B23/164 ,  C09B23/166 ,  C09B23/168 ,  C09B26/06 ,  C09B55/004 ,  C09B55/009 ,  C09B69/02 ,  C09B69/06 ,  G11B7/245 ,  G11B7/2467 ,  G11B7/2472 ,  G11B7/2495 ,  G11B7/2534 ,  G11B7/2542 ,  G11B7/259 ,  G11B2007/24612

    摘要： This invention relates to an optical recording medium, comprising a substrate, a reflecting layer and a recording layer based on compounds of formula (I), (II), (III) or (IV). Attention is drawn to the description for the precise meanings of the substituents. Recording and playback are carried out especially at a wavelength of from 350 to 500 nm, for example using a blue laser. The recording and playback quality is excellent and allows high storage density. Likewise claimed are some novel compounds of formula (I), (II), (III) or (IV), as well as an optical recording medium comprising, in the following arrangement, a) a supporting material consisting of a reflecting metal or, preferably, of a polymer having a reflection metallic layer; b) an optical recording layer; c) a separating layer consisting of a metallic, crosslinked organometallic or dielectric inorganic substance; and c) a covering layer.

    摘要翻译： 本发明涉及一种基于式（I），（II），（III）或（IV）的化合物的基片，反射层和记录层的光记录介质。 注意取代基的精确含义的描述。 特别是在350〜500nm的波长下进行记录和回放，例如使用蓝色激光。 录音和播放质量极佳，可以保持较高的存储密度。 同样要求保护的是式（I），（II），（III）或（IV）的一些新型化合物，以及光学记录介质，其包含以下配置：a）由反射金属组成的支撑材料， 优选具有反射金属层的聚合物; b）光记录层; c）由金属交联的有机金属或介电无机物质组成的分离层; 和c）覆盖层。