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    METHODS TO DETERMINE FLUID FILTRATION RATES THROUGH MAMMALIAN LUMINAL ORGANS
    78.
    发明申请
    METHODS TO DETERMINE FLUID FILTRATION RATES THROUGH MAMMALIAN LUMINAL ORGANS 审中-公开
    通过MAMMALIAN LUMINAL ORGANS确定流体过滤速率的方法

    公开(公告)号：US20170067879A9

    公开(公告)日：2017-03-09

    申请号：US14674638

    申请日：2015-03-31

    Applicant: DTherapeutics, LLC

    Inventor： Ghassan S. Kassab ,  Xiao Lu

    IPC: G01N33/50

    CPC classification number: G01N33/5088 ,  A61B5/02007 ,  A61B5/036 ,  A61B5/04882 ,  A61B5/4047 ,  A61B5/4052 ,  A61B5/418 ,  A61B2503/40 ,  G01N3/12 ,  G01N33/4833

    Abstract: Methods to determine fluid filtration rates through mammalian luminal organs. In one method, the method comprises the steps of positioning a segment of a mammalian luminal organ within a device, the device configured to prevent axial flow conditions through a lumen of the segment from a first end of the segment to an opposite second end of the segment, obtaining a first segment measurement at a first time, obtaining a second segment measurement at a second time, and determining a rate of fluid filtration through a wall of the segment based upon a difference between the first segment measurement and the second segment measurement and a difference in time between the first time and the second time.

    Abstract translation: 通过哺乳动物腔内器官确定流体过滤速率的方法。 在一种方法中，该方法包括以下步骤：将哺乳动物腔内器官的一段定位在装置内，该装置被配置成防止轴向流动条件通过该段的内腔从该段的第一端到另一端的相对的第二端 段，在第一时间获得第一段测量，在第二时间获得第二段测量，并且基于第一段测量和第二段测量之间的差，确定通过所述段的壁的流体过滤速率，以及 第一次和第二次之间的时间差异。

    HYPERURICEMIA MODEL
    79.
    发明申请
    HYPERURICEMIA MODEL 审中-公开
    HYPERURICEMIA模型

    公开(公告)号：US20170055504A1

    公开(公告)日：2017-03-02

    申请号：US15308116

    申请日：2015-05-07

    Applicant: PHOENIXBIO CO., LTD.

    Inventor： Masakazu KAKUNI ,  Yumiko IWASAKI ,  Chise MUKAIDANI

    IPC: A01K67/027 ,  G01N33/50

    CPC classification number: A01K67/0271 ,  A01K67/0276 ,  A01K2207/12 ,  A01K2207/15 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0362 ,  G01N33/50 ,  G01N33/5088 ,  G01N2500/00 ,  G01N2800/708

    Abstract: Provided is a non-human animal that is highly practical as a hyperuricenia model, the non-human animal being the following: (a) a non-human animal obtained by producing a primary chimeric non-human animal by transplantation of human hepatocytes to an immunodeficient non-human animal with liver dysfunction; and subsequently administering a purine base-containing substance to the primary chimeric non-human animal, or (b) a non-human animal obtained by producing a serially transplanted chimeric non-human animal via two steps, a first step being a step of producing a primary chimeric non-human animal by transplantation of human hepatocytes to an immunodeficient non-human animal with liver dysfunction, a second step being a step of transplanting the human hepatocytes grown in the body of the primary chimeric non-human animal to an immunodeficient non-human animal with liver dysfunction, the second step being performed one or more times; and subsequently administering a purine base-containing substance to the serially transplanted chimeric non-human animal.

    Abstract translation: 提供作为高尿酸血症模型非常实用的非人类动物，非人类动物如下：（a）通过将人肝细胞移植到一个或多个第一嵌合非人动物中而获得的非人动物 具有肝功能障碍的免疫缺陷型非人动物; 并且随后将所述含嘌呤碱的物质施用于所述一级嵌合非人动物，或（b）通过两步生产连续移植的嵌合非人动物得到的非人动物，第一步是产生 通过将肝细胞移植到具有肝功能障碍的免疫缺陷型非人动物中的第一嵌合非人动物，第二步是将生长在初级嵌合非人动物体内的人肝细胞移植到免疫缺陷型非人动物的步骤， - 具有肝功能障碍的人类动物，第二步执行一次或多次; 并随后向连续移植的嵌合非人动物施用含嘌呤碱的物质。

    Luminescence-based methods and probes for measuring cytochrome P450 activity
    80.
    发明授权
    Luminescence-based methods and probes for measuring cytochrome P450 activity 有权
    用于测量细胞色素P450活性的基于发光的方法和探针

    公开(公告)号：US09574223B2

    公开(公告)日：2017-02-21

    申请号：US14319219

    申请日：2014-06-30

    Applicant: PROMEGA CORPORATION

    Inventor： James J. Cali ,  Dieter Klaubert ,  William Daily ,  Samuel Kin Sang Ho ,  Susan Frackman ,  Erika Hawkins ,  Keith V. Wood

    IPC: C12Q1/66 ,  A61K49/00 ,  G01N33/58 ,  C07D417/04

    CPC classification number: G01N33/502 ,  A61K49/0008 ,  C07D417/04 ,  C12Q1/66 ,  G01N33/5088 ,  G01N33/582 ,  G01N2333/90245 ,  G01N2333/90251 ,  G01N2500/10

    Abstract: The invention provides compounds, compositions, methods, substrates, and kits useful for analyzing the metabolic activity in cells, tissue, and animals and for screening test compounds for their effect on cytochrome P450 activity. In particular, a one-step and two-step methods using luminogenic molecules, e.g. luciferins or coelenterazines, that are cytochrome P450 substrates and that are also bioluminescent enzyme, e.g., luciferase, pro-substrates are provided. The present method further provides a method for stabilizing and prolonging the luminescent signal in a luciferase-based assay using luciferase stabilizing agents such as reversible luciferase inhibitors.

    Abstract translation: 本发明提供了可用于分析细胞，组织和动物中的代谢活性的化合物，组合物，方法，底物和试剂盒，并用于筛选测试化合物对细胞色素P450活性的影响。 特别地，使用发光分子的一步和两步法。 荧光素或coelenterazine，即细胞色素P450底物，并且也是生物发光酶，例如荧光素酶，原底物。 本发明方法还提供了一种使用荧光素酶稳定剂如可逆荧光素酶抑制剂在基于荧光素酶的测定中稳定和延长发光信号的方法。

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