公开(公告)号：US20140239197A1

公开(公告)日：2014-08-28

申请号：US14269452

申请日：2014-05-05

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Alexander A. MAKAROV ,  Eduard V. DENISOV ,  Gerhard JUNG ,  Wilko BALSCHUN ,  Stevan R. HORNING

IPC: H01J49/02

CPC classification number: H01J49/4245 ,  H01J49/0027 ,  H01J49/02 ,  H01J49/282 ,  H01J49/406 ,  H01J49/425

Abstract: An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′(r, φ, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, φ, z) is the result of a perturbation W to an ideal field U(r, φ, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, φ, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2π radians over an ion detection period Tm.

Abstract translation: 公开了诸如轨道捕获器的静电捕获器，具有电极结构。 产生形式为U'（r，＆phgr; z）的静电捕获场，以捕获陷阱内的离子，使得它们经历同步振荡。 捕获场U'（r，＆phgr; z）是对于理想场U（r，＆phgr; z）的扰动W的结果，其在例如轨道捕获的情况下例如是超对数的。 扰动W可以以各种方式引入，例如通过使陷波器的几何形状变形，使得其不再遵循理想场U（r，＆phgr; z）的等电位，或者通过添加失真场（电 或磁性）。 扰动的幅度使得至少一些捕获的离子具有大于零但小于2的绝对相位扩展; 弧度超过离子检测周期Tm。

公开(公告)号：US20140239171A1

公开(公告)日：2014-08-28

申请号：US14236373

申请日：2012-09-07

Applicant: Ian Thomas Platt ,  Timothy Charles Ruck ,  Almas Khan ,  Christopher John Porter

Inventor： Ian Thomas Platt ,  Timothy Charles Ruck ,  Almas Khan ,  Christopher John Porter

IPC: H01J49/26

CPC classification number: H01J49/26 ,  H01J49/02

Abstract: Techniques are described for performing performance maintenance on a mass spectrometer. Pre-maintenance testing is performed that automating execution of a test sequence in response to a first user interface selection. The maintenance activity performed upon completion of said pre-maintenance testing. Post-maintenance testing is preformed upon completion of said maintenance activity. The post-maintenance testing includes automating execution of the test sequence in response to a second user interface selection. A benchmark comparison is performed to determine whether performance of the mass spectrometer has degraded as a result of performing the maintenance activity, wherein said benchmark comparison is performed automatically in response to completing said post-maintenance testing.

Abstract translation: 描述了在质谱仪上执行性能维护的技术。 执行预维护测试，以响应于第一用户界面选择自动执行测试序列。 完成上述维护前测试后进行的维护活动。 在完成所述维护活动之后执行维护后测试。 后维护测试包括响应于第二用户界面选择自动执行测试序列。 执行基准比较以确定质量分析仪的性能是否因执行维护活动而降级，其中响应于完成所述维护后测试自动执行所述基准比较。

公开(公告)号：US08772710B2

公开(公告)日：2014-07-08

申请号：US14010130

申请日：2013-08-26

Applicant: Purdue Research Foundation

Inventor： Zheng Ouyang ,  Jason Harper ,  Nicholas Charipar ,  Robert Graham Cooks

IPC: H01J49/00 ,  H01J49/10

CPC classification number: H01J37/32009 ,  H01J27/022 ,  H01J37/00 ,  H01J37/32348 ,  H01J49/02 ,  H01J49/105 ,  H01J49/142 ,  H01J2237/0044 ,  H05H1/24 ,  H05H1/2406 ,  H05H1/30 ,  H05H2001/2412 ,  H05H2001/2443 ,  H05H2240/10 ,  H05H2240/20 ,  Y10T436/145555 ,  Y10T436/147777 ,  Y10T436/173076 ,  Y10T436/203332 ,  Y10T436/24

Abstract: The present invention generally relates to a low temperature plasma probe for desorbing and ionizing at least one analyte in a sample material and methods of use thereof. In one embodiment, the invention generally relates to a low temperature plasma probe including: a housing having a discharge gas inlet port, a probe tip, two electrodes, and a dielectric barrier, in which the two electrodes are separated by the dielectric barrier, in which application of voltage from a power supply generates a low temperature plasma, and in which the low temperature plasma is propelled out of the discharge region by the electric field and/or the discharge gas flow.

Abstract translation: 本发明一般涉及用于解吸和电离样品中至少一种分析物的低温等离子体探针及其使用方法。 在一个实施方案中，本发明一般涉及一种低温等离子体探针，其包括：壳体，其具有放电气体入口端口，探针尖端，两个电极和介电屏障，其中两个电极由电介质屏障隔开， 来自电源的电压的施加产生低温等离子体，其中通过电场和/或放电气体流将低温等离子体推出排出区域。

公开(公告)号：US20140151545A1

公开(公告)日：2014-06-05

申请号：US14046447

申请日：2013-10-04

Applicant: THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

Inventor： M. Bonner DENTON ,  Roger P. SPERLINE

IPC: G01N27/62 ,  H01J49/02

CPC classification number: G01N27/622 ,  H01J49/02 ,  H01J49/10

Abstract: An ion mobility spectrometer (IMS) for the detection of trace gaseous molecular compounds dissolved or suspended in a carrier gas, particularly in ambient air, without preconcentration or the trapping of analyte particles. The IMS of the invention comprises an ionization volume of greater than 5 cm3 and preferably greater than 100 cm3. The larger size ionizers of this invention enable analysis of trace (

Abstract translation: 用于检测溶解或悬浮在载气中的痕量气态分子化合物的离子迁移谱仪（IMS），特别是在环境空气中，没有预浓缩或捕获分析物颗粒。 本发明的IMS包括大于5cm 3，优选大于100cm 3的电离体积。 本发明的较大尺寸的离子发生器能够分析气相中痕量（<1ppb）的样品化合物。 为了促进通过IMS的大体积电离和反应区域的有效离子运动，可以在电离区域或电离和反应区域中提供电场梯度。 该系统可以用放射性离子源实现，可以通过光电离形成电晕放电离子源或离子。 在具体实施方案中，特别是当样品气体是环境空气时，样品气体在进入仪器之前是加热器，仪器在高于环境温度的温度下运行，并且可以通过与离开仪器的加热样品气体接触来加热仪器。

公开(公告)号：US20140048704A1

公开(公告)日：2014-02-20

申请号：US14064616

申请日：2013-10-28

Applicant: Micromass UK Limited

Inventor： Robert Harold Bateman ,  Kevin Giles ,  Steven Derek Pringle ,  Jason Lee Wildgoose

IPC: H01J49/40

CPC classification number: G01N27/622 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/0045 ,  H01J49/02 ,  H01J49/062 ,  H01J49/065 ,  H01J49/066 ,  H01J49/40 ,  H01J49/401 ,  H01J49/42

Abstract: A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator and an ion guide arranged downstream of the ion mobility spectrometer or separator. A plurality of axial potential wells are created in the ion guide so that ions received from the ion mobility spectrometer or separator become confined in separate axial potential wells. The potential wells maintain the fidelity and/or composition of ions received from the ion mobility spectrometer or separator. The potential wells are translated along the length of the ion guide.

公开(公告)号：US20140027627A1

公开(公告)日：2014-01-30

申请号：US14037873

申请日：2013-09-26

Applicant: Micromass UK Limited

Inventor： John Brian Hoyes ,  David J. Langridge

IPC: H01J49/06

CPC classification number: H01J49/062 ,  G01N27/622 ,  H01J49/02 ,  H01J49/065

Abstract: An ion guide array is disclosed comprising a first ion guide section and a second ion guide section. Each ion guide section may comprise a plurality of electrodes having an aperture through which ions are transmitted in use. A transfer section is arranged at the exit of the first ion guide section and ions are transmitted radially from the first ion guide section into the second ion guide section. Electrodes in the transfer section may have a radial aperture enabling ions to be transmitted radially from the first ion guide section to the second ion guide section.

Abstract translation: 公开了一种离子导向阵列，包括第一离子引导部分和第二离子引导部分。 每个离子引导部分可以包括具有孔的多个电极，在使用中离子通过该孔传播。 在第一离子引导部的出口设置有转印部，离子从第一离子引导部径向地传递到第二离子引导部。 转印部中的电极可以具有使离子从第一离子引导部向第二离子引导部径向传递的径向孔。

公开(公告)号：US20130240727A1

公开(公告)日：2013-09-19

申请号：US13890558

申请日：2013-05-09

Applicant: SAMSUNG ELECTRO-MECHANICS CO., LTD.

Inventor： Takashi SUMIYOSHI

IPC: H01J49/02

CPC classification number: H01J49/02 ,  G01N30/72 ,  G01N30/86

Abstract: After an analysis condition table for measuring each compound is automatically generated in accordance with a compound table, the loop time is calculated for each measurement section for which the overlapping of measurement events differs. If the loop time exceeds a specified value in a given measurement section of a given compound, the event with the earliest end time and the event with the latest start time are extracted from among the overlapping measurement events, and the intermediate time between the end time and the start time is found to adjust the length of each measurement event. By repeating this process, a parameter in the analysis condition table is corrected so that the loop time becomes equal to or less than the specified value.

Abstract translation: 在根据复合表自动生成用于测量每个化合物的分析条件表之后，针对测量事件的重叠不同的每个测量部分计算循环时间。 如果在给定化合物的给定测量部分中循环时间超过指定值，则从重叠测量事件中提取具有最早结束时间和具有最新开始时间的事件的事件，并且结束时间之间的中间时间 并且发现开始时间来调整每个测量事件的长度。 通过重复该处理，校正分析条件表中的参数，使得循环时间变得等于或小于指定值。

公开(公告)号：US20130228681A1

公开(公告)日：2013-09-05

申请号：US13882732

申请日：2011-11-21

Applicant: Myoung Choul Choi ,  A Leum Park ,  Hyun Sik Kim ,  Seung Yong Kim ,  Jong Shin Yoo

Inventor： Myoung Choul Choi ,  A Leum Park ,  Hyun Sik Kim ,  Seung Yong Kim ,  Jong Shin Yoo

IPC: H01J49/02 ,  H01J49/00

CPC classification number: H01J49/02 ,  H01J49/0027 ,  H01J49/065 ,  H01J49/38

Abstract: A Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) includes: an ionization source generating ions; a deceleration lens, on which the ions generated by the ionization source and spatially dispersed are incident, selectively decelerating the incident ions so as to decrease the distance between the ions; and an ion cyclotron resonance cell on which the ions passing through the deceleration lens are incident. By preventing dispersing of ions due to mass difference and converging the ions using the deceleration lens, the mass range that can be measured at one time can be extended. Also, measurement sensitivity can be improved since the ions are effectively introduced to the ICR cell.

Abstract translation: 傅里叶变换离子回旋共振质谱仪（FT-ICR MS）包括：产生离子的电离源; 由离子源产生的并且空间分散的离子入射的减速透镜选择性地使入射离子减速以减小离子之间的距离; 以及通过减速透镜的离子入射到其上的离子回旋共振单元。 通过防止由于质量差导致的离子分散和使用减速透镜会聚离子，可以延长一次可以测量的质量范围。 此外，由于离子被有效地引入ICR单元，所以可以提高测量灵敏度。

公开(公告)号：US20130200261A1

公开(公告)日：2013-08-08

申请号：US13813894

申请日：2010-08-06

Applicant: Shiro Mizutani ,  Hiroshi Sugawara

Inventor： Shiro Mizutani ,  Hiroshi Sugawara

IPC: H01J49/02

CPC classification number: H01J49/02 ,  H01J49/4215

Abstract: As a control parameter given to a direct-current (DC) voltage generator which generates a DC voltage for ion selection, a “mass-related offset” for allowing an adjustment of the offset for each mass-to-charge ratio is provided in addition to the “gain” and “common offset” which respectively determine the gradient and position of a scan line drawn on a stability diagram during a mass-scan operation. In an automatic adjustment operation using a standard sample, under the control of an automatic regulator, the “gain” and “common offset” are initially set, after which the “mass-related offset” for each mass-to-charge ratio is determined so that the mass-resolving power will be substantially uniform, and these data are stored in a control data memory. In an analysis of a sample of interest, a quadrupole voltage controller controls the DC voltage generator and a radio-frequency (RF) voltage generator according to the control parameters read from the memory.

Abstract translation: 作为产生用于离子选择的直流电压的直流（DC）电压发生器的控制参数，另外还提供了用于允许调整每个质荷比的偏移的“质量相关偏移” 分别确定在质量扫描操作期间在稳定性图上绘制的扫描线的梯度和位置的“增益”和“共同偏移”。 在使用标准样品的自动调整操作中，在自动调节器的控制下，初始设定“增益”和“共同偏差”，之后确定每个质荷比的“质量相关偏移” 使得质量分辨能力将基本均匀，并将这些数据存储在控制数据存储器中。 在分析感兴趣的样本时，四极电压控制器根据从存储器读取的控制参数控制直流电压发生器和射频（RF）电压发生器。

公开(公告)号：US20130112865A1

公开(公告)日：2013-05-09

申请号：US13722301

申请日：2012-12-20

Applicant: Micromass UK Limited

Inventor： Martin Raymond Green ,  Jason Lee Wildgoose

IPC: H01J49/02 ,  H01J49/00

CPC classification number: H01J49/02 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/062 ,  H01J49/10 ,  H01J49/4265

Abstract: A mass spectrometer includes a first ion trap arranged upstream of an analytical second ion trap. The charge capacity of the first ion trap is set at a value such that if all the ions stored within the first ion trap up to the charge capacity limit of the first ion trap are then transferred to the second ion trap, then the analytical performance of the second ion trap is not substantially degraded due to space charge effects.

Abstract translation: 质谱仪包括布置在分析第二离子阱的上游的第一离子阱。 第一离子阱的充电容量被设定为使得如果存储在第一离子阱内的所有离子直到第一离子阱的充电容量极限，则转移到第二离子阱，则分析性能 由于空间电荷效应，第二离子阱基本上不会劣化。