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    Single and multiple operating mode ion sources with atmospheric pressure chemical ionization
    71.
    发明授权
    Single and multiple operating mode ion sources with atmospheric pressure chemical ionization 有权
    单个和多个工作模式离子源与大气压化学电离

    公开(公告)号：US08502140B2

    公开(公告)日：2013-08-06

    申请号：US13183693

    申请日：2011-07-15

    申请人： Craig M. Whitehouse ,  Victor Laiko

    发明人： Craig M. Whitehouse ,  Victor Laiko

    IPC分类号： H01J49/26

    CPC分类号： H01J49/145 ,  H01J49/045 ,  H01J49/168

    摘要： An Atmospheric Pressure Chemical Ionization (APCI) source interfaced to a mass spectrometer is configured with a corona discharge needle positioned inside the APCI inlet probe assembly. Liquid sample flowing into the APCI inlet probe is nebulized and vaporized prior to passing through the corona discharge region all contained in the APCI inlet probe assembly Ions produced in the corona discharge region are focused toward the APCI probe centerline to maximize ion transmission through the APCI probe exit. External electric fields penetrating into the APCI probe exit end opening providing additional centerline focusing of sample ions exiting the APCI probe. The APCI probe is configured to shield the electric field from the corona discharge region while allowing penetration of an external electric field to focus APCI generated ions into an orifice into vacuum for mass to charge analysis. Ions that exit the APCI probe are directed only by external electric fields and gas flow maximizing ion transmission into a mass to charge analyzer. The new APCI probe can be configured to operate as a stand alone APCI source inlet probe, as a reagent ion gun for ionizing samples introduced on solids or liquid sample probes or through gas inlets in a multiple function ion source or as the APCI portion of a combination Electrospray and APCI multiple function ion source. Sample ions and gas phase reagent ions are generated in the APCI probe from liquid or gas inlet species or mixtures of both.

    摘要翻译： 与质谱仪接口的大气压化学电离（APCI）源配置有位于APCI入口探针组件内部的电晕放电针。 流入APCI入口探针的液体样品在通过电晕放电区域之前雾化和蒸发，全部包含在APCI入口探针组件中电晕放电区域中产生的离子将聚焦到APCI探针中心线，以使通过APCI探针的离子传输最大化 出口。 外部电场穿透到APCI探针出口端开口，提供离开APCI探针的样品离子的附加中心线聚焦。 APCI探针被配置为屏蔽来自电晕放电区域的电场，同时允许穿透外部电场以将APCI产生的离子聚焦到孔中以进行质量电荷分析。 离开APCI探头的离子仅由外部电场和气流引导，将离子传输最大化成质量计量分析仪。 新的APCI探针可以配置为作为独立的APCI源入口探针进行操作，作为用于将固体或液体样品探针上引入的样品或通过多功能离子源中的气体入口电离的样品的反应离子枪或作为 组合电喷雾和APCI多功能离子源。 样品离子和气相试剂离子在APCI探针中从液体或气体入口物质或两者的混合物中产生。

    Cyclone separator type mass analyzing system
    72.
    发明授权
    Cyclone separator type mass analyzing system 有权
    旋风分离器型质量分析系统

    公开(公告)号：US08410435B2

    公开(公告)日：2013-04-02

    申请号：US13376840

    申请日：2010-06-09

    申请人： Shinichi Miki ,  Michisato Toyoda

    发明人： Shinichi Miki ,  Michisato Toyoda

    IPC分类号： H01J49/04

    CPC分类号： G01N1/34 ,  G01N1/2211 ,  H01J49/0422 ,  H01J49/168

    摘要： Provided is a small-sized mass analysis system capable of analyzing an analysis target system being under atmospheric pressure. The mass analysis system (7) has a cyclone separator (1) including a hollow shaft motor (19) for rotationally driving a turbo blade (17). Combining a mass analysis device with the cyclone separator makes it possible to remove dust and introduce into the mass analysis device a gas present in a region where the pressure in the cyclone separator is sufficiently reduced.

    摘要翻译： 提供了能够分析大气压下的分析对象系统的小型质量分析系统。 质量分析系统（7）具有旋转分离器（1），其包括用于旋转驱动涡轮叶片（17）的中空轴马达（19）。 将质量分析装置与旋风分离器组合使得可以除去灰尘并将质量分析装置中的气体引入到旋风分离器中的压力充分降低的区域中。

    Devices and Methods for Analyzing Surfaces
    74.
    发明申请
    Devices and Methods for Analyzing Surfaces 审中-公开
    用于分析曲面的设备和方法

    公开(公告)号：US20120286151A1

    公开(公告)日：2012-11-15

    申请号：US13105605

    申请日：2011-05-11

    申请人： Joseph A. Jarrell ,  Michael P. Balogh

    发明人： Joseph A. Jarrell ,  Michael P. Balogh

    IPC分类号： H01J49/26 ,  H01J49/10

    CPC分类号： H01J49/14 ,  H01J49/168

    摘要： Embodiments of the present invention are directed to devices and methods for performing an analysis of a sample having a sample surface. The device and method feature a frame element affixed to a sample holder, jet element and a charged particle analyzer having an ion receiving orifice. The jet element directs a jet of gas towards the sample surface held by said sample holder focused on less than 2.0 mm2 of the sample surface. Ions formed by the electrode means are received by a charged particle analyzer having a ion receiving orifice for receiving one or more sample ions and performing a charged particle analysis with respect to the sample surface. The sample holder moves with respect to the jet element, and charged particle analyzer to permit scanning of a sample surface.

    摘要翻译： 本发明的实施例涉及用于对具有样品表面的样品进行分析的装置和方法。 装置和方法的特征在于固定到样品架，喷射元件和带有离子接收孔的带电粒子分析仪的框架元件。 喷射元件将气体射流引导到聚集在小于2.0mm 2的样品表面上的由所述样品保持器保持的样品表面。 由电极装置形成的离子被具有用于接收一个或多个样品离子并且相对于样品表面进行带电粒子分析的离子接收孔的带电粒子分析仪接收。 样品架相对于喷射元件移动，并且带电粒子分析仪允许扫描样品表面。

    SYSTEM AND METHOD FOR IDENTIFICATION OF BIOLOGICAL TISSUES
    75.
    发明申请
    SYSTEM AND METHOD FOR IDENTIFICATION OF BIOLOGICAL TISSUES 有权
    用于鉴定生物组织的系统和方法

    公开(公告)号：US20120156712A1

    公开(公告)日：2012-06-21

    申请号：US13322343

    申请日：2010-05-27

    申请人： Zoltan Takats

    发明人： Zoltan Takats

    IPC分类号： G01N27/62 ,  C12M1/34 ,  C12Q1/02

    CPC分类号： A61B10/02 ,  G01N1/02 ,  G01N27/62 ,  G01N2001/028 ,  G01N2001/045 ,  G01N2001/2886 ,  H01J49/04 ,  H01J49/165 ,  H01J49/168

    摘要： The present invention provides for a system, method, and device for analyzing, localizing and/or identifying tissue types. The method includes analyzing, localizing and/or identifying one or more tissue samples, characterized in that the method comprises: (a) generating gaseous tissue particles from a site in the one or more tissue samples, (b) transporting the gaseous tissue particles from the site to an analyser, (c) using the analyser for generating tissue-related data based on the gaseous tissue particles, and (d) analyzing, localizing and/or identifying the one or more tissue samples based on the tissue-related data. The invention can either be used in close conjunction with a surgical procedure, when one or more surgical tools are an integrated part of ionization, or as a separate mass spectrometric probe for the analysis of one or more tissue parts.

    摘要翻译： 本发明提供了用于分析，定位和/或识别组织类型的系统，方法和装置。 该方法包括分析，定位和/或识别一个或多个组织样本，其特征在于，所述方法包括：（a）从所述一个或多个组织样品中的部位产生气体组织颗粒，（b）将气态组织颗粒从 （c）使用分析器基于气体组织颗粒产生组织相关数据，以及（d）基于组织相关数据分析，定位和/或识别所述一个或多个组织样本。 当一种或多种外科手术工具是电离的一体化部分时，本发明可以与外科手术紧密结合使用，或者作为用于分析一个或多个组织部分的单独的质谱探针。

    SINGLE AND MULTIPLE OPERATING MODE ION SOURCES WITH ATMOSPHERIC PRESSURE CHEMICAL IONIZATION
    76.
    发明申请
    SINGLE AND MULTIPLE OPERATING MODE ION SOURCES WITH ATMOSPHERIC PRESSURE CHEMICAL IONIZATION 有权
    单一和多种操作模式离子源与大气压力化学离子化

    公开(公告)号：US20120018632A1

    公开(公告)日：2012-01-26

    申请号：US13183693

    申请日：2011-07-15

    申请人： Craig Whitehouse ,  Victor Laiko

    发明人： Craig Whitehouse ,  Victor Laiko

    IPC分类号： H01J49/40 ,  H01J27/26 ,  H01J49/26

    CPC分类号： H01J49/145 ,  H01J49/045 ,  H01J49/168

    摘要： An Atmospheric Pressure Chemical Ionization (APCI) source interfaced to a mass spectrometer is configured with a corona discharge needle positioned inside the APCI inlet probe assembly. Liquid sample flowing into the APCI inlet probe is nebulized and vaporized prior to passing through the corona discharge region all contained in the APCI inlet probe assembly Ions produced in the corona discharge region are focused toward the APCI probe centerline to maximize ion transmission through the APCI probe exit. External electric fields penetrating into the APCI probe exit end opening providing additional centerline focusing of sample ions exiting the APCI probe. The APCI probe is configured to shield the electric field from the corona discharge region while allowing penetration of an external electric field to focus APCI generated ions into an orifice into vacuum for mass to charge analysis. Ions that exit the APCI probe are directed only by external electric fields and gas flow maximizing ion transmission into a mass to charge analyzer. The new APCI probe can be configured to operate as a stand alone APCI source inlet probe, as a reagent ion gun for ionizing samples introduced on solids or liquid sample probes or through gas inlets in a multiple function ion source or as the APCI portion of a combination Electrospray and APCI multiple function ion source. Sample ions and gas phase reagent ions are generated in the APCI probe from liquid or gas inlet species or mixtures of both.

    摘要翻译： 与质谱仪接口的大气压化学电离（APCI）源配置有位于APCI入口探针组件内部的电晕放电针。 流入APCI入口探针的液体样品在通过电晕放电区域之前雾化和蒸发，全部包含在APCI入口探针组件中电晕放电区域中产生的离子将聚焦到APCI探针中心线，以使通过APCI探针的离子传输最大化 出口。 外部电场穿透到APCI探针出口端开口，提供离开APCI探针的样品离子的附加中心线聚焦。 APCI探针被配置为屏蔽来自电晕放电区域的电场，同时允许穿透外部电场以将APCI产生的离子聚焦到孔中以进行质量电荷分析。 离开APCI探头的离子仅由外部电场和气流引导，将离子传输最大化成质量计量分析仪。 新的APCI探针可以配置为作为独立的APCI源入口探针进行操作，作为用于将固体或液体样品探针上引入的样品或通过多功能离子源中的气体入口电离的样品的反应离子枪或作为 组合电喷雾和APCI多功能离子源。 样品离子和气相试剂离子在APCI探针中从液体或气体入口物质或两者的混合物中产生。

    ATMOSPHERIC PRESSURE ION SOURCE FOR MASS SPECTROMETRY
    77.
    发明申请
    ATMOSPHERIC PRESSURE ION SOURCE FOR MASS SPECTROMETRY 有权
    大气压力大气离子源

    公开(公告)号：US20100096542A1

    公开(公告)日：2010-04-22

    申请号：US12368712

    申请日：2009-02-10

    申请人： Craig Whitehouse ,  Thomas White ,  Ross Willoughby ,  Ed Sheehan

    发明人： Craig Whitehouse ,  Thomas White ,  Ross Willoughby ,  Ed Sheehan

    IPC分类号： H01J49/26 ,  H01T19/04 ,  H01J49/04 ,  H01J49/10

    CPC分类号： H01J49/165 ,  H01J49/0431 ,  H01J49/107 ,  H01J49/168 ,  H01J49/26

    摘要： A multiple function atmospheric pressure ion source interfaced to a mass spectrometer comprises multiple liquid inlet probes configured such that the sprays from two or more probes intersect in a mixing region. Gas phase sample ions or neutral species generated in the spray of one probe can react with reagent gas ions generated from one or more other probes by such ionization methods as Electrospray, photoionization, corona discharge and glow discharge ionization. Reagent ions may be optimally selected to promote such processes as Atmospheric Pressure Chemical Ionization of neutral sample molecules, or charge reduction or electron transfer dissociation of multiply charged sample ions. Selected neutral reagent species can also be introduced into the mixing region to promote charge reduction of multiply charged sample ions through ion-neutral reactions. Different operating modes can be performed alternately or simultaneously, and can be rapidly turned on and off under manual or software control.

    摘要翻译： 与质谱仪接口的多功能大气压离子源包括多个液体入口探针，其配置成使得来自两个或更多个探针的喷雾在混合区域相交。 在一个探针的喷雾中产生的气相样品离子或中性物质可以通过诸如电喷雾，光离子化，电晕放电和辉光放电电离的电离方法与从一个或多个其它探针产生的反应气体离子反应。 可以最佳地选择试剂离子以促进诸如中性样品分子的大气压化学电离或多电荷样品离子的电荷还原或电子转移离解的过程。 还可以将选定的中性试剂物质引入混合区域，以通过离子 - 中性反应促进多电荷样品离子的电荷还原。 可以交替或同时执行不同的操作模式，并且可以在手动或软件控制下快速打开和关闭。

    Mass spectrometer
    79.
    发明授权
    Mass spectrometer 有权
    质谱仪

    公开(公告)号：US07417226B2

    公开(公告)日：2008-08-26

    申请号：US10893427

    申请日：2004-07-16

    申请人： Steven Bajic ,  Robert Harold Bateman

    发明人： Steven Bajic ,  Robert Harold Bateman

    IPC分类号： H01J49/10

    CPC分类号： H01J49/168 ,  H01J49/145

    摘要： An Atmospheric Pressure Chemical Ionisation (“APCI”) ion source is disclosed comprising a housing 14 having a corona discharge chamber 1, a reaction chamber 2 and a passage 6 connecting the corona discharge chamber 1 to the reaction chamber 2. Reagent ions are formed in the corona discharge chamber 1 and pass to the reaction chamber 2 via the passage 6. Analyte is sprayed into a heated tube 3. Low to moderately polar analyte molecules pass from the heated tube 3 into the reaction chamber 2 whereupon the analyte molecules are ionised by interacting with reagent ions. In contrast, highly polar analytes are ionised by thermal ionisation processes within the heated tube 3 and hence highly polar analyte ions pass into the reaction chamber 2. Analyte ions entering the reaction chamber 2 are substantially shielded from the effects of an electric field generated in the corona discharge chamber 1 as part of the process of generating reagent ions. The APCI ion source according to the preferred embodiment is able to optimally ionise a sample containing both low to moderately polar analytes and also highly polar analytes.

    摘要翻译： 公开了一种大气压化学电离（“APCI”）离子源，其包括具有电晕放电室1，反应室2和将电晕放电室1连接到反应室2的通道6的壳体14。 在电晕放电室1中形成试剂离子，并通过通道6进入反应室2。 将分析物喷入加热管3中。 低至中等极性的分析物分子从加热管3进入反应室2，于是分析物分子通过与试剂离子相互作用而离子化。 相比之下，高极性分析物通过加热管3内的热离子化过程进行电离，因此高极性分析物离子进入反应室2。 作为产生试剂离子的过程的一部分，进入反应室2的分析物离子基本上不受电晕放电室1中产生的电场的影响的影响。 根据优选实施方案的APCI离子源能够最佳地离子化含有低至中等极性的分析物和高极性分析物的样品。