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236 条记录 (耗时 0.018 秒)

    Process for the synthesis of polyol fatty-acid esters
    72.
    发明授权
    Process for the synthesis of polyol fatty-acid esters 失效
    多元醇脂肪酸酯的合成方法

    公开(公告)号：US5043438A

    公开(公告)日：1991-08-27

    申请号：US477776

    申请日：1990-02-09

    申请人： Markus G. Buter

    发明人： Markus G. Buter

    IPC分类号： C07H15/08 ,  A61K8/00 ,  A61Q19/10 ,  C07C67/02 ,  C07C69/30 ,  C07C69/33 ,  C07H13/06 ,  C11B3/10

    CPC分类号： C07H13/06

    摘要： The present invention pertains to a process for the synthesis of polyol fatty-acid esters by reacting a polyol and a fatty-acid lower-alkyl ester under substantially solvent-free conditions in the presence of a transesterification catalyst and an emulsifier. The process comprises a continuous initial reaction stage in a first reaction zone wherein a steady-state conversion is achieved of over 1% and a further reaction stage in which the reaction mixture from said first zone is further reacted to the required polyol fatty-acid esters in one or more subsequent reaction zones.

    Polyol derivatives, processes for preparing the same and their uses in therapeutics
    75.
    发明授权
    Polyol derivatives, processes for preparing the same and their uses in therapeutics 失效
    多元醇衍生物，其制备方法及其在治疗中的应用

    公开(公告)号：US4423071A

    公开(公告)日：1983-12-27

    申请号：US126191

    申请日：1980-03-03

    申请人： Michel Chignac ,  Claude Grain ,  Fernand Jammot ,  Charles Pigerol ,  Pierre Eymard ,  Bernard Ferrandes

    发明人： Michel Chignac ,  Claude Grain ,  Fernand Jammot ,  Charles Pigerol ,  Pierre Eymard ,  Bernard Ferrandes

    IPC分类号： C07C69/003 ,  A61K31/215 ,  A61K31/22 ,  A61K31/335 ,  A61K31/357 ,  A61P25/08 ,  A61P25/24 ,  C07C67/00 ,  C07C67/10 ,  C07C67/28 ,  C07C69/007 ,  C07C69/013 ,  C07C69/18 ,  C07C69/28 ,  C07C69/30 ,  C07C69/708 ,  C07C69/75 ,  C07C219/06 ,  C07C233/18 ,  C07C233/19 ,  C07C235/08 ,  C07C313/00 ,  C07C323/12 ,  C07D303/16 ,  C07D317/12 ,  C07D317/18 ,  C07D317/20 ,  C07D317/22 ,  C07D317/24 ,  C07D317/72 ,  C07D319/06

    CPC分类号： C07D317/72 ,  C07C327/00 ,  C07D303/16 ,  C07D317/12 ,  C07D317/20 ,  C07D317/24 ,  C07D319/06

    摘要： Mono-, di-, tri- and tetra-esters derived from an acid of the general formula:R--OHin which R represents an acyl radical of the general formula: ##STR1## in which n represents 0 or 1, m represents 0, 1, 2, 3 or 4, R.sub.1 and R.sub.2 each represent a straight- or branched-chain alkyl radical having from 1 to 5 carbon atoms, R.sub.3 represents hydrogen or a straight- or branched-chain alkyl radical having from 1 to 5 carbon atoms, the sum of the carbon atoms in R.sub.1 and R.sub.2 being from 4 to 10 when R.sub.3 represents hydrogen and the sum of the carbon atoms in R.sub.1, R.sub.2 and R.sub.3 being from 6 to 15 when R.sub.3 is different from hydrogen, or R.sub.1 and R.sub.2 when they are taken together represent a tetramethylene, pentamethylene or hexamethylene radical and R.sub.3 represents a straight-chain alkyl radical and an alcohol selected from the group consisting of glycerol, 2,3-epoxy-propanol, 1,2-propanediol, 1,3-propanediol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, 1,2,3-butanetriol, 1,2,4-butanetriol, 1,2,3,4-butanetetrol, 2-buten-1,4-diol, 2-butyn-1,4-diol, diethyleneglycol, a cyclohexanediol preferably 1,2-cyclohexanediol, thiodiglycol, diethanolamine, N-R-substituted-diethanolamine, trimethylolpropane, pentaerythritol and an alcohol of the general formula: ##STR2## in which p represents 0 or 1, R.sub.4 represents methyl, R.sub.5 represents methyl, ethyl, 2-methyl-butyl or R.sub.4 and R.sub.5, when they are taken together represent a pentamethylene radical, with the exception of glyceryl tri-(di-n-propylacetate).These esters are useful in the treatment of central nervous system disorders and including, in particular, convulsive states and seizures, and disorders relating to the field of neuropsychiatry.

    摘要翻译： 衍生自以下通式的酸的单 - ，二 - ，三 - 和四 - 酯：其中R表示通式如下的酰基：其中n表示0或1，m表示0 ，1,2,3或4，R 1和R 2各自表示具有1至5个碳原子的直链或支链烷基，R 3表示氢或具有1至5个碳的直链或支链烷基 原子时，R 3和R 2中的碳原子的总和为4至10，当R 3表示氢时，当R 3不同于氢时，R 1，R 2和R 3中的碳原子之和为6至15，或R 1和R 2 当它们一起表示四亚甲基，五亚甲基或六亚甲基时，R 3表示直链烷基和选自甘油，2,3-环氧丙醇，1,2-丙二醇，1,3 丙二醇，1,2-丁二醇，1,3-丁二醇，1,4-丁二醇，1,2,3-丁三醇，1,2,4-丁三醇，1,2,3,4-丁酮，2-丁醇 1,4-丁二醇，2-丁炔-1,4-二醇，二甘醇，环己二醇优选1,2-环己二醇，硫二甘醇，二乙醇胺，NR-取代二乙醇胺，三羟甲基丙烷，季戊四醇和通式如下的醇： 其中p表示0或1，R4表示甲基，R5表示甲基，乙基，2-甲基 - 丁基或R4和R5，当它们一起表示五亚甲基时，除三 乙酸二正丙酯）。 这些酯可用于治疗中枢神经系统疾病，特别是包括惊厥状态和癫痫发作以及与神经精神病学领域有关的疾病。

    Steffimycinone, 7-deoxysteffimycinone and derivatives
    78.
    发明授权
    Steffimycinone, 7-deoxysteffimycinone and derivatives 失效
    苯乙酰丙酮酮，7-脱氧硫嘧啶酮及其衍生物

    公开(公告)号：US3976667A

    公开(公告)日：1976-08-24

    申请号：US588298

    申请日：1975-06-19

    申请人： Robert C. Kelly

    发明人： Robert C. Kelly

    IPC分类号： C07C50/26 ,  C07C50/36 ,  C07C49/74 ,  C07C69/18 ,  C07C69/21 ,  C07C69/30 ,  C07C69/33 ,  C07C69/61 ,  C07C69/63 ,  C07C69/67 ,  C07C69/68 ,  C07C69/74 ,  C07C69/78 ,  C07C69/84 ,  C07C69/92 ,  C07C69/96 ,  C07C79/46 ,  C07C121/00

    CPC分类号： C07C50/26 ,  C07C50/36 ,  Y10S514/924

    摘要： Antibiotic steffimycinone (U-25,055), produced by acid hydrolysis or methanolysis of antibiotic steffimycin (U-20,661), or steffimycin B, and 7-deoxysteffimycinone (U-25,920) produced by hydrogenolysis of steffimycin or steffimycin B (U-40,615). Steffimycinone is active against various microorganisms, for example, Bacillus subtilis, Mycobacterium avium and Bacillus cereus; 7-deoxysteffimycinone is active against Sarcina lutea and Mycobacterium avium. Thus, these antibiotics can be used to inhibit the growth of the above microorganisms in various environments.

    摘要翻译： 通过苯乙呋霉素或苯乙呋霉素B（U-40,615）的氢解制备的抗生素苯乙炔霉素（U-20,661）的酸水解或甲醇分解产生的抗生素Steffimycinone（U-25,055）或者谷氨酰霉素B和7-脱氧硫羟孕酮酮（U-25,920）。 斯蒂夫霉酮对各种微生物有活性，例如枯草芽孢杆菌，鸟分枝杆菌和蜡状芽孢杆菌; 7-脱氧硫咪唑酮对刺鼻黄杆菌和鸟分枝杆菌有活性。 因此，这些抗生素可用于抑制各种环境中上述微生物的生长。