公开(公告)号：US20140298924A1

公开(公告)日：2014-10-09

申请号：US14309051

申请日：2014-06-19

Applicant: EMD Millipore Corporation

Inventor： Chris Scott ,  Rob Colonna ,  Christopher Barmore ,  Todd Taylor ,  Daniel Morgan

IPC: G01N1/28

CPC classification number: G01N1/28 ,  B01D61/18 ,  B01J20/281 ,  B01L3/50255 ,  G01N1/4077 ,  G01N30/14 ,  G01N2030/146

Abstract: Sample preparation device for receiving in sealing relation one or more filter assemblies and one or more sample containers, each container uniquely positioned within the device to receive filtered sample from a designated filter. The device includes a body, a lid disposed on the body, a container tray, a base, an integrated seal on the body, a valve and a valve actuator. The tray can be disposed in a vacuum chamber defined by the lid and the body, and one or more sample containers can be disposed in the tray. When properly positioned in the tray in the vacuum chamber, each container is in fluid communication with a single respective filter assembly disposed in sealing relation in a respective aperture in the lid. A single actuation of a valve to place the vacuum chamber under vacuum causes the lid to seal to the base and drives the simultaneous filtration of a plurality of samples.

公开(公告)号：US08846337B2

公开(公告)日：2014-09-30

申请号：US14047373

申请日：2013-10-07

Applicant: EMD Millipore Corporation

Inventor： Christian Schann ,  Bruno Duquet ,  Abdel Hajila ,  Frederic Olivieri

IPC: G01N21/76 ,  B05B15/04 ,  C12Q1/24

CPC classification number: C12Q1/24 ,  B05B12/20 ,  G01N21/763

Abstract: The device for spraying a reagent onto a support (81) adapted to retain microorganisms on a predetermined surface (82), comprises a spraying bell (3) as well as a nozzle (71) for emitting a jet of droplets of said reagent into a spraying chamber (34) comprised by said bell (3), said device also comprising an absorbent pad (5) mounted against said bell (3) transversely to said jet and closing said chamber (34) from the opposite side to said nozzle (71) with the exception of a circular central opening (51) provided in said pad (5), the diameter of said central opening (51) being adapted to enable a portion of said jet, when said device faces said support (81) and is at a predetermined distance therefrom, to pass through said central opening (51) over its entire area and be deposited on the whole of said predetermined surface (82) of said support (81).

公开(公告)号：US20140287489A1

公开(公告)日：2014-09-25

申请号：US14221615

申请日：2014-03-21

Applicant: EMD Millipore Corporation

Inventor： Philip J. Lee ,  Terry Gaige ,  Wei Hsuan (Jessie) Ho

IPC: C12M1/00

CPC classification number: C12M23/16 ,  B01L3/502715 ,  B01L3/502761 ,  B01L3/563 ,  B01L7/00 ,  B01L2200/0689 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2300/048 ,  B01L2300/0829 ,  B01L2300/14 ,  B01L2300/18 ,  B01L2300/1894 ,  B01L2400/0487 ,  C12M23/36 ,  C12M23/40 ,  C12M29/10 ,  C12M29/24 ,  C12M41/14 ,  C12M41/18 ,  C12M41/34 ,  C12M41/36 ,  C12M41/40 ,  C12M41/46 ,  C12M41/48 ,  C12Q1/02 ,  G01N33/5005 ,  G01N33/574

Abstract: A micro-incubator manifold for improved microfluidic configurations and systems and methods of manufacture and operation for a manifold and automated microfluidic systems.

Abstract translation: 用于改进微流体结构的微型培养箱歧管以及用于歧管和自动微流体系统的制造和操作的系统和方法。

公开(公告)号：US20140224723A1

公开(公告)日：2014-08-14

申请号：US14190560

申请日：2014-02-26

Applicant: EMD Millipore Corporation

Inventor： Louis Bonhomme ,  John Doyle ,  Kurt Greenizen ,  George Gagne ,  Sean Devin ,  Gerard Lombard ,  Vincent Smith

IPC: B01D63/16 ,  B01D61/14 ,  B01D61/18

CPC classification number: B01D63/16 ,  B01D61/145 ,  B01D61/18 ,  B01D63/08 ,  B01D2313/08 ,  B01L3/502 ,  B01L3/5021 ,  B01L3/5635 ,  B01L2300/0681

Abstract: Filtration device suited for concentration of liquid samples, particularly biomolecules, and a method of concentrating, desalting, purifying and/or fractionating liquid samples. In certain embodiments the device includes a housing having a sample reservoir, and two substantially vertically oriented and spaced apart membranes disposed in the housing. An underdrain is associated with each membrane such that fluid passing through each membrane flows through a respective underdrain into a filtrate collection chamber. The fluid that does not pass through the membrane is collected in the retentate collection chamber, and can be recovered such as by a reverse spinning step, achieving recoveries greater than about 90%. The substantially vertical orientation of the membranes increases the available membrane area by at least 2.7 times the area available in a conventional filter device. The two-panel configuration also maintains more available membrane area in use during the last stages of filtration than a one-panel configuration.

Abstract translation: 适用于浓缩液体样品，特别是生物分子的过滤装置，以及浓缩，脱盐，纯化和/或分馏液体样品的方法。 在某些实施方案中，该装置包括具有样品储存器的壳体和设置在壳体中的两个基本垂直定向和间隔开的膜。 与每个膜相关联的下划线，使得通过每个膜的流体通过相应的下划线流入滤液收集室。 不通过膜的流体被收集在滞留物收集室中，并且可以通过反转纺步骤回收，实现大于约90％的回收率。 膜的基本垂直取向将可用的膜面积增加了传统过滤装置中可用面积的至少2.7倍。 两面板配置在过滤的最后阶段比在单面板配置中还维持使用更多的可用膜面积。

公开(公告)号：US08793076B2

公开(公告)日：2014-07-29

申请号：US13914880

申请日：2013-06-11

Applicant: EMD Millipore Corporation

Inventor： Pascal Rajagopalan ,  Antony Vanheghe ,  Celine Le Ninivin Glipa ,  Aristotelis Dimitrakopoulos

IPC: G01N33/50 ,  B01J49/00

CPC classification number: G01N27/06 ,  G01N33/1826 ,  Y02A20/206

Abstract: Disclosed is a method for analyzing the quantity of organic compounds existing in a liquid, such as ultrapure water, at the outlet from a purification device including in series a filter, an oxidizing device and a polishing device, and further including a resistivity measuring device for measuring the resitivity of water to determine the purity thereof. Only one resistivity measuring cell is used, and the outlet points of the filter and the oxidizing device are connected to the resistivity measuring cell by pipes provided with an analysis valve and/or check valves selectively enabling circulation of the liquid within them.

Abstract translation: 本发明公开了一种分析在串联过滤器，氧化装置和研磨装置的净化装置的出口处存在于超纯水等液体中的有机化合物的量的方法，还包括电阻率测定装置， 测量水的溶解度以确定其纯度。 仅使用一个电阻率测量单元，并且通过配有分析阀和/或选择性地使液体在其内循环的止回阀的管道将过滤器和氧化装置的出口点连接到电阻率测量池。

公开(公告)号：US08747670B2

公开(公告)日：2014-06-10

申请号：US13649365

申请日：2012-10-11

Applicant: EMD Millipore Corporation

Inventor： Louis Bonhomme ,  John Doyle ,  Kurt Greenizen ,  George Gagne ,  Sean Devin ,  Gerard Lombard ,  Vincent Smith

IPC: B01D63/08 ,  B01D63/16 ,  B01D61/18 ,  B01L3/00

CPC classification number: B01D63/16 ,  B01D61/145 ,  B01D61/18 ,  B01D63/08 ,  B01D2313/08 ,  B01L3/502 ,  B01L3/5021 ,  B01L3/5635 ,  B01L2300/0681

Abstract: Filtration device suited for concentration of liquid samples, particularly biomolecules, and a method of concentrating, desalting, purifying and/or fractionating liquid samples. In certain embodiments the device includes a housing having a sample reservoir, and two substantially vertically oriented and spaced apart membranes disposed in the housing. An underdrain is associated with each membrane such that fluid passing through each membrane flows through a respective underdrain into a filtrate collection chamber. The fluid that does not pass through the membrane is collected in the retentate collection chamber, and can be recovered such as by a reverse spinning step, achieving recoveries greater than about 90%. The substantially vertical orientation of the membranes increases the available membrane area by at least 2.7 times the area available in a conventional filter device. The two-panel configuration also maintains more available membrane area in use during the last stages of filtration than a one-panel configuration.

Abstract translation: 适用于浓缩液体样品，特别是生物分子的过滤装置，以及浓缩，脱盐，纯化和/或分馏液体样品的方法。 在某些实施方案中，该装置包括具有样品储存器的壳体和设置在壳体中的两个基本垂直定向和间隔开的膜。 与每个膜相关联的下划线，使得通过每个膜的流体通过相应的下划线流入滤液收集室。 不通过膜的流体被收集在滞留物收集室中，并且可以通过反转纺步骤回收，实现大于约90％的回收率。 膜的基本垂直取向将可用的膜面积增加了传统过滤装置中可用面积的至少2.7倍。 两面板配置在过滤的最后阶段比在单面板配置中还维持使用更多的可用膜面积。

公开(公告)号：US20140124083A1

公开(公告)日：2014-05-08

申请号：US14153114

申请日：2014-01-13

Applicant: EMD Millipore Corporation

Inventor： Martin Morrissey ,  Neil Schauer

IPC: F16L9/00

CPC classification number: F16L9/00 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00808 ,  B01J2219/00813 ,  B01J2219/00833 ,  B01J2219/00968 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/561 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2300/0887 ,  F16L9/127 ,  F16L9/133 ,  F16L9/22 ,  Y10T137/87153

Abstract: A disposable flow path having a manifold system that provides pressure resistance for the disposable device. The disposable device is comprised of a first rigid plastic sheet and a second rigid plastic sheet. Each sheet has two major surfaces and a thickness between them. At least one sheet surface has flow channels formed in it. The flow channels extend away from a first major surface and beyond the normal plane of a second major surface of the sheet. The sheets are liquid tightly sealed to each other at their adjoining first major surfaces. When each sheet contains a flow channel, the flow channels are aligned and in register with each other. One or more fittings can be secured in the flow channel(s) at an edge of the two liquid tightly sealed sheets. Alternatively, tubing is placed in the channels before the sheets are secured to one another.

Abstract translation: 一次性流路，其具有为一次性装置提供耐压性的歧管系统。 一次性装置包括第一刚性塑料片和第二刚性塑料片。 每片具有两个主表面和它们之间的厚度。 至少一个片材表面上形成有流动通道。 流动通道远离第一主表面并超过板的第二主表面的法线平面。 片材在相邻的第一主要表面彼此液体密封。 当每个纸张包含流动通道时，流动通道对齐并彼此对准。 一个或多个配件可以固定在两个液密封片的边缘处的流动通道中。 或者，在片彼此固定之前，将管道放置在通道中。

公开(公告)号：US20140073040A1

公开(公告)日：2014-03-13

申请号：US14080466

申请日：2013-11-14

Applicant: EMD Millipore Corporation

Inventor： Aaron Burke

IPC: C12M1/12

CPC classification number: C12M37/02 ,  A61L2/26 ,  B01D63/00 ,  C12M23/14 ,  C12M29/00 ,  C12M41/00 ,  G01L19/0645

Abstract: A system and method for interfacing non-sterile sensors to a sterile flow stream is disclosed. Typically, sensors cannot be sterilized in the same manner as other components of the flow stream. This results in complex processes to incorporate a sterilized sensor into a sterilized flow stream. By introducing a separation membrane, the desired sensor can be interfaced to the sterile flow stream. By doing so, the sensor need not be sterile, only sufficiently clean. The membrane separates the sterile environment within the flow stream from the sensor, while still permitting the sensor to function.

Abstract translation: 公开了一种用于将非无菌传感器与无菌流动流接口的系统和方法。 通常，传感器不能以与流动流的其它部件相同的方式灭菌。 这导致复杂的过程将消毒的传感器并入灭菌的流动流中。 通过引入分离膜，期望的传感器可以与无菌流动流相连。 通过这样做，传感器不需要无菌，只能充分清洁。 膜将来自传感器的流动中的无菌环境分开，同时仍允许传感器起作用。

公开(公告)号：US08506798B2

公开(公告)日：2013-08-13

申请号：US13688255

申请日：2012-11-29

Applicant: EMD Millipore Corporation

Inventor： Jean-Luc Beulay ,  Virginie Buisson ,  Sebastien Cirou ,  Cecile Delbos ,  Marc Hlavacek ,  Frans Mels ,  Rene Reinbigler ,  Jean-Louis Weissenbach

IPC: B01D36/00 ,  C12M1/12 ,  C12M1/00

CPC classification number: B01D36/00 ,  C12M1/12 ,  C12M47/12 ,  Y10T436/25375 ,  Y10T436/2575

Abstract: Installation for treating a biological liquid, including a circulation pump (5), a filter element (9), a container for collecting treated liquid, a first circuit section connecting a source of said biological liquid to an inlet orifice of said filter element (9), including a circuit element adapted to cooperate with said circulation pump (5); a second circuit section, connecting an outlet orifice of said filter element (9) to said treated liquid collecting container; characterized in that said treated liquid collecting container, said first circuit section and said second circuit section are disposable and said installation further includes a first cart (1) carrying said pump (5) and a second cart (2) including a housing (14) for said collecting container, separable from the first cart (1) and adapted to be at least partly nested in said first cart (1).

公开(公告)号：US20130087490A1

公开(公告)日：2013-04-11

申请号：US13688255

申请日：2012-11-29

Applicant: EMD Millipore Corporation

Inventor： Jean-Luc Beulay ,  Virginie Buisson ,  Sebastien Cirou ,  Cecile Delbos ,  Marc Hlavacek ,  Frans Mels ,  Rene Reinbigler ,  Jean-Louis Weissenbach

IPC: B01D36/00

CPC classification number: B01D36/00 ,  C12M1/12 ,  C12M47/12 ,  Y10T436/25375 ,  Y10T436/2575

Abstract: Installation for treating a biological liquid, including a circulation pump (5), a filter element (9), a container for collecting treated liquid, a first circuit section connecting a source of said biological liquid to an inlet orifice of said filter element (9), including a circuit element adapted to cooperate with said circulation pump (5); a second circuit section, connecting an outlet orifice of said filter element (9) to said treated liquid collecting container; characterized in that said treated liquid collecting container, said first circuit section and said second circuit section are disposable and said installation further includes a first cart (1) carrying said pump (5) and a second cart (2) including a housing (14) for said collecting container, separable from the first cart (1) and adapted to be at least partly nested in said first cart (1).

Abstract translation: 用于处理包括循环泵（5），过滤元件（9），用于收集处理液体的容器的生物液体的安装，将所述生物液体源连接到所述过滤元件（9）的入口孔的第一回路段 ），包括适于与所述循环泵（5）配合的电路元件; 第二电路部分，将所述过滤元件（9）的出口孔连接到所述处理过的液体收集容器; 其特征在于，所述处理过的液体收集容器，所述第一回路部分和所述第二回路部分是一次性的，并且所述装置还包括承载所述泵（5）的第一推车（1）和包括壳体（14）的第二推车（2） 用于所述收集容器，所述收集容器可与所述第一推车（1）分离并且适于至少部分地嵌套在所述第一推车（1）中。