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公开(公告)号：US10809323B2
公开(公告)日：2020-10-20
申请号：US14787040
申请日：2014-04-24
Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd. , Ramot at Tel-Aviv University Ltd.
Inventor： Yael Mardor , Leor Zach , David Guez , David Last , Dianne Daniels
IPC: A61B5/055 , A61B5/00 , G01R33/28 , G01R33/56 , G01R33/48 , G06T7/00 , G16H40/40 , G16H30/40 , G16H40/63 , A61K31/166 , A61K31/7068 , A61K31/555
Abstract: Apparatus for operating MRI is disclosed. The apparatus comprises: a control for operating an MRI scanner to carry out an MRI scan; an input for receiving first and second MRI scans respectively at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from the first and the second MRI scans by analyzing the scans to distinguish between a population in which contrast clearance from the tissue is slower than contrast accumulation, and a population in which clearance is faster than accumulation; and an output to provide an indication of distribution of the populations. The control is configured to carry out the first scan at least five minutes and no more than twenty minutes post contrast administration and to carry out the second scan such that the predetermined time period is at least twenty minutes.
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公开(公告)号：US20200325203A1
公开(公告)日：2020-10-15
申请号：US16914388
申请日：2020-06-28
Applicant: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. , RAMOT AT TEL AVIV UNIVERSITY LTD.
Inventor： Genady KOSTENICH , Mor ORON-HERMAN , Arie ORENSTEIN , Talia SHEKHTER ZAHAVI , Ehud GAZIT , Yoseph SALITRA , Ludmila BUZHANSKY
Abstract: Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.
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公开(公告)号：US10797800B2
公开(公告)日：2020-10-06
申请号：US16308997
申请日：2017-06-08
Applicant: RAMOT at Tel Aviv University Ltd.
Inventor： Mark Shtaif , Antonio Mecozzi , Cristian Antonelli
Abstract: A Kramers-Kronig receiver that may include a reception path; wherein the reception path may include a photodiode that is configured to receive a received signal and output a photocurrent that represents the received signal; wherein the received signal comprises a continuous wave (CW) signal and a modulated signal; wherein a frequency gap between the CW signal and the modulated signal is smaller than a bandwidth of the modulated signal; an analog to digital converter that is configured to generate a digital representation of the photocurrent; and a digital processor that is configured to process the digital representation of the photocurrent to provide a reconstructed modulated signal, wherein the processing is based on a Kramers-Kronig relationship related to the received signal.
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公开(公告)号：US20200284960A1
公开(公告)日：2020-09-10
申请号：US16482717
申请日：2018-02-02
Inventor： Tal ELLENBOGEN , Yehiam PRIOR , Ori AVAYU , Euclides ALMEIDA
Abstract: A multilayer optical element comprises a plurality of layers arranged along an optical axis, each layer having a plurality of nanostructures, wherein a size of—, and a spacing between—, the nanostructures is selected to provide a resonant response to an optical field at different wavelengths for different layers.
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公开(公告)号：US20200277647A1
公开(公告)日：2020-09-03
申请号：US16616356
申请日：2018-05-23
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Doron Shabat , Michal Eli Roth-Konforti
Abstract: The present invention provides turn-ON dioxetane-based chemiluminescence probes based on the Schapp's adamantylidene-dioxetane probe, which are capable of detecting or imaging, more specifically, determining the presence, or measuring the level, of proteases, as well as compositions and uses thereof.
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Patent Agency Ranking
公开(公告)号：US10744162B2
公开(公告)日：2020-08-18
申请号：US16353680
申请日：2019-03-14
Inventor： Daniel Offen , Michal Dadon-Nachum , Tali Ben-Zur , Eldad Melamed , David Yaffe
Abstract: An isolated muscle progenitor cell being MyoD positive, CD34 negative and CD45 negative is disclosed. The muscle progenitor cell is genetically modified to express at least one neurotrophic factor. In addition, cell populations are disclosed, comprising at least four subpopulations of muscle cells each being genetically modified to express a different neurotrophic factor, wherein said neurotrophic factor is selected from the group consisting of glial derived neurotrophic factor (GDNF), insulin growth factor (IGF-1), vascular endothelial growth factor (VEGF) and brain-derived neurotrophic factor (BDNF). Uses of the cell populations are also disclosed.
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公开(公告)号：US20200255305A1
公开(公告)日：2020-08-13
申请号：US16481422
申请日：2018-02-15
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Yoram Gerchman , Hadas Mamane , Vered Cohen Yaniv , Yifaat Betzalel , Avraham Balas
IPC: C02F1/32
Abstract: The present invention provides a method for water disinfection by exposing water, optionally simultaneously, to a combination of at least two ultraviolet (UV) irradiation sources, wherein at least one of said UV irradiation sources emits light at a wavelength of between 250 nm and 280 nm, and at least one of said UV irradiation sources emits light at a wavelength of between 285 nm and 310 nm; and an apparatus for carrying out said method.
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公开(公告)号：US20200243690A1
公开(公告)日：2020-07-30
申请号：US16846337
申请日：2020-04-12
Applicant: RAMOT AT TEL AVIV UNIVERSITY LTD.
Inventor： Gideon Segev , Iddo Amit , Alexander Henning , Yossi Rosenwaks
IPC: H01L29/808 , H01L29/417 , H01L29/06 , B82Y10/00 , H01L29/76 , H01L29/10 , H03K19/00 , H03K17/00 , H01L29/423 , H01L29/40 , H01L29/66 , H01L29/08 , H01L29/775
Abstract: A transistor (100), including a planar semiconducting substrate (36), a source (42) formed on the substrate, a first drain (102) formed on the substrate, and a second drain (104) formed on the substrate in a location physically separated from the first drain. At least one gate (38, 40) is formed on the substrate and is configured to selectably apply an electrical potential to the substrate in either a first spatial pattern, which causes a first conductive path (62) to be established within the substrate from the source to the first drain, or a second spatial pattern, which causes a second conductive path to be established within the substrate from the source to the second drain.
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公开(公告)号：US10679110B2
公开(公告)日：2020-06-09
申请号：US16371243
申请日：2019-04-01
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Ofer Bar-On , Yoav Blau , Jacob Scheuer
IPC: G06K19/07 , G06K19/077
Abstract: A method for creating a nanostructure surface, comprises creating a nanostructure master having a surface being the negative of a shape that, when illuminated with a predefined illumination, provides a unique optical pattern; and creating nanostructure molds from the nanostructure master, wherein each nanostructure mold has a negative of the master surface which, when illuminated with the predefined illumination, provides the unique optical pattern, which may be a hologram. A nanotag may incorporate an image for identification and a unique pattern that can be identified for authentication.
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公开(公告)号：US10676511B2
公开(公告)日：2020-06-09
申请号：US15760878
申请日：2016-09-15
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Jonathan Gershoni , Natalia T. Freund
IPC: C07K14/005 , A61K39/215 , A61K39/12 , A61P31/14
Abstract: Provided are polypeptides derived from the coronaviruses (CoVs) Spike protein (S) characterized by high affinity and specificity the S receptor and its neutralizing antibodies. Further provided are compositions and vaccines, and vaccine-based therapies targeting CoVs, and SARS and MERS viruses in particular.
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