公开(公告)号：US11826572B2

公开(公告)日：2023-11-28

申请号：US17330883

申请日：2021-05-26

Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education

Inventor： Changfeng Tai

IPC: A61N1/36 ,  A61N1/05

CPC classification number: A61N1/36164 ,  A61N1/0551 ,  A61N1/36062 ,  A61N1/36071 ,  A61N1/36153 ,  A61N1/36157

Abstract: A method of blocking a nerve or neuron by applying an electrical stimulation to the nerve or neuron, wherein the electrical stimulation is of an intensity below the excitation threshold of the nerve or neuron for a length of time sufficient to produce a block of nerve conduction or neuron excitation.

公开(公告)号：US20230365457A1

公开(公告)日：2023-11-16

申请号：US18225825

申请日：2023-07-25

Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： SAJAD HAGHANIFAR ,  BRADLEY D. PAFCHEK ,  PAUL W. LEU ,  TONGCHUAN GAO

IPC: C03C15/00 ,  C03C17/06 ,  C03C17/30 ,  B82Y30/00 ,  B82Y40/00

CPC classification number: C03C15/00 ,  C03C17/06 ,  C03C17/30 ,  C03C2217/76 ,  B82Y30/00 ,  C03C2217/77 ,  C03C2217/75 ,  B82Y40/00

Abstract: The invention relates generally to optically high transparency and high haze structures and, more particularly, to plastic, e.g., polymer, and glass structures having a sub-wavelength texture formed on a surface thereof, which is effective to impart the optical properties of high transparency and high haze to the structures. The texture is in a grass-like or needle-like form. Additionally, the optically high transparency and high haze structures may include a transparent conductor. Furthermore, the glass structures may exhibit a self-cleaning function.

公开(公告)号：US20230364301A1

公开(公告)日：2023-11-16

申请号：US18044969

申请日：2021-04-30

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education

Inventor： Stephen Francis Badylak ,  George S. Hussey

IPC: A61L27/36 ,  A61L27/52 ,  A61L27/54

CPC classification number: A61L27/3633 ,  A61L27/52 ,  A61L27/54 ,  A61L2400/06 ,  A61L2430/34

Abstract: A method is disclosed for treating a fistula in a subject, such as, but not limited to, an anal fistula. In some embodiments, the method includes administering locally to the fistula in the subject an effective amount of a composition comprising a mammalian acoustic extracellular matrix (ECM) hydrogel, and optionally trehalose. Compositions of use in these methods are also disclosed.

公开(公告)号：US20230348557A1

公开(公告)日：2023-11-02

申请号：US17795573

申请日：2021-02-05

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education

Inventor： Udai Shankar Kammula ,  Ghanshyam Singh Yadav ,  Chetana Bhaskarla

IPC: C07K14/725 ,  C12N5/0783 ,  C12N15/86 ,  A61P35/00

CPC classification number: C07K14/7051 ,  C12N5/0636 ,  C12N15/86 ,  A61P35/00

Abstract: This document provides isolated immune cells that include an exogenous T cell receptor (TCR) having affinity for an Ataxia-Telangiesctasia Mutated (ATM) peptide, an exogenous TCR having affinity for an AT-rich interactive domain-containing protein 1A (ARID1A) peptide, or both an exogenous TCR having affinity for an ATM peptide and an exogenous TCR having affinity for an ARID1A peptide, as well as methods and materials for making such immune cells. For example, isolated immune cells that included an exogenous TCR having affinity for a mutant ATM and/or exogenous TCR having affinity for an ARID1A peptide, methods and materials for making such immune cells, and methods and materials for using such immune cells to treat mammals (e.g., a human having cancer) are provided.

公开(公告)号：US11802313B2

公开(公告)日：2023-10-31

申请号：US17227186

申请日：2021-04-09

Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education

Inventor： Laurie H. Andolina ,  John T. Greenamyre ,  Sruti Shiva

IPC: C12Q1/68 ,  C12Q1/6883 ,  C12Q1/686

CPC classification number: C12Q1/6883 ,  C12Q1/686 ,  C12Q2561/113 ,  C12Q2563/173 ,  C12Q2600/106 ,  C12Q1/686 ,  C12Q2561/113 ,  C12Q2563/173

Abstract: Methods are disclosed for detecting peripheral mitochondrial DNA damage and dysfunction. Methods are also disclosed that utilize blood samples to detect a neurodegenerative disease, such as Parkinson's disease, and determine the efficacy of therapy.

公开(公告)号：US11793961B2

公开(公告)日：2023-10-24

申请号：US16341123

申请日：2017-10-18

Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education ,  UPMC

Inventor： Youngjae Chun ,  Philip Charles Carullo

IPC: A61M16/04 ,  A61B17/12 ,  A61M25/00

CPC classification number: A61M16/0409 ,  A61M16/0463 ,  A61M16/0488 ,  A61B17/1204 ,  A61B17/12104 ,  A61M25/0074 ,  A61M2202/0403 ,  A61M2205/0266 ,  A61M2210/105 ,  A61M2210/1053

Abstract: A temporary esophagus occlusion device for providing temporary occlusion of the esophagus during intubation of a in patient includes a frame configured to transition between a contracted state, in which it can be swallowed by the patient, and an expanded state, wherein in the expanded state, the frame has a maximum outer diameter sufficient to span an inner diameter of the esophagus of the patient. The device also includes a flexible cover connected to and extending over at least a portion of the frame when the frame is in the expanded state to at least partially block flow of fluid and/or solid materials through the esophagus and a guidewire attached to the frame, sized to be swallowed by the patient along with the frame and having a proximal end portion configured to remain external to the patient's body and a distal end connected to the frame.

公开(公告)号：US11782210B2

公开(公告)日：2023-10-10

申请号：US17658334

申请日：2022-04-07

Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education

Inventor： Paul Richard Ohodnicki, Jr. ,  Jung-Kun Lee ,  Yulin Liu ,  Ruishu Wright ,  Fei Lu ,  Jeffrey Wuenschell

IPC: G02B6/132 ,  G02B6/12

CPC classification number: G02B6/132 ,  G02B2006/12035 ,  G02B2006/12138

Abstract: A method of making an optical fiber-based sensor includes providing an optical fiber, and providing a sensing or protection layer on a surface of the optical fiber by an atomic layer deposition (ALD) process.

公开(公告)号：US11771555B2

公开(公告)日：2023-10-03

申请号：US16777007

申请日：2020-01-30

Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education

Inventor： Vinay Badhwar ,  Young Jae Chun ,  Antonio D'Amore ,  David S. Schwartzman ,  William R. Wagner

IPC: A61F2/24 ,  A61N1/362 ,  A61L27/14 ,  A61L27/50 ,  A61M25/09 ,  A61F2/95

CPC classification number: A61F2/2418 ,  A61F2/243 ,  A61F2/2409 ,  A61F2/2412 ,  A61L27/14 ,  A61L27/50 ,  A61M25/09 ,  A61N1/3629 ,  A61F2002/9505 ,  A61F2210/0019 ,  A61F2240/001 ,  A61F2250/001 ,  A61F2250/0059 ,  A61L2400/16

Abstract: An atrioventricular prosthesis device is provided. The device includes a frame at least partially defining and enclosing a central cavity, the frame having a distal portion, a proximal portion, and a middle portion connected therebetween. The device further includes a valve construct formed, at least in part, from a cell growth scaffold, at least partially disposed within the central cavity defined by the frame. The valve construct includes: an annular portion defining an aperture and being connected to the frame for positioning the valve construct within the central cavity of the frame, and a plurality of leaflets extending longitudinally and radially inward from the annular portion. The frame and valve construct are transitionable to a deployed state, in which a diameter of at least a portion of the frame and the valve construct substantially conform to a diameter of a tricuspid and/or mitral valve opening.

公开(公告)号：US20230285731A1

公开(公告)日：2023-09-14

申请号：US18141310

申请日：2023-04-28

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education

Inventor： Louis D. Falo ,  Geza Erdos

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61K9/0021

Abstract: A method of forming a microneedle array can include forming a microneedle array that has one or more bioactive component. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more bioactive components can be combined with other components to exhibit specific release kinetics when the microneedle array is inserted into the skin of a patient.

公开(公告)号：US11747342B2

公开(公告)日：2023-09-05

申请号：US17177612

申请日：2021-02-17

Applicant: University of Pittsburgh—of the Commonwealth System of Higher Education

Inventor： John A. Kellum ,  Zhiyun Cao ,  Derek Angus ,  Sachin Purushottam Yende ,  Rena Angilena Sowell Robinson

IPC: G01N33/68

CPC classification number: G01N33/6848 ,  G01N2800/26

Abstract: A proteomic expression platform to identify age-related sepsis risk is disclosed using patients with an intra-abdominal infection. A semi-quantitative plasma proteomics workflow was applied which incorporated tandem immuno affinity depletion, iTRAQ labeling, strong cation exchange fractionation, and nanoflow-liquid chromatography coupled to high resolution mass spectrometry. A protein profile was determined that exhibit statistically significant differences in expression levels amongst patients with severe sepsis as a function of age. Representative pathways that are differentially-expressed include, but are not limited to, acute phase response, coagulation signaling, atherosclerosis signaling, lipid metabolism, and production of nitric oxide/reactive oxygen species.