公开(公告)号：US09598448B2

公开(公告)日：2017-03-21

申请号：US15066830

申请日：2016-03-10

Applicant: University of Warwick

Inventor： Ying Fu ,  Peter John Sadler ,  Abraha Habtemariam

IPC: C07F15/00 ,  A61K31/555

CPC classification number: C07F15/002

Abstract: The present invention relates to the use of certain osmium containing complexes such as cytotoxic agents particularly for the treatment of cancer. There is also provided novel osmium containing complexes, as well as pharmaceutical formulations comprising such complexes.

公开(公告)号：US20160333321A1

公开(公告)日：2016-11-17

申请号：US15111615

申请日：2015-01-16

Applicant: THE UNIVERSITY OF WARWICK

Inventor： Nigel J. Dimmock ,  Andrew J. Easton

IPC: C12N7/00 ,  C12Q1/70

CPC classification number: C12N7/00 ,  C12N7/045 ,  C12N2760/16132 ,  C12N2760/16162 ,  C12Q1/701

Abstract: The invention relates to defective interfering viruses and defective interfering virus RNAs that are effective as antiviral agents. The invention also relates to methods for identifying defective interfering virus RNAs that can be used as effective antiviral agents.

Abstract translation: 本发明涉及作为抗病毒剂有效的缺陷性干扰病毒和有缺陷的干扰性病毒RNA。 本发明还涉及用于鉴定可用作有效的抗病毒剂的有缺陷的干扰性病毒RNA的方法。

公开(公告)号：US20160178637A1

公开(公告)日：2016-06-23

申请号：US14911219

申请日：2013-08-09

Applicant: THE UNIVERSITY OF WARWICK

Inventor： Paul Thornalley ,  Naila Rabbani

IPC: G01N33/64 ,  G01N33/50 ,  G01N33/58

CPC classification number: G01N33/64 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/52 ,  G01N33/582 ,  G01N2800/042 ,  G01N2800/044 ,  G01N2800/102 ,  G01N2800/16 ,  G01N2800/166 ,  G01N2800/2821 ,  G01N2800/2835 ,  G01N2800/2871 ,  G01N2800/301 ,  G01N2800/302 ,  G01N2800/32 ,  G01N2800/321 ,  G01N2800/323 ,  G01N2800/347 ,  G01N2800/368 ,  G01N2800/7042

Abstract: The disclosure relates to a fluorescence based assay for the detection of alpha, beta-dicarbonyl containing compounds, for example alpha-oxoaldehyde compounds such as glyoxal, methylglyoxal, hydroxypyruvaldehyde, erythrosone, 3-deoxy-erythrosone, ribosone, 3-deoxyribosone, glucosone, 3-deoxyglucosone and stereoisomers thereof and butan-2,3-dione that uses a fluorogenic probe which is stable under ambient conditions. The fluorogenic probes comprise a 1,2-diaminophenyl moiety. The diaminophenyl probes yield a 20-fold increase in quantum yield when they are a derivative of fluorescein (DAF), rhodamine (DAR), BODIPY or cyanine. The assay is preferably carried out at pH 4-8. Corresponding screening methods for modulators of alpha, beta-dicarbonyl compound concentrations are also disclosed.

Abstract translation: 本公开涉及用于检测含α，β-二羰基化合物的荧光基测定法，例如α-氧代醛化合物，例如乙醛酸，甲基乙二醛，羟基吡喃甲醛，赤藓酮，3-脱氧 - 赤藓酮，核糖酮，3-脱氧核糖，葡萄糖， 3-脱氧葡萄糖喃酮及其立体异构体和使用在环境条件下稳定的荧光探针的丁-2,3-二酮。 荧光探针包含1,2-二氨基苯基部分。 当它们是荧光素（DAF），罗丹明（DAR），BODIPY或花青的衍生物时，二氨基苯基探针的量子产率增加20倍。 该测定优选在pH 4-8下进行。 还公开了α，β-二羰基化合物浓度调节剂的相应筛选方法。

公开(公告)号：US09089516B2

公开(公告)日：2015-07-28

申请号：US13712045

申请日：2012-12-12

Applicant: The University of Warwick

Inventor： Nigel Dimmock

IPC: A61K35/12 ,  A61K39/145 ,  A61K35/76 ,  C07K14/005 ,  C12N7/00 ,  A61K39/00

CPC classification number: A61K39/145 ,  A61K35/76 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/542 ,  A61K2039/543 ,  C07K14/005 ,  C12N7/00 ,  C12N2760/16121 ,  C12N2760/16122 ,  C12N2760/16134

Abstract: Cloned, i.e. defined, defective interfering (DI) influenza A virus is produced in embryonated hens eggs using a method which generates large quantities of DI virus material. Co-administration of cloned DI influenza A virus with a lethal dose of virulent influenza A virus conferred protection in mice compared to a control of inactivated cloned DI influenza A virus. Control mice which received only cloned DI influenza A virus and no lethal challenge of virulent influenza A virus were not protected three weeks later on lethal challenge with infective virus. Cloned DI influenza A virus of one subtype is found to act in vivo as an effective antiviral against the same or any other sub-type of influenza A virus. The antiviral effect has been found to have both a therapeutic and a prophylactic application against influenza A infection in humans, mammals and birds.

Abstract translation: 克隆，即定义的，有缺陷的干扰（DI）甲型流感病毒是使用产生大量DI病毒材料的方法在胚胎母鸡卵中产生的。 与对照灭活的克隆的D型甲型流感病毒相比，克隆的DI甲型流感病毒与致死剂量的毒性流感A病毒的共同给药在小鼠中赋予了保护作用。 只有克隆的D型甲型流感病毒对照小鼠，并且没有致命的甲型流感病毒感染攻击，在感染性病毒的致死性攻击三周后没有得到保护。 发现一种亚型的克隆的甲型流感病毒A型病毒在体内作为针对相同或任何其它亚型甲型流感病毒的有效抗病毒药物起作用。 已经发现抗病毒作用具有针对人，哺乳动物和鸟类中甲型流感感染的治疗和预防性应用。

公开(公告)号：US20250043300A1

公开(公告)日：2025-02-06

申请号：US18715201

申请日：2022-12-13

Applicant: THE UNIVERSITY OF WARWICK

Inventor： Jose F. GUTIERREZ-MARCOS

IPC: C12N15/82 ,  C07K14/415

Abstract: The present invention relates to a method of producing a modified plant, part, cell or protoplast thereof having an increase in a yield-related trait relative to a reference plant, part, cell or protoplast thereof. More particularly, the invention relates to providing the plant, part, cell or protoplast thereof with an RKD transcription factor, a polynucleotide encoding the same, or a gene editing system for modifying an endogenous nucleic acid sequence encoding an RKD transcription factor or regulatory sequence thereof. Said plants have improvements in a yield-related trait, and thereby improved yield, which is especially useful in agriculture.

公开(公告)号：US20240058800A1

公开(公告)日：2024-02-22

申请号：US18498026

申请日：2023-10-30

Applicant: THE UNIVERSITY OF WARWICK

Inventor： Shanwen Tao ,  John Humphreys

IPC: B01J27/24 ,  B01J23/10 ,  B01J23/745 ,  B01J23/755 ,  B01J23/78 ,  C01C1/04

CPC classification number: B01J27/24 ,  B01J23/10 ,  B01J23/745 ,  B01J23/755 ,  B01J23/78 ,  C01C1/0411

Abstract: A composition for catalysis of a Haber-Bosch process to produce ammonia; a process employing the composition and an anion vacant lattice for use in the process.
The composition comprises an anion vacant lattice and a Haber-Bosch catalyst (e.g. Fe or Ru). Suitable anion vacant lattices include oxynitrides and oxides, which may be doped or undoped, including


CeaMbO2-xNy  (Formula III)

M is one or more elements with a valence lower than 4. “a” and “b” are independently in the range 0.05 to 0.95, with the proviso that “a” and “b” together sum to 1 (approximately). X is greater than 0 and less than 2. Y is greater than zero and less than or equal to X.

公开(公告)号：US11713339B2

公开(公告)日：2023-08-01

申请号：US17042489

申请日：2019-03-28

Applicant: UNIVERSITY OF WARWICK

Inventor： Michael Shipman

IPC: A61K38/00 ,  C07K7/02 ,  C07K7/54 ,  G01N33/68

CPC classification number: C07K7/54 ,  G01N33/6803 ,  A61K38/00

Abstract: A method of macrocyclization of peptidomimetics is described which comprises substitution of one or more of the backbone amide C═O bonds with a turn-inducing motif. The method is general with enhancements seen across a range of ring sizes (e.g. tri-, tetra-, penta- and hexapeptides). Specifically, a peptidomimetic macrocycle is described comprising a carbonyl bioisosteric turn-inducing element having the structure:






wherein X is a heteroatom; and
wherein R1 to R6 are each independently selected from alkyl, aryl, heteroaryl and H.

公开(公告)号：US20230076614A1

公开(公告)日：2023-03-09

申请号：US17613911

申请日：2020-06-05

Applicant: THE UNIVERSITY OF WARWICK

Inventor： Nicholas R. WATERFIELD ,  Joseph HEALEY ,  Alexia HAPESHI

IPC: C07K14/195 ,  B82Y5/00

Abstract: The present invention provides use of a Photorhabdus Virulence Cassettes (PVC) effector leader sequence, for packaging a payload into a PVC Needle Complex, and related methods for manufacturing a packaged PVC Needle Complex. The payload is one or more selected from a polypeptide, a nucleic acid, or a combination thereof, and the leader sequence and the payload form an effector fusion that is distinct from a wild-type PVC effector protein.

公开(公告)号：US11536599B2

公开(公告)日：2022-12-27

申请号：US16982398

申请日：2019-03-18

Applicant: The University of Warwick

Inventor： Steve Dixon ,  David Greenshields

IPC: G01F1/66 ,  G01F1/667

Abstract: A method of inferring fluid flow speed through a passage comprises receiving a first signal having a frequency and phase corresponding to that of a first ultrasonic wave detected after passing through the fluid in a direction with a component opposed or aligned to a main direction of the fluid's flow. Receiving a second signal having a frequency and phase corresponding to that of a second ultrasonic wave detected after passing through the fluid in a direction with a component different to that of the first ultrasonic wave with respect to the main direction of the fluid's flow. Inferring the fluid flow speed through the passage based on the relative phase shift between the first and second signals.

公开(公告)号：US20220325251A1

公开(公告)日：2022-10-13

申请号：US17725982

申请日：2022-04-21

Applicant: The University of Warwick

Inventor： Nigel J. DIMMOCK ,  Andrew J. EASTON

IPC: C12N7/00 ,  C12N7/04 ,  C12Q1/70

Abstract: The disclosure relates to defective interfering viruses and defective interfering virus RNAs that are effective as antiviral agents. The disclosure also relates to methods for identifying defective interfering virus RNAs that can be used as effective antiviral agents.