公开(公告)号：US20240019515A1

公开(公告)日：2024-01-18

申请号：US18143920

申请日：2023-05-05

Applicant: Xiamen University

Inventor： Yuqing HUANG ,  Zhong CHEN ,  Yu YANG ,  Liubin WU ,  Bo CHEN

IPC: G01R33/46 ,  G01N24/08

CPC classification number: G01R33/4625 ,  G01N24/087 ,  G01R33/4633

Abstract: A method for processing two-dimensional (2D) nuclear magnetic resonance (NMR) Diffusion Ordered Spectroscopy (DOSY) based on deep learning comprises constructing a simulated dataset by generating simulated data using a mathematical model based on signal characteristics of the 2D NMR DOSY, generating labels for training a deep learning network model, wherein the labels comprise a first two-dimensional matrix, and two dimensions of the first two-dimensional matrix comprise chemical shift and diffusion coefficients, constructing the deep learning network model and setting training parameters of the deep learning network model, training the deep learning network model using the simulated dataset, and testing the deep learning network model.

公开(公告)号：US11865196B2

公开(公告)日：2024-01-09

申请号：US18339195

申请日：2023-06-21

Applicant: Xiamen University ,  Shanghai University

Inventor： Gang Liu ,  Xiao Xu ,  Hongjuan Ma ,  Zhenwen Zhao ,  Hu Chen ,  Pan He ,  Chao Liu ,  Chengchao Chu ,  Dong Li

IPC: A61P35/00 ,  A61K51/12 ,  C08F257/02 ,  C08K3/06 ,  A61N5/10

CPC classification number: A61K51/1251 ,  A61N5/1002 ,  A61P35/00 ,  C08F257/02 ,  C08K3/06 ,  A61N2005/1021

Abstract: An engineered radioactive polymeric microsphere, and a preparation and application thereof. The preparation method includes: adding a styrene monomer and a disperser and/or a crosslinker into a medium, followed by feeding of nitrogen or helium and stirring to obtain a first reaction mixture; heating the first reaction mixture, and adding an initiator, followed by reaction under stirring at a constant temperature to obtain a second reaction mixture; subjecting the second reaction mixture to washing with ethanol and water, and vacuum drying to obtain a crude polymeric microsphere; subjecting the crude polymeric microsphere to radiation-induced graft polymerization with a functional monomer to obtain the functionalized polymeric microsphere; and exposing the functionalized polymeric microsphere to a radionuclide to prepare the engineered radioactive polymeric microsphere.

公开(公告)号：US20240000919A1

公开(公告)日：2024-01-04

申请号：US18252836

申请日：2021-11-12

Applicant: XIAMEN UNIVERSITY ,  XIAMEN INNOVAX BIOTECH CO., LTD.

Inventor： Ying GU ,  Tingting DENG ,  Hui ZHANG ,  Fang HUANG ,  Gege CHEN ,  Yanling LIN ,  Shaowei LI ,  Ningshao XIA

IPC: A61K39/21 ,  C12N7/00 ,  C07K14/005 ,  A61P31/18

CPC classification number: A61K39/21 ,  C12N7/00 ,  C07K14/005 ,  A61P31/18 ,  C12N2740/16122 ,  C12N2740/16134 ,  C07K2319/40 ,  C12N2740/16171 ,  A61K2039/645

Abstract: Provided are a newly designed HIV-1 Env trimer protein, and an HIV-1 pseudovirus and virus expressing the Env trimer protein, and the use thereof for the prevention and/or treatment of HIV infection.

公开(公告)号：US11833760B2

公开(公告)日：2023-12-05

申请号：US18109529

申请日：2023-02-14

Applicant: Xiamen University

Inventor： Wei Zhou ,  Rui Chen ,  Xinning Zhu ,  Tao Luo ,  Weisong Ling ,  Chiqian Xiao

IPC: B29C64/386 ,  B23K26/046 ,  B33Y50/02 ,  B23K26/359 ,  B23K37/04

CPC classification number: B29C64/386 ,  B23K26/046 ,  B23K26/359 ,  B23K37/0417 ,  B33Y50/02

Abstract: A laser conformal manufacturing method of a flexible sensor comprises: obtaining morphology data of a curved surface, and constructing a Standard Triangle Language (STL) model of the curved surface; introducing into a 3D modeling software, and combining the curved surface with a clamper holder; manufacturing to obtain the clamper with the curved surface; coating material to be manufactured on a 3D curved surface of the clamper with the curved surface; positioning to a processing platform of a laser device; constructing a model of a pattern to be manufactured by laser based on the STL model of the curved surface, and constructing an STL model or a dwg model of the pattern to be manufactured; introducing into the laser device, turning on the laser device, and running a 3D dynamic focus system; repeating the steps 4-8, and stripping the flexible sensor from the 3D curved surface.

公开(公告)号：US20230324396A1

公开(公告)日：2023-10-12

申请号：US17790438

申请日：2020-12-25

Applicant: XIAMEN UNIVERSITY ,  XIAMEN INNODX BIOTECH CO., LTD ,  BEIJING WANTAI BIOLOGICAL PHARMACY ENTERPRISE CO., LTD.

Inventor： Tingdong LI ,  Shengxiang GE ,  Xiaoyi GUO ,  Congming HONG ,  Liuwei SONG ,  Shunhua WEN ,  Jiabao TANG ,  Jun ZHANG ,  Ningshao XIA

IPC: G01N33/574 ,  C07K14/05

CPC classification number: G01N33/57488 ,  C07K14/05 ,  G01N2333/05 ,  G01N2469/20

Abstract: Provided are a method for diagnosing nasopharyngeal carcinoma on the basis of the anti-EB virus (EBV) antibody level and a kit used for the method. Also provided are a polypeptide encoded by a BNLF2b gene in EB virus used for the above-mentioned diagnosis and the use thereof for diagnosing nasopharyngeal carcinoma.

公开(公告)号：US20230323369A1

公开(公告)日：2023-10-12

申请号：US18002988

申请日：2021-06-24

Applicant: XIAMEN UNIVERSITY ,  YANG SHENG TANG COMPANY, LTD.

Inventor： Quan YUAN ,  Jiali CAO ,  Yali ZHANG ,  Mingfeng WANG ,  Jian MA ,  Tianying ZHANG ,  Jun ZHANG ,  Ningshao XIA

IPC: C12N15/85 ,  C12N15/52 ,  G01N33/50 ,  C12N9/02

CPC classification number: C12N15/52 ,  C12N9/0069 ,  C12N15/85 ,  G01N33/5023 ,  C12N2510/00 ,  C12N2730/10122 ,  G01N2333/02

Abstract: The present invention belongs to the field of virology, in particular to the field of hepatitis B virus treatment. Provided are a model and a method for screening HBV cccDNA inhibitors. According to the screening model and the method, the detection of a split luciferase is used as an alternative index ofHBV cccDNA detection, and a cccDNA-targeted drug can be screened in high throughput.

公开(公告)号：US20230202113A1

公开(公告)日：2023-06-29

申请号：US18109529

申请日：2023-02-14

Applicant: Xiamen University

Inventor： Wei ZHOU ,  Rui Chen ,  Xinning Zhu ,  Tao LUO ,  Weisong LING ,  Chiqian XIAO

IPC: B29C64/386 ,  B23K26/046 ,  B23K37/04 ,  B23K26/359 ,  B33Y50/02

CPC classification number: B29C64/386 ,  B23K26/046 ,  B23K37/0417 ,  B23K26/359 ,  B33Y50/02

Abstract: A laser conformal manufacturing method of a flexible sensor comprises: obtaining morphology data of a curved surface, and constructing a Standard Triangle Language (STL) model of the curved surface; introducing into a 3D modeling software, and combining the curved surface with a clamper holder; manufacturing to obtain the clamper with the curved surface; coating material to be manufactured on a 3D curved surface of the damper with the curved surface; positioning to a processing platform of a laser device; constructing a model of a pattern to be manufactured by laser based on the STL model of the curved surface, and constructing an STL model or a dwg model of the pattern to be manufactured; introducing into the laser device, turning on the laser device, and running a 3D dynamic focus system; repeating the steps 4-8, and stripping the flexible sensor from the 3D curved surface.

公开(公告)号：US20230193234A1

公开(公告)日：2023-06-22

申请号：US18051933

申请日：2022-11-02

Applicant: Xiamen University ,  Xiamen Zeesan Biotech Co., Ltd.

Inventor： Yongyou ZHANG ,  Dan WANG ,  Najie SONG

IPC: C12N9/24 ,  C12N15/70

CPC classification number: C12N9/2497 ,  C12Y302/02027 ,  C12N15/70 ,  C12N2800/101 ,  C07K2319/21 ,  C07K2319/95

Abstract: A recombinant vector of a thermolabile UNG fused protein and an expressing and purifying method are provided. The method comprises cloning a Cod UNG genetic sequence to a pCold-SUMO vector to construct a recombinant vector pCold-SUMO-Cod UNG, transforming to E. coli BL21 (DE3) competent cells, transforming and expressing molecular chaperone plasmids pG-Tf2, and inducing the expression at a low temperature to obtain a soluble SUMO-Cod UNG fused protein.

公开(公告)号：US20230174592A1

公开(公告)日：2023-06-08

申请号：US17997465

申请日：2021-04-30

Applicant: YANG SHENG TANG COMPANY, LTD. ,  XIAMEN UNIVERSITY

Inventor： Yali ZHANG ,  Shaojuan WANG ,  Yangtao WU ,  Wangheng HOU ,  Jianghui YE ,  Juan WANG ,  Tianying ZHANG ,  Tong CHENG ,  Quan YUAN ,  Ningshao XIA

IPC: C07K14/165 ,  C12N15/63 ,  G01N33/58 ,  C12N5/071 ,  C07K14/705

CPC classification number: C07K14/165 ,  C12N15/63 ,  G01N33/582 ,  C12N5/0602 ,  C07K14/705 ,  C07K2319/60 ,  C07K2319/02

Abstract: Disclosed are a fusion protein probe and a cell model for screening a blocking agent of coronavirus infections, a screening system comprising same, and a method of using the screening system for screening a blocking agent of coronavirus infections. The screening system and method do not involve live viruses, are simple and convenient to operate, have a high accuracy, are suitable for high throughput screening, and are of great significance for the development of coronavirus neutralizing antibodies, preventive vaccines, and small molecule drugs.

公开(公告)号：US11650274B2

公开(公告)日：2023-05-16

申请号：US17712548

申请日：2022-04-04

Applicant: Xiamen University

Inventor： Yuqing Huang ,  Zhong Chen ,  Cunyuan Gao ,  Haolin Zhan

IPC: G01R33/485 ,  G01R33/46

CPC classification number: G01R33/485 ,  G01R33/4625

Abstract: A method for acquiring nuclear magnetic resonance (NMR) phase-sensitive two-dimensional (2D) J-resolved spectrum by suppressing strong coupling spurious peaks, comprising: 1) placing a sample, collecting a conventional one-dimensional (1D) spectrum of the sample, and measuring a time width (pw) of a 90° pulse, wherein the conventional 1D spectrum provides J coupling information and chemical shift information of the sample; and 2) introducing a pulse sequence for suppressing strong coupling, setting parameters of a chirp sweep frequency pulse, a pure shift yielded by chirp excitation (PSYCHE) module, and a J sampling module, and collecting and saving data of a spectrum.