Biaryl derivatives
    81.
    发明授权
    Biaryl derivatives 失效
    双芳基衍生物

    公开(公告)号:US07858800B2

    公开(公告)日:2010-12-28

    申请号:US11629730

    申请日:2005-06-29

    IPC分类号: C07D401/00 A61K31/44

    摘要: The present invention relates to a compound represented by the formula (I): or a pharmaceutically acceptable salt thereof, wherein: R1 is a linear or branched alkoxy group, a cycloalkoxy group, a linear or branched lower alkyl group, etc.; R2 is halogen atom, a lower alkyl group, etc.; Q1 is carbon atom or nitrogen atom; Q2 is carbon atom which may be substituted with oxo group; the formula (III):   (II) is a single bond or a double bond; A is a group selected from the group consisting of the substitutent group α; and R5 is hydrogen atom, a lower alkyl group, cyano group, an alkoxy group or a trialkylsilyl group; having an mGluR1 inhibiting action and being useful as treatment and/or prevention of convulsion, acute pain, cerebral disturbance such as cerebral infarction or transient cerebral ischemia onset, anxiety, chemical dependency or Parkinson's disease.

    摘要翻译: 本发明涉及由式(I)表示的化合物或其药学上可接受的盐,其中:R1是直链或支链烷氧基,环烷氧基,直链或支链低级烷基等; R2是卤原子,低级烷基等; Q1是碳原子或氮原子; Q2是可以被氧代基取代的碳原子; 式(III):(II)是单键或双键; A是选自由取代基α组成的组的基团; R5为氢原子,低级烷基,氰基,烷氧基或三烷基甲硅烷基; 具有mGluR1抑制作用,并且可用作治疗和/或预防惊厥,急性疼痛,脑梗塞如脑梗死或暂时性脑缺血发作,焦虑,化学依赖或帕金森病。

    Biaryl derivatives
    82.
    发明申请
    Biaryl derivatives 失效
    双芳基衍生物

    公开(公告)号:US20070191389A1

    公开(公告)日:2007-08-16

    申请号:US11629730

    申请日:2005-06-29

    摘要: The present invention relates to a compound represented by the formula (I): or a pharmaceutically acceptable salt thereof, wherein: R1 is a linear or branched alkoxy group, a cycloalkoxy group, a linear or branched lower alkyl group, etc.; R2 is halogen atom, a lower alkyl group, etc.; Q1 is carbon atom or nitrogen atom; Q2 is carbon atom which may be substituted with oxo group; the formula (III):   (II) is a single bond or a double bond; A is a group selected from the group consisting of the substitutent group α; and R5 is hydrogen atom, a lower alkyl group, cyano group, an alkoxy group or a trialkylsilyl group; having an mGluR1 inhibiting action and being useful as treatment and/or prevention of convulsion, acute pain, cerebral disturbance such as cerebral infarction or transient cerebral ischemia onset, anxiety, chemical dependency or Parkinson's disease.

    摘要翻译: 本发明涉及由式(I)表示的化合物或其药学上可接受的盐,其中:R 1是直链或支链烷氧基,环烷氧基,直链或支链低级 烷基等; R 2是卤素原子,低级烷基等; Q 1是碳原子或氮原子; Q 2是可以被氧代基取代的碳原子; 公式(III):<?in-line-formula description =“In-line Formulas”end =“lead”?> (II)<?in-line-formula description =”In-line 公式“end =”tail“?>是单键或双键; A是选自由取代基组α组成的组的组; R 5是氢原子,低级烷基,氰基,烷氧基或三烷基甲硅烷基; 具有mGluR1抑制作用,并且可用作治疗和/或预防惊厥,急性疼痛,脑梗塞如脑梗死或暂时性脑缺血发作,焦虑,化学依赖或帕金森病。

    Developing device, image forming device equipped therewith, and developing density adjusting method
    83.
    发明授权
    Developing device, image forming device equipped therewith, and developing density adjusting method 有权
    显影装置,装配有成像装置和显影密度调节方法

    公开(公告)号:US07257336B2

    公开(公告)日:2007-08-14

    申请号:US11033682

    申请日:2005-01-13

    IPC分类号: G03G15/08

    摘要: In case of a developing density correction based on a test image (patch image) density, normally, the developing density is carried out in a short period of time by correction (γ correction) of a developing bias and a grid voltage (S11). When a correction amount of the γ correction exceeds an ordinary range, the γ correction (S11) and adjustment of toner concentration (magnetic permeability reference value) (S5) are carried out in combination. Furthermore, when the toner concentration is changed, the setting of a correction reference of the γ correction (γ correction TBL) and correction timing of the γ correction are accordingly changed (S6, S7). Therefore, in the developing density correction based on the test image density in the developing device using binary developer, it is possible to carry out the developing density correction, which is carried out in a short time, and whose correction width is wide, while maintaining the accuracy of a developing density adjustment.

    摘要翻译: 在基于测试图像(贴片图像)密度的显影浓度校正的情况下,通常,通过显影偏压和电网电压的校正(伽马校正)在短时间内进行显影密度(S11) 。 当伽马校正的校正量超过普通范围时,组合进行伽马校正(S11)和调色剂浓度(磁导率基准值)(S 5)的调整。 此外,当调色剂浓度改变时,相应地改变伽马校正(伽马校正TBL)的校正基准的设置和伽马校正的校正定时(S6,S7)。 因此,在使用二次显影剂的显影装置中基于测试图像浓度的显影浓度校正中,可以执行在短时间内执行的显影浓度校正,并且其校正宽度大,同时保持 发展密度调整的准确性。

    Image forming apparatus with automatic density compensation
    87.
    发明授权
    Image forming apparatus with automatic density compensation 有权
    具有自动浓度补偿的图像形成装置

    公开(公告)号:US06516162B2

    公开(公告)日:2003-02-04

    申请号:US09839835

    申请日:2001-04-20

    IPC分类号: G03G1500

    摘要: The object of this invention is to provide an image forming apparatus capable of preventing decrease in image density at a rear end part of an image. A change in waveform in sensor outputs which is produced when a toner patch image is read by an optical sensor used for the process control is detected. The difference (Vg−Vd) between grid voltage Vg and development bias voltage Vd is changed only between a target value of 300 V corresponding to low-output side threshold value Va and a target value of 100 V corresponding to high-output side threshold value Vb according to the sensor output deflection &Dgr;V so that the difference (Vg−Vd) decreases as the image loss level increases. The difference between the grid voltage Vg and the development bias voltage Vd is set so as to prevent the image loss in the rear end part of an image.

    摘要翻译: 本发明的目的是提供一种能够防止图像后端部的图像浓度降低的图像形成装置。 检测由用于过程控制的光学传感器读取调色剂补片图像时产生的传感器输出中的波形变化。 栅极电压Vg与显影偏压Vd之差(Vg-Vd)仅在对应于低输出侧阈值Va的目标值300V与高输出侧阈值对应的目标值100V之间变化 Vb根据传感器输出偏差DELTAV,使差值(Vg-Vd)随着图像损耗水平的增加而降低。 设定电网电压Vg与显影偏压Vd之间的差异,以防止图像后端部的图像损失。

    Polymer having sulfonic acid group and silver halide photographic photosensitive material using the polymer
    88.
    发明授权
    Polymer having sulfonic acid group and silver halide photographic photosensitive material using the polymer 有权
    使用聚合物的具有磺酸基和卤化银照相感光材料的聚合物

    公开(公告)号:US06337380B1

    公开(公告)日:2002-01-08

    申请号:US09451756

    申请日:1999-12-01

    IPC分类号: C08F12802

    CPC分类号: C08F212/14

    摘要: Provided are: a polymer comprising a repeating unit represented by formula (I): wherein K represents an alkylene group; M represents a monovalent cation group; a dispersant including the polmer; and a silver halide photographic photosensitive material containing water-insoluble photographic solid grains dispersed in use of the dispersant. The dispersant of the invention prevents the surface tension from lowering where the solid fine grains are dispersed, thereby improving dispersing property and dispersion stability. The silver halide photographic photosensitive material according to the invention has good color reproductivity and improves storability before use and latent image storability at the same time.

    摘要翻译: 提供:包含由式(I)表示的重复单元的聚合物:其中K表示亚烷基; M表示一价阳离子基; 包括polmer的分散剂; 以及含有使用分散剂分散的水不溶性照相固体颗粒的卤化银照相感光材料。 本发明的分散剂防止了固体细颗粒分散的表面张力降低,从而提高分散性和分散稳定性。 根据本发明的卤化银照相感光材料具有良好的颜色再现性,同时改善了使用前的保存性和潜像保存性。

    2-oxoimidazole derivatives
    89.
    发明授权
    2-oxoimidazole derivatives 有权
    2-氧代咪唑衍生物

    公开(公告)号:US06258825B1

    公开(公告)日:2001-07-10

    申请号:US09424114

    申请日:1999-11-19

    IPC分类号: A61K31454

    摘要: The present invention relates to a compound represented by Formula [I] wherein represents an aromatic carbo- or heterocyclic ring which may have a substituent; Cy represents a mono-, bi- or tricyclic aliphatic carbocyclic group having 3 to 20 carbon atoms, which may have a substituent; represents a mono- or bicyclic aliphatic nitrogen-containing heterocyclic group having 3 to 14 carbon atoms, which may have a substituent; R1 represents a hydrogen atom, a lower alkenyl group, a lower alkynyl group, a cyclo(lower alkyl) group, an amino group, a lower alkylamino group, a di(lower alkyl)-amino group, a hydroxyl group, a lower alkoxy group, a carboxyl group, a lower alkoxycarbonyl group, a carbamoyl group, a lower alkylcarbamoyl group or a di(lower alkyl)carbamoyl group, or a lower alkyl group which may have a substituent; and R2 represents a hydrogen atom or a lower alkyl group, a salt or ester thereof, a production process for the same, and an analgesic, a reliever against tolerance to a narcotic analgesic represented by morphine, a reliever against dependence on a narcotic analgesic represented by morphine, an analgesic enhancer, an antiobestic, a drug for ameliorating brain function, a remedy for schizophrenia, a remedy for Parkinsonism, a remedy for chorea, an antidepressant, a remedy for diabetes insipidus, a remedy for polyuria, or a remedy for hypotension, comprising an effective ingredient of the same.

    摘要翻译: 本发明涉及由式[I]表示的化合物,其表示可具有取代基的芳族碳 - 或杂环; Cy表示可具有取代基的碳原子数为3〜20的单环,二环或三环脂肪族碳环基,表示可具有取代基的碳原子数为3〜14的单环或二环脂族含氮杂环基, ; R1表示氢原子,低级烯基,低级炔基,环(低级烷基),氨基,低级烷基氨基,二(低级烷基) - 氨基,羟基,低级烷氧基 羧基,低级烷氧基羰基,氨基甲酰基,低级烷基氨基甲酰基或二(低级烷基)氨基甲酰基或可以具有取代基的低级烷基; 并且R 2表示氢原子或低级烷基,其盐或酯,其制备方法,以及止痛剂,对由吗啡代表的麻醉止痛剂的耐受性的缓解剂,对依赖麻醉止痛剂的缓解剂 吗啡,镇痛增强剂,抗胆碱药,用于改善脑功能的药物,精神分裂症的治疗方法,帕金森综合征的补救措施,舞蹈病的补救措施,抗抑郁药,尿崩症的治疗方法,多尿症的治疗方法或治疗方法 低血压,包括其有效成分。