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公开(公告)号：US20190219794A1
公开(公告)日：2019-07-18
申请号：US16360257
申请日：2019-03-21
Applicant: Meso Scale Technologies, LLC.
Inventor： Ian Chamberlin , Charlles M. Clinton , Eli N. Glezer , Bandele Jeffrey-Coker , Manish Kochar , Sandor Kovacs , D.T. Le , Aaron Leimkuehler , George Sigal , Leo Tabakin , Jon Willoughby
CPC classification number: G02B7/36 , G01N21/253 , G01N21/6452 , G01N35/028
Abstract: Apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation are described. They are particularly well suited for conducting automated analysis in a multi-well plate assay format.
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公开(公告)号：US10189023B2
公开(公告)日：2019-01-29
申请号：US14203638
申请日：2014-03-11
Applicant: Meso Scale Technologies, LLC.
Inventor： Eli N. Glezer , Sudeep Kumar , Pankaj Oberoi , George Sigal , Michael Tsionsky
IPC: C07H21/04 , B01L3/00 , C12Q1/6876 , G01N33/543 , C12Q1/6804 , G01N33/68 , C12Q1/6816
Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.
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公开(公告)号：US20190011441A1
公开(公告)日：2019-01-10
申请号：US16136498
申请日：2018-09-20
Applicant: Meso Scale Technologies, LLC.
Inventor： Eli N. Glezer , John Kenten
IPC: G01N33/543 , C12Q1/682 , C12Q1/6848 , C12Q1/6837 , C12Q1/6844
Abstract: The present invention is directed to methods for reducing cross-reactivity between species employed in multiplexed immunoassays.
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公开(公告)号：US20180348217A1
公开(公告)日：2018-12-06
申请号：US16054332
申请日：2018-08-03
Applicant: Meso Scale Technologies, LLC
Inventor： Eli N. Glezer , Mikayla Higgins , John Kenten , George Sigal
IPC: G01N33/564
CPC classification number: G01N33/564 , G01N2800/104 , G01N2800/52
Abstract: The present invention relates to methods of diagnosing lupus in a patient, as well as methods of monitoring the progression of lupus and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
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公开(公告)号：US20180156824A1
公开(公告)日：2018-06-07
申请号：US15847111
申请日：2017-12-19
Applicant: Meso Scale Technologies, LLC.
Inventor： Eli N. Glezer , John Kenten , Sudeep Kumar , Galina Nikolenko
IPC: G01N33/68
CPC classification number: G01N33/6893 , G01N2333/4706 , G01N2333/4727 , G01N2333/70578 , G01N2333/70596 , G01N2333/8146 , G01N2800/347 , G01N2800/52
Abstract: The present invention relates to methods of diagnosing a kidney disorder in a patient, as well as methods of monitoring the progression of a kidney disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
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Patent Agency Ranking
86.发明申请公开(公告)号：US20180017578A1
公开(公告)日：2018-01-18
申请号：US15716743
申请日：2017-09-27
Applicant: Meso Scale Technologies, LLC.
Inventor： Jeff D. Debad , Eli N. Glezer , Sudeep M. Kumar
IPC: G01N33/68
Abstract: Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient's treatment by administering tests of the present invention. Also described are methods for evaluating the effectiveness of a drug or a drug candidate by administering tests of the present invention to samples from patients, animal models, and cell cultures treated with a drug or a drug candidate. Also disclosed are methods for determining the usefulness of analytes, e.g. cytokines, for acting as diagnostic and monitoring markers for inflammatory bowel disease in the various methods of the invention.
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公开(公告)号：US20170205418A1
公开(公告)日：2017-07-20
申请号：US15386346
申请日：2016-12-21
Applicant: Meso Scale Technologies, LLC.
Inventor： Simone Barbero , Eli N. Glezer , Anu Mathew , Mingyue Wang
IPC: G01N33/574 , A61K31/404 , C12Q1/48 , A61K31/44
CPC classification number: G01N33/57438 , A61K31/404 , A61K31/44 , C12Q1/485 , G01N33/5743 , G01N2800/60
Abstract: The present invention relates to methods of diagnosing a kidney disorder in a patient, as well as methods of monitoring the progression of a kidney disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
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公开(公告)号：US20150038365A1
公开(公告)日：2015-02-05
申请号：US14447691
申请日：2014-07-31
Applicant: Meso Scale Technologies, LLC
Inventor： Anahit Aghvanyan , Eli N. Glezer , John Kenten , Sudeep Kumar , Galina Nikolenko , Martin Stengelin , Srikant Vaithilingam
IPC: G01N33/574 , G01N33/50
CPC classification number: G01N33/57423 , G01N2800/52
Abstract: The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
Abstract translation: 本发明涉及诊断患者肺癌的方法，以及监测肺癌进展的方法和/或监测治疗剂或治疗方案的治疗方案的方法。 本发明还涉及结合本文所述的诊断方法使用的测定方法。
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公开(公告)号：US20150025004A1
公开(公告)日：2015-01-22
申请号：US14190237
申请日：2014-02-26
Applicant: Meso Scale Technologies, LLC
Inventor： Eli N. Glezer , John Kenten , Sudeep Kumar , Galina Nikolenko
IPC: G01N33/68
CPC classification number: G01N33/6893 , G01N2333/4706 , G01N2333/4727 , G01N2333/70578 , G01N2333/70596 , G01N2333/8146 , G01N2800/347 , G01N2800/52
Abstract: The present invention relates to methods of diagnosing a kidney disorder in a patient, as well as methods of monitoring the progression of a kidney disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
Abstract translation: 本发明涉及诊断患者肾脏疾病的方法，以及监测肾脏疾病进展的方法和/或监测治疗剂或治疗方案的治疗方案的方法。 本发明还涉及结合本文所述的诊断方法使用的测定方法。
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公开(公告)号：US20140378341A1
公开(公告)日：2014-12-25
申请号：US14478197
申请日：2014-09-05
Applicant: Meso Scale Technologies, LLC
Inventor： Eli N. Glezer , Jonathan K. Leland , Mark A. Billadeau , Joseph M. Leginus , Bandele Jeffrey-Coker , Jeff D. Debad , Koustubh A. Phalnikar , Sriram Jambunathan
IPC: G01N33/543 , G01N21/76
CPC classification number: G01N21/76 , B01J19/0046 , B01J2219/00653 , B01J2219/00725 , B01J2219/0074 , B01L3/5027 , B01L3/502715 , B01L3/5029 , B01L9/527 , B01L2200/0684 , B01L2200/10 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/049 , B01L2400/0688 , B33Y80/00 , C12Q1/001 , C40B40/10 , G01N27/30 , G01N33/5438 , G01N2458/30 , Y10T436/25 , Y10T436/25375 , Y10T436/255
Abstract: Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.
Abstract translation: 测定模块，优选测定盒，被描述为可用于控制模块操作的方面的读取器设备。 模块优选地包括具有集成电极的检测室，其可用于执行电极诱导的发光测量。 描述了以这种控制方式将测定试剂固定在这些电极和其它表面上的方法。 还描述了具有检测室，优选地具有集成电极的测定模块和盒，以及可以包括样品室，废物室，导管，通风口，气泡阱，试剂室，干试剂丸区等的其它流体组分。 在某些优选实施例中，这些模块适于接收和分析在施用器棒上收集的样品。
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