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133 条记录 (耗时 0.139 秒)

    Cancer-linked gene as target for chemotherapy
    86.
    发明申请
    Cancer-linked gene as target for chemotherapy 审中-公开
    癌症相关基因作为化疗靶标

    公开(公告)号：US20060110731A1

    公开(公告)日：2006-05-25

    申请号：US10514535

    申请日：2003-05-15

    申请人： Reinhard Ebner

    发明人： Reinhard Ebner

    IPC分类号： G01N33/574 ,  C12Q1/68 ,  A61K39/395 ,  C07K16/46

    CPC分类号： G01N33/57419 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/82 ,  G01N33/57446 ,  G01N33/6893 ,  G01N2500/00

    摘要： Cancer-linked gene sequences, and derived amino acid sequences, are disclosed along with processes for assaying potential antitumor agents based on their modulation of the expression of these cancer-linked genes. Also disclosed are antibodies that react with the disclosed polypeptides and methods of using the antibodies to treat cancerous conditions, such as by using the antibody to target cancerous cells in vivo for purposes of delivering therapeutic agents thereto. Also described are methods of diagnosing using the gene sequences.

    摘要翻译： 与癌基因序列和衍生的氨基酸序列一起，以及基于它们对这些癌症相关基因表达的调节来测定潜在的抗肿瘤剂的方法进行了公开。 还公开了与所公开的多肽反应的抗体以及使用抗体治疗癌症的方法，例如通过使用该抗体靶向靶向癌细胞的体内用于递送治疗剂的目的。 还描述了使用基因序列进行诊断的方法。

    Human growth factors
    87.
    发明授权
    Human growth factors 失效
    人类生长因子

    公开(公告)号：US06818412B2

    公开(公告)日：2004-11-16

    申请号：US10078337

    申请日：2002-02-21

    申请人： Guo-Liang Yu ,  Patrick J. Dillon ,  Reinhard Ebner ,  Gregory A. Endress

    发明人： Guo-Liang Yu ,  Patrick J. Dillon ,  Reinhard Ebner ,  Gregory A. Endress

    IPC分类号： G01N33567

    CPC分类号： C07K14/475 ,  A61K38/00 ,  C07K2317/92

    摘要： The present invention relates to huXAG-1, huXAG-2 and huXAG-3 proteins which are novel human growth factors. In particular, isolated nucleic acid molecules are provided encoding the huXAG-1, huXAG-2 and huXAG-3 proteins. huXAG-1, huXAG-2 and huXAG-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of huXAG-1, huXAG-2 or huXAG-3 activity. Also provided are diagnostic and therapeutic uses of huXAG-1. huXAG-2 and huXAG-3.

    摘要翻译： 本发明涉及作为新型人生长因子的huXAG-1，huXAG-2和huXAG-3蛋白。 特别地，提供编码huXAG-1，huXAG-2和huXAG-3蛋白的分离的核酸分子。 还提供huXAG-1，huXAG-2和huXAG-3多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定huXAG-1，huXAG-2或huXAG-3活性的激动剂和拮抗剂的筛选方法。 还提供了huXAG-1的诊断和治疗用途。 huXAG-2和huXAG-3。