公开(公告)号：US06468293B2

公开(公告)日：2002-10-22

申请号：US09850287

申请日：2001-05-07

Applicant: Peter M. Bonutti ,  Matthew J. Cremens ,  Ping Liu

Inventor： Peter M. Bonutti ,  Matthew J. Cremens ,  Ping Liu

IPC: A61B1704

CPC classification number: A61B17/0487 ,  A61B2017/0445 ,  A61B2017/045 ,  A61B2017/0454 ,  A61B2017/0456 ,  A61B2017/0458 ,  A61B2017/0464 ,  A61B2017/0488 ,  A61B2017/0496

Abstract: Improved method is provided to secure a suture relative to body tissue. A suture retainer is moved along first and second sections of a suture toward the body tissue. When a predetermined minimum force is being transmitted between the suture retainer and the body tissue, the first and second sections of the suture are gripped with the suture retainer by plastically deforming material of the suture retainer. The material of the suture retainer cold flows under the influence of force applied against the surface areas on the suture retainer. One or more bends are formed in each of the sections of the suture to increase the holding action between the suture retainer and the sections of the suture. The bends may be formed by wrapping a turn of the suture around a portion of the suture retainer. During movement of the suture retainer toward the body tissue, the bends are moved along the first and second sections of the suture.

Abstract translation: 提供改进的方法以相对于身体组织固定缝线。 缝合线保持器沿着缝合线的第一和第二部分朝向身体组织移动。 当在缝线保持器和身体组织之间传递预定的最小力时，缝合线的第一和第二部分通过使缝线保持器的材料塑性变形而用缝合线保持器夹紧。 缝合保持器的材料在施加在缝合线保持器上的表面区域上的力的影响下流动。 在缝合线的每个部分中形成一个或多个弯曲部，以增加缝线保持器和缝合线部分之间的保持作用。 弯曲可以通过围绕缝合线保持器的一部分缠绕缝合线而形成。 在缝线保持器朝向身体组织移动期间，弯曲部沿缝合线的第一和第二部分移动。

公开(公告)号：US5354692A

公开(公告)日：1994-10-11

申请号：US941667

申请日：1992-09-08

Applicant: Hsin M. Yang ,  Michael Newton ,  Ping Liu

Inventor： Hsin M. Yang ,  Michael Newton ,  Ping Liu

IPC: B01J20/281 ,  G01N30/88 ,  G01N33/53 ,  G01N33/543 ,  G01N33/558 ,  G01N37/00

CPC classification number: G01N33/558 ,  Y10S435/805 ,  Y10S435/97 ,  Y10S436/805 ,  Y10S436/81

Abstract: An immunochromatographic assay device for the detection of an analyte in a liquid sample, the device including a housing that contains an opening for the application of the liquid sample and multiple liquid permeable materials located in the housing that are adapted to receive, treat and facilitate the movement of the sample through the housing; preferably, a first liquid permeable material is adapted to receive the liquid sample; a second liquid permeable material is positioned under the first liquid permeable material; a third liquid permeable material is positioned above the second liquid material; means are provided to prevent liquid communication between the first and third liquid permeable materials; a wicking material, in fluid contact with the third liquid permeable material receives the sample; and reagents are positioned in the housing that display the results of the immunoassay.

Abstract translation: 一种用于检测液体样品中的分析物的免疫色谱测定装置，该装置包括壳体，该壳体包含用于施加液体样品的开口和位于壳体中的多个液体可渗透材料，其适于接收，处理和促进 样品通过壳体的运动; 优选地，第一液体可渗透材料适于接收液体样品; 第二液体可渗透材料位于第一液体可渗透材料下方; 第三液体可渗透材料位于第二液体材料上方; 提供了用于防止第一和第三液体可渗透材料之间的液体连通的装置; 与第三液体可渗透材料流体接触的芯吸材料接收样品; 并且试剂位于显示免疫测定结果的壳体中。

公开(公告)号：US11944384B2

公开(公告)日：2024-04-02

申请号：US16969817

申请日：2019-01-29

Applicant: Xuemin Xu ,  Aili Zhang ,  Jianqi Sun ,  Ping Liu ,  Jingfeng Bai

Inventor： Xuemin Xu ,  Aili Zhang ,  Jianqi Sun ,  Ping Liu ,  Wentao Li

IPC: A61B34/10 ,  A61B18/00 ,  A61B18/02 ,  A61B18/14

CPC classification number: A61B34/10 ,  A61B18/02 ,  A61B2018/00041 ,  A61B2018/00404 ,  A61B2018/00577 ,  A61B2018/00791 ,  A61B2018/00863 ,  A61B2018/00988 ,  A61B2018/0293 ,  A61B18/1477 ,  A61B2034/104 ,  A61B2034/105 ,  A61B2034/107

Abstract: The present application relates to computer-based preoperative planning technology, and discloses a preoperative planning method for multimodal ablation treatment and apparatus thereof, which can automatically provide objective, scientific, and quantitative multimodal ablation planning information. In this method, acquiring parameters of an volume to be ablated; calculating property changes of the tissue caused by performing freezing on the volume according to the parameters of the volume to be ablated, and acquiring a first planning data required for the property changes of the tissue to satisfy a first predetermined condition; further calculating property changes of the tissue caused by performing heating on the volume to acquire a second planning data required for the property changes of the tissue to satisfy a second predetermined condition based on the properties satisfying the first predetermined condition; outputting the first planning data and the second planning data.

公开(公告)号：US20170158698A1

公开(公告)日：2017-06-08

申请号：US15128782

申请日：2015-03-23

Applicant: Helen MITCHELL ,  Mark E. FRALEY ,  Andrew J. COOKE ,  Craig A. STUMP ,  Xu-Fang ZHANG ,  Casey C. MCCOMAS ,  Kathy SCHIRRIPA ,  Melody MCWHERTER ,  Ping LIU ,  Dann PARKER ,  Chun Sing LI ,  Qinghua MAO ,  Merck Sharp & Dohme Corp.

Inventor： Helen Mitchell ,  Mark E. Fraley ,  Andrew J. Cooke ,  Craig A. Stump ,  Xu-Fang Zhang ,  Casey C. McComas ,  Kathy Schirripa ,  Melody McWherter ,  Ping Liu ,  Dann Parker ,  Chun Sing Li ,  Qinghua Mao

IPC: C07D487/04 ,  C07D231/40 ,  C07D417/12 ,  C07D401/04 ,  C07D417/14 ,  C07D471/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D277/46 ,  C07D403/14

CPC classification number: C07D487/04 ,  C07D231/40 ,  C07D277/46 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

Abstract: The present invention is directed to substituted five membered heteroaryl benzamide compounds of formula (I) (Formula (I)) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.

公开(公告)号：US20170114056A1

公开(公告)日：2017-04-27

申请号：US15129206

申请日：2015-03-23

Applicant: Helen MITCHELL ,  Mark E. FRALEY ,  Andrew J. COOKE ,  Craig A. STUMP ,  Yi Heng CHEN ,  Douglas C. BESHORE ,  Xu-Fank ZHANG ,  Casey C. MCCOMAS ,  Kathy SCHIRRIPA ,  Melody MCWHERTER ,  Swati P. MERCER ,  Keith P. MOORE ,  Ping LIU ,  Harold B. WOOD ,  Chun Sing LI ,  Qinghua MAO ,  Merck Sharp & Dohme Corp.

Inventor： Helen Mitchell ,  Mark E. Fraley ,  Andrew J. Cooke ,  Craig A. Stump ,  Yi- Heng Chen ,  Xu-Fang Zhang ,  Casey C. McComas ,  Kathy Schirripa ,  Melody McWherter ,  Swati P. Mercer ,  Keith P. Moore ,  Ping Liu ,  Harold B. Wood ,  Chun Sing Li ,  Qinghua Mao ,  Douglas C. Beshore

IPC: C07D471/04 ,  C07D513/04

CPC classification number: C07D403/12 ,  C07D401/12 ,  C07D403/14 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04

Abstract: The present invention is directed to a bicyclic heteroaryl benzamide compounds of formula (I) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.

公开(公告)号：US09417290B1

公开(公告)日：2016-08-16

申请号：US13646663

申请日：2012-10-06

Applicant: Shuoqin Wang ,  Ping Liu ,  John Wang

Inventor： Shuoqin Wang ,  Ping Liu ,  John Wang

IPC: G01R31/36 ,  G01R31/40 ,  G06F15/00 ,  G01R19/00

CPC classification number: G01R31/3651 ,  G01R31/362 ,  G01R31/3624 ,  G01R31/3679 ,  G06F15/00 ,  H01M8/02 ,  H01M10/42

Abstract: The present invention provides impulse-response-based algorithms for high-speed characterization of electrochemical systems (e.g., batteries) with good accuracy. In some variations, a method for dynamic characterization of an electrochemical system comprises selecting an electrochemical system to be characterized; sensing the measured current to or from said electrochemical system; sensing the measured voltage across said electrochemical system; sensing or calculating the time derivatives of the measured current and voltage; and calculating an impulse response using a recursive or matrix-based algorithm (as disclosed herein), wherein said impulse response characterizes said electrochemical system within a selected sampling window. The algorithms are robust, incorporating noise-reduction techniques, and are suitable for real applications under various operating conditions. These algorithms, and the apparatus and systems to implement them, are able to accept various exciting signals to provide dynamic characterization of various states of the electrochemical system.

Abstract translation: 本发明提供了用于以高精度高速表征电化学系统（例如电池）的基于脉冲响应的算法。 在一些变型中，用于电化学系统的动态表征的方法包括选择要表征的电化学系统; 检测来自或来自所述电化学系统的测量电流; 感测所述电化学系统上的测量电压; 感测或计算测得的电流和电压的时间导数; 以及使用递归或基于矩阵的算法（如本文所公开）来计算脉冲响应，其中所述脉冲响应表征所选择的采样窗口内的所述电化学系统。 这些算法是稳健的，结合了降噪技术，适用于各种操作条件下的实际应用。 这些算法以及实现它们的装置和系统能够接受各种激励信号以提供电化学系统的各种状态的动态表征。

公开(公告)号：US20160166873A1

公开(公告)日：2016-06-16

申请号：US14569424

申请日：2014-12-12

Applicant: Ping Liu

Inventor： Ping Liu

IPC: A63B21/072 ,  A63B21/075

CPC classification number: A63B21/0726 ,  A63B21/075 ,  A63B71/0036

Abstract: A handle has opposed ends and a central extent. A grip rotationally receives the central extent of the handle. An adjustment wheel is secured to each end of the handle. A side cover is fixedly secured to each end of the grip. A dowel disk is on the handle adjacent to one side cover with fingers and spaces. A plurality of cam bits are supported on the handle. A safety lock is within the side cover adjacent to the dowel disk. The safety lock has a first end extent and a second end extent with a radial recess and a central extent with an axial projection. A coil spring within the radial recess urges the safety lock radially outwardly. A safety indicator may be seen on one side cover that changes from red to green as the weight selection wheel is turned, indication proper weight selection when green and a potential unsafe condition when red.

Abstract translation: 手柄具有相反的端部和中心范围。 手柄旋转地接收手柄的中心范围。 调节轮固定在手柄的每一端。 侧盖固定地固定在把手的每一端。 一个榫钉盘在与手指和空间的一个侧盖相邻的手柄上。 多个凸轮位被支撑在手柄上。 安全锁在靠近榫钉盘的侧盖内。 安全锁具有第一端部范围和具有径向凹部的第二端部延伸部和具有轴向突出部的中心部分。 径向凹槽内的螺旋弹簧径向向外推动安全锁。 当重量选择轮转动时，一个侧盖上可能会看到一个安全指示器，从红色变为绿色，当绿色显示正确的重量选择，当红色显示可能的不安全状态时。

公开(公告)号：US09257719B1

公开(公告)日：2016-02-09

申请号：US12502234

申请日：2009-07-14

Applicant: Ping Liu ,  Elena Sherman ,  John Wang

Inventor： Ping Liu ,  Elena Sherman ,  John Wang

IPC: H01M10/0567 ,  H01M4/583 ,  H01M4/131 ,  H01M4/133 ,  H01M4/485 ,  H01M10/0525

CPC classification number: H01M10/0567 ,  H01M4/131 ,  H01M4/133 ,  H01M4/382 ,  H01M4/485 ,  H01M4/5825 ,  H01M4/583 ,  H01M4/587 ,  H01M10/0525 ,  Y02E60/122

Abstract: This invention employs a diamine electrolyte additive that enhances performance of lithium-ion batteries both at high and low temperatures, thereby minimizing the conventional performance gap across a wide temperature range, such as −30° C. to 60° C. At low temperatures, diamine additives can enhances cycling kinetics. At high temperatures, diamine additives can minimize capacity fading. In some variations, a lithium-ion battery electrolyte composition comprises a non-aqueous solvent, a lithium salt soluble in the non-aqueous solvent, and a diamine additive having the formula H2N—R—NH2, wherein R is an organic group such as (—CH2—)n, n=2-12.

Abstract translation: 本发明采用在高温和低温下提高锂离子电池的性能的二胺电解质添加剂，从而最小化在宽温度范围（例如-30℃至60℃）下的常规性能间隙。在低温下， 二胺添加剂可增强循环动力学。 在高温下，二胺添加剂可以使容量衰减最小化。 在一些变型中，锂离子电池电解质组合物包含非水溶剂，可溶于非水溶剂的锂盐和具有式H2N-R-NH2的二胺添加剂，其中R是有机基团，例如 （-CH 2 - ）n，n = 2-12。

公开(公告)号：US09252455B1

公开(公告)日：2016-02-02

申请号：US13208341

申请日：2011-08-12

Applicant: Ping Liu ,  Jocelyn Hicks-Garner ,  Adam F. Gross ,  Jun Liu

Inventor： Ping Liu ,  Jocelyn Hicks-Garner ,  Adam F. Gross ,  Jun Liu

IPC: H01M2/16 ,  H01M10/0562

CPC classification number: H01M10/0562 ,  H01M2/1646 ,  H01M2/1686 ,  H01M4/366 ,  H01M4/382 ,  H01M10/052 ,  H01M10/0525 ,  H01M10/0585 ,  H01M12/08 ,  H01M2300/0071 ,  Y02E60/128 ,  Y02T10/7011

Abstract: This invention provides lithium-based batteries that include one or more inorganic barrier layers disposed between the anode and the cathode. The inorganic barrier layer is a lithium-ion conductor and is non-permeable to lithium-containing compounds, such as lithium polysulfides or lithium dendrites. The inorganic barrier layer may be in direct contact with the anode or cathode, or electrically isolated from the anode and cathode. The principles disclosed herein solve the problem of maintaining electrical isolation of the anode and cathode, while providing efficient lithium-ion conduction without crossover of other lithium species that would otherwise limit the power performance of the battery.

公开(公告)号：US09093707B2

公开(公告)日：2015-07-28

申请号：US11816730

申请日：2007-06-11

Applicant: Se-Hee Lee ,  C. Edwin Tracy ,  John Roland Pitts ,  Ping Liu

Inventor： Se-Hee Lee ,  C. Edwin Tracy ,  John Roland Pitts ,  Ping Liu

IPC: H01M10/0562 ,  H01M10/0585 ,  H01M6/40 ,  H01M10/04 ,  H01M6/18 ,  H01M6/20 ,  H01M6/24 ,  H01M10/052 ,  H01M4/66

CPC classification number: H01M6/40 ,  H01M4/661 ,  H01M6/185 ,  H01M6/187 ,  H01M6/20 ,  H01M6/24 ,  H01M10/0436 ,  H01M10/052 ,  H01M10/0562 ,  H01M10/0585 ,  H01M2300/0068 ,  H01M2300/0094 ,  Y02E60/122

Abstract: A lithium metal thin-film battery composite structure is provided that includes a combination of a thin, stable, solid electrolyte layer [18] such as Lipon, designed in use to be in contact with a lithium metal anode layer; and a rapid-deposit solid electrolyte layer [16] such as LiAlF4 in contact with the thin, stable, solid electrolyte layer [18]. Batteries made up of or containing these structures are more efficient to produce than other lithium metal batteries that use only a single solid electrolyte. They are also more resistant to stress and strain than batteries made using layers of only the stable, solid electrolyte materials. Furthermore, lithium anode batteries as disclosed herein are useful as rechargeable batteries.

Abstract translation: 提供了一种锂金属薄膜电池复合结构，其包括薄的，稳定的固体电解质层[18]如Lipon的组合，其设计用于与锂金属阳极层接触; 以及与薄的，稳定的固体电解质层接触的诸如LiAlF 4的快速沉积固体电解质层[16]。 与其他仅使用单一固体电解质的锂金属电池相比，由这些结构构成或包含这些结构的电池比生产更有效。 它们比仅使用稳定的固体电解质材料的层制成的电池更耐压力和应变。 此外，如本文所公开的锂阳极电池可用作可再充电电池。