公开(公告)号：US08591745B2

公开(公告)日：2013-11-26

申请号：US12589499

申请日：2009-10-23

Applicant: Filipe Merino ,  Luis Penacho ,  Miquel Iribarren ,  Antonio Vicente ,  Angel Cabria ,  Juan Carlos Pineiro

Inventor： Filipe Merino ,  Luis Penacho ,  Miquel Iribarren ,  Antonio Vicente ,  Angel Cabria ,  Juan Carlos Pineiro

IPC: B01D35/00

CPC classification number: B01D29/668 ,  B01D29/0077 ,  B01D29/6438 ,  B01D29/66 ,  B01D29/908 ,  B01D61/18 ,  B01D65/02 ,  B01D2201/086 ,  B01D2321/02 ,  B01D2321/04 ,  C02F1/444 ,  C02F2209/03 ,  C02F2209/40 ,  C02F2209/44 ,  C02F2301/024 ,  C02F2301/026

Abstract: The present invention relates to a system and a process of running the system that allows for the long term filtration of product without loss of filtration capability due to clogging or fouling. The system is a normal flow filtration system having one or more filter cartridges attached to an outlet of a housing in the system. The filter cartridge(s) are contained within a bowl and depend preferably vertically from the outlet. Liquid enters the bowl of the housing and contacts the outer surfaces of the one or more cartridges. Impurities are trapped on or in the surface of the filter and the filtered liquid flows through the filter and through the outlet. One or more parameters such as flow rate, transmembrane pressure drop and/or time are measured and when the desired parameter(s) are met, the filtration ceases. A backflushing occurs back through the filter cartridges so as to remove the trapped impurities on or in the filter surface. This backwashed material is directed to an outlet of the bowl that is connected to a drain. Additionally a port formed in the side of the housing adjacent an outer surface of the cartridge(s) can be used to provide a lateral washing of the filter surfaces. The system is then recirculated in a downstream manner to reestablish equilibrium and filtration is the restarted.

Abstract translation: 本发明涉及运行该系统的系统和方法，其允许产品的长期过滤，而不会由于堵塞或结垢而丧失过滤能力。 该系统是具有连接到系统中的壳体的出口的一个或多个过滤器滤芯的正常流量过滤系统。 过滤器滤芯被容纳在碗内并且优选地垂直于出口。 液体进入壳体的碗中并接触一个或多个盒的外表面。 杂质被捕获在过滤器的表面上或其中，并且过滤的液体流过过滤器并通过出口。 测量一个或多个参数，例如流速，跨膜压降和/或时间，并且当满足期望的参数时，过滤停止。 反冲洗通过过滤器滤芯，以便去除过滤器表面上或过滤表面上的被捕获的杂质。 该反冲洗的材料被引导到连接到排水管的碗的出口。 另外，形成在壳体的邻近盒的外表面的一侧的端口可以用于提供过滤器表面的侧向洗涤。 然后将该系统以下游方式再循环以重新建立平衡，并且重新开始过滤。

公开(公告)号：US08591742B2

公开(公告)日：2013-11-26

申请号：US12818287

申请日：2010-06-18

Applicant: Jeremy Perreault ,  Aaron Noyes ,  Mark Carroll

Inventor： Jeremy Perreault ,  Aaron Noyes ,  Mark Carroll

IPC: B01D15/08

CPC classification number: G01N30/52 ,  G01N30/6021 ,  G01N2030/522

Abstract: The present invention provides an automated system and method for maintaining compaction, and therefore increased efficiency, of a media bed within a chromatography column. In the preferred embodiment, an adjustment assembly is slidingly engaged inside one end of the column such that it can be moved along the column's major axis. When idle, the force exerted on this end is equal to the compression on the media. When the column is actively processing chromatographic fluid, this exerted force can be expressed as the sum of the compression on the media, and the force of the fluid being processed. This total force and the fluid pressure are monitored using a load cell and a pressure sensor respectively. The compression force operating on the media bed is then computed based on these measurements and compared to the optimal value. The position of the adjustment assembly within the column is then modified in response to changes in the measured compression force.

Abstract translation: 本发明提供了一种用于保持色谱柱内的介质床的压实并因此提高效率的自动化系统和方法。 在优选实施例中，调节组件滑动地接合在柱的一端内，使得其可以沿柱的长轴移动。 当空闲时，施加在该端的力等于介质上的压缩。 当柱正在积极处理色谱流体时，该施加的力可以表示为介质上的压缩和被处理的流体的力之和。 分别使用称重传感器和压力传感器监测该总力和流体压力。 然后基于这些测量计算在介质床上操作的压缩力，并与最佳值进行比较。 响应于测量的压缩力的变化，调节组件在柱内的位置随后被修改。

公开(公告)号：US20130306539A1

公开(公告)日：2013-11-21

申请号：US13950646

申请日：2013-07-25

Applicant: EMD Millipore Corporation

Inventor： Sebastien Cirou ,  Jean-Louis Weissenbach ,  Rene Reinbigler ,  Jean-Luc Beulay ,  Frans Mels ,  Cecile Delbos

IPC: B01D25/12

CPC classification number: B23P19/04 ,  B01D25/127 ,  B01D25/14 ,  B01D25/164 ,  B01D25/19 ,  B01D61/18 ,  B01D61/20 ,  B01D63/082 ,  B01D2313/02 ,  B01D2313/06 ,  B01D2313/105 ,  B01D2313/125 ,  Y10T29/49826

Abstract: The invention concerns a filtration device comprising a manifold (3) providing fluid connection and mechanical connection comprising a clamping plate (4) movably mounted relative to the manifold (3) and adapted to compress at least one cassette (2) against the manifold (3), means for driving and guiding the clamping plate comprising a rod (6) extending between the manifold (3) and the plate (4), an actuator provided with a body and a member moveable relative to the body, which member is adapted to move through a predetermined travel between an extended position and a retracted position, the body being carried by the manifold (3), and the member carrying the rod (6) and driving the plate (4) via the rod (6) to a clamped position in which the member is in an intermediate retracted position in which it has moved through a shorter travel than the predetermined travel relative to its extended position.

Abstract translation: 本发明涉及一种过滤装置，其包括提供流体连接的歧管（3）和包括相对于歧管（3）可移动地安装并适于将至少一个盒（2）压靠在歧管（3）上的夹板 ），用于驱动和引导夹持板的装置，其包括在歧管（3）和板（4）之间延伸的杆（6），致动器，其设置有主体和相对于主体可移动的构件，该构件适于 在延伸位置和缩回位置之间移动预定行程，主体由歧管（3）承载，并且承载杆（6）并且通过杆（6）驱动板（4）的构件被夹紧 其中构件处于其相对于其延伸位置移动经过比预定行程更短的行程的中间缩回位置的位置。

公开(公告)号：US08579871B2

公开(公告)日：2013-11-12

申请号：US11584301

申请日：2006-10-20

Applicant: Stephen Proulx ,  Joseph Almasian ,  Naren Renganath ,  Stephen Tingley ,  Martin Morrissey

Inventor： Stephen Proulx ,  Joseph Almasian ,  Naren Renganath ,  Stephen Tingley ,  Martin Morrissey

IPC: A61M5/00

CPC classification number: F16K5/00 ,  A61M39/10 ,  A61M39/16 ,  A61M39/18 ,  A61M39/22 ,  A61M2039/1027 ,  A61M2039/222 ,  F16K3/265 ,  F16K13/04 ,  F16K15/18 ,  F16L37/107

Abstract: The present invention relates to a process for the sterile transfer of fluids, be they liquids or gases. It uses a presterilized device comprised of a body having a bore formed through at least a portion of its interior. Contained within the bore is a movable plunger. The body has a first and a second end. The first end contains a face designed to be attached to the upstream component. The second end is connected to a downstream component such as a filter, pipeline, sample bag and the like. The plunger has corresponding first and second ends. The first end of the plunger when it the closed position is in alignment with the face of the body which combined form a steamable surface and a sterile barrier against the environment to the rest of the interior of the body, the plunger and downstream components. The device is attached to an upstream component and the face and the first end of the plunger are steam sterilized in place.

Abstract translation: 本发明涉及一种无菌转移流体（无论是液体还是气体）的方法。 它使用由具有通过其内部的至少一部分形成的孔的主体构成的预灭菌装置。 孔内包含一个可移动的柱塞。 身体有第一和第二端。 第一端包含设计成连接到上游部件的面。 第二端连接到诸如过滤器，管道，样品袋等的下游部件。 柱塞具有相应的第一和第二端。 柱塞在其关闭位置时的第一端与主体的表面对齐，该表面组合形成一个可蒸汽表面，并且一个无菌隔离物抵抗环境的内部其余部分，柱塞和下游部件。 该装置连接到上游部件，柱塞的表面和第一端被蒸汽灭菌就位。

公开(公告)号：US08562875B2

公开(公告)日：2013-10-22

申请号：US13426643

申请日：2012-03-22

Applicant: David P. Yavorsky

Inventor： David P. Yavorsky

IPC: B29C67/20

CPC classification number: B01D39/2079 ,  B01D2239/0407 ,  B01D2239/08 ,  B01J20/10 ,  B01J20/103 ,  B01J20/14 ,  B01J20/165 ,  B01J20/18 ,  B01J20/20 ,  B01J20/28026 ,  B01J20/2803

Abstract: Adsorbent filter media particularly suited for removal of biological contaminants in process liquids. A porous fixed bed of adsorbent material is formed, using only a granular adsorbent and a water-insoluble thermoplastic binder. The resulting composite filter allows for a higher amount of adsorbent with smaller adsorbent particles than conventional depth filters. Elimination of cellulose fiber, as well as the elimination of the thermoset binder, results in reduced contamination of the process liquid.

Abstract translation: 吸附剂过滤介质特别适用于去除工艺液体中的生物污染物。 仅使用粒状吸附剂和水不溶性热塑性粘合剂形成吸附剂材料的多孔固定床。 所得到的复合过滤器允许比常规深度过滤器更大量的具有较小吸附剂颗粒的吸附剂。 消除纤维素纤维以及消除热固性粘合剂导致工艺液体的污染减少。

公开(公告)号：US08557113B2

公开(公告)日：2013-10-15

申请号：US12592901

申请日：2009-12-04

Applicant: Jean Luc Beulay ,  Virginie Buisson ,  Sebastien Cirou ,  Cecile Delbos ,  Marc Hlavacek ,  Frans Mels ,  Rene Reinbigler ,  Jean Louis Weissenbach

Inventor： Jean Luc Beulay ,  Virginie Buisson ,  Sebastien Cirou ,  Cecile Delbos ,  Marc Hlavacek ,  Frans Mels ,  Rene Reinbigler ,  Jean Louis Weissenbach

IPC: B01D17/12 ,  B01D35/02 ,  B01D36/04

CPC classification number: C12M47/02 ,  B01L9/54 ,  B01L2200/02 ,  B01L2200/08 ,  B01L2300/0681 ,  B01L2400/0481 ,  Y10T137/4673 ,  Y10T137/86131 ,  Y10T137/86187

Abstract: The cart comprises a lateral face by which it is adapted to be juxtaposed against another cart. It further comprises a first pump, a second pump disposed below said first pump and laterally offset relative thereto, and a tank adapted to receive a feed container provided to contain said biological liquid, said tank being disposed above said first pump and offset laterally relative thereto. The installation comprises one said cart, a filter and a second cart, juxtaposed against said first cart and of which the upper face supports said filter such that an outlet point of said first pump is situated substantially facing an inlet/outlet aperture of said filter.

Abstract translation: 推车包括侧面，其被适配成与另一个推车并置。 其还包括第一泵，设置在所述第一泵的下方并相对于其横向偏移的第二泵，以及适于容纳设置成容纳所述生物液体的进料容器的罐，所述罐设置在所述第一泵的上方并相对于其横向偏移 。 该装置包括一个所述推车，过滤器和第二推车，与所述第一推车并置，并且其上表面支撑所述过滤器，使得所述第一泵的出口点基本上面对所述过滤器的入口/出口孔。

公开(公告)号：US08549935B2

公开(公告)日：2013-10-08

申请号：US12284666

申请日：2008-09-24

Applicant: James F. Furey ,  Stephen P. Proulx

Inventor： James F. Furey ,  Stephen P. Proulx

IPC: G01N1/10

CPC classification number: G01N1/10 ,  C12M33/00 ,  C12M37/00 ,  G01N1/18 ,  G01N1/26 ,  G01N2001/1056 ,  G01N2001/205

Abstract: The present invention provides a fluid sampling device comprising a port insert, a plurality of flexible conduits, and a plurality of sample containers. The port insert comprises a body having a plurality of shafts therethrough and a rotatably displaceable member for individually opening and closing any of said shafts to enable the flow of fluid therethrough. Flexible conduits (e.g., flexible tubing) are equal in number to the shafts, with each flexible conduit connected to or otherwise in fluid communication with an individual shaft. Similarly, sample containers (e.g., flexible bags) are equal in number to the conduits, with each sample container connected to an individual conduit opposite the connection to the shaft. A specific configuration for the port insert, as well as kit containing sterilized components of the fluid sampling device, are also described.

公开(公告)号：US20130248371A1

公开(公告)日：2013-09-26

申请号：US13887657

申请日：2013-05-06

Applicant: EMD Millipore Corporation

Inventor： Andrej Grabowski

IPC: C02F1/469

CPC classification number: C02F1/4695 ,  B01D61/485 ,  B01D61/52 ,  B01D61/54 ,  B01J47/028 ,  B01J47/04 ,  B01J47/06 ,  B01J49/09 ,  B01J49/30 ,  C02F2209/03 ,  C02F2303/16

Abstract: Device for the removal of ions from a polar liquid, e.g. water, comprising at least one compartment which comprises at least one inlet for an entering polar liquid flow and at least one outlet for an outgoing deionized liquid flow, in which said compartment an electrochemically regenerable ion-exchange material fills a zone through which zone a liquid flow is able to pass, the device being characterized in that it comprises one sensor of at least one dimensional change of the ion-exchange material. The sensor can comprise a photo-sensor or a sensor of mechanical stress. Preferably an apparatus connected to the sensor is able to analyze this dimensional change and to control the electric current. Method of using said device, whereby the electrical current applied to the device is controlled according to the expansion of the resin.

Abstract translation: 用于从极性液体除去离子的装置，例如 水，包括至少一个隔室，其包括用于进入的极性液体流的至少一个入口和用于输出的去离子液体流的至少一个出口，其中所述隔室为电化学可再生的离子交换材料填充通过该区域的液体 流动能够通过，该装置的特征在于它包括离子交换材料的至少一维变化的一个传感器。 传感器可以包括光传感器或机械应力传感器。 优选地，连接到传感器的装置能够分析该尺寸变化并控制电流。 使用所述装置的方法，由此根据树脂的膨胀来控制施加到装置的电流。

公开(公告)号：US20130236926A1

公开(公告)日：2013-09-12

申请号：US13868263

申请日：2013-04-23

Applicant: EMD MILLIPORE CORPORATION

Inventor： Christian Schann ,  Bruno Duquet ,  Abdel Hajila ,  Frederic Olivieri

IPC: G01N21/76

CPC classification number: C12Q1/24 ,  B05B12/20 ,  G01N21/763

Abstract: The device for spraying a reagent onto a support (81) adapted to retain microorganisms on a predetermined surface (82), comprises a spraying bell (3) as well as a nozzle (71) for emitting a jet of droplets of said reagent into a spraying chamber (34) comprised by said bell (3), said device also comprising an absorbent pad (5) mounted against said bell (3) transversely to said jet and closing said chamber (34) from the opposite side to said nozzle (71) with the exception of a circular central opening (51) provided in said pad (5), the diameter of said central opening (51) being adapted to enable a portion of said jet, when said device faces said support (81) and is at a predetermined distance therefrom, to pass through said central opening (51) over its entire area and be deposited on the whole of said predetermined surface (82) of said support (81).

Abstract translation: 用于将试剂喷洒到适于将微生物保留在预定表面（82）上的支撑体（81）上的装置包括喷雾钟（3）以及喷嘴（71），用于将所述试剂的液滴喷射到 喷雾室（34），所述装置还包括一个吸收垫（5），该吸收垫（5）横向于所述射流安装在所述钟形（3）上，并从所述喷嘴（71）的相对侧关闭所述腔室 ），除了设置在所述垫（5）中的圆形中心开口（51）之外，所述中心开口（51）的直径适于使所述装置的一部分当所述装置面向所述支撑件（81）并且是 在其预定距离处穿过所述中心开口（51）遍及其整个区域并且沉积在所述支撑件（81）的整个所述预定表面（82）上。

公开(公告)号：US08524489B2

公开(公告)日：2013-09-03

申请号：US13118831

申请日：2011-05-31

Applicant: Philippe J. Goix ,  Paul J. Lingane ,  Janette T. Phi-Wilson ,  Kenneth F. Uffenheimer

Inventor： Philippe J. Goix ,  Paul J. Lingane ,  Janette T. Phi-Wilson ,  Kenneth F. Uffenheimer

IPC: C12M1/34

CPC classification number: G01N15/1404 ,  G01N21/64

Abstract: A particle analyzer in which tagged particles to be analyzed are drawn through a suspended capillary tube where a predetermined volume in the capillary tube is illuminated. The illumination scattered by said particles is detected by a detector to count all particles. The fluorescent illumination emitted by tagged particles is detected and the output signals from the fluorescent detectors and scatter detector are processed to provide an analysis of the particles.