公开(公告)号：US08722626B2

公开(公告)日：2014-05-13

申请号：US13150526

申请日：2011-06-01

申请人： Jorge Berlanga Acosta ,  Danay Cibrian Vera ,  Diana Garcia Del Barco Herrera ,  Gerardo Enrique Guillén Nieto ,  José Suarez Alba ,  Ernesto Lopez Mola ,  Manuel Selman-Housein Sosa ,  Mariela Vazquez Castillo

发明人： Jorge Berlanga Acosta ,  Danay Cibrian Vera ,  Diana Garcia Del Barco Herrera ,  Gerardo Enrique Guillén Nieto ,  José Suarez Alba ,  Ernesto Lopez Mola ,  Manuel Selman-Housein Sosa ,  Mariela Vazquez Castillo

IPC分类号： A61P19/04 ,  A61K38/08 ,  C07K7/06

CPC分类号： A61K38/05 ,  A61K38/08 ,  A61K38/25

摘要： The present invention is related to the use of secretagogue peptides repeatedly administered as part of a pharmaceutical composition that prevent and eradicate the deposition of pathological fibrotic material in parenchymal tissues of internal organs like the liver, lungs, esophagus, small intestine, kidneys, blood vessels, joints, and other systemic forms of cutaneous fibrosis of any etiopathogenesis. Additionally, these peptides prevent and eradicate deposition of amiloid and hyaline materials in any of their correspondent chemical forms and tissue manifestations in the brain, cerebellum, blood vessels, liver, intestines, kidneys, spleen, pancreas, joints and the skin, among others. By this way, cellular, tissular and organ dysfunctions generated by these depositions are corrected. The peptides of the present invention are infiltrated or topically applied, contributing to prevent and eradicate keloids and hypertrophic scars in the skin, derived as sequelae of burns and other cutaneous trauma.

摘要翻译： 本发明涉及使用作为药物组合物的一部分反复施用的促分泌素肽，其用于预防和消除病理性纤维化物质在诸如肝，肺，食管，小肠，肾脏，血管等脏器的实质组织中的沉积 ，关节和其他全身形式的皮肤纤维化的任何发病机制。 此外，这些肽预防和消除了在脑，小脑，血管，肝，肠，肾，脾脏，胰腺，关节和皮肤等中的任何相应的化学形式和组织表现的淀粉样和透明物质的沉积。 通过这种方式，校正由这些沉积产生的细胞，组织和器官功能障碍。 本发明的肽被渗透或局部应用，有助于预防和消除作为烧伤和其它皮肤创伤后遗症的皮肤中的瘢痕疙瘩和肥厚性瘢痕。

公开(公告)号：US08673313B2

公开(公告)日：2014-03-18

申请号：US12671335

申请日：2008-07-31

申请人： Isis del Carmen Torrens Madrazo ,  Maribel Guerra Vallespi ,  Milaid Granadillo Rodriguez ,  Osvaldo Reyes Acosta ,  Boris Ernesto Acevedo Castro

发明人： Isis del Carmen Torrens Madrazo ,  Maribel Guerra Vallespi ,  Milaid Granadillo Rodriguez ,  Osvaldo Reyes Acosta ,  Boris Ernesto Acevedo Castro

IPC分类号： A61K39/12 ,  A61K39/02

CPC分类号： A61K39/12 ,  A61K2039/585 ,  A61K2039/6031 ,  C12N2710/20034

摘要： The present invention relates to use of a new cell penetrating peptides (CPP) and in particular to the region 32-51 of protein Limulus antilipopolisacárido (LALF) and its analogous. This invention refers to compositions containing these peptides associated to biomolecules with therapeutics properties. This invention consist of compositions comprise the covalent fusion of biomolecules, between this human papillomavirus antigens (HPV) to these CPP for induce a potent immune cellular responses against HPV and HPV protein antigen-exhibiting cells including HPV-associated tumors. The referred compositions are applicable in the pharmaceutical industry as vaccine for therapeutic use in human.

摘要翻译： 本发明涉及使用新的细胞穿透肽（CPP），特别涉及蛋白鲎抗脂蛋白（LALF）的区域32-51及其类似物。 本发明涉及包含与具有治疗学性质的生物分子相关联的这些肽的组合物。 本发明由组合物组成，包括生物分子的共价融合，在该人乳头状瘤病毒抗原（HPV）与这些CPP之间，用于诱导对HPV和HPV蛋白抗原呈递细胞（包括HPV相关肿瘤）的有效免疫细胞应答。 所提及的组合物可用作制药工业中用于人类治疗用途的疫苗。

公开(公告)号：US08541395B2

公开(公告)日：2013-09-24

申请号：US13322917

申请日：2010-05-26

申请人： Krishnamurti De Morais Carvalho ,  Dòris Maria Fernandes Carvalho ,  Maria Denise Fernandes Carvalho ,  Ogari de Castro Pacheco ,  Roberto Carlos Debom Moreira

发明人： Krishnamurti De Morais Carvalho ,  Dòris Maria Fernandes Carvalho ,  Maria Denise Fernandes Carvalho ,  Ogari de Castro Pacheco ,  Roberto Carlos Debom Moreira

IPC分类号： A61K31/585

CPC分类号： A61K31/585

摘要： The present invention is directed to the use of telocinobufagin, or its pharmaceutically acceptable derivatives, in the manufacture of a medicament for the treatment or prevention of acute and chronic pains. The present invention also refers to a pharmaceutical composition comprising an effective amount of telocinobufagin; also provides a method to induce analgesia in response to acute and chronic pains that comprehends administering an effective amount of telocinobufagin to human beings or animals. According to the outcomes of in vivo assays, telocinobufagin is more potent than morphine, though without presenting the known side effects of opioids. In addition, in vivo and in vitro essays showed that TBC does not present cardiotoxicity.

摘要翻译： 本发明涉及telocinobufagin或其药学上可接受的衍生物在制备用于治疗或预防急性和慢性疼痛的药物中的用途。 本发明还涉及包含有效量的telocinobufagin的药物组合物; 还提供了一种诱导镇痛作用的方法，以应对急性和慢性疼痛，其理解向人或动物施用有效量的telocinobufagin。 根据体内测定的结果，telocinobufagin比吗啡更有效，尽管没有呈现阿片样物质的已知副作用。 此外，体内和体外散文表明，TBC不存在心脏毒性。

公开(公告)号：US20130217618A1

公开(公告)日：2013-08-22

申请号：US13865437

申请日：2013-04-18

申请人： Centro de Ingenieria Genetica y Biotecnologia

发明人： Orlando Borras Hidalgo ,  Roxana Caridad Portieles Alvarez ,  Merardo Pujol Ferrer ,  Gil Alberto Enriquez Obregon ,  Ernesto Manuel Gonzalez Ramos ,  Camilo Ayra Pardo ,  Carlos Guillermo Borroto Nordelo

IPC分类号： A01N37/18

CPC分类号： A01N37/18 ,  C07K14/415 ,  C12N15/8279 ,  C12N15/8282

摘要： The present invention reveals a nucleic acid sequence from Nicotiana megalosiphon encoding for an anti-pathogenic protein. The invention comprises the use of this nucleic acid molecule in transgenic plants of agricultural interest to confer resistance to pathogens. The invention also includes a bioproduct that comprises this anti-pathogenic protein to control plant pathogen agents.

摘要翻译： 本发明揭示了编码抗病原性蛋白质的烟草巨乳的核酸序列。 本发明包括在农业感兴趣的转基因植物中使用该核酸分子来赋予对病原体的抗性。 本发明还包括一种生物产物，其包含该抗病原性蛋白质以控制植物病原体。

公开(公告)号：US08420311B2

公开(公告)日：2013-04-16

申请号：US12298808

申请日：2007-04-26

申请人： Vivian Huerta Galindo ,  Glay Chinea Santiago ,  Noralvis Fleitas Salazar ,  Alejandro Miguel Martin Dunn ,  Monica Sarria Nunez ,  Osmany Guirola Cruz ,  Patricia Gabriela Toledo Mayora ,  Aniel Sanchez Puente ,  Vladimir Armando Besada Perez ,  Osvaldo Reyes Acosta ,  Hilda Elisa Garay Perez ,  Ania Cabrales Rico ,  Alexis Musacchio Lasa ,  Gabriel Ramon Padron Palomares ,  Luis Javier Gonzalez Lopez

发明人： Vivian Huerta Galindo ,  Glay Chinea Santiago ,  Noralvis Fleitas Salazar ,  Alejandro Miguel Martin Dunn ,  Monica Sarria Nunez ,  Osmany Guirola Cruz ,  Patricia Gabriela Toledo Mayora ,  Aniel Sanchez Puente ,  Vladimir Armando Besada Perez ,  Osvaldo Reyes Acosta ,  Hilda Elisa Garay Perez ,  Ania Cabrales Rico ,  Alexis Musacchio Lasa ,  Gabriel Ramon Padron Palomares ,  Luis Javier Gonzalez Lopez

IPC分类号： C12Q1/70 ,  A61K39/12

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C07K14/70596 ,  C07K14/8107 ,  C12N2770/24122 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/394 ,  Y02A50/396

摘要： The present invention is related to a method for blocking the infection of cells by dengue virus, based on interfering the direct interaction of the viral envelope protein with a cellular receptor or its indirect interaction with said cellular receptor through a carrier protein, as well as related uses; wherein said cellular receptor is the alpha-2 macroglobulin receptor, also known as the low density receptor-related protein or as CD91, and said carrier protein is human alpha-2 macroglobulin.

摘要翻译： 本发明涉及一种基于干扰病毒包膜蛋白与细胞受体的直接相互作用或其通过载体蛋白与所述细胞受体的间接相互作用而阻断登革热病毒感染细胞的方法，以及相关的 用途; 其中所述细胞受体是α-2巨球蛋白受体，也称为低密度受体相关蛋白或CD91，所述载体蛋白是人α-2巨球蛋白。

公开(公告)号：US08367620B2

公开(公告)日：2013-02-05

申请号：US12281085

申请日：2007-02-28

申请人： Rolando Eduardo Rodriguez Fernandez ,  Ania De La Nuez Veulens ,  Mario Pablo Estrada Garcia ,  Rebeca Martinez Rodriguez ,  Glay Chinea Santiago ,  Osvaldo Reyes Acosta ,  Julio Raul Fernandez Masso ,  Diana Garcia del Barco Herrera ,  Jorge Amador Berlanga Acosta ,  Alexis Musacchio Lasa

发明人： Rolando Eduardo Rodriguez Fernandez ,  Ania De La Nuez Veulens ,  Mario Pablo Estrada Garcia ,  Rebeca Martinez Rodriguez ,  Glay Chinea Santiago ,  Osvaldo Reyes Acosta ,  Julio Raul Fernandez Masso ,  Diana Garcia del Barco Herrera ,  Jorge Amador Berlanga Acosta ,  Alexis Musacchio Lasa

IPC分类号： C07K7/06 ,  C07K7/08

CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K7/06 ,  C07K14/60

摘要： Peptidic chemical compounds obtained by in silico molecular modelling, having a structure that enables them to perform the same functions of peptidic growth hormone secretagogues. The invention also comprises the preparations containing such compounds and the use in medicines, food additives, nutritional supplements or other formulations of human or animal use.

摘要翻译： 通过在硅分子模拟中获得的肽化学化合物，其具有使得它们能够执行肽生长激素促分泌素相同功能的结构。 本发明还包括含有这些化合物的制剂以及在药物，食品添加剂，营养补充剂或人或动物使用的其它制剂中的用途。

公开(公告)号：US20120308661A1

公开(公告)日：2012-12-06

申请号：US13578211

申请日：2011-02-10

申请人： Raimundo Ubieta Gómez ,  Ana Aguilera Barreto ,  Eduardo Martínez Díaz ,  Rolando Paez Meireles ,  Antonio Sereno Guerra

发明人： Raimundo Ubieta Gómez ,  Ana Aguilera Barreto ,  Eduardo Martínez Díaz ,  Rolando Paez Meireles ,  Antonio Sereno Guerra

IPC分类号： A61K9/50 ,  A61P1/04 ,  B05D7/00 ,  A61K38/18

CPC分类号： A61K38/1808 ,  A61K9/48 ,  A61K9/50 ,  A61K9/5026 ,  A61K9/5078 ,  A61K47/02 ,  A61K47/183 ,  A61K47/38

摘要： The present invention comprises a pellet of epidermal growth factor and methionine or K2S2O7, a capsule which comprises these pellets, processes for theirs preparations and it use for the treatment of ulcerative colitis.

摘要翻译： 本发明包括表皮生长因子和甲硫氨酸颗粒或K 2 S 2 O 7，其包含这些颗粒的胶囊，其制备方法及其用于治疗溃疡性结肠炎。

公开(公告)号：US08268306B2

公开(公告)日：2012-09-18

申请号：US12857194

申请日：2010-08-16

申请人： Jesus Mena Campos ,  Eulogio Pimentel Vazquez ,  Armando Tomas Hernadez Garcia ,  Liuven Veloz Gonzalez ,  Marieta Marin Bruzos ,  Oscar Compte Alberto ,  Marilin Domingo Puente ,  Licette Leon Barreras ,  Merardo Pujol Ferrero ,  Juan Diego Mencho Ponce ,  Carlos Borroto Nordelo

发明人： Jesus Mena Campos ,  Eulogio Pimentel Vazquez ,  Armando Tomas Hernadez Garcia ,  Liuven Veloz Gonzalez ,  Marieta Marin Bruzos ,  Oscar Compte Alberto ,  Marilin Domingo Puente ,  Licette Leon Barreras ,  Merardo Pujol Ferrero ,  Juan Diego Mencho Ponce ,  Carlos Borroto Nordelo

IPC分类号： A01N59/02 ,  A01P5/00 ,  A61K38/47 ,  A61P33/00

CPC分类号： A01N63/00 ,  A01N63/02 ,  A01N2300/00

摘要： This invention relates to pesticide and antiparasitic compositions for the control of pests, diseases and parasites attacking plants and animals. The compositions include, at least one chitinolytic agent or a chitinolytic activity-inducing agent, and sulfide or a sulfide-producing agent from microorganisms or chemical compounds, wherein the chitinolytic agent or the chitinolytic activity-inducing agent and sulfur or a sulfur-producing agent obtaining from microorganisms or chemical compounds are concurrently applied at a range significantly lower than any of the above-mentioned compounds, when they are individually to attain effective control.

摘要翻译： 本发明涉及用于防治害虫，疾病和寄生虫攻击植物和动物的农药和抗寄生虫剂组合物。 所述组合物包括至少一种chitinotictic试剂或chitinolytic活性诱导剂，以及来自微生物或化学化合物的硫化物或硫化物生成剂，其中所述chitinolytic试剂或所述chitinolytic活性诱导剂和硫或硫产生剂 当微生物或化合物单独获得有效控制时，从微生物或化合物获得的同时应用于显着低于任何上述化合物的范围。

公开(公告)号：US07947287B2

公开(公告)日：2011-05-24

申请号：US12099646

申请日：2008-04-08

申请人： Silvio Ernesto Perea Rodriquez ,  Osvaldo Reyes Acosta ,  Nelson Francisco Santiago Vispo ,  Yaquelin Puchades Izaguirre ,  Ricardo Silva Rodriguez ,  Alejandro Moro Soria ,  Alicia Santos Savio ,  Luis Javier Gonzalez Lopez ,  Belkis Gonzalez Barrios

发明人： Silvio Ernesto Perea Rodriquez ,  Osvaldo Reyes Acosta ,  Nelson Francisco Santiago Vispo ,  Yaquelin Puchades Izaguirre ,  Ricardo Silva Rodriguez ,  Alejandro Moro Soria ,  Alicia Santos Savio ,  Luis Javier Gonzalez Lopez ,  Belkis Gonzalez Barrios

IPC分类号： A61K39/12

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K48/00 ,  C07K7/06 ,  C07K2319/10 ,  C12N7/00 ,  C12N2710/20022 ,  C12N2710/20032

摘要： This invention is related to the Molecular Pharmacology field and especially to the development of peptides useful for treating epithelial tumors and mainly those associated to oncogenic types of HPVs. The main objective of this invention is to identify peptides whose structure permits to block the Casein Kinase II (CKII) phosphorylation domain by direct interaction with such a site. In the present invention it is shown eleven cyclic peptides with different aminoacid sequences which inhibit the CKII phosphorylation in vitro, exhibit cytotoxicity on HPV-16 transformed cells (CaSki) and also increase the sensitivity of these cells to the cytostatic effect of interferon (IFN). Furthermore, the invention relates to the use of these peptides conjugated or fused to other peptides and chemical compounds which penetrates into cells as well as with the use of both peptide and chemical mimetic molecules.

摘要翻译： 本发明涉及分子药理学领域，特别涉及可用于治疗上皮肿瘤和主要与致癌型HPV相关的肽的发展。 本发明的主要目的是鉴定其结构允许通过与这种位点的直接相互作用阻断酪蛋白激酶II（CKII）磷酸化结构域的肽。 在本发明中，显示了11种具有不同氨基酸序列的环肽，其在体外抑制CKII磷酸化，对HPV-16转化细胞（CaSki）表现出细胞毒性，并且还增加了这些细胞对干扰素（IFN）的细胞抑制作用的敏感性， 。 此外，本发明涉及这些肽与其它肽和化合物共轭或融合的用途，这些肽和化合物可以渗入细胞以及使用肽和化学模拟分子。

公开(公告)号：US07691971B2

公开(公告)日：2010-04-06

申请号：US10580508

申请日：2004-12-02

申请人： Rolando Pajon Feyt ,  Enrique Guillen Nieto Gerardo ,  Gretel Sardinas Garcia ,  Nunez Lazaro Hiram Betancourt ,  Serra Lila Rosa Castellanos ,  Negrin Yasser Perera ,  Diaz Darien Garcia ,  Perez Olivia Niebla ,  Menendez Evelin Caballero ,  Blanco Sonia Gonzalez

发明人： Rolando Pajon Feyt ,  Enrique Guillen Nieto Gerardo ,  Gretel Sardinas Garcia ,  Nunez Lazaro Hiram Betancourt ,  Serra Lila Rosa Castellanos ,  Negrin Yasser Perera ,  Diaz Darien Garcia ,  Perez Olivia Niebla ,  Menendez Evelin Caballero ,  Blanco Sonia Gonzalez

IPC分类号： C07K14/00 ,  C07K17/00

CPC分类号： C07K14/22 ,  A61K39/00 ,  A61K2039/523 ,  A61K2039/53

摘要： Use of a novel vaccine antigen applied in a preventive or therapeutic way against diseases in general, being such disease of bacterial, viral, cancer related, or other origin.The technical objective that this invention pursues is the development of formulations with the ability to increase the protective spectrum of existing vaccines and hence expanding it against different pathogens.In order to achieve this goal the NMB1125 protein was isolated and identified as a component of outer membrane preparations of Neisseria meningitidis capable of inducing bactericidal activity.Additionally, the gene codifying for NMB1125 protein was cloned and expressed, and the said polypeptide was purified and its immunogenicity evaluated in animal models. The sequence data from homologous genes showed, due to the high degree of conservation, its high value as a target antigen of a cross-reactive response when it is presented by different routes. Resultant formulations of this invention are of use in the pharmaceutical industry as vaccine formulations for human use.

摘要翻译： 使用以预防或治疗方式应用的新型疫苗抗原，通常可以防止一般疾病，这些细菌，病毒，癌症相关或其它来源的疾病。 本发明所追求的技术目标是开发具有增加现有疫苗的保护性能并因此扩增其抵抗不同病原体的能力的制剂。 为了达到这个目标，NMB1125蛋白被分离并鉴定为能够诱导杀菌活性的脑膜炎奈瑟氏球菌外膜制剂的组分。 另外，克隆和表达编码NMB1125蛋白的基因，并且将所述多肽纯化，并在动物模型中评估其免疫原性。 来自同源基因的序列数据显示，由于高度的保守性，当通过不同途径呈现时，其作为交叉反应性应答的靶抗原的高值显示出来。 本发明的所得制剂在制药工业中用作人类使用的疫苗制剂。