Recombinant attenuated clostridium organisms and vaccine
    83.
    发明授权
    Recombinant attenuated clostridium organisms and vaccine 有权
    重组减毒梭菌生物体和疫苗

    公开(公告)号:US07972604B2

    公开(公告)日:2011-07-05

    申请号:US12869813

    申请日:2010-08-27

    IPC分类号: A61K39/02

    摘要: The present invention discloses attenuated Clostridium perfringens organisms that express a substantially nontoxic alpha-toxin. The expressed alpha-toxin is a deletion mutein that relative to the alpha-toxin of the mature alpha-toxin of Clostridium perfringens strain 13, is missing at least nine consecutive amino acid residues including His68. The present invention also discloses attenuated organisms that encode the muteins, as well as the use of such attenuated organisms as vaccines.

    摘要翻译: 本发明公开了表达基本上无毒的α-毒素的减毒产气荚膜梭菌生物体。 表达的α-毒素是相对于产气荚膜梭菌菌株13的成熟α-毒素的α-毒素的缺失突变蛋白缺失至少九个连续的氨基酸残基,包括His68。 本发明还公开了编码突变蛋白的减毒生物,以及这些减毒生物体作为疫苗的用途。

    Recombinant attenuated Clostridium organisms and vaccine
    84.
    发明授权
    Recombinant attenuated Clostridium organisms and vaccine 有权
    重组减毒梭菌有机体和疫苗

    公开(公告)号:US07807456B2

    公开(公告)日:2010-10-05

    申请号:US12640645

    申请日:2009-12-17

    IPC分类号: C12N15/00

    摘要: The present invention discloses attenuated Clostridium perfringens organisms that express a substantially nontoxic alpha-toxin. The expressed alpha-toxin is a deletion mutein that relative to the alpha-toxin of the mature alpha-toxin of Clostridium perfringens strain 13, is missing at least nine consecutive amino acid residues including His68. The present invention also discloses attenuated organisms that encode the muteins, as well as the use of such attenuated organisms as vaccines.

    摘要翻译: 本发明公开了表达基本上无毒的α-毒素的减毒产气荚膜梭菌生物体。 表达的α-毒素是相对于产气荚膜梭菌菌株13的成熟α-毒素的α-毒素的缺失突变蛋白缺失至少九个连续的氨基酸残基,包括His68。 本发明还公开了编码突变蛋白的减毒生物,以及这些减毒生物体作为疫苗的用途。

    Recombinant attenuated clostridium organisms and vaccine
    86.
    发明授权
    Recombinant attenuated clostridium organisms and vaccine 有权
    重组减毒梭菌生物体和疫苗

    公开(公告)号:US07732187B2

    公开(公告)日:2010-06-08

    申请号:US11734454

    申请日:2007-04-12

    IPC分类号: C12N1/20

    摘要: The present invention discloses attenuated Clostridium perfringens organisms that express a substantially nontoxic alpha-toxin. The expressed alpha-toxin is a deletion mutein that relative to the alpha-toxin of the mature alpha-toxin of Clostridium perfringens strain 13, is missing at least nine consecutive amino acid residues including His68. The present invention also discloses attenuated organisms that encode the muteins, as well as the use of such attenuated organisms as vaccines.

    摘要翻译: 本发明公开了表达基本上无毒的α-毒素的减毒产气荚膜梭菌生物体。 表达的α-毒素是相对于产气荚膜梭菌菌株13的成熟α-毒素的α-毒素的缺失突变蛋白缺失至少九个连续的氨基酸残基,包括His68。 本发明还公开了编码突变蛋白的减毒生物,以及这些减毒生物体作为疫苗的用途。

    Method for controlling ectoparasites
    88.
    发明授权
    Method for controlling ectoparasites 失效
    控制外寄生虫的方法

    公开(公告)号:US5750514A

    公开(公告)日:1998-05-12

    申请号:US439419

    申请日:1995-05-11

    申请人: Jeffery A. Meyer

    发明人: Jeffery A. Meyer

    摘要: An improved method for controlling infestations of flies on an animal wherein a solution of an ectoparasiticide is applied to the skin or coat of the animal comprises increasing the concentration of the ectoparasiticide to about 3% to about 90% of the composition and proportionately reducing the volume of the solution administered to the animal such that the animal receives the same amount of the ectoparasiticide as it would have received prior to the concentration of the solution.

    摘要翻译: 用于控制动物感染动物的改进方法,其中将外寄生虫杀螨剂的溶液施用于动物的皮肤或外皮包括将外用寄生虫抗病毒剂的浓度增加至组合物的约3%至约90%,并相应地减小体积 施用于动物的溶液,使得动物接受与溶液浓缩之前接收的相同量的杀螨剂。