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81.发明申请公开(公告)号：US20120177657A1
公开(公告)日：2012-07-12
申请号：US13426295
申请日：2012-03-21
申请人： Vega MASIGNANI , Maria SCARSELLI , Barbara CAPECCHI , Victoria SHARMA , Susan W. BARNETT , Indresh K. SRIVASTAVA , Rino RAPPUOLI
发明人： Vega MASIGNANI , Maria SCARSELLI , Barbara CAPECCHI , Victoria SHARMA , Susan W. BARNETT , Indresh K. SRIVASTAVA , Rino RAPPUOLI
CPC分类号： C07K14/70514 , C07K2319/01
摘要： Fusion proteins comprising CD4 minimal modules that bind to HIV Env polypeptides in a non-CD4 backbone are described. Also described are complexes of these fusion proteins with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides are also provided.
摘要翻译： 描述了包含在非CD4主链中结合HIV Env多肽的CD4最小模块的融合蛋白。 还描述了这些融合蛋白与Env的复合物以及使用多核苷酸和多肽的诊断，治疗和预防的方法。
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公开(公告)号：US20120114693A1
公开(公告)日：2012-05-10
申请号：US13349326
申请日：2012-01-12
IPC分类号： A61K39/21 , A61P37/04 , A61K39/12 , A61K39/193 , A61K39/00 , A61K39/235
CPC分类号： A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/545 , A61K2039/57 , C12N15/86 , C12N2710/24143 , C12N2740/16134 , C12N2740/16234 , C12N2770/36143
摘要： Mucosal delivery of antigens using, for example, a replication-defective gene delivery vehicle, particularly replication-defective alphavirus vectors and particles, is described. Also described are compositions comprising a mucosal adjuvant and one or more antigens derived from HIV. Also provided is the use of these gene delivery vehicles in inducing mucosal, local, and/or systemic immune responses following mucosal immunization regimes.
摘要翻译： 描述了使用例如复制缺陷基因递送载体，特别是复制缺陷型甲病毒载体和颗粒的粘膜递送抗原。 还描述了包含粘膜佐剂和一种或多种源自HIV的抗原的组合物。 还提供了这些基因递送载体在粘膜免疫方案后诱导粘膜，局部和/或全身免疫应答的用途。
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83.发明申请公开(公告)号：US20120015345A1
公开(公告)日：2012-01-19
申请号：US13088273
申请日：2011-04-15
CPC分类号： C07K14/005 , C12N2770/24122 , C12Q1/701
摘要： West Nile virus capture oligonucleotides, primers and probes derived from conserved regions of the West Nile virus genome are disclosed. Also disclosed are nucleic acid-based assays using the capture oligonucleotides, primers and probes.
摘要翻译： 公开了西尼罗病毒捕获寡核苷酸，衍生自西尼罗河病毒基因组保守区域的引物和探针。 还公开了使用捕获寡核苷酸，引物和探针的基于核酸的测定。
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84.发明授权Methods of therapy for B-cell malignancies using antagonist anti-CD40 antibodies 失效使用拮抗性抗-CD40抗体治疗B细胞恶性肿瘤的方法公开(公告)号：US08088383B2
公开(公告)日：2012-01-03
申请号：US12891415
申请日：2010-09-27
申请人： Keting Chu , Lorianne K. Masuoka
发明人： Keting Chu , Lorianne K. Masuoka
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2878 , A01K2217/05 , A61K2039/505 , C07K2317/21 , C12N2799/026
摘要： Methods of therapy for B-cell malignancies are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity when the antibody binds a CD40 antigen on a normal human B cell, exhibits antagonist activity when the antibody binds a CD40 antigen on a malignant human B cell, and can exhibit antagonist activity when the antibody binds a CD40 antigen on a normal human B cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of malignant human B cells.
摘要翻译： 提供了B细胞恶性肿瘤治疗方法。 所述方法包括向有需要的患者施用治疗有效量的拮抗性抗CD40抗体或其抗原结合片段。 当抗体结合正常人B细胞上的CD40抗原时，拮抗性抗-CD40抗体或其抗原结合片段没有明显的激动剂活性，当抗体结合恶性人B细胞上的CD40抗原时，拮抗剂抗CD40抗体或其抗原结合片段， 当抗体结合正常人B细胞上的CD40抗原时，可以显示拮抗剂活性。 抗CD40抗体或其抗原结合片段的拮抗作用有益地抑制恶性人B细胞的增殖和/或分化。
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公开(公告)号：US08025890B2
公开(公告)日：2011-09-27
申请号：US11434184
申请日：2006-05-16
申请人： John Telford , Vega Masignani , Maria Scarselli , Guido Grandi , Herve Tettelin , Claire Fraser
发明人： John Telford , Vega Masignani , Maria Scarselli , Guido Grandi , Herve Tettelin , Claire Fraser
CPC分类号： C07K14/315 , A61K38/00 , A61K39/00 , A61K39/092 , A61K2039/505 , A61K2039/53 , C07K16/1275 , C07K16/40 , C07K2319/00 , C12N9/1088 , C12Y205/01018 , Y02A50/464 , Y02A50/466
摘要： The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
摘要翻译： 本发明提供了来自B族链球菌（无乳链球菌）和A型链球菌（化脓链球菌）的蛋白质，包括氨基酸序列和相应的核苷酸序列。 给出数据以显示蛋白质是疫苗，免疫原性组合物和/或诊断的有用抗原。 蛋白质也是抗生素的靶标。
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公开(公告)号：US07955604B2
公开(公告)日：2011-06-07
申请号：US11434127
申请日：2006-05-16
申请人： John Telford , Vega Masignani , Maria Scarselli , Guido Grandi , Herve Tettelin , Claire Fraser
发明人： John Telford , Vega Masignani , Maria Scarselli , Guido Grandi , Herve Tettelin , Claire Fraser
CPC分类号： C07K14/315 , A61K38/00 , A61K39/00 , A61K39/092 , A61K2039/505 , A61K2039/53 , C07K16/1275 , C07K16/40 , C07K2319/00 , C12N9/1088 , C12Y205/01018 , Y02A50/464 , Y02A50/466
摘要： The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
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87.发明申请IMMUNOGENIC COMPOSITIONS FOR GRAM POSITIVE BACTERIA SUCH AS STREPTOCOCCUS AGALACTIAE 失效AM AM E E E E E E E E E E E E E E E E E E E E E E E公开(公告)号：US20110110982A1
公开(公告)日：2011-05-12
申请号：US12906510
申请日：2010-10-18
申请人： John Telford , Guido Grandi , Immaculada Margarit Y. Ros , Cira Daniela Rinaudo , Domenico Maione
发明人： John Telford , Guido Grandi , Immaculada Margarit Y. Ros , Cira Daniela Rinaudo , Domenico Maione
CPC分类号： A61K39/092 , A61K39/0208 , A61K39/05 , A61K39/08 , A61K39/085 , A61K39/09 , A61K39/095 , A61K2039/523 , C07K16/1267 , Y02A50/396
摘要： The invention relates to the identification of a new adhesin islands within the genomes of several Group A and Group B Streptococcus serotypes and isolates. The adhesin islands are thought to encode surface proteins which are important in the bacteria's virulence. Thus, the adhesin island proteins of the invention may be used in immunogenic compositions for prophylactic or therapeutic immunization against GAS or GBS infection. For example, the invention may include an immunogenic composition comprising one or more of the discovered adhesin island proteins.
摘要翻译： 本发明涉及鉴定几组A组和B组链球菌血清型和分离株的基因组中的新粘附素岛。 粘附素岛被认为编码在细菌的毒力中重要的表面蛋白质。 因此，本发明的粘附素岛蛋白可用于免疫原性组合物，用于针对GAS或GBS感染的预防性或治疗性免疫。 例如，本发明可以包括包含一种或多种所发现的粘附素岛蛋白的免疫原性组合物。
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公开(公告)号：US20110065146A1
公开(公告)日：2011-03-17
申请号：US12770905
申请日：2010-04-30
申请人： Susan W. Barnett , Jan zur Megede , Indresh Srivastava , Ying Lian , Karin Hartog , Hong Liu , Catherine Greer , Mark Selby , Christopher Walker
发明人： Susan W. Barnett , Jan zur Megede , Indresh Srivastava , Ying Lian , Karin Hartog , Hong Liu , Catherine Greer , Mark Selby , Christopher Walker
IPC分类号： C12P21/00
CPC分类号： C12N7/00 , A61K39/00 , A61K48/00 , A61K2039/5156 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , C07K14/005 , C12N15/86 , C12N2740/16023 , C12N2740/16043 , C12N2740/16052 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2770/24222 , C12N2800/108 , C12N2840/20 , C12N2840/203
摘要： The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation of packaging cell lines, and production of Env-, tat- or Gag-containing proteins. The invention provides methods of producing Virus-Like Particles (VLPs), as well as, uses of the VLPs including, but not limited to, vehicles for the presentation of antigens and stimulation of immune response in subjects to whom the VLPs are administered.
摘要翻译： 本发明涉及HIV多肽在各种细胞类型中的有效表达，包括但不限于哺乳动物，昆虫和植物细胞。 描述了编码含有HIV Gag的多肽的合成表达盒，以及包括DNA免疫，产生包装细胞系以及产生含有Env，tat或Gag的蛋白质的应用中的表达盒的用途。 本发明提供了生产病毒样颗粒（VLP）的方法，以及VLP的使用，包括但不限于用于呈递抗体的媒介物和在施用VLP的受试者中刺激免疫应答。
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公开(公告)号：US07893096B2
公开(公告)日：2011-02-22
申请号：US10814480
申请日：2004-03-29
IPC分类号： A01N43/64 , A01N43/78 , A01N43/76 , A01N43/50 , A01N43/52 , A01N43/36 , A01N43/38 , A61K31/41 , A61K31/425 , A61K31/42 , A61K31/415 , A61K31/40
CPC分类号： A61K31/12 , A61K31/122 , A61K31/175 , A61K31/18 , A61K31/343 , A61K31/352 , A61K31/381 , A61K31/40 , A61K31/4015 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/428 , A61K31/433 , A61K31/437 , A61K31/4439 , A61K31/4453 , A61K31/4709 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/4985 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/585 , A61K31/695 , A61K39/39 , A61K2039/55511 , Y02A50/388 , Y02A50/407 , Y02A50/466 , Y02A50/484
摘要： The invention provides immunostimulatory compositions comprising a small molecule immuno-poteniator (SMIP) compound and methods of administration thereof. Also provided are methods of administering a SMIP compound in an effective amount to enhance the immune response of a subject to an antigen. Further provided are novel compositions and methods of administering SMIP compounds alone or in combination with another agent for the treatment of cancer, infectious diseases and/or allergies/asthma.
摘要翻译： 本发明提供包含小分子免疫抑制剂（SMIP）化合物的免疫刺激组合物及其施用方法。 还提供了有效量施用SMIP化合物以增强受试者对抗原的免疫应答的方法。 还提供了单独或与另一种药物组合施用SMIP化合物以治疗癌症，感染性疾病和/或过敏/哮喘的新型组合物和方法。
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公开(公告)号：US07888004B2
公开(公告)日：2011-02-15
申请号：US12287006
申请日：2008-10-03
CPC分类号： C07K14/005 , A61K39/00 , A61K47/593 , A61K47/62 , A61K2039/53 , A61K2039/57 , C12N2770/24222
摘要： Polypeptides comprising a mutant non-structural Hepatitis C virus useful in diagnostic and/or immunogenic compositions are disclosed, in which the mutant is an N-terminal mutation that functionally disrupts the catalytic domain of NS3. Polynucleotides encoding these polypeptides, host cells transformed with polynucleotides and methods of using the polypeptides and polynucleotides are also disclosed.
摘要翻译： 公开了包含可用于诊断和/或免疫原性组合物的突变非结构性丙型肝炎病毒的多肽，其中所述突变体是功能性破坏NS3的催化结构域的N-末端突变。 还公开了编码这些多肽的多核苷酸，用多核苷酸转化的宿主细胞和使用多肽和多核苷酸的方法。
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