公开(公告)号：US20190046421A1

公开(公告)日：2019-02-14

申请号：US15765012

申请日：2016-10-07

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Satoshi YAMAKI ,  Taichi HARADA ,  Takashi MATSUDA

IPC: A61K8/06 ,  A61K8/26 ,  A61K8/86 ,  A61K8/894 ,  A61K8/04 ,  A61K8/49 ,  A61K8/37 ,  A61Q17/04

CPC classification number: A61K8/064 ,  A61K8/025 ,  A61K8/0254 ,  A61K8/046 ,  A61K8/26 ,  A61K8/37 ,  A61K8/4966 ,  A61K8/585 ,  A61K8/60 ,  A61K8/86 ,  A61K8/891 ,  A61K8/894 ,  A61K2800/48 ,  A61K2800/592 ,  A61K2800/612 ,  A61Q17/04

Abstract: A sprayable sunscreen cosmetic contains substantially no ultraviolet ray scattering agents which cause whiteness, and which is transparent immediately after being applied/sprayed, and that has excellent ultraviolet ray protection effect and a good sensation in use. The ultraviolet ray protection effect is not reduced, and the effects improve when in contact with water. A water-in-oil emulsified sunscreen cosmetic comprises: (A) 6 to 40 mass % of an ultraviolet ray absorbing agent; (B) an organically modified clay mineral; (C) an oil phase thickener other than the aforementioned (B); (D) a silicone-based surfactant having an HLB of less than 8; (E) a spherical resin powder; and (F) a volatile silicone oil; wherein a ratio defined as [total amount of ingredient (B) and ingredient (C)]/[total amount of (G) non-volatile liquid oils other than silicone oils] is at least 0.04 and less than 0.68.

公开(公告)号：US10172332B2

公开(公告)日：2019-01-08

申请号：US15076836

申请日：2016-03-22

Applicant: Shiseido Company, Ltd.

Inventor： Yuzo Yoshida ,  Tsutomu Soma ,  Shigeyoshi Fujiwara

IPC: A01N63/00 ,  A01N65/00 ,  C12N5/071 ,  A01K67/027 ,  A61K35/36 ,  A61L27/38 ,  A61K8/98 ,  A61Q7/00 ,  C12N5/0775

Abstract: Provided is a method for regenerating hair follicles by transplanting a composition containing CD36-expressing dermal sheath cells (DSc) to a human. The composition may be prepared by sorting CD36-expressing dermal sheath cells from a hair follicle tissue by use of a cell-sorting technique along with an antibody to CD36. The composition may also contain dermal papilla cells (DPc).

公开(公告)号：US10105307B2

公开(公告)日：2018-10-23

申请号：US13577032

申请日：2011-01-28

Applicant: Noriko Tomita ,  Hirotaka Takada ,  Hiroyuki Kakoki ,  Takashi Minami ,  Yoriko Mune ,  Takayuki Miyazaki ,  Yuko Suzuki

Inventor： Noriko Tomita ,  Hirotaka Takada ,  Hiroyuki Kakoki ,  Takashi Minami ,  Yoriko Mune ,  Takayuki Miyazaki ,  Yuko Suzuki

IPC: A61K8/81 ,  A61Q1/02 ,  A61Q1/06 ,  A61Q1/10 ,  A61K8/31 ,  A61K8/891

Abstract: Provided is a makeup cosmetic which has a good feeling of use, without showing tautness or stiffness as in the case of using a silicone-based resin film or an offensive odor as in the case of using polyisoprene, and exhibits a good effect of preventing color migration. This makeup cosmetic is characterized by comprising polyisobutylene having a relative mass of 30,000-100,000 and a volatile hydrocarbon oil. Also provided are a top coating agent, which can be appropriately applied on the aforesaid makeup cosmetic, imparts glossiness and shows little color migration or blurring, a makeup kit comprising the aforesaid makeup cosmetic and the top coating agent, and a makeup method using the makeup kit.

公开(公告)号：US20180289610A1

公开(公告)日：2018-10-11

申请号：US15764738

申请日：2016-09-30

Applicant: SHISEIDO COMPANY, LTD.

Inventor： SATOSHI YAMAKI ,  Kouichi NAGAI ,  Yuki SUGIYAMA

IPC: A61K8/86 ,  A61Q17/04 ,  A61K8/37 ,  A61K8/35 ,  A61K8/894 ,  A61K8/41 ,  A61K8/92

Abstract: A sunscreen cosmetic exerts stably an excellent ultraviolet shielding effect without undergoing photodegradation even in a system where 4-tert-butyl-4′-methoxydibenzoylmethane and ethylhexyl methoxycinnamate coexist. The sunscreen cosmetic comprises (a) 0.5-5.0 mass % of 4-tert-butyl-4′-methoxydibenzoylmethane, (b) 3.0-10 mass % of ethylhexyl methoxycinnamate, (c) 5.0 mass % or more of an amphipathic substance, and (d) a liquid oil component containing an ester oil having an IOB of 0.05-0.60, characterized in that the contents of components (a), (b) and (c) satisfy the requirement 0.5≤[(a)+(b)]/(c)≤3.5.

公开(公告)号：US20180252730A1

公开(公告)日：2018-09-06

申请号：US15580855

申请日：2016-06-10

Applicant: Kanazawa University ,  Shiseido Company. Ltd

Inventor： Takashi Wada ,  Kengo FURUICHI ,  Norihiro SAKAI ,  Yasunori IWATA ,  Akinori HARA ,  Yusuke NAKADE ,  Kenji HAMASE ,  Yurika MIYOSHI ,  Maiko NAKANE ,  Masashi MITA

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  G01N33/6806 ,  G01N2800/347

Abstract: The present invention addresses the problem of developing an analytical method which makes it possible to diagnose early or mild renal disorders. The method is based on calculating a disease-state index value for renal disorders on the basis of the quantities of D-form and/or L-form amino acids, from feces or intestinal content. By comparing the disease-state index value with a threshold value determined from the disease-state index values of a renal failure patient group and a healthy subject group, it is possible to diagnose a mild renal disorder patient group.

公开(公告)号：US10047068B2

公开(公告)日：2018-08-14

申请号：US15312788

申请日：2015-05-21

Applicant: Shiseido Company, Ltd

Inventor： Yosuke Tojo ,  Masashi Mita ,  Wolfgang Lindner

IPC: C07D401/04

Abstract: The problem addressed by the present invention is to provide a novel method for separating and purifying pure enantiomer of lenalidomide. Pure enantiomer of lenalidomide can be separated and purified by using, as the mobile phase, an organic solvent selected from the group consisting of aprotic solvents, secondary alcohols, and mixtures thereof.

公开(公告)号：US09968542B2

公开(公告)日：2018-05-15

申请号：US14434249

申请日：2013-10-11

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Takahiro Kishina ,  Katsuyuki Kaneko ,  Amane Tatsuta ,  Yukiko Sato ,  Minako Shudo ,  Masahiko Yamaguchi ,  Hiroyo Usuki ,  Mikino Nosaka ,  Nozomi Takeshita

IPC: A61K8/81 ,  A61K8/60 ,  A61K8/86 ,  A61K8/34 ,  A61Q1/02 ,  A61Q1/14 ,  A61K8/06

CPC classification number: A61K8/8135 ,  A61K8/062 ,  A61K8/345 ,  A61K8/60 ,  A61K8/86 ,  A61K2800/59 ,  A61Q1/02 ,  A61Q1/14

Abstract: A makeup base for skin that is applied to the skin before applying a makeup cosmetic is provided. The makeup base is not smeared or removed by sweat or cold water, but, when rubbed with warm water, is easily removed from the skin together with the makeup cosmetic and without using a cosmetic cleanser. The makeup base includes a water-containing aqueous phase as a continuous phase, which includes (a) a vinyl acetate polymer, (b) polyhydric alcohol, and (c) a hydrophilic nonionic surfactant. The (a) the vinyl acetate polymer is 0.5 to 7 mass % in the makeup base and is dispersed as particles in the aqueous phase, (b) the polyhydric alcohol is 0.5 to 5.5 parts by mass relative to 1 part by mass of (a) the vinyl acetate polymer, and (c) the hydrophilic nonionic surfactant is 1 to 5 mass % in the makeup base.

公开(公告)号：US09933436B2

公开(公告)日：2018-04-03

申请号：US14426404

申请日：2012-09-07

Applicant: Yuzo Yoshida ,  Kentaro Kajiya ,  Michael Detmar

Inventor： Yuzo Yoshida ,  Kentaro Kajiya ,  Michael Detmar

IPC: G01N33/68 ,  C12Q1/68 ,  G01N33/50

CPC classification number: G01N33/6881 ,  C12Q1/6881 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5044 ,  G01N2333/4703 ,  G01N2500/10 ,  G01N2800/20

Abstract: The present invention relates to a method of evaluating cellulite using fibulin-3 and/or sarcoglycan gamma as an indicator in a harvested skin sample, and a method of evaluating a drug for improving, preventing or treating cellulite using fibulin-3 and/or sarcoglycan gamma as an indicator in cultured cells.

公开(公告)号：US09789345B2

公开(公告)日：2017-10-17

申请号：US13146418

申请日：2010-01-27

Applicant: Hideto Ueda ,  Koji Abe ,  Akio Nasu

Inventor： Hideto Ueda ,  Koji Abe ,  Akio Nasu

IPC: A61Q17/04 ,  A61K8/03 ,  A61K8/06 ,  A61K8/73 ,  A61K8/99

CPC classification number: A61Q17/04 ,  A61K8/03 ,  A61K8/06 ,  A61K8/064 ,  A61K8/73 ,  A61K8/99 ,  A61K2800/882

Abstract: To provide a low-viscosity water-in-oil emulsion sunscreen cosmetic composition which is extremely excellent in UV protective enhancing effect (as the protective boosting effect of the UV absorption capability thereof) over a broad UV radiation region and has superior feeling in use (smooth feeling, dry feeling, and non-sticky feeling, etc.). A water-in-oil emulsion sunscreen cosmetic composition comprising (a) from 0.01 to 10% by mass of a water-soluble polymer and (b) from 0.01 to 30% by mass of a UV absorbent, and having a viscosity of at most 10,000 mPa·s (as measured with a B-type viscometer at 30° C.), wherein the aqueous phase accounts for at most 45% by mass.

公开(公告)号：US09757312B2

公开(公告)日：2017-09-12

申请号：US13941467

申请日：2013-07-13

Applicant: Akira Matsuo ,  Tomomi Furukawara

Inventor： Akira Matsuo ,  Tomomi Furukawara

IPC: A61K8/18 ,  A61K8/04 ,  A61K8/73 ,  A61K8/895 ,  A61Q19/00 ,  A61K8/02

CPC classification number: A61K8/042 ,  A61K8/0241 ,  A61K8/18 ,  A61K8/73 ,  A61K8/895 ,  A61K2800/262 ,  A61Q19/00

Abstract: The present invention is a skin cosmetic comprising agar hydrogel particles having an average particle size of 0.2-5 mm obtained by stirring and cooling, in an oil based solvent, an agar aqueous solution prepared such that the breaking stress after the cooling/solidification is 0.005-0.1 MPa and an oil based gel prepared by mixing fine particles of silicone that are three-dimensionally cross-linked chemically and silicone oil and/or hydrocarbon oil.The object of the present invention is to provide a cosmetic that gives a moderate massaging sensation at the time of use.