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    RECONFIGURABLE CHEMICAL SYNTHESIS SYSTEMS AND METHODS
    86.
    发明申请
    RECONFIGURABLE CHEMICAL SYNTHESIS SYSTEMS AND METHODS 审中-公开

    公开(公告)号：US20180311638A1

    公开(公告)日：2018-11-01

    申请号：US15953983

    申请日：2018-04-16

    Applicant: Massachusetts Institute of Technology

    Inventor： Klavs F. Jensen ,  Dale Arlington Thomas, III

    IPC: B01J19/00

    CPC classification number: B01J19/0093 ,  B01J19/004 ,  B01J2219/00788 ,  B01J2219/00795 ,  B01J2219/00889 ,  B01J2219/00894 ,  B01J2219/00905 ,  B01L3/502 ,  B01L3/561 ,  B01L2200/026 ,  B01L2200/028 ,  B01L2400/0487

    Abstract: Aspects of the present disclosure relate to reconfigurable chemical synthesis systems and related components and methods. In some embodiments, the described systems comprise one or more fluidic connector units, wherein each fluidic connector unit comprises a plurality of flexible conduits. In certain cases, a system comprising one or more fluidic connector units is configured to synthesize a first chemical compound by providing a plurality of fluidic connections between a plurality of fluid outlets (e.g., outlets of chemical reagent sources, outlets of pumps) and a plurality of fluid inlets (e.g., inlets of reaction modules, inlets of pumps) through the plurality of flexible conduits. In certain cases, the system is subsequently reconfigured by resetting the system (e.g., disconnecting each fluidic connection) and/or configuring the system to synthesize a second, different chemical compound (e.g., disconnecting one or more fluidic connections and providing one or more additional fluidic connections). According to some embodiments, in order to avoid tangling the flexible conduits during reconfiguration of the system, the fluidic connections are disconnected according to certain inventive methods described herein. In certain embodiments, fluidic connections are disconnected in reverse order relative to the order in which they were formed (e.g., the newest fluidic connection is disconnected first, the oldest fluidic connection is disconnected last). In certain embodiments, certain fluidic connections are targeted for disconnection, and additional fluidic connections are disconnected if they overlap the targeted fluidic connections and were formed more recently than the targeted fluidic connections. The fluidic connection and/or disconnection steps may, in some embodiments, be performed by a robotic manipulator.

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