Method for accurate mass determination with ion trap/time-of-flight mass spectrometer
    88.
    发明授权
    Method for accurate mass determination with ion trap/time-of-flight mass spectrometer 有权
    使用离子阱/飞行时间质谱仪进行精确质量测定的方法

    公开(公告)号:US07138624B2

    公开(公告)日:2006-11-21

    申请号:US11016848

    申请日:2004-12-21

    Applicant: Yoshiaki Kato

    Inventor: Yoshiaki Kato

    Abstract: Accurate mass measurement is carried out for product ions of a sample. A method for accurate mass determination of ions with Trap-TOF/μs includes steps of generating ions of an analyte sample and a standard material; introducing the ions of the analyte sample and the standard material together into an ion trap to trap them; selecting a precursor ion from the ions of the analyte sample to leave the precursor ion and a standard material ion in the ion trap and eliminate other ions; exciting and dissociating the precursor ion to generate product ions; ejecting the precursor ion, its product ions, and the standard material ion trapped in the ion trap to introduce these ions into the TOF mass spectrometer; and measuring a mass spectrum with the TOF mass spectrometer, where correction for accurate masses of the product ions is carried out based on the standard material ion measured.

    Abstract translation: 对样品的产物离子进行准确的质量测量。 用Trap-TOF / mus精确质量测定离子的方法包括产生分析物样品和标准材料的离子的步骤; 将分析物样品和标准材料的离子一起引入离子阱以捕获它们; 从分析物样品的离子中选择前体离子以离开前体离子和离子阱中的标准物质离子并除去其它离子; 激发和解离前体离子以产生产物离子; 喷射前体离子,其产物离子和捕获在离子阱中的标准物质离子将这些离子引入TOF质谱仪中; 并使用TOF质谱仪测量质谱,其中基于测量的标准材料离子进行产物离子的精确质量的校正。

    Ionization gauge
    89.
    发明申请
    Ionization gauge 有权
    电离计

    公开(公告)号:US20050184735A1

    公开(公告)日:2005-08-25

    申请号:US10799446

    申请日:2004-03-12

    CPC classification number: H01J41/04 G01L21/32

    Abstract: An ionization gauge for isolating an electron source from gas molecules includes the electron source for generating electrons, a collector electrode for collecting ions formed by the impact between the electrons and gas molecules, and an electron window which isolates the electron source from the gas molecules. The ionization gauge can have an anode which defines an anode volume and retains the electrons in a region of the anode. The ionization gauge can have a plurality of electron sources and/or collector electrodes. The collector electrode(s) can be located within the anode volume or outside the anode volume. The ionization gauge can have a mass filter for separating the ions based on mass-to-charge ratio. The ionization gauge can be a Bayard-Alpert type that measures pressure or a residual gas analyzer that determines a gas type.

    Abstract translation: 用于从气体分子中分离电子源的电离计包括用于产生电子的电子源,用于收集由电子和气体分子之间的冲击形成的离子的集电极,以及将电子源与气体分子隔离的电子窗口。 电离计可以具有限定阳极体积并将电子保持在阳极区域中的阳极。 电离计可以具有多个电子源和/或集电极。 集电极可以位于阳极体积内或阳极体积外。 电离计可以具有用于基于质荷比分离离子的质量过滤器。 电离计可以是衡量压力的Bayard-Alpert型,也可以是确定气体类型的残留气体分析仪。

    Open channel solid phase extraction systems and methods
    90.
    发明申请
    Open channel solid phase extraction systems and methods 有权
    开放通道固相萃取系统及方法

    公开(公告)号:US20050106585A1

    公开(公告)日:2005-05-19

    申请号:US10866283

    申请日:2004-06-09

    Abstract: The invention provides, inter alia, methods of extracting an analyte from a solution comprising the steps of: passing a solution containing an analyte through an extraction channel having a solid phase extraction surface, whereby analyte adsorbs to the extraction surface of said extraction channel; and eluting the analyte by passing a desorption solution through the channel, wherein the method includes a step wherein a multiple-pass solution is passed through at least some substantial portion of the extraction channel at least twice. Non-limiting examples multiple-pass solutions include a solution containing an analyte, a wash solution and/or a desorption solution.

    Abstract translation: 本发明尤其提供从溶液中提取分析物的方法,包括以下步骤:将含有分析物的溶液通过具有固相萃取表面的提取通道,由此分析物吸附到所述提取通道的提取表面; 并通过使解吸溶液通过通道洗脱分析物,其中该方法包括一个步骤,其中多次通过溶液至少部分提取通道的至少一部分至少两次。 非限制性实例多道次解决方案包括含有分析物,洗涤溶液和/或解吸溶液的溶液。

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