公开(公告)号：US20180012741A1

公开(公告)日：2018-01-11

申请号：US15201786

申请日：2016-07-05

Applicant: Bruker Daltonik GmbH

Inventor： Roland JERTZ

IPC: H01J49/00 ,  H01J49/38

CPC classification number: H01J49/0036 ,  H01J49/38

Abstract: The invention relates to reducing harmonic signals in FT-ICR spectra. Since harmonic signals in quadrupolar 2ω-detection can be more abundant for the same ion motion in the ICR cell as compared to harmonic signals in classical dipolar 1ω-detection, they could hitherto not be reduced to satisfactory levels by any known method, such as gated deflection during ion introduction into, and correcting for an offset electric field axis in the ICR cell. The present disclosure foresees, in addition to other methods carried out for improving the measurement conditions as the case may be, performing the quadrupolar 2ω-detection at least twice, where the phase of the ion excitation radio frequency is turned by 180° in the second measurement. From the sum transient, a Fourier-transformed spectrum is derived. As a result, the broad band spectra of complex substance mixtures like crude oil become cleaner, and misinterpretations of false (harmonic) peaks are minimized.

公开(公告)号：US20170358437A1

公开(公告)日：2017-12-14

申请号：US15531367

申请日：2015-11-24

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Takashi BABA ,  Alex BERYLAND

IPC: H01J49/06 ,  H01J49/38

CPC classification number: H01J49/063 ,  H01J49/38

Abstract: Methods and systems for analyzing ions in a magnetic ion trap are provided herein. In accordance with various aspects of the present teachings, the methods and systems described herein enable Fourier transform ion cyclotron resonance mass spectrometry across relatively narrow gap magnetic fields substantially perpendicular to the axis along which the ions are injected into the ion trap. As a result, smaller, less expensive magnets can be used to produce the high-intensity, uniform magnetic fields utilized in high performance FT-ICR/MS applications. Accordingly, the present teachings enable permanent magnets (as well as electromagnets) to generate these magnetic fields, potentially reducing the cost, size, and/or complexity of the systems described herein relative to conventional FT-ICR systems.

公开(公告)号：US20170032950A1

公开(公告)日：2017-02-02

申请号：US15303226

申请日：2015-04-14

Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)

Inventor： Yury Tsybin ,  Anton Kozhinov ,  Konstantin Nagornov

IPC: H01J49/38 ,  H01J49/00

CPC classification number: H01J49/38 ,  H01J49/0031 ,  H01J49/027

Abstract: The present invention relates to a method and device for measuring m/z ratios of ions in ion cyclotron resonance (ICR) mass spectrometry. The described ion traps for ICR mass spectrometry are distinct from the previous configurations by having one or many narrow aperture (flat) detection electrodes that could be moved radially inward the ICR trap, for example on the plane where radiofrequency excitation potential is minimal, closer to the post-excitation ion trajectories.

Abstract translation: 本发明涉及一种用于测量离子回旋共振（ICR）质谱中离子的m / z比的方法和装置。 所描述的用于ICR质谱的离子阱不同于先前的配置，通过具有一个或许多窄孔径（平坦的）检测电极，其可以在ICR陷阱的径向向内移动，例如在射频激发电位最小的平面上，更接近 后激发离子轨迹。

公开(公告)号：US20160320366A1

公开(公告)日：2016-11-03

申请号：US15143064

申请日：2016-04-29

Applicant: Dayan Goodenowe

Inventor： Dayan Goodenowe

IPC: G01N33/49 ,  H01J49/38 ,  H01J49/00

CPC classification number: G01N33/49 ,  G01N33/57484 ,  G01N33/6896 ,  G01N33/92 ,  G01N2560/00 ,  G01N2800/50 ,  G01N2800/7042 ,  H01J49/0031 ,  H01J49/38

Abstract: The present invention relates to methods for the diagnosis and risk assessment of plasmalogen deficiency mediated diseases of aging. The present invention describes the relationship between plasmalogen biosynthesis dysfunction and the biochemical and clinical manifestations of age related disorders. Specifically the present invention describes an increased prevalence of colon cancer, prostate cancer, lung cancer, breast cancer, ovary cancer, kidney cancer, cognitive impairment and dementia in subjects suffering from adult onset plasmalogen biosynthesis disorder (AO-PBD).

Abstract translation: 本发明涉及用于诊断和评估缺血性贫血的老化疾病的方法。 本发明描述了质膜生物合成功能障碍与年龄相关疾病的生化和临床表现之间的关系。 具体地说，本发明描述了患有成人起始型血浆原生质合成障碍（AO-PBD）的受试者中结肠癌，前列腺癌，肺癌，乳腺癌，卵巢癌，肾癌，认知障碍和痴呆症的患病率增加。

公开(公告)号：US09230791B2

公开(公告)日：2016-01-05

申请号：US14358809

申请日：2011-11-28

Applicant: Hyun Sik Kim ,  Seung Young Kim ,  Mo Yang

Inventor： Hyun Sik Kim ,  Seung Young Kim ,  Mo Yang

IPC: H01J49/08 ,  H01J49/10 ,  H01J43/04 ,  H01J49/00 ,  H01J49/42 ,  H01J27/02 ,  H01J49/14 ,  H01J43/24 ,  H01J49/38

CPC classification number: H01J49/08 ,  H01J27/028 ,  H01J43/04 ,  H01J43/246 ,  H01J49/0045 ,  H01J49/0054 ,  H01J49/10 ,  H01J49/147 ,  H01J49/38 ,  H01J49/426

Abstract: An anion generating and electron capture dissociation apparatus using cold electrons, which comprises a cold electron generation module configured to generate a large quantity of cold electrons from ultraviolet photons radiated into a mass spectrometer vacuum chamber which is in a high vacuum state has a plurality of ultraviolet diodes configured to emit the ultraviolet photons in the mass spectrometer vacuum chamber. Micro-channel plate (MCP) electron multiplier plates induce and amplify initial electron emissions of the ultraviolet photons from the ultraviolet diodes, and generate a large quantity of electron beams from a rear plate. An electron focusing lens is configured to focus the electron beams amplified through the MCP electron multiplier plates. A grid is configured to adjust energy and an electric current of the electron beams together with the electron focusing lens.

Abstract translation: 使用冷电子的阴离子产生和电子捕获解离装置，其包括被配置为从辐射到处于高真空状态的质谱仪真空室的紫外光子产生大量冷电子的冷电子发生模块，具有多个紫外线 配置为在质谱仪真空室中发射紫外光子的二极管。 微通道板（MCP）电子倍增板诱导和放大来自紫外二极管的紫外光子的初始电子发射，并从背板产生大量的电子束。 电子聚焦透镜被配置为聚焦通过MCP电子倍增器板放大的电子束。 栅格被配置为与电子聚焦透镜一起调节电子束的能量和电流。

公开(公告)号：US20150106028A1

公开(公告)日：2015-04-16

申请号：US13467693

申请日：2012-05-09

Applicant: Omer Refa KOSEOGLU ,  Adnan Al-Hajji ,  Hendrik Muller ,  Hanadi H. Jawad

Inventor： Omer Refa KOSEOGLU ,  Adnan Al-Hajji ,  Hendrik Muller ,  Hanadi H. Jawad

IPC: H01J49/00 ,  G01N33/28 ,  H01J49/38 ,  G06F19/00

CPC classification number: H01J49/38 ,  G01N33/2811 ,  G01N33/2823 ,  G01N33/2829 ,  G16C20/30

Abstract: A system, method and computer program product are provided for calculating the cetane number, octane number, pour point, cloud point and aniline point of crude oil fractions from the density and Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) of a sample of the crude oil.

Abstract translation: 提供一种系统，方法和计算机程序产品，用于从密度和傅里叶变换离子回旋共振质谱（FT-ICR MS）计算原油馏分的十六烷值，辛烷值，倾点，浊点和苯胺点 原油样品。

公开(公告)号：US08835840B1

公开(公告)日：2014-09-16

申请号：US12886412

申请日：2010-09-20

Applicant: Kelvin G. Lynn ,  Marc H. Weber

Inventor： Kelvin G. Lynn ,  Marc H. Weber

IPC: H01J49/42 ,  H01J49/38

CPC classification number: H01J49/424 ,  H01J49/38

Abstract: Micromachined holes in stacks of silicon wafers can be used to define high aspect ratio charged particle storage volumes. Each wafer can define a section of a tubular trap, and electric fields in each wafer can be controlled independently so that charged particles can be stored and shuttled among the sections.

Abstract translation: 可以使用硅晶片堆叠中的微加工孔来定义高纵横比带电粒子的存储体积。 每个晶片可以限定管状陷阱的一部分，并且可以独立地控制每个晶片中的电场，使得带电粒子可以在部分之间被存储和穿梭。

公开(公告)号：US20080296494A1

公开(公告)日：2008-12-04

申请号：US11659075

申请日：2005-08-02

Applicant: Michel Heninger ,  Joel Lemaire ,  Gerard Mauclaire ,  Pierre Boissel

Inventor： Michel Heninger ,  Joel Lemaire ,  Gerard Mauclaire ,  Pierre Boissel

IPC: H01J49/38

CPC classification number: H01J49/38

Abstract: The invention concerns a vacuum magnetic ion trap comprising an assembly forming a permanent magnet including at least two magnetized structures (30, 32) in the form of hollow cylinders, one convergent radial structure, magnetized along a convergent radial direction, and one divergent radial structure, magnetized along a divergent radial direction, said convergent and divergent radial magnetized structures (30, 32) being arranged along a common longitudinal axis (XX′). Said trap also comprises a sealed chamber (4) containing an ion confinement cell (8) fixed between said at least two magnetized structures (30, 32) and including at least two trapping electrodes (10) connectable to a voltage generator (12).

Abstract translation: 本发明涉及一种真空磁离子阱，其包括形成永磁体的组件，所述永磁体包括中空圆筒形式的至少两个磁化结构（30,32），沿会聚径向磁化的一个会聚径向结构和一个发散径向结构 沿着发散的径向方向磁化，所述收敛和发散的径向磁化结构（30,32）沿着共同的纵向轴线（XX'）布置。 所述捕集器还包括密封室（4），其包含固定在所述至少两个磁化结构（30,32）之间并且可连接到电压发生器（12）的至少两个捕获电极（10）的离子限制室（8）。

公开(公告)号：US07038200B2

公开(公告)日：2006-05-02

申请号：US10833938

申请日：2004-04-28

Applicant: Evgenij Nikolaev

Inventor： Evgenij Nikolaev

IPC: H01J49/38 ,  H01J49/14

CPC classification number: H01J49/38

Abstract: The invention describes an ion cyclotron resonance (ICR) mass spectrometer with an ICR trap, the ICR trap having as trapping electrodes two ion reflecting electrode structures operated by RF voltages without any DC voltage. The usual apertured ion trapping electrodes are replaced by multitudes of structural elements, electrically conducting, and repeating spatially in one or two directions of a surface, neighboring structure elements being connected each to different phases of an RF voltage. In the simplest case a grid of parallel wires can be used. The surface of such structures reflects ions of both polarities, if the mass-to-charge ratio of the ions is higher than a threshold.

Abstract translation: 本发明描述了具有ICR捕集器的离子回旋共振（ICR）质谱仪，ICR捕集阱具有作为捕获电极的两个离子反射电极结构，由没有任何DC电压的RF电压操作。 通常的有孔离子捕获电极被多个结构元件代替，导电并在空间上在表面的一个或两个方向上重复地进行，相邻的结构元件分别连接到RF电压的不同相位。 在最简单的情况下，可以使用平行线的格栅。 如果离子的质荷比高于阈值，则这种结构的表面反映了两种极性的离子。

公开(公告)号：US06960761B2

公开(公告)日：2005-11-01

申请号：US09842383

申请日：2001-04-25

Applicant: David E. Clemmer

Inventor： David E. Clemmer

IPC: G01N27/62 ,  G01N27/64 ,  H01J49/26 ,  H01J49/38 ,  H01J49/40 ,  B01D59/44 ,  B01J49/00

CPC classification number: G01N27/622 ,  H01J49/004 ,  H01J49/38

Abstract: An ion separation instrument includes an ion source coupled to at least a first ion mobility spectrometer having an ion outlet coupled to a mass spectrometer. Instrumentation is further included to provide for passage to the mass spectrometer only ions defining a preselected ion mobility range. In one embodiment, the ion mobility spectrometer is provided with electronically controllable inlet and outlet gates, wherein a control circuit is operable to control actuation of the inlet and outlet gates as a function of ion drift time to thereby allow passage therethrough only of ions defining a mobility within the preselected ion mobility range. In another embodiment, an ion trap is disposed between the ion mobility spectrometer and mass spectrometer and is controlled in such a manner so as to collect a plurality of ions defining a mobility within the preselected ion mobility range prior to injection of such ions into the mass spectrometer. In yet another embodiment, an ion inlet of the ion trap may be electronically controlled relative to operation of the ion mobility spectrometer as a function of ion drift time to thereby allow passage therein only of ions defining a mobility within the preselected ion mobility range. The mass spectrometer is preferably a Fourier Transform Ion Cyclotron Resonance mass spectrometer, and the resulting ion separation instrument may further include therein various combinations of ion fragmentation, ion mass filtering, ion trap, charge neutralization and/or mass reaction instrumentation.

Abstract translation: 离子分离仪器包括耦合到具有耦合到质谱仪的离子出口的至少第一离子迁移谱仪的离子源。 进一步包括仪器以提供通过质谱仪只有限定预选离子迁移范围的离子。 在一个实施例中，离子迁移谱仪提供有电子可控的入口和出口门，其中控制电路可操作以控制入口和出口门的致动作为离子漂移时间的函数，从而仅允许通过限定 预选离子迁移范围内的迁移率。 在另一个实施方案中，将离子阱设置在离子迁移谱仪和质谱仪之间，并以这样的方式进行控制，以便在将这样的离子注入质量之前收集限定预选离子迁移率范围内的迁移率的多个离子 光谱仪 在另一个实施方案中，离子阱的离子入口可以相对于离子迁移谱仪的操作而电子控制，作为离子漂移时间的函数，从而允许仅限定在预选离子迁移率范围内的迁移率的离子。 质谱仪优选为傅里叶变换离子回旋共振质谱仪，所得到的离子分离仪器还可以包括离子碎片化，离子质量过滤，离子阱，电荷中和和/或质量反应仪器的各种组合。