公开(公告)号：US20150353676A1

公开(公告)日：2015-12-10

申请号：US14396594

申请日：2013-04-22

申请人： NANOPROTEAGEN LTD.

发明人： Harpal Singh

IPC分类号： C08G63/06 ,  A61K9/51 ,  A61K38/08 ,  A61K31/704

CPC分类号： A61K38/08 ,  A61K9/0019 ,  A61K9/5146 ,  A61K9/5153 ,  A61K31/337 ,  A61K31/454 ,  A61K31/473 ,  A61K31/505 ,  A61K31/704 ,  A61K47/34 ,  A61K47/6933 ,  A61K47/6935 ,  A61K47/6937 ,  B82Y30/00 ,  C08G63/664 ,  Y10T428/2982

摘要： The present invention relates to the field of nanotechnology, in particular, to the production of biodegradable polymeric nanoparticles. The present invention provides a biodegradable polymeric nanoparticle made up of a block copolymer and a process for producing the same. The nanoparticles are produced without the use of any emulsifiers and have a size ranging from 30-120 nm. The methods of controlling the drug loading capacity are disclosed along with the process of producing entity-loaded nanoparticles. Compositions comprising the nanoparticles and their use in therapeutics, diagnostics and theranostics are also disclosed.

摘要翻译： 本发明涉及纳米技术领域，特别涉及可生物降解的聚合物纳米颗粒的生产。 本发明提供一种由嵌段共聚物组成的可生物降解的聚合物纳米颗粒及其制造方法。 在不使用任何乳化剂的情况下制备纳米颗粒，其尺寸范围为30-120nm。 公开了控制药物负载能力的方法以及生产实体负载纳米颗粒的方法。 还公开了包含纳米颗粒的组合物及其在治疗，诊断和治疗中的用途。

公开(公告)号：US09150690B2

公开(公告)日：2015-10-06

申请号：US13819199

申请日：2011-06-27

申请人： Yoshitake Takahashi ,  Takuma Naotsuka ,  Ken Sudo ,  Hiroyuki Ome

发明人： Yoshitake Takahashi ,  Takuma Naotsuka ,  Ken Sudo ,  Hiroyuki Ome

IPC分类号： C08G63/80 ,  C08L67/04 ,  C08G63/06 ,  C08G63/82 ,  C08G63/08 ,  C08G63/91

CPC分类号： C08G63/80 ,  C08G63/06 ,  C08G63/08 ,  C08G63/823 ,  C08G63/912 ,  C08G2261/126 ,  C08L67/04 ,  C08L2205/025 ,  C08L2205/05

摘要： A method of producing a polylactic acid block copolymer constituted of a segment(s) composed of L-lactic acid units and a segment(s) composed of D-lactic acid units, includes obtaining a mixture by mixing poly-L-lactic acid and poly-D-lactic acid one of which has a weight average molecular weight of 60,000 to 300,000 and the other of which has a weight average molecular weight of 10,000 to 50,000, the mixture having a weight average molecular weight of not less than 90,000 and a degree of stereocomplexation (Sc) satisfying: Sc=ΔHh/(ΔHl+ΔHh)×100>60 (wherein ΔHh represents the heat of fusion of stereocomplex crystals (J/g), and ΔHl represents the heat of fusion of crystals of poly-L-lactic acid alone and crystals of poly-D-lactic acid alone (J/g)); and subsequently subjecting the mixture to solid-phase polymerization at a temperature lower than the melting point of the mixture.

摘要翻译： 由L-乳酸单元构成的链段和由D-乳酸单元构成的链段构成的聚乳酸嵌段共聚物的制造方法包括：将聚-L-乳酸和 聚D-乳酸的重均分子量为60000〜300000，另一个重均分子量为10,000〜50,000，该重均分子量不小于90,000， 满足：Sc =＆Dgr; Hh /（＆Dgr; Hl +＆Dgr; Hh）×100> 60（其中＆Dgr; Hh表示立体络合物晶体的熔融热（J / g）和＆Dgr; H1 表示单独的聚-L-乳酸晶体和单独的聚-D-乳酸晶体的熔合热（J / g））; 然后在比混合物的熔点低的温度下使混合物进行固相聚合。

公开(公告)号：US09149561B2

公开(公告)日：2015-10-06

申请号：US13800853

申请日：2013-03-13

申请人： Tepha, Inc.

发明人： Said Rizk ,  Dennis W. Connelly ,  Matthew Bernasconi ,  Andrew J. Carter ,  David P. Martin ,  Simon F. Williams

IPC分类号： A61K47/30 ,  A61L27/18 ,  C08G63/06 ,  B29C45/00 ,  A61L31/12 ,  A61L27/44 ,  A61L27/46 ,  A61L27/58 ,  A61L31/14

CPC分类号： A61L27/18 ,  A61L27/446 ,  A61L27/46 ,  A61L27/58 ,  A61L31/127 ,  A61L31/128 ,  A61L31/148 ,  B29C45/0055 ,  C08G63/06

摘要： Compositions of P4HB and processes to injection mold these compositions have been developed. These compositions are prepared from P4HB polymers and blends having intrinsic viscosities less than 3.2 dl/g but greater than 0.8 dl/g, moisture contents of less than 0.5% by weight, and more preferably less than 0.05% by weight, and using a polymer melt temperature during molding of at least 150° C. A preferred embodiment comprises a P4HB molding with an intrinsic viscosity of less than 3.2 dl/g that degrades rapidly in vivo.

摘要翻译： 已经开发了P4HB的组合物和注射成型方法。 这些组合物由P4HB聚合物和特性粘度小于3.2dl / g但大于0.8dl / g，水分含量小于0.5wt％，更优选小于0.05wt％的共混物制备，并使用聚合物 成型期间的熔融温度至少为150℃。优选的实施方案包括特性粘度小于3.2dl / g的P4HB模塑，其体内迅速降解。

公开(公告)号：US20150210801A1

公开(公告)日：2015-07-30

申请号：US14419414

申请日：2013-07-11

申请人： KANEKA CORPORATION ,  RIKEN

发明人： Hideki Abe ,  Noriyuki Suzuki ,  Tetsuya Minami ,  Nobuo Nakamura

IPC分类号： C08G63/06

CPC分类号： C08L67/04 ,  C08G63/06 ,  C08G63/08 ,  C08K5/053

摘要： An object is to increase crystallization speed, which is a drawback of polyhydroxyalkanoate, to improve processability in processing such as injection molding or blow molding and increase the speed of processing and is, in addition, to refine the crystal of polyhydroxyalkanoate to suppress a change of mechanical properties with passage of time of a resulting molded article. Disclosed herein is a polyester resin composition containing polyhydroxyalkanoate and pentaerythritol.

摘要翻译： 目的是提高结晶速度，这是聚羟基链烷酸酯的缺点，以提高加工中的加工性能，例如注射成型或吹塑成型，并提高加工速度，此外，为了改善聚羟基链烷酸酯的结晶以抑制 机械性能随着所得模塑制品的时间流逝。 本文公开了含有聚羟基链烷酸酯和季戊四醇的聚酯树脂组合物。

公开(公告)号：US09062159B2

公开(公告)日：2015-06-23

申请号：US14129111

申请日：2011-11-03

申请人： Hong Li ,  Quanxing Zhang ,  Wei Jiang ,  Bingcai Pan

发明人： Hong Li ,  Quanxing Zhang ,  Wei Jiang ,  Bingcai Pan

IPC分类号： C08G63/87 ,  A61L27/18 ,  A61K47/34 ,  A61L17/00 ,  C08G63/06 ,  C08G63/08 ,  C08G63/82 ,  A61L27/54 ,  A61L17/12

CPC分类号： C08G63/87 ,  A61K47/34 ,  A61L17/00 ,  A61L17/12 ,  A61L27/18 ,  A61L27/54 ,  A61L2300/602 ,  A61L2430/02 ,  C08G63/06 ,  C08G63/08 ,  C08G63/78 ,  C08G63/823 ,  C08L67/04

摘要： A method for synthesizing a medical grade biodegradable material, poly(lactic-co-glycolic acid), copolycondensation of lactic acid and glycolic acid catalyzed by biomass creatinine. The present invention uses commercialized creatinine (a type of biomaterial organic guanidine compounds—the arginine metabolite creatinine (CR) in human body) as the catalyst and industrial lactic acid (LA, mass content 85%, aqueous solution) and glycolic acid (GA, 95%) as the monomer to synthesize the high biosafety of medical poly(lactic-co-glycolic acid) in terms of two steps polycondensation without solvent. The method of the present invention has the following characters: green technology is used, raw materials required are low in costs, operation is simple and convenient, and it is easy for industrialization; the catalyst, creatinine, used in the invention has high biocompatibility and biosafety, and no cytotoxicity; the poly(lactic-co-glycolic acid) synthesized is free of any metal and other toxic residues; Further, the molecular weight distribution for all synthesized products is narrow and the molecular weight is controllable within 1.8-17.7×104; and the poly(lactic-co-glycolic acid) synthesized is suitable for use as implantable material for hard tissue repair, surgical sutures, and the carrier for targeting drugs and controlled release drugs.

摘要翻译： 用于合成医用级生物降解材料的方法，聚（乳酸 - 共 - 乙醇酸），由生物体肌酐催化的乳酸和乙醇酸的共缩聚。 本发明使用商业化肌酐（一种生物材料有机胍化合物 - 人体中的精氨酸代谢物肌酸酐（CR））作为催化剂和工业乳酸（LA，质量含量85％，水溶液）和乙醇酸（GA， 95％）作为单体，以两步缩聚无溶剂的方式合成医用聚（乳酸 - 共 - 乙醇酸）的高生物安全性。 本发明的方法具有以下特征：使用绿色技术，所需原料成本低，操作简单方便，工业化容易; 本发明使用的催化剂，肌酸酐具有高生物相容性和生物安全性，无细胞毒性; 合成的聚（乳酸 - 共 - 乙醇酸）不含任何金属和其他有毒残留物; 此外，所有合成产物的分子量分布窄，分子量可控于1.8-17.7×104; 合成的聚（乳酸 - 共 - 乙醇酸）适用于硬组织修复，手术缝合线和用于靶向药物和控释药物的载体的植入材料。

公开(公告)号：US20150118152A1

公开(公告)日：2015-04-30

申请号：US14528605

申请日：2014-10-30

申请人： Tepha, Inc.

发明人： Amit Ganatra ,  Bhavin Shah ,  Said Rizk ,  David P. Martin ,  Simon F. Williams

IPC分类号： A61L27/18 ,  A61L31/04 ,  A61L31/06 ,  C08G63/06 ,  A61L27/26

CPC分类号： A61L27/18 ,  A61L27/26 ,  A61L31/041 ,  A61L31/06 ,  B29C70/52 ,  C08G63/06 ,  C08L67/04

摘要： Compositions of P4HB (poly-4-hydroxybutyrate) and copolymers thereof, have been developed for pultrusion, as well as processes to produce profiles from these compositions by pultrusion. These pultrusion processes provide profiles without causing structural damage to the surface of the profile. The profiles may be used in medical applications. These compositions include P4HB, and copolymers thereof, having intrinsic viscosities less than 3.2 dl/g but greater than 0.8 dl/g. The profile may be formed using conditions such as: pull rate of 0.1 to 100 mm/min, die temperature of up to 95° C., rod stock temperature up to 95° C., draw ratio of up to 100×, pulling force of greater than 10 MPa, and clamping pressure at least 10% higher than the pulling force. Preferably, the profile is formed by pulling the rod stock through a series of dies placed at intervals with the hole sizes decreasing in diameter by 0.1 to 10 mm.

摘要翻译： P4HB（聚-4-羟基丁酸酯）及其共聚物的组合物已被开发用于拉挤成型，以及通过拉挤成型由这些组合物生产型材的方法。 这些拉挤成型工艺提供轮廓，而不会对轮廓的表面造成结构损坏。 型材可用于医疗应用。 这些组合物包括特性粘度小于3.2dl / g但大于0.8dl / g的P4HB及其共聚物。 型材可以使用以下条件形成：拉伸速度为0.1至100mm / min，模具温度高达95℃，棒材温度高达95℃，拉伸比可达100×，拉力 大于10MPa，并且夹紧压力比拉力高至少10％。 优选地，通过将​​棒材拉伸通过一系列模具来形成轮廓，所述一系列模具以直径减小0.1至10mm的孔径间隔放置。

公开(公告)号：US09012593B2

公开(公告)日：2015-04-21

申请号：US13810884

申请日：2011-06-14

申请人： Sun Hwa Chang ,  Sang Mi Kang ,  Dae Yeon Kim ,  Jin Kyu Lee

发明人： Sun Hwa Chang ,  Sang Mi Kang ,  Dae Yeon Kim ,  Jin Kyu Lee

IPC分类号： C08G63/02 ,  C08G63/06 ,  C08G63/19 ,  C08G63/685 ,  C08G63/78 ,  C08L67/03 ,  C09K19/38 ,  C08G64/00

CPC分类号： C08G63/065 ,  C08G63/19 ,  C08G63/685 ,  C08G63/78 ,  C08L67/03 ,  C09K19/3809

摘要： Methods of preparing an aromatic liquid crystalline polyester resin and an aromatic liquid crystalline polyester resin compound are disclosed. A method of preparing an aromatic liquid crystalline polyester resin may include: acetylating a first monomer including an amino group by a reaction with a carboxylic acid anhydride; acetylating a second monomer including a hydroxyl group and not including an amino acid group with an additional carboxylic acid anhydride; and synthesizing an aromatic liquid crystalline polyester prepolymer by a condensation polymerization reaction of the acetylated first and second monomers with dicarboxylic acid. A method of preparing an aromatic liquid crystalline polyester resin compound may use the aromatic liquid crystalline polyester resin prepared according to the forgoing method.

摘要翻译： 公开了制备芳族液晶聚酯树脂和芳族液晶聚酯树脂化合物的方法。 制备芳族液晶聚酯树脂的方法可以包括：通过与羧酸酐的反应乙酰化包括氨基的第一单体; 用另外的羧酸酐乙酰化包含羟基并且不包括氨基酸基团的第二单体; 并通过乙酰化的第一和第二单体与二羧酸的缩聚反应合成芳族液晶聚酯预聚物。 制备芳族液晶聚酯树脂化合物的方法可以使用根据前述方法制备的芳族液晶聚酯树脂。

公开(公告)号：US20150087802A1

公开(公告)日：2015-03-26

申请号：US14316363

申请日：2014-06-26

申请人： UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN ,  THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY

发明人： Kevin O'Connor ,  Maciej GUZIK ,  Ramesh PADAMATI ,  Shane KENNY

IPC分类号： C08G63/06 ,  C12P7/62

CPC分类号： C08G63/06 ,  C12P7/625 ,  Y02E50/13

摘要： A method for producing polyhydroxyalkanoate (PHA) comprises the steps of culturing in a culture medium comprising pyrolysis wax obtained from the pyrolysis of polyethylene and optionally a surfactant one or more bacterial strains which are capable of accumulating PHA from pyrolysis wax, and recovering the PHA from the culture medium. Typically, the bacterial strains are selected from the group consisting of: A. calcoaceticus BD413; A. calcoaceticus RR8; B. sepacia RR10; P. aeruginosa 3924; P. aeruginosa GL-1; P. aeruginosa PAO1; P. aeruginosa RR1; and P. olevorans.

摘要翻译： 一种生产聚羟基链烷酸酯（PHA）的方法包括以下步骤：在包含由聚乙烯热解得到的热解蜡和任选的表面活性剂的培养基中培养，所述热解蜡能够从热解蜡中积聚PHA，并从PHD中回收PHA 培养基。 通常，细菌菌株选自：A.calcoaceticus BD413; 胆碱乙酸杆菌RR8; B.分裂RR10; 铜绿假单胞菌3924; 铜绿假单胞菌GL-1; 铜绿假单胞菌PAO1; 铜绿假单胞菌RR1; 和P. olevorans。

公开(公告)号：US20150065682A1

公开(公告)日：2015-03-05

申请号：US14473079

申请日：2014-08-29

申请人： Elevance Renewable Sciences, Inc.

发明人： Suresh Narine ,  Laziz Bouzidi ,  Shaojun Li ,  Jesmy Jose ,  Ghazaleh Pourfallah

IPC分类号： C08G63/06

CPC分类号： C08G63/06 ,  C07C59/01 ,  C07C69/675 ,  C08G63/08

摘要： The synthesis of certain medium and long chain ω-hydroxy esters and certain ω-hydroxy fatty acids is disclosed. Such ω-hydroxy esters and ω-hydroxy fatty acids are derived from natural oils, and their corresponding polymers were obtained by melt polycondensation. Additionally, the present effort investigates the effects of structural and molecular parameters on the thermal and mechanical properties of ω-hydroxy ester based polymers. Additionally, the present effort investigates the co-polymerization of ω-hydroxy ester based polymers.

摘要翻译： 公开了某些中长链ω-羟基酯和某些ω-羟基脂肪酸的合成。 这种ω-羟基酯和ω-羟基脂肪酸衍生自天然油，其相应的聚合物通过熔融缩聚获得。 此外，本努力研究结构和分子参数对ω-羟基酯基聚合物的热和机械性能的影响。 另外，本发明的努力研究了ω-羟基酯基聚合物的共聚合。

公开(公告)号：US08920789B2

公开(公告)日：2014-12-30

申请号：US13360567

申请日：2012-01-27

申请人： Joel S. Goldberg ,  Joe Brice Weinberg

发明人： Joel S. Goldberg ,  Joe Brice Weinberg

IPC分类号： G01N33/566 ,  A61K31/765 ,  A61K31/225 ,  C08G63/06 ,  C07C69/68 ,  A61P35/00 ,  C12N5/09 ,  G01N33/50 ,  G01N33/574

CPC分类号： C08G63/06 ,  A61K31/765 ,  C07C59/08 ,  C12N5/0693 ,  C12N2533/40 ,  G01N33/5011 ,  G01N33/57407

摘要： The invention provides method for sequestering or trapping L-lactate in or near a tumor cell comprising contacting an isolated polymer of D-lactic acid (PDLA) or an equivalent, derivative or analog thereof with the tumor cell so that the PDLA binds L-lactate in or near the cell and thereby sequestering or trapping L-lactate in or near the tumor cells.

摘要翻译： 本发明提供了在肿瘤细胞内或附近螯合或捕获L-乳酸的方法，其包括将分离的D-乳酸聚合物（PDLA）或其等同的衍生物或类似物与肿瘤细胞接触，使得PDLA结合L-乳酸 在细胞内或细胞附近，从而在肿瘤细胞中或附近螯合或捕获L-乳酸盐。