公开(公告)号：US20230235270A1

公开(公告)日：2023-07-27

申请号：US18002707

申请日：2021-06-22

申请人： ASTRAVEUS

发明人： Jérémie LAURENT ,  Giulia GHINATTI ,  Vincent THISSE ,  Xue HOU

IPC分类号： C12M1/00 ,  C12M3/06 ,  C12M1/26 ,  C12M1/34

CPC分类号： C12M47/08 ,  C12M23/16 ,  C12M23/40 ,  C12M33/12 ,  C12M41/40

摘要： A device for homogenizing a multicomponent fluid including a main channel, a first and a second buffer channels, a collector connected to the main channel with a main conduct, to the first buffer channel with a first fiber and to the second buffer channel with a second fiber. The collector further includes a flow separation point aimed at dividing the main conduct into the first and second fibers, a pumping unit configured to move the multicomponent fluid from the main channel to the first or the second buffer channels through the collector and move the multicomponent fluid from the first or the second buffer channels to the main channel through the collector.

公开(公告)号：US20220410161A1

公开(公告)日：2022-12-29

申请号：US17780254

申请日：2020-12-04

申请人： ASTRAVEUS

发明人： Jérémie LAURENT ,  Xue HOU

IPC分类号： B01L3/00

摘要： A microfluidic device, intended for processing particles, in particular cells. This device includes a processing chamber with at least two elongated segments, one input seeding channel and one output seeding channel configured to define a seeding flow, and connection channels configured to allow the seeding flow through all the processing chambers serially.

公开(公告)号：US12102999B2

公开(公告)日：2024-10-01

申请号：US17417537

申请日：2019-12-27

申请人： ASTRAVEUS

发明人： Jérémie Laurent ,  Vincent Thisse

IPC分类号： B01L3/00 ,  B01F23/00 ,  B01F23/41 ,  B01F101/23 ,  B01L3/02 ,  B23Q17/24 ,  C12M1/34 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/686 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/39 ,  G01N21/45 ,  G01N21/64 ,  G01N30/12 ,  G01N30/68 ,  G01N30/70 ,  G01N30/72 ,  G01N30/88 ,  G01N33/00 ,  G01N33/18 ,  G01N33/50 ,  G01N33/543 ,  G01N33/68 ,  G01N35/04 ,  G01N35/10

CPC分类号： B01L3/502715 ,  B01L3/0289 ,  B01L3/50273 ,  B01L2200/0673 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2300/028 ,  B01L2300/0681 ,  B01L2300/0883 ,  B01L2300/14 ,  B01L2300/1883

摘要： A device for handling a particle suspension, in particular a cell suspension, which includes at least one channel for flowing the particle suspension, a pumping unit configured to move a driving fluid and control element for controlling the pumping unit. Also, a method for handling a particle suspension, which includes flowing the particle suspension in or out of at least one channel using a driving fluid for driving the particle suspension in the channel.

公开(公告)号：US20230249177A1

公开(公告)日：2023-08-10

申请号：US18003207

申请日：2021-06-22

申请人： ASTRAVEUS

发明人： Jérémie LAURENT ,  Xue HOU

IPC分类号： B01L3/00 ,  B01L3/02

CPC分类号： B01L3/502715 ,  B01L3/0293 ,  B01L2200/146 ,  B01L2300/0681 ,  B01L2400/0487 ,  B01L2400/0655

摘要： A liquid delivery device that includes a channel having an inner section lower than 9 mm2 and inner volume lower than 50 mL, a gas mass flowmeter connected to the inlet of the channel, and a pressure control unit suitable to control pressure inside the channel by flowing gas through the gas flowmeter.

公开(公告)号：US20230145770A1

公开(公告)日：2023-05-11

申请号：US17916280

申请日：2020-04-03

申请人： ASTRAVEUS

发明人： Nicolas JAMOND ,  Jérémie LAURENT

IPC分类号： B29C43/56 ,  B29C43/36 ,  B29C43/10 ,  B29C43/52 ,  B29C59/02

CPC分类号： B29C43/56 ,  B29C43/3607 ,  B29C43/10 ,  B29C43/52 ,  B29C59/022 ,  B29C2059/023 ,  B29C2043/562 ,  B29C2043/3233

摘要： This molding apparatus is intended for the manufacturing of a molded article from a raw material intended to be arranged in a first region of an embossing chamber of the molding apparatus. The embossing chamber includes a mold and a counter-mold, the molds being arranged on two opposite sides of the first region. The molding apparatus further includes a second chamber having a common wall with the embossing chamber and a pressurization system configured to generate a predefined pressure differential between the embossing chamber and the second chamber, the common wall including at least one embossing actuator, the embossing actuator being configured to generate a movement of at least one of the molds so as to mold the raw material when a predefined pressure differential is applied.

公开(公告)号：US20230016447A1

公开(公告)日：2023-01-19

申请号：US17783092

申请日：2020-12-18

申请人： ASTRAVEUS

发明人： Jérémie LAURENT ,  Giulia GHINATTI ,  Philippe KERGOURLAY

IPC分类号： B01L3/00

摘要： A system for processing biological particles including bioprocessing microfluidic devices, reservoirs, buffer tanks and two fluidic connection systems. A first fluidic connection system includes valves and connecting elements between valves, so that each reservoir or port configured to connect a reservoir may be in fluidic connection with each buffer tank, and a second fluidic connection system includes valves and connecting elements between valves, so that each bioprocessing microfluidic device may be in fluidic connection with each buffer tank.

公开(公告)号：US20220266247A1

公开(公告)日：2022-08-25

申请号：US17636722

申请日：2020-08-28

申请人： ASTRAVEUS

发明人： Jérémie LAURENT ,  Nicolas JAMOND ,  Vincent THISSE ,  Philippe KERGOURLAY

IPC分类号： B01L3/00

摘要： An apparatus suitable for clamping at least one microfluidic device, which includes (i) a fluid-tight chamber having a fluid inlet, the chamber being configured to receive a microfluidic device to be clamped by compression of at least one deformable part of the microfluidic device under the action of a pressure of a clamping fluid in the chamber, and (ii) a perfusion fluid management system configured to adjust the pressure of a perfusion fluid in the microfluidic device in such a way that, during a clamping operation, the pressure of the clamping fluid in the chamber is strictly higher than the pressure of the perfusion fluid in the microfluidic device.

公开(公告)号：US20210284942A1

公开(公告)日：2021-09-16

申请号：US17252390

申请日：2019-06-21

申请人： Jérémie LAURENT ,  ASTRAVEUS ,  ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS ,  UNIVERSITE DE PARIS

发明人： Jérémie LAURENT ,  Nicolas JAMOND ,  Andrew SHAILER-SMITH ,  Laetitia PINTE

IPC分类号： C12M3/06 ,  C12M1/04 ,  C12M1/00

摘要： A microfluidic device for processing particles, including: an elongated chamber including elongated segment(s), input seeding channel(s) and one output seeding channel defining a seeding flow transverse to the longitudinal direction of the segment, input harvest channel(s) and one output harvest channel defining a harvest flow in the longitudinal direction, wherein, for the segment, a single input seeding tree defines input seeding channels and a single output seeding tree defines output seeding channels, junctions of the input seeding channels and output seeding channels with the processing chamber being distributed along the segment on both sides of the chamber, wherein: Rs_input ⁢ S 2 ⁢ 1 ( ∑ k ⁢ V k * S k ) / V TOTs ⁢ _ ⁢ inpu ⁢ t is higher than 50, S21 being the segment cross section perpendicular to the transverse direction, (Σk Vk*Sk)/VTOTs_input being, the sum of the products of the volume and the cross section of the input seeding channel, divided by the total volume V TOTs_input of the input seeding channels.