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公开(公告)号：US10201599B2
公开(公告)日：2019-02-12
申请号：US15251308
申请日：2016-08-30
发明人： Jeremy Kroll , Mike Roof
IPC分类号： A61K39/02 , A61K45/00 , A61K47/00 , A61K39/116 , A61K39/00 , A61K39/38 , A61K39/112 , A61K39/12 , C12N7/00 , A61K39/39 , A61K35/74 , A61K39/295
摘要： The present invention provides combination vaccines that comprise an immunological agent effective for reducing the incidence of or lessening the severity of PPE caused by L. intracellularis, and one or more immunological active components effective in treatment and/or prophylaxis of at least one further disease-causing organism for swine. Moreover, the present invention also relates to a kit that comprises an immunological agent effective for reducing the incidence of or lessening the severity of PPE caused by L. intracellularis, and one or more immunological active components effective in treatment and/or prophylaxis of at least one further disease-causing organism for swine.
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公开(公告)号：US20180271969A1
公开(公告)日：2018-09-27
申请号：US15760891
申请日：2016-10-06
申请人： Boehringer Ingelheim Vetmedica, Inc. , Université de Montréal , Université du Québec à Montréal
发明人： Marcelo GOTTSCHALK , Guillaume GOYETTE-DESJARDINS , Jennifer Anne Kempker , Axel NEUBAUER , René ROY , Mariela SEGURA , Tze Chieh SHIAO
IPC分类号： A61K39/09
CPC分类号： A61K39/092 , A61K2039/55544 , A61K2039/55566 , A61K2039/575 , A61K2039/70
摘要： The present invention relates to an immunogenic composition comprising polysaccharide-protein conjugates wherein each conjugate contains a capsular polysaccharide prepared from Streptococcus suis serotypes 1, 2, 7 and/or 9 or any other serotype conjugated to a carrier protein. The immunogenic composition is useful for the protection of disease in an animal subject.
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公开(公告)号：US09987349B2
公开(公告)日：2018-06-05
申请号：US15076381
申请日：2016-03-21
发明人： Michael B Roof , Phillip Wayne Hayes , Marc Allan Eichmeyer , Gregory Paul Nitzel , Merrill Lynn Schaeffer
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/5258 , A61K2039/545 , A61K2039/552 , A61K2039/55516 , A61K2039/55555 , A61K2039/55566 , C12N7/00 , C12N2750/10022 , C12N2750/10023 , C12N2750/10034 , C12N2750/10051 , C12N2750/10071 , C12N2750/14143
摘要： The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.
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4.发明授权公开(公告)号：US09505808B2
公开(公告)日：2016-11-29
申请号：US14504839
申请日：2014-10-02
申请人： Luis Alejandro Hernandez , Christine Margaret Muehlenthaler , Eric Martin Vaughn , Gregory Haiwick
发明人： Luis Alejandro Hernandez , Christine Margaret Muehlenthaler , Eric Martin Vaughn , Gregory Haiwick
IPC分类号： A61K39/12 , C12N7/00 , C07K14/005 , A61K39/00
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C12N7/00 , C12N2710/14043 , C12N2750/10022 , C12N2750/10023 , C12N2750/10034 , C12N2750/10051 , C12N2799/026 , C12P21/02
摘要： Vaccination methods to control PCV2 infection with different PCV2 subtypes are disclosed. Specifically, a PCV2 subtype b (PCV2b) ORF2 proteins or immunogenic compositions comprising a PCV2b ORF2 protein are used in a method for the treatment or prevention of an infection with PCV2 of the same PCV2b and/or different subtype; the reduction, prevention or treatment of clinical signs caused by an infection with PCV2 of the same PCV2b or a different subtype; and/or the prevention or treatment of a disease caused by an infection with PCV2 of the same PCV2b and/or a different subtype. The present invention in particular relates to PCV2 subtype b (PCV2b) ORF2 proteins characterized in that they contain at least one mutation in the BC loop that such that the expressed protein is preferably expressed in a higher amount compared to a PCV2 ORF2 protein that does not contain such mutation.
摘要翻译： 公开了用不同PCV2亚型控制PCV2感染的疫苗接种方法。 具体地说，在用于治疗或预防相同PCV2b和/或不同亚型的PCV2的感染的方法中使用包含PCV2b ORF2蛋白的PCV2亚型b（PCV2b）ORF2蛋白或免疫原性组合物; 减少，预防或治疗由相同PCV2b或不同亚型的PCV2感染引起的临床症状; 和/或预防或治疗由相同PCV2b和/或不同亚型的PCV2感染引起的疾病。 本发明特别涉及PCV2亚型b（PCV2b）ORF2蛋白，其特征在于它们在BC环中含有至少一个突变，使得与不携带的PCV2 ORF2蛋白相比，表达的蛋白优选以更高的量表达 含有这种突变。
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5.发明授权公开(公告)号：US09375469B2
公开(公告)日：2016-06-28
申请号：US14061249
申请日：2013-10-23
IPC分类号： C07K14/00 , A61K39/145 , C07K14/005 , A61K39/12 , A61K39/00
CPC分类号： A61K39/145 , A61K39/00 , A61K39/12 , A61K2039/53 , A61K2039/55555 , A61K2039/55566 , C07K14/005 , C12N2760/16122 , C12N2760/16134
摘要： The present invention relates to novel hemagglutinin H5 proteins, nucleic acids and vectors encoding for those as well as vaccines comprising any of such H5 proteins, nucleic acids or vectors encoding for those H5 proteins. Moreover, the present invention also relates to the medicinal use of any of such compositions in humans and animals.
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6.发明授权Use of a PCV2 immunogenic composition for lessening clinical symptoms in pigs 有权使用PCV2免疫原性组合物来减轻猪的临床症状公开(公告)号：US09011868B2
公开(公告)日：2015-04-21
申请号：US13106606
申请日：2011-05-12
申请人： Michael Roof , Phillip Hayes , Marc Eichmeyer , Greg Nitzel , Merrill Schaeffer
发明人： Michael Roof , Phillip Hayes , Marc Eichmeyer , Greg Nitzel , Merrill Schaeffer
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/5258 , A61K2039/545 , A61K2039/552 , A61K2039/55516 , A61K2039/55555 , A61K2039/55566 , C12N7/00 , C12N2750/10022 , C12N2750/10023 , C12N2750/10034 , C12N2750/10051 , C12N2750/10071 , C12N2750/14143
摘要： The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.
摘要翻译： 本发明涉及包含用于治疗几种临床表现（疾病）的猪圆环病毒2型（PCV2）抗原的免疫原性组合物的用途。 优选地，临床表现与PCV2感染相关。 优选地，它们包括淋巴结病，淋巴细胞减少和/或多核/巨细胞组织细胞。 此外，临床症状包括与猪中的一种或多种以下症状相结合的淋巴结病：（1）间质性肺炎与小叶间水肿，（2）皮肤苍白或黄疸，（3）斑驳萎缩性肝脏，（4）胃溃疡 ，（5）肾炎和（6）生殖障碍，例如 流产，死胎，木乃伊等。此外，临床症状包括Pia样病变，通常已知与细胞内劳森氏菌感染有关。
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公开(公告)号：US20150093404A1
公开(公告)日：2015-04-02
申请号：US14504839
申请日：2014-10-02
申请人： Luis Alejandro HERNANDEZ , Christine Margaret MUEHLENTHALER , Eric Martin VAUGHN , Gregory HAIWICK
发明人： Luis Alejandro HERNANDEZ , Christine Margaret MUEHLENTHALER , Eric Martin VAUGHN , Gregory HAIWICK
IPC分类号： C07K14/005 , C12N7/00
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C12N7/00 , C12N2710/14043 , C12N2750/10022 , C12N2750/10023 , C12N2750/10034 , C12N2750/10051 , C12N2799/026 , C12P21/02
摘要： Vaccination methods to control PCV2 infection with different PCV2 subtypes are disclosed. Specifically, a PCV2 subtype b (PCV2b) ORF2 proteins or immunogenic compositions comprising a PCV2b ORF2 protein are used in a method for the treatment or prevention of an infection with PCV2 of the same PCV2b and/or different subtype; the reduction, prevention or treatment of clinical signs caused by an infection with PCV2 of the same PCV2b or a different subtype; and/or the prevention or treatment of a disease caused by an infection with PCV2 of the same PCV2b and/or a different subtype. The present invention in particular relates to PCV2 subtype b (PCV2b) ORF2 proteins characterized in that they contain at least one mutation in the BC loop that such that the expressed protein is preferably expressed in a higher amount compared to a PCV2 ORF2 protein that does not contain such mutation.
摘要翻译： 公开了用不同PCV2亚型控制PCV2感染的疫苗接种方法。 具体地说，在用于治疗或预防相同PCV2b和/或不同亚型的PCV2的感染的方法中使用包含PCV2b ORF2蛋白的PCV2亚型b（PCV2b）ORF2蛋白或免疫原性组合物; 减少，预防或治疗由相同PCV2b或不同亚型的PCV2感染引起的临床症状; 和/或预防或治疗由相同PCV2b和/或不同亚型的PCV2感染引起的疾病。 本发明特别涉及PCV2亚型b（PCV2b）ORF2蛋白，其特征在于它们在BC环中含有至少一个突变，使得与不携带的PCV2 ORF2蛋白相比，表达的蛋白优选以更高的量表达 含有这种突变。
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公开(公告)号：US08940309B2
公开(公告)日：2015-01-27
申请号：US14476791
申请日：2014-09-04
申请人： William Charles Ohnesorge , Isabelle Freiin Von Richthofen , Marika Christine Genzow , Martina Von Freyburg , Carola Kissel , Luc-Etienne Fabry , Knut Elbers , Kathleen Kwan Young Park
发明人： William Charles Ohnesorge , Isabelle Freiin Von Richthofen , Marika Christine Genzow , Martina Von Freyburg , Carola Kissel , Luc-Etienne Fabry , Knut Elbers , Kathleen Kwan Young Park
CPC分类号： A61K39/0241 , A61K39/40 , A61K2039/521 , A61K2039/552 , C12N1/20 , C12R1/35
摘要： The present invention provides a one phase, aqueous vaccine composition for immunizing an animal against infection by Mycoplasma hyopneumoniae, comprising: an immunizing amount of a Mycoplasma hyopneumoniae bacterin, an acrylic acid polymer in the concentration range between 0.8 and 1.2 mg/ml, and a pharmaceutically acceptable carrier, and substantially no oil. It is especially useful for immunizing a pig against infection by Mycoplasma hyopneumoniae for at least 20 weeks after a single administration, which effective immunity is reached within 4 weeks after vaccination.
摘要翻译： 本发明提供一种用于免疫动物免受猪肺炎支原体感染的单相水性疫苗组合物，其包含：免疫量的猪肺炎支原体菌苗，浓度范围为0.8-1.2mg / ml的丙烯酸聚合物和 药学上可接受的载体，基本上不含油。 在单次给药后至少20周免疫猪免于猪肺炎支原体感染特别有用，在接种后4周内有效免疫。
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公开(公告)号：US20140377298A1
公开(公告)日：2014-12-25
申请号：US14483097
申请日：2014-09-10
申请人： Vicky FACHINGER , Knut ELBERS , Axel LISCHEWSKI , Marion KIXMOELLER , Francois-Xavier ORVEILLON , Isabelle FREIIN VON RICHTHOFEN , Michael D. PIONTKOWSKI
发明人： Vicky FACHINGER , Knut ELBERS , Axel LISCHEWSKI , Marion KIXMOELLER , Francois-Xavier ORVEILLON , Isabelle FREIIN VON RICHTHOFEN , Michael D. PIONTKOWSKI
CPC分类号： A61K39/12 , A61K31/155 , A61K31/7036 , A61K2039/5252 , A61K2039/545 , A61K2039/55 , A61K2039/552 , A61K2039/55555 , C12N7/00 , C12N2750/10034
摘要： The present invention relates to a method for the treatment or prophylaxis of a PCV2 infection or for reduction of clinical symptoms caused by or associated with a PCV2 infection in animals a) having anti-PCV2 antibodies and/or b) being young piglets of 1 to 22 days of age, comprising the step of administering an effective amount of a PCV2 antigen to that animal in need of such treatment. Preferably, those animals are pigs or young piglets.
摘要翻译： 本发明涉及一种用于治疗或预防PCV2感染或减少由PCV2感染引起的或与动物相关的临床症状的方法a）具有抗PCV2抗体和/或b）是1至 22天龄，包括向需要这种治疗的动物施用有效量的PCV2抗原的步骤。 优选地，这些动物是猪或幼仔。
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公开(公告)号：US20140365388A1
公开(公告)日：2014-12-11
申请号：US14294513
申请日：2014-06-03
CPC分类号： G06Q30/018 , G06F19/325 , G06Q50/02
摘要： The present disclosure provides systems and methods for developing and managing a protocol for use in a livestock operation. The method includes receiving, at a computing platform, input from a user, generating, using the computing platform, the protocol based on the user input, wherein the protocol includes at least one activity period including at least one action, and distributing the protocol to at least one end user.
摘要翻译： 本公开提供了用于开发和管理用于家畜操作的协议的系统和方法。 该方法包括在计算平台处接收来自用户的输入，使用所述计算平台根据所述用户输入生成所述协议，其中所述协议包括至少一个活动期间，包括至少一个动作，并将所述协议分发到 至少一个最终用户。
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