公开(公告)号：US20220008618A1

公开(公告)日：2022-01-13

申请号：US17482920

申请日：2021-09-23

申请人： CorMatrix Cardiovascular, Inc.

发明人： Robert G Matheny

IPC分类号： A61L27/36 ,  A61F2/06 ,  A61F2/00 ,  A61L27/34 ,  A61L27/54 ,  A61L27/58 ,  A61K31/4418 ,  A61L27/38 ,  A61L27/50

摘要： Cardiovascular prostheses for treating, reconstructing and replacing damaged or diseased cardiovascular tissue. The prostheses are in the form of sheet structures that are formed from a composition that includes adolescent mammalian dermal tissue and a plurality of exogenously added exosomes. In some instances, the composition also includes at least one exogenously added cell, such as an embryonic stem cell, a mesenchymal stem cell and a hematopoietic stem cell. The prostheses are adapted to induce neovascularization, stem cell proliferation and, thereby, remodeling of damaged biological tissue and regeneration of new biological tissue and structures, when the prostheses are delivered to the damaged biological tissue.

公开(公告)号：US20210161656A1

公开(公告)日：2021-06-03

申请号：US17177001

申请日：2021-02-16

申请人： CorMatrix Cardiovascular, Inc.

发明人： Robert G Matheny

IPC分类号： A61F2/24 ,  A61L27/38 ,  A61L27/36 ,  A61L27/50

摘要： A prosthetic valve comprising a tubular shaped sheet member comprising an extracellular matrix (ECM) composition, the sheet member having a plurality of ribbons having proximal and distal ends, the distal ends of the ribbons projecting from the sheet member proximal end.

公开(公告)号：US10952845B2

公开(公告)日：2021-03-23

申请号：US16193669

申请日：2018-11-16

申请人： CorMatrix Cardiovascular, Inc.

发明人： Robert G Matheny

IPC分类号： A61F2/24 ,  A61L27/36 ,  A61L27/50 ,  A61L27/54

摘要： A percutaneous transseptal surgical implantation method for replacing a defective atrioventricular (AV) valve with a conical shaped prosthetic valve formed from extracellular matrix (ECM) tissue. When the method is employed to replace a native mitral valve, the method positions the prosthetic tissue valve in the mitral valve region, whereby the valve does not obstruct the outflow tract of the aortic valve and prevents the leaflets of the aortic valve from coapting.

公开(公告)号：US20210052663A1

公开(公告)日：2021-02-25

申请号：US17089963

申请日：2020-11-05

申请人： CorMatrix Cardiovascular, Inc.

发明人： Robert G. Matheny

IPC分类号： A61K35/35 ,  A61K35/12 ,  A61K38/18 ,  A61K45/06 ,  A61K48/00 ,  A61L27/36 ,  A61L27/38 ,  A61L27/54 ,  A61M1/12 ,  A61K35/28 ,  A61K35/34 ,  A61P9/10 ,  A61K35/44

摘要： Methods for treating cardiovascular disorders that include administration of an ECM based composition to damaged cardiovascular tissue in conjunction with a treatment remedy, such as transmyocardial revascularization (TMR), which induces enhanced bioremodeling of the damaged cardiovascular tissue and regeneration of new cardiovascular tissue and associated structures with site-specific structural and functional properties.

公开(公告)号：US10857263B2

公开(公告)日：2020-12-08

申请号：US16238730

申请日：2019-01-03

申请人： CorMatrix Cardiovascular, Inc.

发明人： Robert G Matheny

IPC分类号： A61B17/04 ,  A61L27/36 ,  A61F2/24 ,  A61L27/50 ,  A61L27/54

摘要： A percutaneous transseptal surgical implantation method for replacing a defective atrioventricular (AV) valve with a conical shaped prosthetic valve formed from extracellular matrix (ECM) tissue. When the method is employed to replace a native mitral valve, the method positions the prosthetic tissue valve in the mitral valve region, whereby the valve does not obstruct the outflow tract of the aortic valve and prevents the leaflets of the aortic valve from coapting.

公开(公告)号：US10512711B2

公开(公告)日：2019-12-24

申请号：US14682188

申请日：2015-04-09

申请人： CorMatrix Cardiovascular, Inc.

发明人： Robert G Matheny

IPC分类号： A61L27/54 ,  A61L27/14 ,  A61L27/36 ,  A61L27/58 ,  A61K38/00

摘要： The invention is to articles made from extracellular matrix sheets that encase biodegradable polymeric material. Methods of healing wounds or regenerating tissue at sites of defect by placing said articles in mammals are claimed. The biodegradable polymer can change quality upon contact with a physiological parameter such as temperature or pH that causes, for example, a liquid polymer to gel or harden. The degradation of the polymer can be controlled to suit a tissue regeneration or wound healing time course. Additional components such as proteins, cells and drugs can be added to the biopolymer composition.

公开(公告)号：US09295758B2

公开(公告)日：2016-03-29

申请号：US14193008

申请日：2014-02-28

申请人： CORMATRIX CARDIOVASCULAR, INC.

发明人： Robert G Matheny

IPC分类号： A61L27/36 ,  A61L27/54 ,  A61K35/38 ,  A61K35/34 ,  A61K48/00 ,  A61L27/38 ,  A61L27/40 ,  A61K38/17 ,  A61K38/18 ,  A61K35/545 ,  A61K31/726 ,  A61K31/7088 ,  A61K35/37 ,  A61K35/407 ,  A61K35/22 ,  A61K38/39 ,  A61L27/58 ,  A61K35/50 ,  A61K9/00

CPC分类号： A61L27/54 ,  A61K9/0019 ,  A61K31/7088 ,  A61K31/726 ,  A61K35/22 ,  A61K35/34 ,  A61K35/37 ,  A61K35/38 ,  A61K35/407 ,  A61K35/50 ,  A61K35/545 ,  A61K38/1741 ,  A61K38/1825 ,  A61K38/1841 ,  A61K38/39 ,  A61K48/00 ,  A61L27/227 ,  A61L27/3629 ,  A61L27/3633 ,  A61L27/367 ,  A61L27/3683 ,  A61L27/3687 ,  A61L27/3834 ,  A61L27/3873 ,  A61L27/40 ,  A61L27/58 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/426 ,  A61L2300/45 ,  A61L2300/64 ,  A61L2400/06 ,  A61L2430/20 ,  A61L2430/30

摘要： Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.

公开(公告)号：US09283302B2

公开(公告)日：2016-03-15

申请号：US13896424

申请日：2013-05-17

申请人： CORMATRIX CARDIOVASCULAR, INC.

发明人： Robert G Matheny

IPC分类号： A61K35/12 ,  A61K9/16 ,  A61F13/00 ,  A61L33/00 ,  A61N1/362 ,  A61L27/36 ,  A61L31/00 ,  A61F2/02 ,  A61L27/54 ,  A61K35/38 ,  A61K35/22 ,  A61F2/24 ,  A61K38/00

CPC分类号： A61L27/3629 ,  A61F2/0077 ,  A61F2/02 ,  A61F2/24 ,  A61F2002/0086 ,  A61F2210/0076 ,  A61K35/12 ,  A61K35/22 ,  A61K35/37 ,  A61K35/38 ,  A61K35/42 ,  A61K38/005 ,  A61K38/1825 ,  A61L27/227 ,  A61L27/34 ,  A61L27/3604 ,  A61L27/362 ,  A61L27/3625 ,  A61L27/3633 ,  A61L27/3679 ,  A61L27/3683 ,  A61L27/38 ,  A61L27/3804 ,  A61L27/3834 ,  A61L27/50 ,  A61L27/54 ,  A61L31/005 ,  A61L31/041 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/20 ,  A61L2300/23 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/40 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/418 ,  A61L2300/434 ,  A61L2300/45 ,  A61L2300/64 ,  A61L2400/02 ,  A61L2400/12 ,  A61L2400/18 ,  A61L2430/20 ,  A61N1/375 ,  A61N1/3752

摘要： A remodelable encasement structure comprising a pouch formed from at least one sheet of bioremodelable material, the pouch including an internal region and at least one lead conduit, the internal region being configured to receive a device therein, the lead conduit being configures to receive at least one device lead therein, the bioremodelable material comprising an extracellular matrix (ECM) composition that includes an ECM component derived from a mammalian source.

摘要翻译： 一种可重塑的包装结构，包括由至少一片生物可重塑材料形成的袋，所述袋包括内部区域和至少一个引线导管，所述内部区域被配置为在其中容纳装置，所述引线导管配置为至少接收 所述生物可重塑材料包含细胞外基质（ECM）组合物，其包含源自哺乳动物来源的ECM组分。

公开(公告)号：US09125972B2

公开(公告)日：2015-09-08

申请号：US13875058

申请日：2013-05-01

申请人： CorMatrix Cardiovascular, Inc.

发明人： Robert G Matheny

IPC分类号： A61K9/14 ,  A61K35/12 ,  A61K9/48 ,  C12N5/02 ,  A61L27/38 ,  A61K48/00 ,  A61L27/36 ,  A61K35/38 ,  A61L27/40 ,  A61K38/17 ,  A61K38/18 ,  A61K35/34 ,  A61K35/545 ,  A61K31/726 ,  A61L27/54 ,  A61K31/7088 ,  A61K35/37 ,  A61K35/407 ,  A61K35/22 ,  A61K38/39 ,  A61L27/58 ,  A61K9/00

CPC分类号： A61L27/54 ,  A61K9/0019 ,  A61K31/7088 ,  A61K31/726 ,  A61K35/22 ,  A61K35/34 ,  A61K35/37 ,  A61K35/38 ,  A61K35/407 ,  A61K35/50 ,  A61K35/545 ,  A61K38/1741 ,  A61K38/1825 ,  A61K38/1841 ,  A61K38/39 ,  A61K48/00 ,  A61L27/227 ,  A61L27/3629 ,  A61L27/3633 ,  A61L27/367 ,  A61L27/3683 ,  A61L27/3687 ,  A61L27/3834 ,  A61L27/3873 ,  A61L27/40 ,  A61L27/58 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/426 ,  A61L2300/45 ,  A61L2300/64 ,  A61L2400/06 ,  A61L2430/20 ,  A61L2430/30

摘要： Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.

公开(公告)号：US09119899B2

公开(公告)日：2015-09-01

申请号：US13782115

申请日：2013-03-01

申请人： CORMATRIX CARDIOVASCULAR, INC

发明人： Robert Matheny

IPC分类号： A61K9/14 ,  A61K35/12 ,  A61K9/48 ,  C12N5/02 ,  A61L27/36 ,  A61K45/06 ,  A61K48/00 ,  A61K38/18 ,  A61K35/35 ,  A61L27/38 ,  A61L27/54

CPC分类号： A61K35/35 ,  A61K35/12 ,  A61K38/18 ,  A61K38/1808 ,  A61K38/1841 ,  A61K38/185 ,  A61K38/1866 ,  A61K45/06 ,  A61K48/00 ,  A61L27/3604 ,  A61L27/3629 ,  A61L27/3633 ,  A61L27/367 ,  A61L27/3826 ,  A61L27/3834 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/434 ,  A61L2300/64 ,  A61L2430/20 ,  A61M1/122 ,  A61M2205/05

摘要： Methods for treating a cardiovascular disorder comprising concomitant administration of one or more extracellular matrix (ECM) based compositions directly to damaged or diseased cardiovascular tissue associated with the cardiovascular disorder, and provision of ventricular assistance. In a preferred embodiment, the ECM based compositions include an ECM material derived from a mammalian source.

摘要翻译： 用于治疗心血管疾病的方法包括将一种或多种基于细胞外基质（ECM）的组合物直接施用于与心血管疾病相关的受损或患病的心血管组织并提供心室辅助。 在优选的实施方案中，基于ECM的组合物包括衍生自哺乳动物来源的ECM材料。