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公开(公告)号：US20210177925A1
公开(公告)日：2021-06-17
申请号：US16636291
申请日：2018-08-02
申请人： GIULIANI S.P.A.
IPC分类号： A61K36/53 , A61K31/132 , A61K47/36 , A61K47/02 , A61K9/00 , A61K31/4188
摘要： The invention relates to a synergistic composition comprising a dry extract of plant of genus Galeopsis and a compound promoting autophagy selected from biotin and R-N1-spermidine or a salt thereof, wherein R is hydrogen or methyl and mixtures thereof. The synergistic compositions according to the invention may be in the form of a topical formulation or oral formulation and is useful as a promoter of autophagy especially in cells of human scalp hair follicles and in promoting hair growth and/or in the treatment of hair thinning or hair loss.
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公开(公告)号：US20210000801A1
公开(公告)日：2021-01-07
申请号：US16969246
申请日：2019-02-13
申请人： GIULIANI S.P.A.
发明人： Giammaria GIULIANI , Barbara MARZANI , Daniela PINTO , Sergio BARONI , Ralf PAUS , Nathan HAWKSHAW
IPC分类号： A61K31/427 , A61K8/49 , A61P17/14 , A61Q7/00
摘要： The present invention relates to the use of iminooxothiazolidine derivatives for preventing or treating hair growth disorders. The iminooxothiazolidine derivatives may be formulated as compositions suitable for either the systemic administration or the local application to the scalp.
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公开(公告)号：US09668984B2
公开(公告)日：2017-06-06
申请号：US13128394
申请日：2009-11-10
申请人： Giammaria Giuliani , Anna Benedusi , Sergio Baroni
发明人： Giammaria Giuliani , Anna Benedusi , Sergio Baroni
IPC分类号： A61K31/202 , C07C57/03 , C07C33/02 , A61K31/045 , A61K31/11 , A61K31/22 , A61K31/231 , A61K31/232
CPC分类号： A61K31/11 , A61K31/045 , A61K31/22 , A61K31/231 , A61K31/232
摘要： The object of the present invention is the use of compounds designed to inhibit the activity of the enzyme 5α-reductase. This is a novel use of compounds of general formula (I): CH3(—CH═CH)n—R (I) where n=from 2 to 7, and R is chosen from among: CHO, CH2OH, CH2O—CO—R′, CO—O(−), where R′ is chosen from among H, and the alky from C1 to C22, each compound of general formula (I) being used as such or in mixtures with other compounds, as the active principle in a pharmaceutical or cosmetic composition designed to inhibit the action of the enzyme 5α-reductase, and of the pharmaceutical or cosmetic compositions deriving therefrom.
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4.发明授权公开(公告)号：US09394335B2
公开(公告)日：2016-07-19
申请号：US14653091
申请日：2013-12-18
申请人： GIULIANI S.P.A.
CPC分类号： C07J63/008 , A61K8/63 , A61Q1/14 , A61Q5/02 , A61Q19/00 , A61Q19/005 , A61Q19/08
摘要： An ester of glycyrrhetinic acid with (poly)glycerol-sorbitol and cosmetic compositions thereof is described. The introduction of sorbitol in the (poly)glycerol chain determines an increase in solubility of the ester of the invention increasing solubility in water and the possibility of using glycyrrhetinic acid in cosmetic applications.
摘要翻译： 描述了甘草次酸与（聚）甘油 - 山梨糖醇的酯和其化妆品组合物。 在（聚）甘油链中引入山梨醇决定了本发明的酯在水中的溶解度的增加，以及在化妆品应用中使用甘草次酸的可能性。
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5.发明授权公开(公告)号：US09237753B2
公开(公告)日：2016-01-19
申请号：US12374246
申请日：2007-07-03
申请人： Giammaria Giuliani , Anna Benedusi , Raffaella Di Cagno , Maria De Angelis , Antonella Luisi , Marco Gobbetti
发明人： Giammaria Giuliani , Anna Benedusi , Raffaella Di Cagno , Maria De Angelis , Antonella Luisi , Marco Gobbetti
IPC分类号： C12N1/20 , A21D8/04 , A21D13/04 , A21D13/06 , C12R1/01 , C12R1/225 , C12R1/24 , C12R1/25 , A21D10/00
CPC分类号： A21D8/04 , A21D8/045 , A21D10/002 , A21D13/04 , A21D13/047 , A21D13/066 , A21D13/40 , A23Y2220/05 , A23Y2220/13 , A23Y2220/17 , A23Y2220/25 , A23Y2220/29 , A23Y2220/35 , A23Y2220/37 , A23Y2220/39 , A23Y2220/63 , A23Y2220/65 , A23Y2220/67 , A23Y2220/81 , C12N1/20 , C12R1/01 , C12R1/225 , C12R1/24 , C12R1/25
摘要： The present invention concerns a mixture of lactic bacteria for yeasting of gluten-free baked products. Particularly, the invention concerns the use of “natural yeast” based on selected lactic bacteria as yeasting agent for the production of gluten-free bread, with improved sensory and nutritional property, designed for celiac patients feeding.
摘要翻译： 本发明涉及用于无麸质焙烤产品的酵母的乳酸菌混合物。 特别地，本发明涉及基于选择的乳酸菌的“天然酵母”作为酵母剂用于生产无麸质面包的用途，其具有改进的感官和营养特性，其设计用于腹腔食物喂养。
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6.发明授权Therapeutic, dietary or cosmetic use of compounds with specific anti-apoptotic activity toward caspase-3, and compositions containing these compounds 有权对胱天蛋白酶-3具有特异性抗凋亡活性的化合物的治疗，膳食或化妆品用途以及含有这些化合物的组合物公开(公告)号：US08729033B2
公开(公告)日：2014-05-20
申请号：US13127446
申请日：2009-10-30
申请人： Giammaria Giuliani , Anna Benedusi , Sergio Baroni
发明人： Giammaria Giuliani , Anna Benedusi , Sergio Baroni
IPC分类号： A61K31/047 , C07H17/07
CPC分类号： C07H17/07
摘要： This invention regards the use of zeaxanthin and/or rutin, as such or further combined with spermidine, as the active principle in a pharmaceutical, dietary, or cosmetic composition, acting to inhibit caspase-3 and therefore to control apoptosis by preventing programmed cell death.The indication for this composition according to the invention is primarily the treatment of scalp disorders characterized by excessive cellular turnover including chemotherapy-induced alopecia, alopecia areata, androgenetic alopecia and telogen effluvium.
摘要翻译： 本发明涉及玉米黄质和/或芦丁，或与亚精胺进一步联合作为药物，膳食或化妆品组合物中的活性成分，用于抑制胱天蛋白酶-3，因此通过预防程序性细胞死亡来控制凋亡 。 根据本发明的该组合物的适应症主要是治疗特征在于过度细胞周转的头皮疾病，包括化疗诱导的脱发，斑秃，雄激素性脱发和休止期脱落。
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7.发明申请PROCESS FOR THE PREPARATION OF 2,4,6-OCTATRIENE-1-OIC ACID AND 2,4,6-OCTATRIENE-1-OL 审中-公开制备2,4,6-亚甲基-1-酸和2,4,6-十八烯-1-醇的方法公开(公告)号：US20120022282A1
公开(公告)日：2012-01-26
申请号：US13260260
申请日：2010-04-16
IPC分类号： C07C51/09 , C07C69/587 , C07C69/96 , C07C29/147
CPC分类号： C07C51/09 , C07C29/147 , C07C51/02 , C07C67/343 , C07C68/02 , C07C69/587 , C07C33/02 , C07C57/03 , C07C69/96
摘要： The present invention concerns a process for synthesis of 2,4,6-octatriene-1-oic acid and 2,4,6-octatriene-1-ol, which comprises the following stages: a) reaction between 2,4-trans-hexadienal and triethyl phosphonoacetate to give ethyl 2,4,6-trans-octatrienoate; b) alkaline hydrolysis of ethyl 2,4,6-trans-octatrienoate to give the corresponding alkaline salt; c) acidification of said salt to give 2,4,6-trans-octatrienoic acid, which can be separated or can undergo the following further stages: d) reaction of the 2,4,6-trans-octatrienoic acid with ethyl chloroformiate to give the mixed anhydride formed by 2,4,6-trans-octatrienoic acid and ethyl carbonic acid; e) reduction of said mixed anhydride with sodium borohydride to give 2,4,6-trans-octatrienol; and optionally a purification stage of the end product.
摘要翻译： 本发明涉及合成2,4,6-辛三烯-1-酸和2,4,6-辛二烯-1-醇的方法，其包括以下步骤：a）2,4-反式 - 己二烯醛和膦酰基乙酸三乙酯，得到2,4,6-反式 - 八碳三烯酸乙酯; b）碱性水解2,4,6-反式 - 八辛酸乙酯，得到相应的碱性盐; c）酸化所述盐以得到2,4,6-反式八碳三烯酸，其可被分离或可经历以下进一步的步骤：d）将2,4,6-反式 - 八碳三烯酸与氯甲酸乙酯反应 得到由2,4,6-反式 - 八碳三烯酸和乙基碳酸形成的混合酸酐; e）用硼氢化钠还原所述混合酸酐得到2,4,6-反式 - 八氢化萘酚; 和任选的最终产物的纯化阶段。
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8.发明授权
公开(公告)号：US5449520A
公开(公告)日：1995-09-12
申请号：US130624
申请日：1993-10-01
IPC分类号： A61K9/00 , A61K9/12 , A61K31/23 , A61K31/235 , A61K31/555 , A61K31/57 , A61K31/60 , A61K36/00 , A61K36/53 , A61K45/00 , A61P1/00 , A61P1/04 , A61P29/00 , A61P31/04 , A61F9/02
CPC分类号： A61K9/0031 , A61K9/122
摘要： The invention provides a pharmaceutical composition for the rectal administration of active principles which exhibit a prevalently topical medication action at the colon level, characterized in that said active principles are formulated in a fluid vehicle able to generate a foam on rectal administration.
摘要翻译： 本发明提供了一种用于直肠施用活性成分的药物组合物，其在结肠水平上表现出普遍的局部用药作用，其特征在于所述活性成分被配制成能够在直肠给药时产生泡沫的流体载体。
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9.发明授权Bile acid unsaturated derivatives and pharmaceutical compositions containing them 失效双酸不饱和衍生物和含有它们的药物组合物
公开(公告)号：US5096898A
公开(公告)日：1992-03-17
申请号：US650751
申请日：1991-02-05
申请人： Roberto Pellicciari , Aldo Roda
发明人： Roberto Pellicciari , Aldo Roda
IPC分类号： A61K31/575 , A61P1/16 , C07J9/00 , C07J31/00 , C07J75/00
CPC分类号： C07J31/006 , C07J9/005 , Y02P20/55
摘要： Bile acid derivatives of formula I ##STR1## wherein: R is hydrogen or hydroxy;X is a carboxy or a SO.sub.3 H group, have valuable pharmacologic properties.
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公开(公告)号：US10675239B2
公开(公告)日：2020-06-09
申请号：US16477694
申请日：2018-01-11
申请人： GIULIANI S.P.A.
IPC分类号： A61K8/9789 , A61Q7/00
摘要： The present invention relates to the use of a plant extract from the genus Galeopsis species tetrahit or a composition that contains it to stimulate hair growth or improve the appearance or hair fullness. The composition containing the plant extract is applied in both cosmetic and medical-trichological fields and can be applied topically on the scalp or administered orally.
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