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公开(公告)号：US20210105980A1
公开(公告)日：2021-04-15
申请号：US17050199
申请日：2019-04-25
摘要： A method of tracking an animal (4) in a population of animals (4) comprises: applying a visual identifier (41) to the animal (4); associating reference identifier data of the visual identifier (41) to animal data of the animal (4); capturing a digital image of the visual identifier (41) applied to the animal (4); recognizing the visual identifier (41) by digitally processing the captured digital image; and identifying the animal (4) upon recognition of the visual identifier (41).
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公开(公告)号：US20180312546A1
公开(公告)日：2018-11-01
申请号：US15981316
申请日：2018-05-16
发明人： Haitao Guo , Dawei Cai , Andrea Cuconati , Changhua Ji
IPC分类号： C07K14/005 , G01N33/50
CPC分类号： C07K14/005 , C07K2319/40 , C07K2319/42 , C12N2730/10122 , C12N2730/10151 , C12N2830/006 , G01N33/502 , G01N2333/02
摘要： The present invention relates to methods and uses for screening anti-hepadnaviral substances, wherein the substances are screened for the capacity to inhibit covalently closed circular (ccc) DNA of a hepadnavirus, like hepatitis B virus. The methods and uses take advantage of cells comprising a nucleic sequence encoding a tagged hepadnavirus e antigen, like Hepatitis B virus e antigen (HBeAg). Furthermore, the present invention provides nucleic acid sequences encoding a tagged hepadnavirus e antigen and proteins encoded thereby. Also kits for use in the screening methods are provided.
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公开(公告)号：US11639394B2
公开(公告)日：2023-05-02
申请号：US16581756
申请日：2019-09-25
摘要： The invention relates to bispecific antigen binding molecules comprising (a) at least one moiety capable of specific binding to OX40, and (b) at least one moiety capable of specific binding to epithelial cell adhesion molecule (EpCAM), and to methods of producing these molecules and to methods of using the same.
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公开(公告)号：US20230120311A1
公开(公告)日：2023-04-20
申请号：US17946743
申请日：2022-09-16
发明人： Kirsten Andrea Graeser , Urs Schwitter , Frank Stowasser , Florence Nicole Antoinette Tixeront , Rene Trussardi
IPC分类号： C07D413/12
摘要： Described herein are amorphous and crystalline forms of pharmaceutically acceptable salts of the TAAR1 agonist 5-ethyl-4-methyl-N-[4-[(2S) morpholin-2-yl]phenyl]-1H-pyrazole-3-carboxamide. Also described are pharmaceutical compositions suitable for administration to a mammal that include the TAAR1 agonist, and methods of using the TAAR1 agonist, alone and in combination with other compounds, for treating diseases or conditions that are associated with TAAR1 activity.
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公开(公告)号：US20230119360A1
公开(公告)日：2023-04-20
申请号：US17843740
申请日：2022-06-17
发明人： Lu GAO , Yonghong ZHU , Søren OTTOSEN , Henrik MUELLER , Xue ZHOU , Julie Elisabeth Françoise BLAISING , Yuyan JIN , Qingyan BO , Gaurav TYAGI
IPC分类号： A61K31/519 , A61K48/00 , A61P31/20
摘要： The present invention is directed to compositions and methods for treating hepatitis B virus infection. In particular, the present invention is directed to a combination therapy comprising administration of a therapeutic oligonucleotide targeting HBV and a TLR7 agonist for use in the treatment of a chronic hepatitis B patient.
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公开(公告)号：US11608376B2
公开(公告)日：2023-03-21
申请号：US16721272
申请日：2019-12-19
发明人： Guy Georges , Thomas Hofer , Ralf Hosse , Christian Klein , Ekkehard Moessner , Johannes Sam , Pablo Umaña , Jenny Thom , Stephan Gasser , Jean-Baptiste Vallier , Tanja Fauti
摘要： The present invention relates to tumor targeted bispecific agonistic antigen binding molecules characterized by monovalent binding to CD28, methods for their production, pharmaceutical compositions containing these antibodies, and methods of using the same.
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公开(公告)号：US20230071733A1
公开(公告)日：2023-03-09
申请号：US17834096
申请日：2022-06-07
发明人： Laura Codarri Deak , Christian Klein , Laura Lauener , Stefan Seeber , Pablo Umana , Inja Waldhauer
摘要： The present invention generally relates to immunoconjugates, particularly immunoconjugates comprising a mutant interleukin-2 polypeptide and a bispecific antigen binding molecule that binds to PD-1 and Tim-3. In addition, the invention relates to polynucleotide molecules encoding the immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
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公开(公告)号：US20230060373A1
公开(公告)日：2023-03-02
申请号：US17540534
申请日：2021-12-02
发明人： Heidi Rye Hudlebusch , Alexander Herbert Stephan , Lykke Pedersen , Christoffer Sondergaard , Erik Funder
IPC分类号： C12N15/113 , A61P25/28 , A61K31/7115 , A61K31/712 , A61K31/7125
摘要： The present invention relates to antisense LNA oligonucleotides (oligomers) complementary to ATXN3 pre-mRNA sequences, which are capable of inhibiting the expression of ATXN3 protein. Inhibition of ATXN3 expression is beneficial for the treatment of spinocerebellar ataxia.
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公开(公告)号：US20230057891A1
公开(公告)日：2023-02-23
申请号：US17786963
申请日：2020-12-18
IPC分类号： C07D487/04
摘要： The application provides a compound having the general formula (I) wherein R1, R2, R3 and R4 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
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公开(公告)号：US20230050901A1
公开(公告)日：2023-02-16
申请号：US17749496
申请日：2022-05-20
发明人： Charles BELL , Joerg BENZ , Luca GOBBI , Uwe GRETHER , Katrin GROEBKE ZBINDEN , Benoit HORNSPERGER , Buelent KOCER , Carsten KROLL , Bernd KUHN , Marius Daniel Rinaldo LUTZ , Fionn O'HARA , Hans RICHTER , Martin RITTER , Didier ROMBACH , Martin KURATLI
IPC分类号： C07D498/04 , C07D519/00
摘要： The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, X, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
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