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    NANOFIBERS CONTAINING LATENT REACTIVE GROUPS
    6.
    发明申请
    NANOFIBERS CONTAINING LATENT REACTIVE GROUPS 有权
    含有反应性组合的纳米纤维素

    公开(公告)号：US20110020917A1

    公开(公告)日：2011-01-27

    申请号：US12666173

    申请日：2008-06-20

    申请人： Jie Wen ,  Patrick Guire

    发明人： Jie Wen ,  Patrick Guire

    IPC分类号： C12M1/00 ,  C08F8/00

    CPC分类号： D01D5/003 ,  A61L27/50 ,  A61L29/14 ,  A61L31/14 ,  A61L2400/12 ,  B05D3/067 ,  B29C35/08 ,  C12M23/20 ,  D01D5/0007 ,  D01F1/10 ,  D01F6/625 ,  D06M15/263 ,  D06M15/273 ,  D06M15/285 ,  D06M2400/01

    摘要： A nanofiber is formed by combining one or more natural or synthetic polymeric materials and one or more than one cross-linking agents having at least two latent reactive activatable groups. The latent reactive activatable nanofiber may be used to modify the surface of a substrate by activating at least one of the latent reactive activatable groups to bond the nanofiber to the surface by the formation of a covalent bond between the surface of the substrate and the latent reactive activatable group. Some of the remaining latent reactive activatable group(s) are left accessible on the surface of the substrate, and may be used for further surface modification of the substrate. Biologically active materials may be immobilized on the nanofiber modified surface by reacting with the latent reactive groups that are accessible on the surface of the substrate.

    摘要翻译： 通过组合一种或多种天然或合成聚合物材料和具有至少两个潜在反应性可活化基团的一种或多种交联剂形成纳米纤维。 潜在的可反应活化的纳米纤维可用于通过活化至少一个潜在的反应性可活化基团来修饰底物的表面，以通过在基材的表面和潜在的反应性之间形成共价键将纳米纤维结合到表面 可激活组。 剩余的潜在反应性可活化基团中的一些在基材的表面上是可接近的，并且可以用于基材的进一步的表面改性。 生物活性物质可以通过与底物表面上可触及的潜在反应性基团反应而固定在纳米纤维改性表面上。

    Crystallization Inhibitor Compositions for Implantable Urological Devices
    8.
    发明申请
    Crystallization Inhibitor Compositions for Implantable Urological Devices 审中-公开

    公开(公告)号：US20190091375A1

    公开(公告)日：2019-03-28

    申请号：US16079218

    申请日：2017-02-24

    申请人： Innovative Surface Technologies, Inc.

    发明人： Kristin Taton

    IPC分类号： A61L29/16 ,  A61K31/194 ,  A61K38/18 ,  A61L29/08 ,  A61L29/14 ,  A61K31/765 ,  A61L29/04 ,  A61L29/06

    摘要： Inventive concepts relate generally to the field of implantable urological devices, and more particularly to compositions that inhibit crystallization of urine components. Described are implantable urological devices including a surface and a crystallization inhibitor composition, the crystallization inhibitor composition including: (a) an inhibitor of urine component crystallization in combination with a biodegradable polymer, or a polyalkene homopolymer or copolymer, or (b) a biodegradable polymer that includes an inhibitor of urine component crystallization, wherein the crystallization inhibitor composition provides controlled release of the inhibitor of urine component crystallization from the surface of the device into a subject. Methods of making the implantable urological devices are also described.

    NANOFIBERS CONTAINING LATENT REACTIVE GROUPS
    10.
    发明申请
    NANOFIBERS CONTAINING LATENT REACTIVE GROUPS 审中-公开
    含有反应性组合的纳米纤维素

    公开(公告)号：US20140199468A1

    公开(公告)日：2014-07-17

    申请号：US14201965

    申请日：2014-03-10

    申请人： Innovative Surface Technologies, Inc.

    发明人： Jie Wen ,  Patrick E. Guire

    IPC分类号： D01D5/00 ,  B05D3/06 ,  B29C35/08

    CPC分类号： D01D5/003 ,  A61L27/50 ,  A61L29/14 ,  A61L31/14 ,  A61L2400/12 ,  B05D3/067 ,  B29C35/08 ,  C12M23/20 ,  D01D5/0007 ,  D01F1/10 ,  D01F6/625 ,  D06M15/263 ,  D06M15/273 ,  D06M15/285 ,  D06M2400/01

    摘要： A nanofiber is formed by combining one or more natural or synthetic polymeric materials and one or more than one cross-linking agents having at least two latent reactive activatable groups. The latent reactive activatable nanofiber may be used to modify the surface of a substrate by activating at least one of the latent reactive activatable groups to bond the nanofiber to the surface by the formation of a covalent bond between the surface of the substrate and the latent reactive activatable group. Some of the remaining latent reactive activatable group(s) are left accessible on the surface of the substrate, and may be used for further surface modification of the substrate. Biologically active materials may be immobilized on the nanofiber modified surface by reacting with the latent reactive groups that are accessible on the surface of the substrate.

    摘要翻译： 通过组合一种或多种天然或合成聚合物材料和具有至少两个潜在反应性可活化基团的一种或多种交联剂形成纳米纤维。 潜在的可反应活化的纳米纤维可用于通过活化至少一个潜在的反应性可活化基团来修饰底物的表面，以通过在基材的表面和潜在的反应性之间形成共价键将纳米纤维结合到表面 可激活组。 剩余的潜在反应性可活化基团中的一些在基材的表面上是可接近的，并且可以用于基材的进一步的表面改性。 生物活性物质可以通过与底物表面上可触及的潜在反应性基团反应而固定在纳米纤维改性表面上。