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    Coatings for Controlled Release of Highly Water Soluble Drugs
    1.
    发明申请
    Coatings for Controlled Release of Highly Water Soluble Drugs 有权
    用于控制释放高水溶性药物的涂料

    公开(公告)号：US20160067385A1

    公开(公告)日：2016-03-10

    申请号：US14786842

    申请日：2014-04-25

    申请人： INNOVATIVE SURFACE TECHNOLOGIES, INC.

    发明人： Kristin Taton ,  Lawin Laurie ,  Patrick Guire

    IPC分类号： A61L29/08 ,  A61L29/10 ,  A61L29/06 ,  A61L29/16

    CPC分类号： A61L29/085 ,  A61L27/34 ,  A61L27/54 ,  A61L29/06 ,  A61L29/106 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/104 ,  A61L2300/206 ,  A61L2300/602 ,  A61L2300/608 ,  A61L2420/02 ,  A61L2420/08 ,  C08L83/04

    摘要： The present disclosure relates to a multilayer coatings that include a hydrophobic encasing layer and allow controlled release of a water soluble drug. The encasing layer encases water soluble, or hydrophilic, drugs with a flexible layer and comes in good intimate contact with the water soluble drug layer. Thus, the encasing layer conforms to the water soluble drug and can control the release of the drug. Advantageously, major cuts or fissures in the coating do not cause the water soluble drug to leak or burst out; rather, the encasing layer continues to provide modulated release of the drug. The present disclosure also includes methods of making the coating, methods of using the coating, and articles that include the coating.

    摘要翻译： 本公开涉及包括疏水包封层并允许水溶性药物的受控释放的多层涂层。 包裹层用柔性层包裹水溶性或亲水性药物，并与水溶性药物层保持良好的紧密接触。 因此，包裹层符合水溶性药物并且可以控制药物的释放。 有利地，涂层中的主要切口或裂缝不会导致水溶性药物泄漏或爆裂; 相反，包裹层继续提供药物的调节释放。 本公开还包括制备涂层的方法，使用涂层的方法和包括涂层的制品。

    Coatings for controlled release of water soluble drugs
    5.
    发明授权
    Coatings for controlled release of water soluble drugs 有权

    公开(公告)号：US10098989B2

    公开(公告)日：2018-10-16

    申请号：US15730006

    申请日：2017-10-11

    申请人： INNOVATIVE SURFACE TECHNOLOGIES, INC.

    发明人： Kristin Taton ,  Laurie Lawin ,  Patrick Guire

    IPC分类号： A61L29/08 ,  A61L29/06 ,  A61L29/16 ,  A61L29/10 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16

    摘要： The present disclosure relates to multilayer coatings that include a hydrophobic encasing layer and allow controlled release of a water soluble drug. The encasing layer encases water soluble, or hydrophilic, drugs with a flexible layer and comes in good intimate contact with the water soluble drug layer. Thus, the encasing layer conforms to the water soluble drug and can control the release of the drug. Advantageously, major cuts or fissures in the coating do not cause the water soluble drug to leak or burst out; rather, the encasing layer continues to provide modulated release of the drug. The present disclosure also includes methods of making the multilayer coatings, methods of using the multilayer coatings, and articles that include the multilayer coatings.