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公开(公告)号：US20210238208A1
公开(公告)日：2021-08-05
申请号：US17050905
申请日：2019-04-18
发明人： Takehiko FUJINO , Shiro MAWATARI , Toyoharu YAMASHITA , Mitsuru KITAMURA , Tatsuo OKAUCHI , Shamim HOSSAIN
摘要： A compound presented by the following Chemical Formula 1, a racemic form, or a salt thereof: wherein, X represents an oxygen atom, a nitrogen atom, a sulfur atom, or a carbon atom, R1 represents R1a—Y—R1b (wherein R1a and R1b each independently represent a saturated or unsaturated aliphatic hydrocarbon group, an aromatic group, a heterocyclic group, or a combination thereof, and Y represents an oxygen atom, a nitrogen atom, a sulfur atom, or a carbon atom), R2 represents a saturated or unsaturated aliphatic hydrocarbon group, and R3 represents choline, ethanolamine, inositol, or serine.
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公开(公告)号：US11066432B2
公开(公告)日：2021-07-20
申请号：US15533528
申请日：2015-05-13
发明人： Takehiko Fujino , Shiro Mawatari
IPC分类号： C07F9/10 , A23J7/00 , A61K31/685 , C11B11/00 , A61K35/618 , A23L33/12 , A23L2/52
摘要： [PROBLEM TO BE SOLVED] It enables any superior ether phospholipids to the conventional ones and a method for producing the same in an easy manner on a massive scale, in light of effects of treating and improving brain diseases such as Alzheimer's disease, Parkinson disease, depression and schizophrenia, metabolic diseases such as diabetes, various infectious diseases, and immune disorders. [SOLUTION] Ether phospholipids are obtained from bivalve tissues such as clams and corbicula by extraction processing. The ether phospholipids exhibit significantly superior effects of the above as compared to the conventional ether phospholipids derived from chicken tissues.
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公开(公告)号：US20210361681A1
公开(公告)日：2021-11-25
申请号：US16622473
申请日：2019-04-18
发明人： Takehiko FUJINO , Shiro MAWATARI
IPC分类号： A61K31/685 , A61K35/57 , A61K35/618 , A61K35/655 , A61P29/00 , C12P13/00
摘要： A method for manufacturing a functional material that contains plasmalogen, the method including treating an animal tissue containing plasmalogen with protease, and extracting the animal tissue treated with protease with an extraction liquid containing ethanol.
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公开(公告)号：US20180127680A1
公开(公告)日：2018-05-10
申请号：US15572348
申请日：2015-05-12
申请人： Takehiko Fujino , Shiro Mawatari
发明人： Takehiko Fujino , Shiro Mawatari
CPC分类号： C11B3/003 , C07F9/10 , C07F9/103 , C11B1/10 , C11B3/006 , C11B7/0058 , C11B11/00 , C12P7/6481 , C12P9/00
摘要： [PROBLEM TO BE SOLVED] To provide a method for producing ether phospholipids of high purity by an easy process. [SOLUTION] This production method comprises: (A) a step of extracting total lipids from organisms with non-polar organic solvent and branched alcohol mixture; and (B) a step of reacting the total lipids obtained by the step (A) with phospholipase A1 to decompose mixed diacyl-glycerophospholipids. This makes it possible to produce plasmalogen-type glycerophospholipids or ether phospholipids of high purity by an easy process.
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公开(公告)号：US12111307B2
公开(公告)日：2024-10-08
申请号：US16973172
申请日：2019-06-10
CPC分类号： G01N33/491 , G01N15/10 , G01N2015/012 , G01N2015/1006 , G01N2015/1028 , G01N2800/7042
摘要： A method for assessing aging of erythrocytes that includes preparing an erythrocyte suspension from a blood sample; allowing the erythrocyte suspension to pass through a first filter, separating aged erythrocytes that do not pass through the first filter, and non-aged erythrocytes that pass through the first filter, and to calculate a deformability of erythrocytes, allowing the separated non-aged erythrocyte suspension to pass through a second filter having micropores which diameter is smaller than the first filter, separating mild aged erythrocytes that do not pass through the second filter and juvenile erythrocytes that pass through the second filter, and to calculate a deformability of the non-aged erythrocytes; and assessing aging of erythrocytes, using the deformability of erythrocyte and the deformability of non-aged erythrocyte.
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公开(公告)号：US10653708B2
公开(公告)日：2020-05-19
申请号：US15625151
申请日：2017-06-16
发明人： Takehiko Fujino , Shiro Mawatari
IPC分类号： A61K35/618 , A61K31/661 , A61K35/57 , C12P7/64
摘要： The present invention relates to uses of ether phospholipids in treating and preventing various diseases, including, but not limited to, neurodegenerative or brain diseases such as Alzheimer's disease, cognitive impairment, brain fatigue, Parkinson disease, depression, anxiety disorder, insomnia and schizophrenia; metabolic syndrome such as diabetes and obesity; various infectious diseases such as viral diseases; diseases related to inflammation; heart diseases, and immune disorders. Preferably, the ether phospholipids are derived from extracting bivalves, which provides superior efficacies in treating and preventing the diseases.
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公开(公告)号：US10324100B2
公开(公告)日：2019-06-18
申请号：US15478487
申请日：2017-04-04
发明人： Takehiko Fujino , Shiro Mawatari
摘要： The present invention provides methods for quantifying an amount of plasmalogens in samples with high accuracy in an easy, convenient and inexpensive manner by using a hydrolysis processing to samples and a lipid extraction followed by the measurement using High Performance Liquid Chromatography (HPLC) with Evaporative Light Scattering Detector (ELSD) or Mass Spectrometer (MS), a fluorescence plate reader or a plate reader. The present invention also relates to a method for examining a subject by using the above method, a biomarker for disease detection, a method for using the biomarker for the disease detection, as well as a kit for the disease detection.
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公开(公告)号：US20180327433A1
公开(公告)日：2018-11-15
申请号：US15533528
申请日：2015-05-13
发明人： Takehiko FUJINO , Shiro MAWATARI
CPC分类号： C07F9/103 , A23J7/00 , A23L2/52 , A23L33/12 , A23V2002/00 , A61K31/685 , A61K35/618 , C07F9/10 , C11B11/00
摘要： [PROBLEM TO BE SOLVED] It enables any superior ether phospholipids to the conventional ones and a method for producing the same in an easy manner on a massive scale, in light of effects of treating and improving brain diseases such as Alzheimer's disease, Parkinson disease, depression and schizophrenia, metabolic diseases such as diabetes, various infectious diseases, and immune disorders. [SOLUTION] Ether phospholipids are obtained from bivalve tissues such as clams and corbicula by extraction processing. The ether phospholipids exhibit significantly superior effects of the above as compared to the conventional ether phospholipids derived from chicken tissues.
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公开(公告)号：US12060379B2
公开(公告)日：2024-08-13
申请号：US17050905
申请日：2019-04-18
发明人： Takehiko Fujino , Shiro Mawatari , Toyoharu Yamashita , Mitsuru Kitamura , Tatsuo Okauchi , Shamim Hossain
摘要： A compound presented by the general formula (1), its racemic form, or their salt thereof:
wherein in general formula (1), X represents an oxygen atom, nitrogen atom, sulfur atom, or carbon atom, R1 represents R1a—Y—R1b, wherein R1a and R1b independently represent a saturated or unsaturated aliphatic hydrocarbon group, aromatic group, heterocyclic group, or a combination thereof, and Y represents an oxygen atom, nitrogen atom, sulfur atom, or carbon atom, R2 independently represents a saturated or unsaturated aliphatic hydrocarbon group, and R3 represents choline, ethanolamine, inositol, or serine.-
公开(公告)号：US20180284143A1
公开(公告)日：2018-10-04
申请号：US15478487
申请日：2017-04-04
发明人： Takehiko Fujino , Shiro Mawatari
CPC分类号： G01N33/92 , C07F9/103 , C12Q1/26 , C12Q1/28 , C12Q1/44 , G01N2333/92 , G01N2800/04 , G01N2800/042 , G01N2800/28 , G01N2800/2814 , G01N2800/2835 , G01N2800/2864 , G01N2800/323 , G01N2800/50
摘要： The present invention provides methods for quantifying an amount of plasmalogens in samples with high accuracy in an easy, convenient and inexpensive manner by using a hydrolysis processing to samples and a lipid extraction followed by the measurement using High Performance Liquid Chromatography (HPLC) with Evaporative Light Scattering Detector (ELSD) or Mass Spectrometer (MS), a fluorescence plate reader or a plate reader. The present invention also relates to a method for examining a subject by using the above method, a biomarker for disease detection, a method for using the biomarker for the disease detection, as well as a kit for the disease detection.
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