公开(公告)号：US11524061B2

公开(公告)日：2022-12-13

申请号：US17167893

申请日：2021-02-04

申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. ,  THE OHIO STATE UNIVERSITY

发明人： Ramesh Kumar Selvaraj ,  Gabriel Akerele ,  Sankar Renu ,  Renukaradhya J. Gourapura

IPC分类号： A61K39/08 ,  A61K39/00

摘要： The present disclosure relates to nanoparticle compositions for use as vaccines against Clostridium perfringens in poultry which causes necrotic enteritis in poultry. Such compositions include one or more Clostridium perfringens extracellular proteins entrapped in a polyanhydride or chitosan nanoparticle. The one or more Clostridium perfringens extracellular proteins may include one or more Clostridium perfringens toxins, such as, for example, alpha toxin (CPA), beta toxin (CPB), epsilon toxin (ETX), iota toxin (ITX), perfringolysin O (PFO), enterotoxin (CPE), beta2 toxin (CPB2), or NetB toxin. In some aspects, the composition further includes a Salmonella enteritidis flagellar protein. The present invention also includes methods for the oral delivery of one or more Clostridium perfringens extracellular proteins to the mucosal membrane of the intestinal tract of a bird of the order Galliformes.

公开(公告)号：US20210163440A1

公开(公告)日：2021-06-03

申请号：US16630677

申请日：2018-07-12

申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ,  OHIO STATE UNIVERSITY

发明人： Kevin HODGETTS ,  Chien-Liang Glenn LIN

IPC分类号： C07D401/04 ,  C07D401/14 ,  C07D417/14 ,  C07D413/14 ,  C07D213/75 ,  C07D239/42 ,  C07D241/20 ,  C07D241/18 ,  A61P25/28

摘要： The present application provides pyridine, pyrimidine, and pyrazine derivatives that activate excitatory amino acid transporter 2 (EAAT2), and methods of using the derivatives for treating or preventing diseases, disorders, and conditions associated with glutamate excitotoxicity.

公开(公告)号：US10787433B2

公开(公告)日：2020-09-29

申请号：US16070393

申请日：2017-01-13

申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ,  OHIO STATE UNIVERSITY

发明人： Kevin Hodgetts ,  Chien-Liang Glenn Lin

IPC分类号： C07D401/14 ,  C07D413/14 ,  C07D401/04 ,  C07D237/20 ,  C07D417/14 ,  A61P25/00 ,  A61P35/00 ,  A61P29/00

摘要： Pyradizine derivatives that activity the excitatory amino acid transporter 2 (EAAT2) of the formula: and methods of use thereof for treating or preventing diseases, disorders, and conditions with glutamate toxicity.

公开(公告)号：US10725040B2

公开(公告)日：2020-07-28

申请号：US16450476

申请日：2019-06-24

申请人： NATIONWIDE CHILDREN'S HOSPITAL, INC. ,  THE OHIO STATE UNIVERSITY

发明人： Subinoy Das ,  Lauren O. Bakaletz

IPC分类号： G01N33/53 ,  A61K39/00 ,  A61K39/07 ,  G01N33/569 ,  C12Q1/04 ,  A61B10/00

摘要： The invention provides for a proteomic approach for identification of specific bacterial protein profiles that may be used in the development of methods for the diagnosis of bacterial chronic sinusitis. The invention provides for methods for determining the presence of pathogenic bacteria in the upper respiratory tract of a subject using protein profiles of the pathogenic bacteria. The invention also provides for methods of diagnosing a bacterial infection of the upper respiratory tract of a subject using protein profiles of a pathogenic bacteria. In addition, the invention provides for devices, immunoassays and kits for identifying pathogenic bacteria in the upper respiratory tract.

公开(公告)号：US10307490B2

公开(公告)日：2019-06-04

申请号：US13900969

申请日：2013-05-23

申请人： The Ohio State University

发明人： Robert J. Lee ,  Young Bok Lee ,  Deog Joong Kim ,  Chang Ho Ahn

IPC分类号： A61K38/08 ,  A61K45/06 ,  A61K9/127 ,  A61K31/7088 ,  C12N15/113 ,  A61K31/713 ,  A61K47/64 ,  A61K38/10 ,  A61K38/48 ,  C07K16/00 ,  A61K47/54 ,  A61K47/59 ,  A61K47/69 ,  A61K48/00

摘要： Described is a lipid nanoparticle composition that includes a macromolecule conjugated to a polymer and a targeting agent. The composition can include a therapeutic agent. The therapeutic agent can be an antisense oligonucleotide (ASO). Exemplary ASOs are targeted to a portion of a nucleic acid encoding Akt-1, and which modulates the expression of Akt-1; or targeted to a portion of a nucleic acid encoding HIF-1, and which modulates the expression of HIF-1. Also described is a lipid nanoparticle composition that includes a macromolecule conjugated to a polymer and a therapeutic agent that is an ASO such as an ASO targeted to a portion of a nucleic acid encoding Akt-1, and which modulates the expression of Akt-1 or an ASO targeted to a portion of a nucleic acid encoding HIF-1, and which modulates the expression of HIF-1. Pharmaceutical formulations, methods of making the lipid nanoparticles, and methods of using the lipid nanoparticles, for example for treating cancers, are also disclosed.

公开(公告)号：US09610562B2

公开(公告)日：2017-04-04

申请号：US13582339

申请日：2011-03-02

申请人： Susan V. Olesik ,  Joseph W. Zewe

发明人： Susan V. Olesik ,  Joseph W. Zewe

IPC分类号： B01J20/32 ,  C01B31/02 ,  B01J20/20 ,  B32B3/30 ,  B01J20/30 ,  G01N1/40

CPC分类号： B01J20/324 ,  B01J20/20 ,  B01J20/205 ,  B01J20/3057 ,  B01J20/3078 ,  B32B3/30 ,  C01B32/05 ,  G01N1/405 ,  G01N2600/00 ,  Y10T428/24802

摘要： Preparation of a molecularly imprinted carbon is described. The molecularly imprinted carbon has a surface that is imprinted on the molecular level for a specific template molecule of interest, making it highly selective for analytes corresponding to at least a portion of the template molecule. Devices including the molecularly imprinted carbon and their use in methods of detecting analytes are also described. As an example, dibutyl butylphosphonate (DBBP), a surrogate for chemical warfare agents, was used as a template molecule. Electrospun molecularly imprinted SU-8 and pyrolyzed polymer (PP) solid-phase microextraction (SPME) devices were prepared; their ability to preferentially extract DBBP from an aqueous matrix, with and without interferences present, was evaluated via comparison with non-imprinted SU-8 and PP SPME fibers. The electrospun devices demonstrated a higher selectivity for DBBP, as evidenced by their extraction time profiles. The MI-SPME fibers tested extracted at least 60% more DBBP than their non-imprinted counterparts.

公开(公告)号：US09598364B2

公开(公告)日：2017-03-21

申请号：US14468408

申请日：2014-08-26

申请人： Taipei Medical University ,  Ohio State University ,  National Taiwan University

发明人： Ching-Shih Chen ,  Jing-Ping Liou ,  Hsing-Jin Liu ,  Kuo-Sheng Hung ,  Pei-Wen Shan ,  Wen-Ta Chiu ,  Che-Ming Teng

IPC分类号： C07D209/08 ,  C07D209/12 ,  C07D209/40 ,  C07D209/18 ,  C07D209/30

CPC分类号： C07D209/08 ,  C07D209/12 ,  C07D209/18 ,  C07D209/30 ,  C07D209/40

摘要： Indolyl or indolinyl compounds of formula (I): wherein bond, n, R1, R2, R3, R4, R5, and R6, are defined herein. Also disclosed is a method for treating cancer with these compounds.

公开(公告)号：US20160215352A1

公开(公告)日：2016-07-28

申请号：US15095382

申请日：2016-04-11

申请人： The Ohio State University

发明人： Carlo M. Croce ,  George A. Calin ,  Stefano Volinia

IPC分类号： C12Q1/68 ,  C12N15/113

CPC分类号： C12Q1/6886 ,  A61K31/7105 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/113 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2320/11 ,  C12N2320/12 ,  C12N2320/30 ,  C12N2330/10 ,  C12Q1/6837 ,  C12Q2600/158 ,  C12Q2600/178

摘要： Described herein are methods for treating prostate cancer using microRNAs. Also described are methods and compositions for the diagnosis and treatment of solid cancers. Methods of identifying inhibitors of tumorigenesis are also provided.

摘要翻译： 本文描述的是使用微小RNA治疗前列腺癌的方法。 还描述了用于诊断和治疗固体癌症的方法和组合物。 还提供鉴定肿瘤发生抑制剂的方法。

公开(公告)号：US20160186184A1

公开(公告)日：2016-06-30

申请号：US15062404

申请日：2016-03-07

申请人： The Ohio State University Research Foundation ,  The Government of the United States of America, as represented by the Secretary of the Department of

发明人： Carlo M. Croce ,  Stefan Ambs

IPC分类号： C12N15/113 ,  A61K31/713 ,  A61K31/7105

CPC分类号： C12N15/113 ,  A61K31/7105 ,  A61K31/713 ,  C12N15/1135 ,  C12N15/1137 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2320/30 ,  C12N2320/31 ,  C12Q1/6876 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/178

摘要： Methods and compositions for the treatment of prostate associated disorders are disclosed.

摘要翻译： 公开了用于治疗前列腺相关疾病的方法和组合物。

公开(公告)号：US20160186177A1

公开(公告)日：2016-06-30

申请号：US15070644

申请日：2016-03-15

申请人： The Ohio State University

发明人： Carlo M. Croce ,  George A. Calin ,  Stefano Volinia

IPC分类号： C12N15/113

CPC分类号： C12Q1/6886 ,  A61K31/7105 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/113 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2320/11 ,  C12N2320/12 ,  C12N2320/30 ,  C12N2330/10 ,  C12Q1/6837 ,  C12Q2600/158 ,  C12Q2600/178

摘要： Described herein are methods and compositions for the diagnosis and treatment of lung cancers. Methods of identifying inhibitors of tumorigenesis are also provided.

摘要翻译： 本文描述了用于诊断和治疗肺癌的方法和组合物。 还提供鉴定肿瘤发生抑制剂的方法。