利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

73 条记录 (耗时 0.024 秒)

    Pepsinized collagen implants and biomedical uses thereof
    4.
    发明授权
    Pepsinized collagen implants and biomedical uses thereof 有权
    胃蛋白酶胶原植入物及其生物医学用途

    公开(公告)号：US09452240B2

    公开(公告)日：2016-09-27

    申请号：US14209320

    申请日：2014-03-13

    申请人： Orthovita, Inc.

    发明人： Venkat R. Garigapati

    IPC分类号： A61L27/24 ,  A61L27/56 ,  A61L27/54

    CPC分类号： A61L27/24 ,  A61L27/54 ,  A61L27/56 ,  A61L2430/02 ,  A61L2430/34

    摘要： Disclosed are pepsinized collagen implants, such as membranes and sponges, and methods of making them, which entails solubilizing pepsinized collagen in a buffer containing a polyol, e.g., mannitol or sorbitol, wherein the buffer has a substantially neutral pH. Methods of using the pepsinized collagen implants for clinical applications are also disclosed.

    摘要翻译： 公开了胃蛋白酶胶原植入物，例如膜和海绵及其制备方法，其需要将胃蛋白酶胶原蛋白溶解在含有多元醇例如甘露糖醇或山梨醇的缓冲液中，其中缓冲液具有基本上中性的pH。 还公开了将胃蛋白酶胶原植入物用于临床应用的方法。

    COLLAGEN AND ALGINATE-BASED FORMULATIONS FOR HEMOSTASIS
    7.
    发明申请
    COLLAGEN AND ALGINATE-BASED FORMULATIONS FOR HEMOSTASIS 审中-公开
    基于胶原和ALGINATE的制剂用于HEMOSTASIS

    公开(公告)号：US20140271610A1

    公开(公告)日：2014-09-18

    申请号：US13796068

    申请日：2013-03-12

    申请人： ORTHOVITA, INC.

    发明人： James San Antonio

    IPC分类号： A61L26/00

    CPC分类号： A61L26/0052 ,  A61L2400/04 ,  C08L89/06 ,  C08L5/04

    摘要： The present invention relates to composition(s) comprising collagen, calcium ions and alginate, wherein the composition polymerizes in situ when contacted with blood. The composition may further comprise an erythrocyte aggregation agent and/or a platelet activation agent. The composition may be formulated into two separate formulations. The first formulation comprises collagen in a calcium-containing solution and a second formulation comprises an aqueous alginate solution. The two formulations can be mixed prior to the contact with blood or mixed coincident with the contact with blood.

    摘要翻译： 本发明涉及包含胶原，钙离子和藻酸盐的组合物，其中所述组合物在与血液接触时就地聚合。 组合物还可以包含红细胞聚集剂和/或血小板活化剂。 组合物可以配制成两种分开的制剂。 第一种制剂包含含钙溶液中的胶原蛋白，第二种制剂包含海藻酸水溶液。 两种制剂可以在与血液接触之前混合或与血液接触混合。

    MATERIALS AND METHODS FOR REPAIR OF CARTILAGE DEFECTS
    8.
    发明申请
    MATERIALS AND METHODS FOR REPAIR OF CARTILAGE DEFECTS 有权
    修复缺损缺损的材料和方法

    公开(公告)号：US20140114280A1

    公开(公告)日：2014-04-24

    申请号：US13793142

    申请日：2013-03-11

    申请人： ORTHOVITA, INC.

    发明人： Marc Long

    IPC分类号： A61L26/00 ,  A61B17/16

    CPC分类号： A61L27/24 ,  A61B17/16 ,  A61B17/1604 ,  A61B17/1631 ,  A61L2430/06

    摘要： In one embodiment, the present invention includes a method for repairing a cartilage defect including: preparing a cartilage defect by removing unwanted or damaged tissue; creating at least one perforation into or through subchondral bone, below and/or adjacent to the cartilage defect to induce the flow of bone fluid; allowing the bone fluid to bleed through the at least one perforation up into the cartilage defect to fill at least a portion of the cartilage defect; and applying a biomaterial into the defect to produce a clot for cartilage regeneration.

    摘要翻译： 在一个实施方案中，本发明包括修复软骨缺损的方法，包括：通过去除不想要的或损坏的组织来制备软骨缺损; 在软骨缺损下方和/或邻近的软骨下骨中产生至少一个穿孔，以引起骨液的流动; 允许骨液通过所述至少一个穿孔渗透到所述软骨缺损中以填充所述软骨缺损的至少一部分; 并将生物材料应用于缺损以产生用于软骨再生的凝块。

    Non-resorbable implantable guides
    9.
    发明授权
    Non-resorbable implantable guides 有权
    不可吸收的植入式导轨

    公开(公告)号：US08652154B2

    公开(公告)日：2014-02-18

    申请号：US11617404

    申请日：2006-12-28

    申请人： Harvinder Sandhu ,  Maarten Persenaire ,  James P. Murphy ,  Charanpreet S. Bagga

    发明人： Harvinder Sandhu ,  Maarten Persenaire ,  James P. Murphy ,  Charanpreet S. Bagga

    IPC分类号： A61B17/08 ,  A61B1/32

    CPC分类号： A61B17/3423 ,  A61B17/0218 ,  A61B17/3431 ,  A61B17/3439 ,  A61B90/39 ,  A61B2090/3904

    摘要： Surgical devices permitting a surgeon to access repeatedly tissue at a particular surgical site in a patient to perform multiple surgeries over time. The devices have two substantially planar and parallel leaves that are sterile, nonresorbable, and biocompatible. Each leaf forms a continuous structure and defines the entire longitudinal length of the device to accommodate the size and location of the surgical site. A base member is located in situ and adjacent the surgical site. An anchoring surface secures the device to the tissue of the patient at the surgical site. The leaves have a conjoined portion such that a manual force is required to separate the leaves, thereby expeditiously creating a pathway through which access to the tissue at the surgical site is realized with minimal tissue dissection, and the proximal ends of the leaves are not conjoined to facilitate separation of the leaves and creation of the pathway.

    摘要翻译： 手术装置允许外科医生在病人的特定外科手术部位反复进行组织，随着时间的推移进行多次手术。 这些装置具有两个基本上平面和平行的叶片，其是无菌的，不可再吸收的和生物相容的。 每个叶片形成连续的结构并且限定了装置的整个纵向长度以适应手术部位的尺寸和位置。 基部构件位于原位并且邻近手术部位。 锚固表面将装置固定在外科手术部位的患者组织上。 叶子具有结合部分，使得需要手动力来分离叶子，从而迅速地创建一个途径，通过该路径可以实现最少组织切除的外科手术部位的组织进入，并且叶片的近端不结合 以促进叶片的分离和途径的产生。