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公开(公告)号：US11413224B2
公开(公告)日：2022-08-16
申请号：US16306881
申请日：2017-06-21
摘要： An oil-gel-form external preparation for skin contains a compound represented by the following General Formula (1), an isomer thereof, and/or a pharmaceutically acceptable salt thereof. A partially cross-linked methyl polysiloxane; allows easy penetration of the compound from the preparation into the skin while enhancing the percutaneous absorbability and improving the intradermal retentivity. In the formula, R1 represents a C1-C4 linear or branched alkyl group substituted by a carboxyl group(s), or a C1-C4 linear or branched alkyl group substituted by a carboxylic acid ester group(s) having a C1-C4 alkyl chain, and R2 and R3 each independently represent a C1-C4 linear or branched alkyl group.
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2.发明授权Titania fine-particle composite and compositions containing the titania fine-particle composite 有权二氧化钛微粒复合材料和含有二氧化钛微粒复合材料的组合物公开(公告)号：US08945520B2
公开(公告)日：2015-02-03
申请号：US12989145
申请日：2009-04-28
申请人： Eiji Takahashi
发明人： Eiji Takahashi
IPC分类号： A61K8/29 , A61Q17/04 , C09C1/36 , A61K8/11 , A61K8/362 , A61K8/39 , A61K8/81 , B82Y30/00 , A61Q1/02
CPC分类号： A61K8/8147 , A61K8/0241 , A61K8/11 , A61K8/29 , A61K8/345 , A61K8/362 , A61K8/39 , A61K8/8164 , A61K2800/412 , A61Q1/02 , A61Q17/04 , B82Y30/00 , C01P2002/82 , C01P2004/64 , C01P2006/22 , C09C1/3661 , C09C1/3669 , C09C1/3676 , C09C1/3692
摘要： Provided are a novel titania fine-particle composite which has high transparency, high stability, and high ultraviolet-absorbing power and excellent redispersibility, and skin-care external preparations which contain the titania fine-particle composite and exert high ultraviolet protective effect. The titania fine-particle composite can be produced by adding one or more selected from among carboxylic acids and carboxylic acid derivatives represented by general formula (1), and polymers containing the carboxylic acids or carboxylic acid derivatives as a constituent monomer to an aqueous acid dispersion of titania fine particles, and neutralizing the resulting dispersion with an alkali to form a titania fine-particle composite composed of titania fine particles functioning as cores and the carboxylic monomer or polymer deposited on the surface of the cores. In the titania fine-particle composite, titania fine particles functioning as cores have a high degree of crystallization and the intermolecular interaction between titania fine particles and the carboxylic monomer or polymer is strong. Therefore, the titania fine-particle composite can be uniformly dispersed in a dispersion medium to attain high transparency and high stability. Further, skin-care external preparations which exert high ultraviolet protective effect can be produced by adding the titania fine-particle composite.
摘要翻译： 提供了具有高透明度，高稳定性，高紫外线吸收力和优异的再分散性的新型二氧化钛微粒复合体，以及含有二氧化钛微粒复合体并具有高紫外线保护作用的护肤外用剂。 二氧化钛微粒复合体可以通过将选自由通式（1）表示的羧酸和羧酸衍生物中的一种或多种，以及含有羧酸或羧酸衍生物作为构成单体的聚合物加入到酸性分散体 的二氧化钛细颗粒，并用碱中和所得分散体以形成由作为核心的二氧化钛细颗粒和沉积在芯的表面上的羧基单体或聚合物组成的二氧化钛微粒复合体。 在二氧化钛微粒复合体中，作为芯的二氧化钛微粒具有高结晶度，二氧化钛微粒与羧酸单体或聚合物之间的分子间相互作用强。 因此，可以将二氧化钛微粒复合体均匀地分散在分散介质中，以获得高透明性和高稳定性。 此外，通过添加二氧化钛微粒复合体可以制造出具有高紫外线保护作用的护肤外用制剂。
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3.发明授权公开(公告)号：US08865208B2
公开(公告)日：2014-10-21
申请号：US12601481
申请日：2008-04-10
IPC分类号： A61K9/127 , A61K8/44 , A61K8/41 , A61K8/64 , A61K8/34 , A61K36/00 , A61K8/68 , A61K8/63 , A61K8/14 , A61K31/56 , A61K8/60 , A61Q19/00 , A61K8/97 , A61K8/67 , A61K31/05 , A61K31/352 , A61K8/39 , A61K31/7048 , A61K8/86 , A61K8/368 , A61K8/37 , A61K8/49 , A61K31/16 , A61K31/164 , A61K31/19 , A61K9/00
CPC分类号： A61K9/0014 , A61K8/14 , A61K8/347 , A61K8/368 , A61K8/375 , A61K8/39 , A61K8/41 , A61K8/44 , A61K8/4913 , A61K8/498 , A61K8/602 , A61K8/63 , A61K8/64 , A61K8/676 , A61K8/68 , A61K8/86 , A61K8/97 , A61K31/05 , A61K31/16 , A61K31/164 , A61K31/19 , A61K31/352 , A61K31/56 , A61K31/7048 , A61K36/00 , A61Q19/00
摘要： Disclosed is a technique for allowing an active ingredient as an agent for improving or maintaining the dermal environment to reach a dermis. Specifically disclosed is a vesicle comprising the following components 1) to 3): 1) an α,ε-bis(γ-N—(C10-30)acylglutamyl)lysine and/or a salt thereof; 2) ceramide and/or a derivative thereof; and 3) one or more selected from a glycerin fatty acid ester, a polyglycerin fatty acid ester and a pyroglutamic acid glycerin fatty acid ester. The acyl group in the α,ε-bis(γ-N—(C10-30)acylglutamyl)lysine is preferably a lauroyl group. The ceramide or the derivative thereof is preferably ceramide type-2 or ceramide type-3. The vesicle can encapsulate an active ingredient. The vesicle can be contained in an external preparation for the skin.
摘要翻译： 公开了一种允许活性成分作为改善或维持皮肤环境以达到真皮的药剂的技术。 具体公开的是包含以下组分1）至3）的囊泡：1）α，β-二（γ-N-（C10-30）酰基谷氨酰基）赖氨酸和/或其盐; 2）神经酰胺和/或其衍生物; 和3）选自甘油脂肪酸酯，聚甘油脂肪酸酯和焦谷氨酸甘油脂肪酸酯中的一种或多种。 α，β-二（γ-N-（C10-30）酰谷氨酰）赖氨酸中的酰基优选为月桂酰基。 神经酰胺或其衍生物优选为神经酰胺型-2或神经酰胺型-3。 囊泡可以包封活性成分。 囊泡可以包含在皮肤的外用制剂中。
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4.发明申请公开(公告)号：US20140235577A1
公开(公告)日：2014-08-21
申请号：US14244600
申请日：2014-04-03
IPC分类号： A61K31/695 , A61K31/56
CPC分类号： A61K31/695 , A61K8/26 , A61K8/416 , A61K8/891 , A61K9/0014 , A61K31/56 , A61K33/06 , A61K35/02 , A61K47/32 , A61K47/34 , A61K2800/75 , A61Q17/00 , A61K2300/00
摘要： To provide An external skin agent that prevents onset of atopic skin inflammations and is low irritant to skin, which is characterized by including: 1) clay modified by a compound having a quaternary amino group; and 2) a polymer or copolymer that has a side chain including a structure similar to a biological component.
摘要翻译： 提供防止特应性皮肤炎症发作的皮肤外用剂，对皮肤的刺激性低，其特征在于包括：1）由具有季氨基的化合物改性的粘土; 和2）具有包含类似于生物组分的结构的侧链的聚合物或共聚物。
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5.发明授权公开(公告)号：US08741323B2
公开(公告)日：2014-06-03
申请号：US11722338
申请日：2005-11-25
IPC分类号： A61Q19/00
CPC分类号： A61K31/695 , A61K8/26 , A61K8/416 , A61K8/891 , A61K9/0014 , A61K31/56 , A61K33/06 , A61K35/02 , A61K47/32 , A61K47/34 , A61K2800/75 , A61Q17/00 , A61K2300/00
摘要： To provide An external skin agent that prevents onset of atopic skin inflammations and is low irritant to skin, which is characterized by including: 1) clay modified by a compound having a quaternary amino group; and 2) a polymer or copolymer that has a side chain including a structure similar to a biological component.
摘要翻译： 提供防止特应性皮肤炎症发作的皮肤外用剂，对皮肤的刺激性低，其特征在于包括：1）由具有季氨基的化合物改性的粘土; 和2）具有包含类似于生物组分的结构的侧链的聚合物或共聚物。
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公开(公告)号：US08526689B2
公开(公告)日：2013-09-03
申请号：US12526855
申请日：2007-02-14
申请人： Kenya Hirayama , Taro Katayama , Kazuhiro Yamazaki
发明人： Kenya Hirayama , Taro Katayama , Kazuhiro Yamazaki
IPC分类号： G06K9/00
CPC分类号： G06K9/0014
摘要： On the methods of creating corneocyte specimen for providing useful information for appropriate selection of cosmetic products or assessment of the skin condition, it is intended to provide a method of indicating an unstained image of corneocytes or the like in an observable pseudocolor in a method of creating corneocyte specimen, without resorting to staining the corneocyte specimen. The state of corneocytes of skin is input into a computer as an enlarged image by using, for example, a digital microscope. Then, the RGB values of the individual pixels in the image are converted with the use of a conversion system such as a conversion formula, a conversion table or a conversion chart and an image is indicated in a pseudocolor by using the individual RGB values converted.
摘要翻译： 关于提供适当选择化妆品或评估皮肤状况的有用信息的角质细胞标本的方法，旨在提供一种在可观察到的伪色中指示角质形成的未染色图像的方法， 角膜细胞标本，无需染色角质细胞标本。 通过使用例如数字显微镜，将皮肤的角质细胞的状态作为放大图像输入计算机。 然后，通过使用诸如转换公式，转换表或转换图的转换系统来转换图像中的各个像素的RGB值，并且通过使用转换的各个RGB值在伪色中指示图像。
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7.发明申请TITANIA FINE-PARTICLE COMPOSITE AND COMPOSITIONS CONTAINING THE TITANIA FINE-PARTICLE COMPOSITE 有权TITANIA微粒复合材料和组合物，包含钛铁合金微粒复合材料公开(公告)号：US20110038817A1
公开(公告)日：2011-02-17
申请号：US12989145
申请日：2009-04-28
申请人： Eiji Takahashi
发明人： Eiji Takahashi
CPC分类号： A61K8/8147 , A61K8/0241 , A61K8/11 , A61K8/29 , A61K8/345 , A61K8/362 , A61K8/39 , A61K8/8164 , A61K2800/412 , A61Q1/02 , A61Q17/04 , B82Y30/00 , C01P2002/82 , C01P2004/64 , C01P2006/22 , C09C1/3661 , C09C1/3669 , C09C1/3676 , C09C1/3692
摘要： Provided are a novel titania fine-particle composite which has high transparency, high stability, and high ultraviolet-absorbing power and excellent redispersibility, and skin-care external preparations which contain the titania fine-particle composite and exert high ultraviolet protective effect. The titania fine-particle composite can be produced by adding one or more selected from among carboxylic acids and carboxylic acid derivatives represented by general formula (1), and polymers containing the carboxylic acids or carboxylic acid derivatives as a constituent monomer to an aqueous acid dispersion of titania fine particles, and neutralizing the resulting dispersion with an alkali to form a titania fine-particle composite composed of titania fine particles functioning as cores and the carboxylic monomer or polymer deposited on the surface of the cores In the titania fine-particle composite, titania fine particles functioning as cores have a high degree of crystallization and the intermolecular interaction between titania fine particles and the carboxylic monomer or polymer is strong. Therefore, the titania fine-particle composite can be uniformly dispersed in a dispersion medium to attain high transparency and high stability. Further, skin-care external preparations which exert high ultraviolet protective effect can be produced by adding the titania fine-particle composite.
摘要翻译： 提供了具有高透明度，高稳定性，高紫外线吸收力和优异的再分散性的新型二氧化钛微粒复合体，以及含有二氧化钛微粒复合体并具有高紫外线保护作用的护肤外用剂。 二氧化钛微粒复合体可以通过将选自由通式（1）表示的羧酸和羧酸衍生物中的一种或多种，以及含有羧酸或羧酸衍生物作为构成单体的聚合物加入到酸性分散体 的二氧化钛细颗粒，并用碱中和所得分散体，形成由作为核心的二氧化钛微粒和沉积在芯的表面上的羧基单体或聚合物组成的二氧化钛微粒复合体。在二氧化钛微粒复合体中， 作为核心的二氧化钛微粒具有高度的结晶度，二氧化钛微粒与羧酸单体或聚合物之间的分子间相互作用强。 因此，可以将二氧化钛微粒复合体均匀地分散在分散介质中，以获得高透明性和高稳定性。 此外，通过添加二氧化钛微粒复合体可以制造出具有高紫外线保护作用的护肤外用制剂。
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公开(公告)号：US20100111382A1
公开(公告)日：2010-05-06
申请号：US12526855
申请日：2007-02-14
申请人： Kenya Hirayama , Taro Katayama , Kazuhiro Yamazaki
发明人： Kenya Hirayama , Taro Katayama , Kazuhiro Yamazaki
IPC分类号： G06K9/00
CPC分类号： G06K9/0014
摘要： On the methods of creating corneocyte specimen for providing useful information for appropriate selection of cosmetic products or assessment of the skin condition, it is intended to provide a method of indicating an unstained image of corneocytes or the like in an observable pseudocolor in a method of creating corneocyte specimen, without resorting to staining the corneocyte specimen. The state of corneocytes of skin is input into a computer as an enlarged image by using, for example, a digital microscope. Then, the RGB values of the individual pixels in the image are converted with the use of a conversion system such as a conversion formula, a conversion table or a conversion chart and an image is indicated in a pseudocolor by using the individual RGB values converted.
摘要翻译： 关于提供适当选择化妆品或评估皮肤状况的有用信息的角质细胞标本的方法，旨在提供一种在可观察到的伪色中指示角质形成的未染色图像的方法， 角膜细胞标本，无需染色角质细胞标本。 通过使用例如数字显微镜，将皮肤的角质细胞的状态作为放大图像输入计算机。 然后，通过使用诸如转换公式，转换表或转换图的转换系统来转换图像中的各个像素的RGB值，并且通过使用转换的各个RGB值在伪色中指示图像。
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9.发明申请ORGANIC INORGANIC COMPOSITE POWDER, METHOD OF PRODUCING THE SAME, AND COMPOSITION CONTAINING THE POWDER 审中-公开有机无机复合粉末及其制造方法以及含有粉末的组合物公开(公告)号：US20090162302A1
公开(公告)日：2009-06-25
申请号：US12093680
申请日：2006-06-15
申请人： Yutaka Takasuga , Eiji Takahashi
发明人： Yutaka Takasuga , Eiji Takahashi
IPC分类号： C08K3/08 , C04B14/00 , C08K3/12 , C08K3/22 , A61K8/29 , A61K8/28 , A61K8/27 , A61K8/04 , A61K8/19 , B05D5/00 , A61Q1/02
CPC分类号： A61Q19/00 , A61K8/11 , A61K2800/412 , A61Q17/04 , B22F1/0059 , B22F9/24 , B82Y30/00 , C01P2002/30 , C01P2004/04 , C01P2004/10 , C01P2004/62 , C01P2004/64 , C08K3/22 , C08K5/09 , C08K9/08 , C09C1/043 , C09C1/24 , C09C1/3676 , C09C3/08 , C09C3/10 , C09D7/61 , C09D7/62 , C09D7/67 , C09D7/70 , C09D11/03 , C09D11/037 , C09D133/02
摘要： The present invention provides an organic inorganic composite powder which has a specific particle shape in accordance with to a washing solvent, which contains fine inorganic particles, and which easily disperses in water by: precipitating a metal salt dissolved in a reaction solvent from the reaction solvent through neutralization or reduction in the presence of a polymer or monomer dissolved in the reaction solvent; polymerizing the monomer after precipitation of the metal salt in the case where the monomer forms no composite with the metal salt during precipitation in the presence of the monomer; washing the obtained precipitate with a specific washing solvent; and drying the resultant.
摘要翻译： 本发明提供一种有机无机复合粉末，其具有与洗涤溶剂相应的特定粒子形状，其含有无机微粒，并且易于分散于水中：将溶解在反应溶剂中的金属盐从反应溶剂中沉淀出来 通过溶解在反应溶剂中的聚合物或单体的存在进行中和或还原; 在单体存在下，在沉淀期间单体不与金属盐形成复合物的情况下，金属盐析出后使单体聚合; 用特定的洗涤溶剂洗涤所得沉淀物; 并干燥所得物。
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公开(公告)号：US20060229912A1
公开(公告)日：2006-10-12
申请号：US11398417
申请日：2006-04-05
摘要： A beauty information providing system, includes: a first computer used in counseling of a customer who visits a merchandise store; a second computer used in counseling of a customer who visits an aesthetic treatment salon; a server connected to the first and second computers via communication networks; evaluation result creating unit which creates results of evaluating a customer's skin based on at least results of analysis on images of corneocytes collected from the customer's skin, results of analysis on enlarged images of the customer's skin, and the customer's answers to a skin evaluation questionnaire; and screen data creating unit which creates screen data for showing the evaluation results, screen data for showing skin care advice suited to the evaluation results, and screen data for showing an aesthetic treatment recipe suited to the evaluation results.
摘要翻译： 美容信息提供系统包括：用于咨询访问商品商店的顾客的第一台电脑; 用于咨询访问审美沙龙的顾客的第二台电脑; 通过通信网络连接到第一和第二计算机的服务器; 评估结果创建单元，其至少基于从客户皮肤收集的角质细胞的图像的分析结果和客户皮肤的放大图像的分析结果以及客户对皮肤评估问卷的回答来创建评估客户皮肤的结果; 以及屏幕数据创建单元，其创建用于显示评估结果的屏幕数据，用于显示适合于评估结果的皮肤护理建议的屏幕数据，以及用于显示适合于评估结果的美学处理方法的屏幕数据。
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