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公开(公告)号：US12116617B2
公开(公告)日：2024-10-15
申请号：US16989545
申请日：2020-08-10
发明人： Sum Chan , Qibo Jiang , Richard E. Reitz
摘要： Provided are methods for determining the amount of total thiamine in a body fluid sample using liquid chromatography and mass spectrometry. Total thiamine is converted to free thiamine by treatment with an acid phosphatase prior to thiamine separation and quantification.
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公开(公告)号：US11885820B2
公开(公告)日：2024-01-30
申请号：US17408298
申请日：2021-08-20
CPC分类号： G01N33/82 , G01N30/7233 , G01N30/88 , G01N2030/8813 , H01J49/0031 , H01J49/0045 , Y10T436/203332 , Y10T436/24
摘要： The invention relates to the detection of vitamin D metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D metabolites by mass spectrometry.
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公开(公告)号：US20230420235A1
公开(公告)日：2023-12-28
申请号：US18466168
申请日：2023-09-13
发明人： Qibo Jiang , Sum Chan , Richard E Reitz
CPC分类号： H01J49/0031 , G01N33/82 , G01N33/49 , H01J49/004 , Y10T436/145555
摘要： Provided are methods of detecting the presence or amount of the active form of vitamin B6, pyridoxal 5′-phosphate, in a body fluid sample using tandem mass spectrometry coupled with liquid chromatography.
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公开(公告)号：US20230375575A1
公开(公告)日：2023-11-23
申请号：US18364356
申请日：2023-08-02
发明人： Brett Holmquist , Nigel Clarke
CPC分类号： G01N33/82 , G01N33/6848 , G01N33/6851 , H01J49/0027 , Y10T436/212 , H01J49/00 , G01N2560/00
摘要： The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry.
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公开(公告)号：US11821889B2
公开(公告)日：2023-11-21
申请号：US17715202
申请日：2022-04-07
发明人： Changming Yang , Sum Chan
CPC分类号： G01N33/487 , G01N30/72 , G01N30/7233 , G01N33/6848 , G01N33/82 , H01J49/0027 , H01J49/0031 , H01J49/0054 , G01N2030/027 , Y10T436/147777
摘要： Methods are described for measuring the amount of a vitamin B2 in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying vitamin B2 in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques.
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公开(公告)号：US20230266347A1
公开(公告)日：2023-08-24
申请号：US18142153
申请日：2023-05-02
发明人： Brett HOLMQUIST , Nigel CLARKE , Anne Caston , Richard E. Reitz
IPC分类号： G01N33/82
CPC分类号： G01N33/82 , Y10T436/10 , Y10T436/20 , Y10T436/203332 , Y10T436/24
摘要： Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydorxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay.
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公开(公告)号：US11669228B2
公开(公告)日：2023-06-06
申请号：US17346843
申请日：2021-06-14
发明人： Peter Wilkinson , Kerry O'Brien
IPC分类号： G06F3/0484 , G16H15/00 , G06F16/20 , G06F16/951 , G06F3/0482 , G06F3/04847
CPC分类号： G06F3/0484 , G06F3/0482 , G06F3/04847 , G06F16/20 , G06F16/951 , G16H15/00
摘要： Computer systems and methods may display multi-dimensional data sets in a dynamically-generated ocular view, which may show the relationship between data points in the different dimensions. For example, such a data set may include in one dimension results of one or more laboratory tests and, in another dimension, body systems or functions that the respective tests may relate to. The ocular view may depict the relationships between the tests and the systems. By being generated dynamically, moreover, the ocular view may be able to present this information for arbitrary sets of test results, without a template having been generated in advance to specify the layout of some particular combination of results.
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公开(公告)号：US20230114103A1
公开(公告)日：2023-04-13
申请号：US17893950
申请日：2022-08-23
发明人： Nigel CLARKE
摘要： Provided are methods for determining the amount of tamoxifen and its metabolites in a sample by mass spectrometry. In some aspects, the methods provided herein determine the amount of N-Desmethyl Tamoxifen. In some aspects, the methods provided herein determine the amount of N-Desmethyl Tamoxifen and other tamoxifen metabolites. In some aspects, the methods provided herein determine the amount of tamoxifen, N-Desmethyl Tamoxifen, and other tamoxifen metabolites.
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公开(公告)号：US20230039315A1
公开(公告)日：2023-02-09
申请号：US17949863
申请日：2022-09-21
发明人： Cory Bystrom , Shijun Sheng , Nigel Clarke , Richard Reitz
摘要： Methods are provided for determining the amount of an IGF-I and/or IGF-II protein in a sample using high resolution/high accuracy mass spectrometry. The methods generally comprise enriching an IGF-I and/or IGF-II protein in a sample, ionizing an IGF-I and/or IGF-II protein from the sample to generate IGF-I and/or IGF-II protein ions, and determining the amount of IGF-I and/or IGF-II protein ions with high resolution/high accuracy mass spectrometry.
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公开(公告)号：US11486007B2
公开(公告)日：2022-11-01
申请号：US15315874
申请日：2015-06-03
发明人： Susanne Pedersen , Lawrence LaPointe , Rohan Baker , Amber C. Donahue , Yen-lin Peng , Frederic Waldman
IPC分类号： C12Q1/68 , C12P19/34 , C12Q1/6886
摘要： Disclosed herein is a combination of genomic sequences whose methylation patterns have utility for the improved detection and differentiation between colorectal neoplasms. Further disclosed herein are methods, nucleic acids and kits for detecting or differentiating between colorectal neoplasms.
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