公开(公告)号：US3956501A

公开(公告)日：1976-05-11

申请号：US494748

申请日：1974-08-05

申请人： Laszlo Beregi ,  Charles Malen ,  Pierre Hugon ,  Jacques Duhault

发明人： Laszlo Beregi ,  Charles Malen ,  Pierre Hugon ,  Jacques Duhault

IPC分类号： A61K31/24 ,  A61K31/335 ,  A61K31/357 ,  A61P3/04 ,  A61P3/06 ,  A61P3/08 ,  C07C67/00 ,  C07C227/00 ,  C07C227/08 ,  C07C227/10 ,  C07C229/14 ,  C07C229/36 ,  C07D317/54 ,  C07D317/58 ,  C07C101/16 ,  C07D317/64

CPC分类号： C07D317/54

摘要： N-substituted glycinates of the formula: ##EQU1## optical isomers and acid addition salts thereof, wherein R is cyclopentyl, cyclohexyl, benzyl, halobenzyl, lower alkylbenzyl, lower alkoxybenzyl, methylenedioxybenzyl or trifluoromethylbenzyl.These compounds are used as medicines especially in the treatment of obesity or other metabolic diseases needing weight reduction and regulation.

摘要翻译： 其中R为环戊基，环己基，苄基，卤代苄基，低级烷基苄基，低级烷氧基苄基，亚甲二氧基苄基或三氟甲基苄基的N-取代甘氨酸盐，其分子式如下：CH2-CH-NH-CH2-COOR | CH3光学异构体及其酸加成盐。

公开(公告)号：US4001420A

公开(公告)日：1977-01-04

申请号：US463912

申请日：1974-04-25

申请人： Charles Malen ,  Pierre Desnoyers

发明人： Charles Malen ,  Pierre Desnoyers

IPC分类号： A61K31/425

CPC分类号： A61K31/425

摘要： m-(thiazol-4-yl) benzoic acids substituted in 2- and optionally 5-position of the thiazol ring by lower alkyl, phenylalkyl, phenyl, halo-phenyl, lower alkylphenyl or lower alkoxyphenyl, and on the phenyl ring of the benzoic acid moiety by halogen, hydroxyl, lower alkyl or lower alkoxy. These compounds possess fibrinolytic, platelet stickiness decreasing and antiulcer properties and have an impact on the immunological processes.

公开(公告)号：US3989834A

公开(公告)日：1976-11-02

申请号：US558043

申请日：1975-03-13

申请人： Charles Malen ,  Pierre Roger ,  Jean-Claude Poignant ,  Xavier Pascaud

发明人： Charles Malen ,  Pierre Roger ,  Jean-Claude Poignant ,  Xavier Pascaud

IPC分类号： A61K31/165 ,  A61K31/275 ,  A61K31/40 ,  A61K31/435 ,  A61K31/445 ,  A61K31/535 ,  A61P1/04 ,  A61P1/14 ,  C07C67/00 ,  C07C231/00 ,  C07C231/02 ,  C07C231/12 ,  C07C237/04 ,  C07D207/08 ,  C07D207/09 ,  C07D211/34 ,  C07D211/60 ,  C07D295/15 ,  C07D211/06

CPC分类号： C07D207/08 ,  C07D211/34 ,  C07D211/60 ,  C07D295/15 ,  Y10S514/925

摘要： This invention relates to ortho-alkoxy anilines having the amino group substituted with an amino lower alkyl carboxylic residue, as well as their physiologically-compatible acid-addition salts and their optically-active isomers.

公开(公告)号：US3988464A

公开(公告)日：1976-10-26

申请号：US427999

申请日：1973-12-26

申请人： Charles Malen ,  Monique Desnos ,  Michel Laubie ,  Jean-Claude Poignant

发明人： Charles Malen ,  Monique Desnos ,  Michel Laubie ,  Jean-Claude Poignant

IPC分类号： C07D243/04 ,  A61K31/13 ,  A61K31/33 ,  A61K31/415 ,  A61K31/42 ,  A61K31/421 ,  A61K31/425 ,  A61K31/426 ,  A61K31/495 ,  A61K31/496 ,  A61K31/505 ,  A61K31/535 ,  A61K31/5377 ,  A61K31/54 ,  A61K31/55 ,  A61P9/00 ,  A61P9/12 ,  A61P25/00 ,  A61P25/04 ,  A61P25/18 ,  A61P25/20 ,  A61P27/02 ,  C07C209/08 ,  C07C209/60 ,  C07C211/17 ,  C07C275/18 ,  C07C335/08 ,  C07D233/48 ,  C07D239/14 ,  C07D247/02 ,  C07D263/16 ,  C07D263/28 ,  C07D265/06 ,  C07D265/08 ,  C07D267/06 ,  C07D277/18 ,  C07D279/06 ,  C07D281/02 ,  A01N9/22 ,  A01N9/28

CPC分类号： C07C335/08 ,  C07C275/18 ,  C07D233/48 ,  C07D263/28 ,  C07D265/06 ,  C07D277/18 ,  C07C2101/02

摘要： The present invention relates to cyclopropylmethyl amines substituted by a heterocyclic radical.More particularly the heterocyclic radical is a nitrogen containing ring with 5, 6 or 7 links interrupted by another hetero atom selected from the group consisting of oxygen, sulphur and imino--NH--The invention also relates to the acid addition salts thereof with physiologically compatible mineral or organic acids.The invention extends to the processes for making them and the intermediates produced hereto.The invention also includes the pharmaceutical compositions incorporating as active ingredient at least one compound of the invention with an inert carrier.The compounds have therapeutic utility namely on the cardio-vascular diseases and on the neuro-psychological disturbances.

摘要翻译： 本发明涉及被杂环基取代的环丙基甲胺。

公开(公告)号：US3983249A

公开(公告)日：1976-09-28

申请号：US536669

申请日：1974-12-26

申请人： Stewart J. Ehrreich ,  Lester Zitowitz

发明人： Stewart J. Ehrreich ,  Lester Zitowitz

IPC分类号： A61K31/395 ,  A61K31/435 ,  A61K31/445 ,  A61K31/55 ,  C07D209/52 ,  A61K31/18

CPC分类号： C07D209/52 ,  A61K31/395 ,  A61K31/445 ,  A61K31/55

摘要： This application is directed to certain novel sulfonyl urea compounds, to their use as antianginal agents, and to the use of certain prior art sulfonyl ureas as antianginal agents. The sulfonyl ureas are characterized in that they are N-arylsulfonyl-N'-methyl-N'(aza-3-bicycloalkyl) ureas and N-arylsulfonyl-N'-(aza-3-bicycloalkyl) ureas.

摘要翻译： 本申请涉及某些新型磺酰脲化合物，用作抗心绞痛剂，以及某些现有技术磺酰脲类作为抗血管药的用途。 磺酰脲的特征在于它们是N-芳基磺酰基-N'-甲基-N'（氮杂-3-二环烷基）脲和N-芳基磺酰基-N' - （氮杂-3-二环烷基）脲。

公开(公告)号：US3970663A

公开(公告)日：1976-07-20

申请号：US615452

申请日：1975-09-22

申请人： Gilbert Regnier ,  Roger Canevari ,  Xavier Pascaud

发明人： Gilbert Regnier ,  Roger Canevari ,  Xavier Pascaud

IPC分类号： C07D239/42 ,  C07D401/12 ,  C07D403/12 ,  C07D213/56

CPC分类号： C07D401/12 ,  C07D239/42 ,  C07D403/12 ,  Y10S514/926

摘要： Heterocyclic amides of the formula: ##EQU1## wherein: X is N or CH;n is O or 1 andR is ##EQU2## wherein: R.sub.1 is hydrogen or methyl, R.sub.2 and R.sub.3 which are the same, are lower alkyl or joined together, represent a polymethylenic chain from C.sub.4 to C.sub.7 optionally including an oxygen atom, andR' is saturated or unsaturated acyclic hydrocarbon radicals from C.sub.1 to C.sub.20, cycloalkyl from C.sub.3 to C.sub.7, Ar - A- or ##EQU3## wherein: A is a single bond or a saturated or unsaturated acyclic hydrocarbon chain from C.sub.1 to C.sub.6 optionally including an oxygen atom, andAr and R" are aromatic, alkoxy aromatic, methylenedioxy aromatic or polymethylenedioxy aromatic.These compounds are used as medicine, especially in the treatment of gastric hypersecretion, gastroduodenal ulcers and central nervous system disorders.

摘要翻译： 式：CO-NH-（CH2）n-RH2N的杂环酰胺其中：

公开(公告)号：US3969521A

公开(公告)日：1976-07-13

申请号：US515785

申请日：1974-10-17

申请人： Jean-Claude Poignant

发明人： Jean-Claude Poignant

IPC分类号： B41K3/08 ,  B41K5/02 ,  B65C1/00 ,  B65C11/02 ,  A61K31/475

CPC分类号： B65C11/021 ,  B41K5/023 ,  B41K5/026

摘要： Pharmaceutical compositions containing tetrahydroalstonine or a therapeutically acceptable salt thereof are disclosed. These compositions are useful for treating circulation disorders and more particularly brain circulation disorders.

摘要翻译： 公开了含有四氢奥沙星或其治疗上可接受的盐的药物组合物。 这些组合物可用于治疗循环障碍，特别是脑循环障碍。

公开(公告)号：US4010267A

公开(公告)日：1977-03-01

申请号：US562226

申请日：1975-03-26

申请人： Gilbert Regnier ,  Roger Canevari ,  Michel Laubie ,  Jean-Claude Poignant

发明人： Gilbert Regnier ,  Roger Canevari ,  Michel Laubie ,  Jean-Claude Poignant

IPC分类号： A61K31/495 ,  A61P9/08 ,  A61P25/26 ,  C07D317/46 ,  C07D317/72 ,  C07D405/12 ,  C07D417/12 ,  C07D295/08

CPC分类号： C07D317/72 ,  C07D317/46 ,  Y10S514/929

摘要： Benzodioxole compounds of the formula: vasodilator ##STR1## WHEREIN R.sub.1 is hydrogen, lower alkyl, aryl, haloaryl, lower-alkylaryl, lower-alkoxyaryl, methylenedioxyaryl, ethylenedioxyaryl, trifluoromethylaryl, nitroaryl or aminoaryl,R.sub.2 is lower-alkyl, aryl, haloaryl, lower-alkylaryl, lower-alkoxyaryl, methylenedioxyaryl, ethylenedioxyaryl, trifluoromethylaryl, nitroaryl or aminoaryl, orR.sub.1 + r.sub.2 are --(CH.sub.2).sub.4 --, --(CH.sub.2).sub.5 -- or --(CH.sub.2).sub.6 -- andHet is pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, quinazolinyl, 1,3,5 triazinyl or 1,3-thiazolyl, each being optionally substituted by lower-alkyl, lower-alkoxy, hydroxyl or phenyl.These compounds are used as medicines especially as peripheral vasocilator agent and central nervous system stimulant.