公开(公告)号：US08414182B2

公开(公告)日：2013-04-09

申请号：US12414597

申请日：2009-03-30

申请人： Brian Kevin Paul ,  Anna Evelyn Garrison

发明人： Brian Kevin Paul ,  Anna Evelyn Garrison

IPC分类号： B01F13/00

CPC分类号： B01F13/0059 ,  B01F5/061 ,  B01F5/0646 ,  B01F5/0647 ,  B01F5/065 ,  B01F5/0682 ,  B01F5/0689 ,  B01F13/1013 ,  B01F13/1022 ,  B01F2005/0621 ,  B01F2005/0636 ,  B01F2215/0404

摘要： A micromixer device has at least one fluid inlet channel and at least one fluid outlet channel. A plurality of pathways extend between the fluid inlet channel and the fluid outlet channel. The width of at least some of the plurality of pathways varies in a substantially parabolic manner along at least one dimension of the micromixer device.

摘要翻译： 微混合器装置具有至少一个流体入口通道和至少一个流体出口通道。 多个通道在流体入口通道和流体出口通道之间延伸。 多个通路中的至少一些路径的宽度以微混合器装置的至少一个维度基本抛物线的方式变化。

公开(公告)号：US08273245B2

公开(公告)日：2012-09-25

申请号：US13292903

申请日：2011-11-09

申请人： Goran Nadezda Jovanovic ,  Sundar V. Atre ,  Brian Kevin Paul ,  Vincent Thomas Remcho ,  Chih-hung Chang

发明人： Goran Nadezda Jovanovic ,  Sundar V. Atre ,  Brian Kevin Paul ,  Vincent Thomas Remcho ,  Chih-hung Chang

IPC分类号： B01D63/00 ,  B01D61/00 ,  C02F1/44

CPC分类号： B01D61/18 ,  A61M1/16 ,  A61M1/1698 ,  A61M1/3472 ,  A61M2205/3334 ,  A61M2205/3368 ,  A61M2205/50 ,  B01D63/08 ,  B01D63/088 ,  B01D71/10 ,  B01D71/68 ,  B01D2313/21 ,  B01D2313/38

摘要： The present disclosure describes devices useful for microscale fluid purification, separation, and synthesis. Such devices generally comprise a fluid membrane that separates two or more fluids flowing through plural microchannels operatively associated with the membrane. Often, the membrane is a semipermeable membrane, such as might be used with a filtration device, such as a dialyzer. Devices of the present invention can be combined with other microscale devices to make systems. For example, the devices may be coupled with one or more microchemical microfactories, one or more micromixers, one or more microheaters, etc. Examples of devices made according to the present invention included an oxygenator, a dialyzer, microheat exchangers, etc.

摘要翻译： 本公开描述了可用于微量流体纯化，分离和合成的装置。 这种装置通常包括流体膜，其分离流过与膜操作性相关联的多个微通道的两个或更多个流体。 通常，膜是半透膜，例如可以与过滤装置如透析器一起使用。 本发明的装置可以与其他微型装置组合以制造系统。 例如，这些装置可以与一个或多个微化学微生物，一个或多个微混合器，一个或多个微量加热器等连接。根据本发明制造的装置的实例包括氧合器，透析器，微热交换器等。

公开(公告)号：US07947827B2

公开(公告)日：2011-05-24

申请号：US11825146

申请日：2007-07-02

申请人： George S. Bailey, Jr. ,  Carole Jubert

发明人： George S. Bailey, Jr. ,  Carole Jubert

IPC分类号： C07B47/00 ,  C07D487/22

CPC分类号： A61K31/555 ,  C07D487/22

摘要： Pharmaceutical formulation for the prophylaxis, pretreatment and treatment of a poisoning caused by exposure to (either singly or as a mixture of agents) organophosphorus cholinesterase inhibitors, vesicating agents, polycyclic aromatic hydrocarbons, and aflatoxin B1. This invention is characterized by active substance comprised of a metaloporphyrin molecule with an associated metal moiety (Cu, Mg) of suitable purity and chemical composition to provide a bioavailable oral dosage form to attain predictable concentrations in target tissues and bodily fluids (plasma, bronchial secretions, etc.) sufficient to counteract the effects of toxic substances through chemical complexation or catalysis of toxin degradation. Although these metaloporphyrins are semisynthetic products of chlorophyll, the preferred starting material is chlorophyll a (Chla) extracted and purified from Spirulina pacifica or other sources. A specific method is invented to achieve a critical combination of purity and yield beyond those currently available.

摘要翻译： 用于预防，预处理和治疗由暴露于（单独或作为混合物）的有机磷胆碱酯酶抑制剂，泡沫剂，多环芳烃和黄曲霉毒素B1引起的中毒的药物制剂。 本发明的特征在于活性物质由具有适当纯度和化学组成的相关金属部分（Cu，Mg）的金属卟啉分子组成，以提供生物可利用的口服剂型，以在靶组织和体液（血浆，支气管分泌物）中获得可预测的浓度 等）足以通过化学络合或催化毒素降解来抵消有毒物质的影响。 虽然这些金属卟啉是叶绿素的半合成产物，但优选的起始物质是从螺旋藻或其他来源提取和纯化的叶绿素a（Chla）。 发明了一种具体的方法来实现超过目前可获得的纯度和产量的关键组合。

公开(公告)号：US07746452B2

公开(公告)日：2010-06-29

申请号：US12089902

申请日：2006-11-21

申请人： Leslie H. Fuchigami ,  Pinghai Ding ,  Guy E. Barnes, Jr.

发明人： Leslie H. Fuchigami ,  Pinghai Ding ,  Guy E. Barnes, Jr.

IPC分类号： G01N21/00

CPC分类号： G01N21/3151 ,  G01N2001/021

摘要： Methods for determining chlorophyll content comprise providing a sample, subjecting the sample to light at a first wavelength and detecting a first wavelength response, subjecting the sample to light at a second wavelength and detecting a second wavelength response, and calculating a chlorophyll content of the sample based on at least the first wavelength response and the second wavelength response. Optional approaches include detecting the nitrogen content and/or water content of the sample. Associated apparatus for determining chlorophyll content, which may comprise a handheld device, is also disclosed.

摘要翻译： 用于测定叶绿素含量的方法包括提供样品，使样品以第一波长的光照射并检测第一波长响应，使样品以第二波长发光并检测第二波长响应，并计算样品的叶绿素含量 基于至少第一波长响应和第二波长响应。 可选方法包括检测样品的氮含量和/或水含量。 还公开了用于确定可能包括手持设备的叶绿素含量的相关装置。

公开(公告)号：US07534377B2

公开(公告)日：2009-05-19

申请号：US10520364

申请日：2003-07-14

申请人： Douglas A. Keszler ,  Jennifer L. Stone-Sundberg ,  Ning Ye ,  Michael A. Hruschka

发明人： Douglas A. Keszler ,  Jennifer L. Stone-Sundberg ,  Ning Ye ,  Michael A. Hruschka

IPC分类号： G02B5/30 ,  G02F1/355 ,  C01F17/00 ,  C01B35/12 ,  H01S3/10 ,  G02F3/02 ,  H01S3/30

CPC分类号： C30B29/22 ,  C01B35/12 ,  C30B9/00 ,  C30B29/10 ,  G02F1/3551

摘要： Novel nonlinear optical materials are described having the general formula MxM′yScz(BO3)4 where M and M′are metals, typically rare earth metals, and the sum of x, y, and z is about four. One example of such a material is La0.7Y0.3Sc3(BO3)4. Exemplary crystalline materials according to the general formula exhibit useful optical characteristics and desirable physical properties for nonlinear optical applications. Novel compositions and devices using the nonlinear optical materials also are described.

摘要翻译： 描述了具有通式MxM'yScz（BO3）4的新型非线性光学材料，其中M和M'为金属，通常为稀土金属，x，y和z之和为约4。 这种材料的一个例子是La0.7Y0.3Sc3（BO3）4。 根据通式的典型结晶材料对于非线性光学应用显示出有用的光学特性和期望的物理性质。 还描述了使用非线性光学材料的新型组合物和装置。

公开(公告)号：US07507380B2

公开(公告)日：2009-03-24

申请号：US11086074

申请日：2005-03-21

申请人： Chih-Hung Chang ,  Brian Kevin Paul ,  Vincent Thomas Remcho

发明人： Chih-Hung Chang ,  Brian Kevin Paul ,  Vincent Thomas Remcho

IPC分类号： B01J8/00 ,  B01J10/00 ,  B32B3/20 ,  B32B3/12

CPC分类号： B01F5/0475 ,  B01F5/0485 ,  B01F13/0062 ,  B01F13/0066 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00833 ,  B01J2219/00844 ,  B01J2219/00853 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00912 ,  B01J2219/00914 ,  B01J2219/00916 ,  B01J2219/0097 ,  B01J2219/00972 ,  C08G83/003 ,  F28F2210/02 ,  Y10T428/24562 ,  Y10T428/24612 ,  Y10T428/24661 ,  Y10T428/24744

摘要： Embodiments of an apparatus, system, and method for chemical synthesis and/or analysis are disclosed. One embodiment of a disclosed apparatus comprises a laminated, microfluidic structure defining a reactor and a separator. Such apparatuses, or portions thereof, generally have dimensions ranging from about 1 micrometer to about 100 micrometers. To implement synthetic processes, disclosed embodiments of the apparatus generally include at least one valve, and often plural, selectively actuatable valves. Detectors, including optical detectors, also can be used to detect product and other materials as they flow by, or are otherwise presented to, the detector. Individual apparatuses may be coupled both in series and in parallel to form a system for making chemical compounds. The apparatus is particularly useful for making compounds requiring iterative reaction schemes, and further can be used to make compounds having morphological structures that resemble the morphology of the apparatus itself, such as dendrimers.

摘要翻译： 公开了用于化学合成和/或分析的装置，系统和方法的实施例。 公开的装置的一个实施例包括限定反应器和分离器的层压的微流体结构。 这种装置或其部分通常具有约1微米至约100微米的尺寸。 为了实现合成过程，所公开的设备的实施例通常包括至少一个阀，并且通常是多个可选择性致动的阀。 检测器，包括光学检测器，也可用于检测产品和其他材料，因为它们流过或以其他方式呈现给检测器。 单个装置可以串联耦合并联，以形成用于制备化合物的系统。 该装置对于制备需要迭代反应方案的化合物特别有用，并且还可用于制备具有类似于装置本身形态的形态结构的化合物，例如树枝状大分子。

公开(公告)号：US06951714B2

公开(公告)日：2005-10-04

申请号：US10053243

申请日：2002-01-16

申请人： Stephen Giovannoni ,  Stephanie Connon

发明人： Stephen Giovannoni ,  Stephanie Connon

IPC分类号： C12M1/00 ,  C12N1/00 ,  C12N1/20 ,  C12Q1/02 ,  C12Q1/00 ,  C12P19/34 ,  C12Q1/04 ,  C12Q1/68 ,  C07H21/0204

CPC分类号： C12N1/20

摘要： Methods for isolating microbial species, particularly previously uncultured species, from non-laboratory source environments (such as soil, freshwater, seawater, etc.) are disclosed. These methods can include the use of cultures in arrays, and cells deposited on solid surfaces in arrays for detection, and flow cytometry and/or cell sorting and/or dilution cultures.

摘要翻译： 公开了从非实验室源环境（如土壤，淡水，海水等）分离微生物物种，特别是以前未培养的物种的方法。 这些方法可以包括使用阵列中的培养物，以及沉积在用于检测的阵列中的固体表面上的细胞，以及流式细胞术和/或细胞分选和/或稀释培养物。

公开(公告)号：US06906188B2

公开(公告)日：2005-06-14

申请号：US10354694

申请日：2003-01-29

申请人： James David White ,  Kurt Frederick Sundermann ,  Rich Garrett Carter

发明人： James David White ,  Kurt Frederick Sundermann ,  Rich Garrett Carter

IPC分类号： C07D277/20 ,  C07D417/06 ,  C07D225/02 ,  C07D321/00 ,  C07D327/02 ,  C07D411/06

CPC分类号： C07D277/20 ,  C07D417/06

摘要： A method for making epothilones and epothilone analogs is described, as are novel compounds made by the method. Exemplary novel compounds include those according to the formula: With respect the formula, G is selected from the group consisting of R2 substituents independently are selected from the group consisting of H and lower alkyl groups; Z is selected from the group consisting of the halogens and —CN; M is selected from the group consisting of O and NR3; R3 is selected from the group consisting of H, lower alkyl, R4CO, R4OCO, and R4SO2; R4 is selected from the group consisting of H, lower alkyl, and aryl; T is selected from the group consisting of CH2, CO, HCOH and protected derivatives thereof; W is H or OR; and X and Y independently are selected from the group consisting of O, NH, S, CO, and C. Embodiments of the method provide convenient access to analogs of the epothilones, such as those having alternate stereochemistry and those containing an ester, amide, thioester, or alkyne moieties in the macrocycle.

摘要翻译： 描述了制备埃坡霉素和埃坡霉素类似物的方法，以及通过该方法制备的新型化合物。 示例性的新化合物包括根据下式的化合物：关于式，G选自R 2 2取代基，独立地选自H和低级烷基; Z选自卤素和-CN; M选自O和NR 3; R 3选自H，低级烷基，R 4 CO，R 4 OCO和R 4， / SO 2 SO 2; R 4选自H，低级烷基和芳基; T选自CH 2 CO，HCOH及其被保护的衍生物; W为H或OR; X和Y独立地选自O，NH，S，CO和C.这些方法的实施方案提供方便地获得埃坡霉素的类似物，例如具有交替立体化学的那些类似物，以及含有酯，酰胺， 硫代酯或炔烃部分。

公开(公告)号：US5433778A

公开(公告)日：1995-07-18

申请号：US241263

申请日：1994-05-11

申请人： Arthur W. Sleight

发明人： Arthur W. Sleight

IPC分类号： C01B25/45 ,  C04B35/447 ,  C01G28/02

CPC分类号： C01B25/45 ,  C04B35/447

摘要： Compounds that satisfy the general formula A.sub.1-Y.sup.4+ A.sub.Y.sup.1+ A.sub.Y.sup.3+ V.sub.2-X E.sub.X O.sub.7 exhibit isotropic NTE behavior above a temperature of about 100.degree. C. Y is from about 0.0 to about 0.4, and more preferably is about 0.2. X is from about 0.6 to about 1.4, and is more preferably about 1. Particularly suitable NTE compounds have X about 1 and Y about 0. A.sup.4+ is selected from the group consisting of Hf, Zr, Zr.sub.a M.sub.b, Hf.sub.a M.sub.b and mixtures thereof wherein a plus b equals one and M is selected from the group consisting of Ti, Ce, Th, U, Mo, W, Pb, Sn, Ge and Si. More preferably, A.sup.4+ is selected from the group consisting of Hf and Zr. A.sup.1+ is selected from the group consisting of the alkali earth metals, A.sup.3+ is selected from the group consisting of the rare earth metals, and E is selected from the group consisting of P and As. The NTE materials may be incorporated into compositions such as epoxy and ceramic compositions.

摘要翻译： 满足通式A1-Y4 + AY1 + AY3 + V2-XEXO7的化合物在约100℃的温度下表现出各向同性的NTE行为.Y为约0.0至约0.4，更优选为约0.2。 X为约0.6至约1.4，更优选为约1.特别合适的NTE化合物具有X约1且Y约为0. A4 +选自Hf，Zr，ZraMb，HfaMb及其混合物，其中加号 b等于1，M选自Ti，Ce，Th，U，Mo，W，Pb，Sn，Ge和Si。 更优选地，A4 +选自Hf和Zr。 A1 +选自碱土金属，A3 +选自稀土金属，E选自P和As。 NTE材料可以掺入到诸如环氧树脂和陶瓷组合物的组合物中。

公开(公告)号：US5340983A

公开(公告)日：1994-08-23

申请号：US884705

申请日：1992-05-18

申请人： Max L. Deinzer ,  James A. Laramee

发明人： Max L. Deinzer ,  James A. Laramee

IPC分类号： G01N23/225 ,  G01N27/62 ,  H01J27/20 ,  H01J37/08 ,  H01J49/14

CPC分类号： H01J49/147

摘要： Methods and apparatuses are disclosed for mass-analysis of a sample for particular analytes of interest. An electron monochromator is coupled to any of a number of different types of mass analyzer and used to generate slow electrons used to produce ions of target molecules for mass analysis. The electrons have a narrow energy bandwidth and high intensity, even at nearly zero kinetic energy levels. The median energy level of the electrons can be preset, permitting selection of specific target molecules to be ionized. Both positive and negative-ion mass analysis can be performed. Electron-capture negative-ion mass spectrometry is particularly enhanced, with a sensitivity about three orders of magnitude greater than in results obtained using conventional negative-ion equipment. Also, a buffer gas is eliminated, allowing substantial reductions in negative-ion equipment size, weight, and energy consumption. The mass analyzer can be an ion trap, making possible sensitive analysis of low concentrations of chemical analytes, such as environmental contaminants, using a hand-held instrument. Multiple mass analyzers, or combinations of a mass analyzer with other analytical instruments such a gas chromatograph, can be coupled to the electron monochromator.

摘要翻译： 公开了用于对特定分析物感兴趣的样品进行质量分析的方法和装置。 电子单色仪耦合到多种不同类型的质量分析仪中的任何一种，并用于产生用于产生靶分子离子的慢电子进行质量分析。 电子具有窄的能量带宽和高强度，即使在几乎零的动能水平。 可以预设电子的中值能级，允许选择要离子化的特定靶分子。 可以进行正负离子质量分析。 电子捕获负离子质谱特别增强，其灵敏度比使用常规负离子设备获得的结果大约三个数量级。 此外，消除了缓冲气体，从而大大减少了负离子设备的尺寸，重量和能量消耗。 质量分析仪可以是离子阱，可以使用手持式仪器对低浓度化学分析物（如环境污染物）进行敏感分析。 多个质量分析器或质谱仪与其他分析仪器如气相色谱仪的组合可以耦合到电子单色仪。